Richard T Kloos

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. doi request reprint Approach to the patient with a positive serum thyroglobulin and a negative radioiodine scan after initial therapy for differentiated thyroid cancer
    Richard T Kloos
    The Ohio State University, 446 McCampbell Hall, 1581 Dodd Drive, Columbus, OH 43210 1296, USA
    J Clin Endocrinol Metab 93:1519-25. 2008
  2. doi request reprint Thyroid cancer recurrence in patients clinically free of disease with undetectable or very low serum thyroglobulin values
    Richard T Kloos
    Department of Internal Medicine, The Ohio State University Medical Center, 446 McCampbell Hall, 1581 Dodd Drive, Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 95:5241-8. 2010
  3. doi request reprint Medullary thyroid cancer: management guidelines of the American Thyroid Association
    Richard T Kloos
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, The Arthur G James Cancer Hospital, Columbus, Ohio 43210, USA
    Thyroid 19:565-612. 2009
  4. pmc Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer
    Elaine T Lam
    Departments of Internal Medicine, Center for Biostatistics, The Ohio State University, Columbus, OH, USA
    J Clin Oncol 28:2323-30. 2010
  5. pmc MicroRNA signature in thyroid fine needle aspiration cytology applied to "atypia of undetermined significance" cases
    Rulong Shen
    Department of Pathology, Arthur G James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Thyroid 22:9-16. 2012
  6. ncbi request reprint Expression of sodium iodide symporter in the lacrimal drainage system: implication for the mechanism underlying nasolacrimal duct obstruction in I(131)-treated patients
    Kenneth E Morgenstern
    Department of Ophthalmology, Division of Oculoplastic Surgery, The Ohio State University, Columbus, OH, USA
    Ophthal Plast Reconstr Surg 21:337-44. 2005
  7. ncbi request reprint Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors
    Manju L Prasad
    Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Mod Pathol 18:48-57. 2005
  8. ncbi request reprint PET imaging in differentiated thyroid cancer: where does it fit and how do we use it?
    Nathan C Hall
    Division of Nuclear Medicine, The Ohio State University, The Arthur G James Cancer Hospital and Richard J Solove Research Center, Columbus, Ohio 43210 1296, USA
    Arq Bras Endocrinol Metabol 51:793-805. 2007
  9. pmc Micro-single-photon emission computed tomography image acquisition and quantification of sodium-iodide symporter-mediated radionuclide accumulation in mouse thyroid and salivary glands
    Michael P Brandt
    Molecular, Cellular, and Developmental Biology Graduate Program, Department of Physiology and Cell Biology, The Ohio State University, 1645 Neil Ave, Columbus, OH 43210, USA
    Thyroid 22:617-24. 2012
  10. pmc SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility
    Huiling He
    Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 98:E973-80. 2013

Collaborators

Detail Information

Publications35

  1. doi request reprint Approach to the patient with a positive serum thyroglobulin and a negative radioiodine scan after initial therapy for differentiated thyroid cancer
    Richard T Kloos
    The Ohio State University, 446 McCampbell Hall, 1581 Dodd Drive, Columbus, OH 43210 1296, USA
    J Clin Endocrinol Metab 93:1519-25. 2008
    ..Here a case is presented that adds the complexity of advanced age, and one approach to these challenging patients is offered...
  2. doi request reprint Thyroid cancer recurrence in patients clinically free of disease with undetectable or very low serum thyroglobulin values
    Richard T Kloos
    Department of Internal Medicine, The Ohio State University Medical Center, 446 McCampbell Hall, 1581 Dodd Drive, Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 95:5241-8. 2010
    ..This was a retrospective clinical study...
  3. doi request reprint Medullary thyroid cancer: management guidelines of the American Thyroid Association
    Richard T Kloos
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, The Arthur G James Cancer Hospital, Columbus, Ohio 43210, USA
    Thyroid 19:565-612. 2009
    ....
  4. pmc Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer
    Elaine T Lam
    Departments of Internal Medicine, Center for Biostatistics, The Ohio State University, Columbus, OH, USA
    J Clin Oncol 28:2323-30. 2010
    ..Sorafenib, a multikinase inhibitor targeting Ret and VEGFR, showed antitumor activity in preclinical studies of MTC...
