Thomas J Kodadek

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc No Splicing, no dicing: non-proteolytic roles of the ubiquitin-proteasome system in transcription
    Thomas Kodadek
    Department of Chemistry, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA
    J Biol Chem 285:2221-6. 2010
  2. pmc Solid-phase synthesis of peptoid-like oligomers containing diverse diketopiperazine units
    Sujit Suwal
    Department of Chemistry and Cancer Biology, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
    Org Biomol Chem 12:5831-4. 2014
  3. pmc The hydrophobic patch of ubiquitin is required to protect transactivator-promoter complexes from destabilization by the proteasomal ATPases
    Chase T Archer
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9185, USA
    Nucleic Acids Res 38:789-96. 2010
  4. pmc Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates
    Jiyong Lee
    Division of Translational Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Chem Biol 6:258-60. 2010
  5. ncbi request reprint A jack of all trades to combat drug-resistant Gram-negative bacteria
    Thomas Kodadek
    Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA Department of Cancer Biology, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA Electronic address
    Chem Biol 20:1202-3. 2013
  6. doi request reprint Synthesis of libraries of peptidomimetic compounds containing a 2-oxopiperazine unit in the main chain
    Sujit Suwal
    Department of Chemistry, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458, USA
    Org Biomol Chem 11:2088-92. 2013
  7. pmc Chemistry and biology of orexin signaling
    Thomas Kodadek
    Departments of Chemistry and Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA
    Mol Biosyst 6:1366-75. 2010
  8. pmc Synthetic receptors with antibody-like binding affinities
    Thomas Kodadek
    Departments of Chemistry and Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA
    Curr Opin Chem Biol 14:713-20. 2010
  9. doi request reprint The rise, fall and reinvention of combinatorial chemistry
    Thomas Kodadek
    Department of Chemistry, The Scripps Research Institute, Scripps Florida, FL 33458, USA
    Chem Commun (Camb) 47:9757-63. 2011
  10. pmc Development of antibody surrogates for the treatment of cancers and autoimmune disease
    Thomas Kodadek
    Department of Chemistry, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA
    Curr Opin Chem Biol 14:721-7. 2010

Research Grants

  1. Post-translational modification of activators
    Thomas Kodadek; Fiscal Year: 2005
  2. New Chemistry for Analysis of Multi-protein complexes
    Thomas Kodadek; Fiscal Year: 2005
  3. Post-translational modification of activators
    Thomas Kodadek; Fiscal Year: 2004
  4. Role of the APIS Complex In Pol II Transcription
    Thomas Kodadek; Fiscal Year: 2004
  5. Chemical Inhibitors of the Proteasomal ATPases
    Thomas J Kodadek; Fiscal Year: 2010
  6. New Chemistry for Analysis of Multi-protein complexes
    Thomas Kodadek; Fiscal Year: 2003
  7. NEW CHEMISTRY FOR THE STUDY OF MULTIPROTEIN COMPLEXES
    Thomas Kodadek; Fiscal Year: 2000
  8. NEW CHEMISTRY FOR THE STUDY OF MULTIPROTEIN COMPLEXES
    Thomas Kodadek; Fiscal Year: 1999
  9. Role of the APIS Complex In Pol II Transcription
    Thomas Kodadek; Fiscal Year: 2002
  10. New Chemistry for Analysis of Multi-protein complexes
    Thomas Kodadek; Fiscal Year: 2002

Collaborators

  • Anna E Speers
  • Kristi D Lynn
  • Sujit Suwal
  • Xiaodan Liu
  • Bani Kanta Sarma
  • Chase T Archer
  • Jiyong Lee
  • Benjamin F Cravatt
  • Melissa Dix
  • Andrea M Zuhl
  • Daniel A Bachovchin
  • Muhammed Yousufuddin
  • Hyun Suk Lim
  • D Gomika Udugamasooriya

