Research Topics
Genomes and GenesSpecies | Richard T KloosSummaryAffiliation: The Ohio State University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Thyroid cancer recurrence in patients clinically free of disease with undetectable or very low serum thyroglobulin valuesRichard T Kloos
Department of Internal Medicine, The Ohio State University Medical Center, 446 McCampbell Hall, 1581 Dodd Drive, Columbus, Ohio 43210, USA
J Clin Endocrinol Metab 95:5241-8. 2010..This was a retrospective clinical study...- Approach to the patient with a positive serum thyroglobulin and a negative radioiodine scan after initial therapy for differentiated thyroid cancerRichard T Kloos
The Ohio State University, 446 McCampbell Hall, 1581 Dodd Drive, Columbus, OH 43210 1296, USA
J Clin Endocrinol Metab 93:1519-25. 2008..Here a case is presented that adds the complexity of advanced age, and one approach to these challenging patients is offered... - Medullary thyroid cancer: management guidelines of the American Thyroid AssociationRichard T Kloos
Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, The Arthur G James Cancer Hospital, Columbus, Ohio 43210, USA
Thyroid 19:565-612. 2009.... 
Phase II clinical trial of sorafenib in metastatic medullary thyroid cancerElaine T Lam
Departments of Internal Medicine, Center for Biostatistics, The Ohio State University, Columbus, OH, USA
J Clin Oncol 28:2323-30. 2010..Sorafenib, a multikinase inhibitor targeting Ret and VEGFR, showed antitumor activity in preclinical studies of MTC...- MicroRNA signature in thyroid fine needle aspiration cytology applied to "atypia of undetermined significance" casesRulong Shen
Department of Pathology, Arthur G James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
Thyroid 22:9-16. 2012..We selected eight miRs (miR-146b, -221, -187, -197, -346, -30d, -138, and -302c) to examine the potential use of miRs to supplement diagnostic cytology in cases designated as "atypia of undetermined significance.".. 
Expression of sodium iodide symporter in the lacrimal drainage system: implication for the mechanism underlying nasolacrimal duct obstruction in I(131)-treated patientsKenneth E Morgenstern
Department of Ophthalmology, Division of Oculoplastic Surgery, The Ohio State University, Columbus, OH, USA
Ophthal Plast Reconstr Surg 21:337-44. 2005..We hypothesized that NIS is expressed in the lacrimal sac and nasolacrimal duct and that active accumulation of I(131) is responsible for the clinical observations seen in these patients...- Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumorsManju L Prasad
Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, USA
Mod Pathol 18:48-57. 2005..An immunohistochemical panel consisting of GAL3, FN1 and HBME1 may be useful in the diagnosis of follicular cell-derived thyroid tumors... - PET imaging in differentiated thyroid cancer: where does it fit and how do we use it?Nathan C Hall
Division of Nuclear Medicine, The Ohio State University, The Arthur G James Cancer Hospital and Richard J Solove Research Center, Columbus, Ohio 43210 1296, USA
Arq Bras Endocrinol Metabol 51:793-805. 2007..This article reviews the utility and limitations of FDG-PET in DTC management, and offers practical recommendations... - Micro-single-photon emission computed tomography image acquisition and quantification of sodium-iodide symporter-mediated radionuclide accumulation in mouse thyroid and salivary glandsMichael P Brandt
Molecular, Cellular, and Developmental Biology Graduate Program, Department of Physiology and Cell Biology, The Ohio State University, 1645 Neil Ave, Columbus, OH 43210, USA
Thyroid 22:617-24. 2012..In this study, we investigated the effects of region-of-interest (ROI) selection, collimation, scan time, and imaging orbit on image acquisition and quantification of thyroidal and salivary radionuclide accumulation in mice... - Variable expression of coxsackie-adenovirus receptor in thyroid tumors: implications for adenoviral gene therapyDerek K Marsee
Medical Scientist Program, The Ohio State University, Columbus, Ohio, USA
Thyroid 15:977-87. 2005..Our study warrants a functional method to evaluate adenoviral infectivity should be developed and instituted prior to clinical trials of adenoviral gene therapy in patients with advanced thyroid cancer... - Lack of therapeutic effect of the histone deacetylase inhibitor vorinostat in patients with metastatic radioiodine-refractory thyroid carcinomaJennifer A Woyach
Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