  5. pmc MicroRNA signature in thyroid fine needle aspiration cytology applied to "atypia of undetermined significance" cases
    Rulong Shen
    Department of Pathology, Arthur G James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Thyroid 22:9-16. 2012
    ..We selected eight miRs (miR-146b, -221, -187, -197, -346, -30d, -138, and -302c) to examine the potential use of miRs to supplement diagnostic cytology in cases designated as "atypia of undetermined significance."..
  6. ncbi request reprint Expression of sodium iodide symporter in the lacrimal drainage system: implication for the mechanism underlying nasolacrimal duct obstruction in I(131)-treated patients
    Kenneth E Morgenstern
    Department of Ophthalmology, Division of Oculoplastic Surgery, The Ohio State University, Columbus, OH, USA
    Ophthal Plast Reconstr Surg 21:337-44. 2005
    ..We hypothesized that NIS is expressed in the lacrimal sac and nasolacrimal duct and that active accumulation of I(131) is responsible for the clinical observations seen in these patients...
  7. ncbi request reprint Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors
    Manju L Prasad
    Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Mod Pathol 18:48-57. 2005
    ..An immunohistochemical panel consisting of GAL3, FN1 and HBME1 may be useful in the diagnosis of follicular cell-derived thyroid tumors...
  8. ncbi request reprint PET imaging in differentiated thyroid cancer: where does it fit and how do we use it?
    Nathan C Hall
    Division of Nuclear Medicine, The Ohio State University, The Arthur G James Cancer Hospital and Richard J Solove Research Center, Columbus, Ohio 43210 1296, USA
    Arq Bras Endocrinol Metabol 51:793-805. 2007
    ..This article reviews the utility and limitations of FDG-PET in DTC management, and offers practical recommendations...
  9. pmc Micro-single-photon emission computed tomography image acquisition and quantification of sodium-iodide symporter-mediated radionuclide accumulation in mouse thyroid and salivary glands
    Michael P Brandt
    Molecular, Cellular, and Developmental Biology Graduate Program, Department of Physiology and Cell Biology, The Ohio State University, 1645 Neil Ave, Columbus, OH 43210, USA
    Thyroid 22:617-24. 2012
    ..In this study, we investigated the effects of region-of-interest (ROI) selection, collimation, scan time, and imaging orbit on image acquisition and quantification of thyroidal and salivary radionuclide accumulation in mice...
  10. pmc SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility
    Huiling He
    Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 98:E973-80. 2013
    ..Papillary thyroid carcinoma (PTC) shows high heritability, yet efforts to find predisposing genes have been largely negative...
  11. ncbi request reprint Variable expression of coxsackie-adenovirus receptor in thyroid tumors: implications for adenoviral gene therapy
    Derek K Marsee
    Medical Scientist Program, The Ohio State University, Columbus, Ohio, USA
    Thyroid 15:977-87. 2005
    ..Our study warrants a functional method to evaluate adenoviral infectivity should be developed and instituted prior to clinical trials of adenoviral gene therapy in patients with advanced thyroid cancer...
  12. pmc Lack of therapeutic effect of the histone deacetylase inhibitor vorinostat in patients with metastatic radioiodine-refractory thyroid carcinoma
    Jennifer A Woyach
    Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Clin Endocrinol Metab 94:164-70. 2009
    ..This phase II study was undertaken to assess objective response to vorinostat in patients with advanced thyroid cancer...
  13. doi request reprint In thyroidectomized patients with thyroid cancer, a serum thyrotropin of 30 μU/mL after thyroxine withdrawal is not always adequate for detecting an elevated stimulated serum thyroglobulin
    Laticia A Valle
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA
    Thyroid 23:185-93. 2013
    ....
  14. ncbi request reprint Papillary thyroid cancer: medical management and follow-up
    Richard T Kloos
    The Ohio State University, 446 McCampbell Hall, 1581 Dodd Drive, Columbus, OH 43210 1296, USA
    Curr Treat Options Oncol 6:323-38. 2005
    ....
  15. ncbi request reprint A single recombinant human thyrotropin-stimulated serum thyroglobulin measurement predicts differentiated thyroid carcinoma metastases three to five years later
    Richard T Kloos
    Division of Endocrinology, Shands Hospital, 1600 SW Archer Road, P O Box 100226, Gainesville, Florida 32610 0226, USA
    J Clin Endocrinol Metab 90:5047-57. 2005
    ..Testing for residual differentiated thyroid carcinoma relies heavily upon recombinant human (rh)TSH-stimulated serum thyroglobulin (Tg) levels, but the positive predictive value is often low...