Detail Information

Publications13

  1. pmc No Splicing, no dicing: non-proteolytic roles of the ubiquitin-proteasome system in transcription
    Thomas Kodadek
    Department of Chemistry, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA
    J Biol Chem 285:2221-6. 2010
    ..These various non-proteolytic roles of the UPP in transcription are reviewed here, and plausible mechanistic models are discussed...
  2. pmc Solid-phase synthesis of peptoid-like oligomers containing diverse diketopiperazine units
    Sujit Suwal
    Department of Chemistry and Cancer Biology, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
    Org Biomol Chem 12:5831-4. 2014
    ..Diketopiperazine (DKP) units are found in many bioactive small molecules. Here we report facile chemistry for incorporating diverse DKP units within peptoid and peptoid-like libraries made by solid-phase split and pool synthesis. ..
  3. pmc The hydrophobic patch of ubiquitin is required to protect transactivator-promoter complexes from destabilization by the proteasomal ATPases
    Chase T Archer
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9185, USA
    Nucleic Acids Res 38:789-96. 2010
    ..Together, these data implicate the hydrophobic patch of ubiquitin as required to protect transactivators from destabilization by the proteasomal ATPases...
  4. pmc Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates
    Jiyong Lee
    Division of Translational Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Chem Biol 6:258-60. 2010
    ....
  5. ncbi request reprint A jack of all trades to combat drug-resistant Gram-negative bacteria
    Thomas Kodadek
    Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA Department of Cancer Biology, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA Electronic address
    Chem Biol 20:1202-3. 2013
    ..They demonstrate that the molecule has effects on many aspects of bacterial metabolism and also modulates host immune responses. ..
  6. doi request reprint Synthesis of libraries of peptidomimetic compounds containing a 2-oxopiperazine unit in the main chain
    Sujit Suwal
    Department of Chemistry, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458, USA
    Org Biomol Chem 11:2088-92. 2013
    ..This modified sub-monomer synthesis is suitable for the creation of high quality combinatorial libraries...
  7. pmc Chemistry and biology of orexin signaling
    Thomas Kodadek
    Departments of Chemistry and Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA
    Mol Biosyst 6:1366-75. 2010
    ..This review provides an overview of recent development in deciphering the biology of orexin signaling as well as efforts to manipulate orexin signaling pharmacologically...
  8. pmc Synthetic receptors with antibody-like binding affinities
    Thomas Kodadek
    Departments of Chemistry and Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA
    Curr Opin Chem Biol 14:713-20. 2010
    ..However, significant efforts are underway to develop a new generation of protein ligands with improved properties. This article reviews progress towards this goal and suggests fruitful strategies for future research...
  9. doi request reprint The rise, fall and reinvention of combinatorial chemistry
    Thomas Kodadek
    Department of Chemistry, The Scripps Research Institute, Scripps Florida, FL 33458, USA
    Chem Commun (Camb) 47:9757-63. 2011
    ..Meeting these challenges will not be easy. Here I review some recent advances in this area and provide some thoughts on likely important developments in the next few years...
  10. pmc Development of antibody surrogates for the treatment of cancers and autoimmune disease
    Thomas Kodadek
    Department of Chemistry, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA
    Curr Opin Chem Biol 14:721-7. 2010
    ..There is considerable interest in developing small-molecule therapeutics that utilize this mechanism of action and so act as a kind of antibody surrogate. Progress and challenges in this interesting field are reviewed here...
  11. pmc Rapid development of a potent photo-triggered inhibitor of the serine hydrolase RBBP9
    Xiaodan Liu
    Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
    Chembiochem 13:2082-93. 2012
    ..This technology provides rapid access to photo-activated tool compounds capable of selectively blocking the function of particular serine hydrolases...
  12. pmc GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer
    Kristi D Lynn
    Division of Surgical Oncology, Department of Surgery, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 76259, USA
    BMC Cancer 10:397. 2010
    ..We have reported previously the development of an antagonistic VEGFR2 peptoid (GU40C4) that has promising anti-angiogenic activity in vitro and in vivo...
  13. pmc Acyl hydrazides as peptoid sub-monomers
    Bani Kanta Sarma
    Department of Chemistry, Scripps Research Institute, Scripps Florida, 130 Scripps Way, 3A2, Jupiter, FL 33458, USA
    Chem Commun (Camb) 47:10590-2. 2011
    ..A high-quality one bead one compound library of tetramers was made by split and pool synthesis and we found that the identity of the molecule on a single bead could be determined by tandem MALDI mass spectrometry...