J Clin Endocrinol Metab 94:164-70. 2009..This phase II study was undertaken to assess objective response to vorinostat in patients with advanced thyroid cancer... - A single recombinant human thyrotropin-stimulated serum thyroglobulin measurement predicts differentiated thyroid carcinoma metastases three to five years laterRichard T Kloos
Division of Endocrinology, Shands Hospital, 1600 SW Archer Road, P.O. Box 100226, Gainesville, Florida 32610-0226, USA
J Clin Endocrinol Metab 90:5047-57. 2005..1 mIU/liter and frequent imaging and TSH-stimulated Tg testing are unnecessary... - The role of microRNA genes in papillary thyroid carcinomaHuiling He
Human Cancer Genetics Program, Department of Pathology, Ohio State University, Columbus, OH 43210, USA
Proc Natl Acad Sci U S A 102:19075-80. 2005..We conclude that up-regulation of several miRs and regulation of KIT are involved in PTC pathogenesis, and that sequence changes in genes targeted by miRNAs can contribute to their regulation... - Papillary thyroid cancer: medical management and follow-upRichard T Kloos
The Ohio State University, 446 McCampbell Hall, 1581 Dodd Drive, Columbus, OH 43210 1296, USA
Curr Treat Options Oncol 6:323-38. 2005.... - Application of the Cre/loxP system to enhance thyroid-targeted expression of sodium/iodide symporterXiaoqin Lin
Department of Physiology and Cell Biology, Ohio State University, Columbus, Ohio 43210, USA
J Clin Endocrinol Metab 89:2344-50. 2004..Finally, Tg promoter activity was partially restored in malignant thyroid cells by forced expression of the paired domain-containing transcription factor (Pax-8), allowing the Cre/loxP system to mildly enhance radioiodide uptake... - Long-term efficacy of lymph node reoperation for persistent papillary thyroid cancerOsama Al-Saif
Department of Surgery, The Ohio State University, Columbus, Ohio 43210, USA
J Clin Endocrinol Metab 95:2187-94. 2010..The objective of the study was to determine the outcome of surgical resection of metastatic papillary thyroid cancer (PTC) in cervical lymph nodes after failure of initial surgery and I(131) therapy... - The relationship between body mass index and thyroid cancer pathology features and outcomes: a clinicopathological cohort studyJohn E Paes
Divisions of Endocrinology, Diabetes, and Metabolism, The Ohio State University College of Medicine and Arthur G James Comprehensive Cancer Center, Columbus, Ohio 43235, USA
J Clin Endocrinol Metab 95:4244-50. 2010..We hypothesized that a higher body mass index (BMI) would be associated with aggressive thyroid cancer features and a higher incidence of persistent/recurrent disease... - Frequency of germline PTEN mutations in differentiated thyroid cancerRebecca Nagy
Division of Human Genetics, The Ohio State University Medical Center and Comprehensive Cancer Center, Columbus, Ohio 43240, USA
Thyroid 21:505-10. 2011..These results suggest that by adding head circumference to the clinical assessment, thyroid cancer specialists can more effectively identify patients needing referral for cancer genetic services... - Phase II trial of sorafenib in metastatic thyroid cancerRichard T Kloos
Ohio State University, Department of Internal Medicine, Molecular Virology, Immunology, and Genetics, Pathology, Radiology, Center for Biostatistics, Ohio State University, Columbus, OH 43210, USA
J Clin Oncol 27:1675-84. 2009..Based on the pivotal role of Ras-Raf-MAP-ERK signaling and vascular endothelial growth factor (VEGF) in papillary thyroid cancer (PTC), we conducted a phase II clinical trial of sorafenib targeting RAF and VEGF receptor kinases in PTC... - Telomere length and telomerase reverse transcriptase gene copy number in patients with papillary thyroid carcinomaJaroslaw Jendrzejewski
Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, 804 Biomedical Research Tower 460 West 12th Avenue Columbus, Ohio 43210, USA
J Clin Endocrinol Metab 96:E1876-80. 2011..However, one study reported that telomeres were markedly shorter and the telomerase reverse transcriptase (TERT) gene was amplified and up-regulated in germline DNA from patients with fPTC compared with sPTC... - Is diagnostic iodine-131 scanning with recombinant human TSH useful in the follow-up of differentiated thyroid cancer after thyroid ablation?Ernest L Mazzaferri
Department of Internal Medicine, University of Florida, Gainesville 32608 4653, USA
J Clin Endocrinol Metab 87:1490-8. 2002..An elevated rhTSH-stimulated Tg greater than 2 ng/ml warrants further study... - Single photon emission computed tomography imaging for temporal dynamics of thyroidal and salivary radionuclide accumulation in 17-allyamino-17-demothoxygeldanamycin-treated thyroid cancer mouse modelYu Yu Liu
The Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, USA
Endocr Relat Cancer 18:27-37. 2011..Finally, the effect of 17-allyamino-17-demothoxygeldanamycin on increasing thyroidal, but not salivary, radioiodine accumulation was validated in both WT mice and Tg-PTC1 preclinical thyroid cancer mouse model... - In thyroidectomized patients with thyroid cancer, a serum thyrotropin of 30 μU/mL after thyroxine withdrawal is not always adequate for detecting an elevated stimulated serum thyroglobulinLaticia A Valle
Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA
Thyroid 23:185-93. 2013.... - Anaplastic thyroid cancerRyan L Neff
Department of Surgery, Division of Surgical Oncology, The Ohio State University, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, Columbus, OH 43210 1228, USA
Endocrinol Metab Clin North Am 37:525-38, xi. 2008..Enrollment in meaningful clinical trials should be given the highest priority at all decision points... - Allelic variation in gene expression in thyroid tissueHuiling He
Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio 43210, USA
Thyroid 15:660-7. 2005..DUOX1 variation in expression was seen in 3 of 13 patients with PTC and 6 of 27 patients with benign disease. Further studies are needed to determine the significance of these and other allelic variations... - Phase II study of celecoxib in metastatic differentiated thyroid carcinomaEwa Mrozek
Division of Hematology, Departments of Internal Medicine, The Ohio State University Thyroid Cancer Unit, The Ohio State University Medical Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, Ohio 43210, USA
J Clin Endocrinol Metab 91:2201-4. 2006..The patient with partial response was on therapy along with seven other patients when the study was terminated. CONCLUSIONS: Celecoxib 400 mg orally twice per day fails to halt progressive metastatic DTC in most patients... - Nasolacrimal drainage system obstruction from radioactive iodine therapy for thyroid carcinomaRichard T Kloos
Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
J Clin Endocrinol Metab 87:5817-20. 2002..A causal relationship between (131)I administration and NDSO is strongly suspected. Patients reporting epiphora should be evaluated promptly by an oculoplastic surgeon... - Imaging of metastatic pulmonary tumors following NIS gene transfer using single photon emission computed tomographyDerek K Marsee
Medical Scientist Program, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
Cancer Gene Ther 11:121-7. 2004..Post-mortem analysis revealed that tumors 3 mm in diameter could be detected by SPECT with pinhole collimation. These studies demonstrate the feasibility of SPECT to detect pulmonary tumors expressing exogenous NIS in mice... - CITED1 protein expression suggests Papillary Thyroid Carcinoma in high throughput tissue microarray-based studyManju L Prasad
Department of Pathology, Ohio State University, Columbus, Ohio 43210, USA
Thyroid 14:169-75. 2004..CITED1 is preferentially expressed in PTC and may be used as a diagnostic marker of it... - The prevalence of occult medullary thyroid carcinoma at autopsyLaticia A Valle
Department of Internal Medicine, Division of Endocrinology, Diabetes, and Metabolism, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
J Clin Endocrinol Metab 96:E109-13. 2011..The prevalence of occult medullary thyroid carcinoma (MTC) in the general population is unknown but may be important when considering strategies to diagnose clinically relevant MTC in nodular goiter or other populations... - Thyroid carcinomaSteven I Sherman
University of Texas M.D. Anderson Cancer Center, USA
J Natl Compr Canc Netw 3:404-57. 2005 - Thyroid carcinomaSteven I Sherman
The University of Texas M.D. Anderson Cancer Center, USA
J Natl Compr Canc Netw 5:568-621. 2007 - Management guidelines for patients with thyroid nodules and differentiated thyroid cancerDavid S Cooper
Sinai Hospital of Baltimore and Johns Hopkins University School of Medicine, MD, USA
Thyroid 16:109-42. 2006 - Iodine biokinetics and dosimetry in radioiodine therapy of thyroid cancer: procedures and results of a prospective international controlled study of ablation after rhTSH or hormone withdrawalHeribert Hänscheid
Klinik und Poliklinik fur Nuklearmedizin, Universitat Wurzburg, D 97080 Wurzburg, Germany
J Nucl Med 47:648-54. 2006..7 GBq (131)I in differentiated thyroid cancer after stimulation with recombinant human TSH (rhTSH) or by thyroid hormone withdrawal (THW) are presented...