  16. pmc The role of microRNA genes in papillary thyroid carcinoma
    Huiling He
    Human Cancer Genetics Program, Department of Pathology, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 102:19075-80. 2005
    ..We conclude that up-regulation of several miRs and regulation of KIT are involved in PTC pathogenesis, and that sequence changes in genes targeted by miRNAs can contribute to their regulation...
  17. pmc The relationship between body mass index and thyroid cancer pathology features and outcomes: a clinicopathological cohort study
    John E Paes
    Divisions of Endocrinology, Diabetes, and Metabolism, The Ohio State University College of Medicine and Arthur G James Comprehensive Cancer Center, Columbus, Ohio 43235, USA
    J Clin Endocrinol Metab 95:4244-50. 2010
    ..We hypothesized that a higher body mass index (BMI) would be associated with aggressive thyroid cancer features and a higher incidence of persistent/recurrent disease...
  18. pmc Frequency of germline PTEN mutations in differentiated thyroid cancer
    Rebecca Nagy
    Division of Human Genetics, The Ohio State University Medical Center and Comprehensive Cancer Center, Columbus, Ohio 43240, USA
    Thyroid 21:505-10. 2011
    ..These results suggest that by adding head circumference to the clinical assessment, thyroid cancer specialists can more effectively identify patients needing referral for cancer genetic services...
  19. ncbi request reprint Application of the Cre/loxP system to enhance thyroid-targeted expression of sodium/iodide symporter
    Xiaoqin Lin
    Department of Physiology and Cell Biology, Ohio State University, Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 89:2344-50. 2004
    ..Finally, Tg promoter activity was partially restored in malignant thyroid cells by forced expression of the paired domain-containing transcription factor (Pax-8), allowing the Cre/loxP system to mildly enhance radioiodide uptake...
  20. doi request reprint Long-term efficacy of lymph node reoperation for persistent papillary thyroid cancer
    Osama Al-Saif
    Department of Surgery, The Ohio State University, Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 95:2187-94. 2010
    ..The objective of the study was to determine the outcome of surgical resection of metastatic papillary thyroid cancer (PTC) in cervical lymph nodes after failure of initial surgery and I(131) therapy...
  21. pmc Telomere length and telomerase reverse transcriptase gene copy number in patients with papillary thyroid carcinoma
    Jaroslaw Jendrzejewski
    Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, 804 Biomedical Research Tower 460 West 12th Avenue Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 96:E1876-80. 2011
    ..However, one study reported that telomeres were markedly shorter and the telomerase reverse transcriptase (TERT) gene was amplified and up-regulated in germline DNA from patients with fPTC compared with sPTC...
  22. ncbi request reprint Is diagnostic iodine-131 scanning with recombinant human TSH useful in the follow-up of differentiated thyroid cancer after thyroid ablation?
    Ernest L Mazzaferri
    Department of Internal Medicine, University of Florida, Gainesville 32608 4653, USA
    J Clin Endocrinol Metab 87:1490-8. 2002
    ..An elevated rhTSH-stimulated Tg greater than 2 ng/ml warrants further study...
  23. pmc Phase II trial of sorafenib in metastatic thyroid cancer
    Richard T Kloos
    Ohio State University, Department of Internal Medicine, Molecular Virology, Immunology, and Genetics, Pathology, Radiology, Center for Biostatistics, Ohio State University, Columbus, OH 43210, USA
    J Clin Oncol 27:1675-84. 2009
    ..Based on the pivotal role of Ras-Raf-MAP-ERK signaling and vascular endothelial growth factor (VEGF) in papillary thyroid cancer (PTC), we conducted a phase II clinical trial of sorafenib targeting RAF and VEGF receptor kinases in PTC...
  24. doi request reprint Single photon emission computed tomography imaging for temporal dynamics of thyroidal and salivary radionuclide accumulation in 17-allyamino-17-demothoxygeldanamycin-treated thyroid cancer mouse model
    Yu Yu Liu
    The Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, USA
    Endocr Relat Cancer 18:27-37. 2011
    ..Finally, the effect of 17-allyamino-17-demothoxygeldanamycin on increasing thyroidal, but not salivary, radioiodine accumulation was validated in both WT mice and Tg-PTC1 preclinical thyroid cancer mouse model...