Research Grants20

  1. Post-translational modification of activators
    Thomas Kodadek; Fiscal Year: 2005
    ..We anticipate that these studies will emerge as a paradigm for understanding an important new aspect of the activity of a large percentage of gene-specific transcription factors. ..
  2. New Chemistry for Analysis of Multi-protein complexes
    Thomas Kodadek; Fiscal Year: 2005
    ..Finally, a new aspect application of this oxidative chemistry is proposed: the development of a general method by which to identify the protein target(s) of bioactive small molecules. ..
  3. Post-translational modification of activators
    Thomas Kodadek; Fiscal Year: 2004
    ..We anticipate that these studies will emerge as a paradigm for understanding an important new aspect of the activity of a large percentage of gene-specific transcription factors. ..
  4. Role of the APIS Complex In Pol II Transcription
    Thomas Kodadek; Fiscal Year: 2004
    ..It is anticipated that these experiments will shed important new light on this new and exciting aspect of transcription enzymology. ..
  5. Chemical Inhibitors of the Proteasomal ATPases
    Thomas J Kodadek; Fiscal Year: 2010
    ..Future experiments would also include testing their activity in various mouse models of cancer. ..
  6. New Chemistry for Analysis of Multi-protein complexes
    Thomas Kodadek; Fiscal Year: 2003
    ..Finally, a new aspect application of this oxidative chemistry is proposed: the development of a general method by which to identify the protein target(s) of bioactive small molecules. ..
  7. NEW CHEMISTRY FOR THE STUDY OF MULTIPROTEIN COMPLEXES
    Thomas Kodadek; Fiscal Year: 2000
    ..Multiprotein complexes mediate essentially all processes that are thought to lead to cancer when they malfunction, including the decoding of genetic information and regulation of the cell cycle. ..
  8. NEW CHEMISTRY FOR THE STUDY OF MULTIPROTEIN COMPLEXES
    Thomas Kodadek; Fiscal Year: 1999
    ..Multiprotein complexes mediate essentially all processes that are thought to lead to cancer when they malfunction, including the decoding of genetic information and regulation of the cell cycle. ..
  9. Role of the APIS Complex In Pol II Transcription
    Thomas Kodadek; Fiscal Year: 2002
    ..It is anticipated that these experiments will shed important new light on this new and exciting aspect of transcription enzymology. ..
  10. New Chemistry for Analysis of Multi-protein complexes
    Thomas Kodadek; Fiscal Year: 2002
    ..Finally, a new aspect application of this oxidative chemistry is proposed: the development of a general method by which to identify the protein target(s) of bioactive small molecules. ..
  11. Chemical Inhibitors of the Proteasomal ATPases
    Thomas Kodadek; Fiscal Year: 2009
    ..Future experiments would also include testing their activity in various mouse models of cancer. ..
  12. Post-translational modification of activators
    Thomas Kodadek; Fiscal Year: 2007
    ..We anticipate that these studies will emerge as a paradigm for understanding an important new aspect of the activity of a large percentage of gene-specific transcription factors. ..
  13. Post-translational modification of activators
    Thomas Kodadek; Fiscal Year: 2006
    ..We anticipate that these studies will emerge as a paradigm for understanding an important new aspect of the activity of a large percentage of gene-specific transcription factors. ..
  14. BASIC AND APPLIED STUDIES OF PEPTIDE-PEPTIDE COMPLEXES
    Thomas Kodadek; Fiscal Year: 2003
    ..These studies will hopefully lead to a better understanding of how one would design peptide receptors de novo that are able to function in aqueous solution. ..
  15. BASIC AND APPLIED STUDIES OF PEPTIDE-PEPTIDE COMPLEXES
    Thomas Kodadek; Fiscal Year: 2001
    ..These studies will hopefully lead to a better understanding of how one would design peptide receptors de novo that are able to function in aqueous solution. ..
  16. BASIC AND APPLIED STUDIES OF PEPTIDE-PEPTIDE COMPLEXES
    Thomas Kodadek; Fiscal Year: 2002
    ..These studies will hopefully lead to a better understanding of how one would design peptide receptors de novo that are able to function in aqueous solution. ..
  17. Role of the APIS Complex In Pol II Transcription
    Thomas Kodadek; Fiscal Year: 2003
    ..It is anticipated that these experiments will shed important new light on this new and exciting aspect of transcription enzymology. ..
  18. New Chemistry for Analysis of Multi-protein complexes
    Thomas Kodadek; Fiscal Year: 2004
    ..Finally, a new aspect application of this oxidative chemistry is proposed: the development of a general method by which to identify the protein target(s) of bioactive small molecules. ..