  25. ncbi request reprint Allelic variation in gene expression in thyroid tissue
    Huiling He
    Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio 43210, USA
    Thyroid 15:660-7. 2005
    ..DUOX1 variation in expression was seen in 3 of 13 patients with PTC and 6 of 27 patients with benign disease. Further studies are needed to determine the significance of these and other allelic variations...
  26. doi request reprint Anaplastic thyroid cancer
    Ryan L Neff
    Department of Surgery, Division of Surgical Oncology, The Ohio State University, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, Columbus, OH 43210 1228, USA
    Endocrinol Metab Clin North Am 37:525-38, xi. 2008
    ..Enrollment in meaningful clinical trials should be given the highest priority at all decision points...
  27. ncbi request reprint Phase II study of celecoxib in metastatic differentiated thyroid carcinoma
    Ewa Mrozek
    Division of Hematology, Departments of Internal Medicine, The Ohio State University Thyroid Cancer Unit, The Ohio State University Medical Center, Arthur G James Cancer Hospital and Richard J Solove Research Institute, Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 91:2201-4. 2006
    ..There is increased cyclooxygenase-2 (COX-2) expression in malignant thyroid nodules compared with nonneoplastic and benign thyroid tissue...
  28. ncbi request reprint Nasolacrimal drainage system obstruction from radioactive iodine therapy for thyroid carcinoma
    Richard T Kloos
    Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Clin Endocrinol Metab 87:5817-20. 2002
    ..A causal relationship between (131)I administration and NDSO is strongly suspected. Patients reporting epiphora should be evaluated promptly by an oculoplastic surgeon...
  29. ncbi request reprint Imaging of metastatic pulmonary tumors following NIS gene transfer using single photon emission computed tomography
    Derek K Marsee
    Medical Scientist Program, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Gene Ther 11:121-7. 2004
    ..Post-mortem analysis revealed that tumors 3 mm in diameter could be detected by SPECT with pinhole collimation. These studies demonstrate the feasibility of SPECT to detect pulmonary tumors expressing exogenous NIS in mice...
  30. doi request reprint The prevalence of occult medullary thyroid carcinoma at autopsy
    Laticia A Valle
    Department of Internal Medicine, Division of Endocrinology, Diabetes, and Metabolism, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 96:E109-13. 2011
    ..The prevalence of occult medullary thyroid carcinoma (MTC) in the general population is unknown but may be important when considering strategies to diagnose clinically relevant MTC in nodular goiter or other populations...
  31. ncbi request reprint CITED1 protein expression suggests Papillary Thyroid Carcinoma in high throughput tissue microarray-based study
    Manju L Prasad
    Department of Pathology, Ohio State University, Columbus, Ohio 43210, USA
    Thyroid 14:169-75. 2004
    ..CITED1 is preferentially expressed in PTC and may be used as a diagnostic marker of it...
  32. ncbi request reprint Thyroid carcinoma
    Steven I Sherman
    University of Texas M D Anderson Cancer Center, USA
    J Natl Compr Canc Netw 3:404-57. 2005
  33. ncbi request reprint Thyroid carcinoma
    Steven I Sherman
    The University of Texas M D Anderson Cancer Center, USA
    J Natl Compr Canc Netw 5:568-621. 2007
  34. ncbi request reprint Management guidelines for patients with thyroid nodules and differentiated thyroid cancer
    David S Cooper
    Sinai Hospital of Baltimore and Johns Hopkins University School of Medicine, MD, USA
    Thyroid 16:109-42. 2006
  35. ncbi request reprint Iodine biokinetics and dosimetry in radioiodine therapy of thyroid cancer: procedures and results of a prospective international controlled study of ablation after rhTSH or hormone withdrawal
    Heribert Hänscheid
    Klinik und Poliklinik fur Nuklearmedizin, Universitat Wurzburg, D 97080 Wurzburg, Germany
    J Nucl Med 47:648-54. 2006
    ..7 GBq (131)I in differentiated thyroid cancer after stimulation with recombinant human TSH (rhTSH) or by thyroid hormone withdrawal (THW) are presented...