W H Klein

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Function and evolution of Otx proteins
    W H Klein
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Biochem Biophys Res Commun 258:229-33. 1999
  2. doi request reprint Rewiring the retinal ganglion cell gene regulatory network: Neurod1 promotes retinal ganglion cell fate in the absence of Math5
    Chai An Mao
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Medical School, Houston, TX 77030, USA
    Development 135:3379-88. 2008
  3. ncbi request reprint Two Otx proteins generated from multiple transcripts of a single gene in Strongylocentrotus purpuratus
    X Li
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Biol 187:253-66. 1997
  4. ncbi request reprint MyoD cannot compensate for the absence of myogenin during skeletal muscle differentiation in murine embryonic stem cells
    A Myer
    Department of Biochemistry and Molecular Biology and Graduate Program in Genes and Development, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
    Dev Biol 229:340-50. 2001
  5. pmc Requirement for math5 in the development of retinal ganglion cells
    S W Wang
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 15:24-9. 2001
  6. pmc Beta-catenin is essential for lamination but not neurogenesis in mouse retinal development
    Xueyao Fu
    Department of Biochemistry and Molecular Biology, Unit 1000, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Dev Biol 299:424-37. 2006
  7. ncbi request reprint A gene network downstream of transcription factor Math5 regulates retinal progenitor cell competence and ganglion cell fate
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Dev Biol 280:467-81. 2005
  8. ncbi request reprint Involvement of Tcf/Lef in establishing cell types along the animal-vegetal axis of sea urchins
    L Huang
    Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Dev Genes Evol 210:73-81. 2000
  9. ncbi request reprint Identification of a differentially expressed RNA helicase by gene trapping
    D S Wagner
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas, 77030, USA
    Biochem Biophys Res Commun 262:677-84. 1999
  10. ncbi request reprint Abnormal polarization and axon outgrowth in retinal ganglion cells lacking the POU-domain transcription factor Brn-3b
    S W Wang
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Mol Cell Neurosci 16:141-56. 2000

Detail Information

Publications57

  1. ncbi request reprint Function and evolution of Otx proteins
    W H Klein
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Biochem Biophys Res Commun 258:229-33. 1999
    ..The consequence of such an evolutionary event would be to link a highly conserved signal transduction pathway to a set of novel downstream genes that make use of Otx for their transcription...
  2. doi request reprint Rewiring the retinal ganglion cell gene regulatory network: Neurod1 promotes retinal ganglion cell fate in the absence of Math5
    Chai An Mao
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Medical School, Houston, TX 77030, USA
    Development 135:3379-88. 2008
    ..We conclude that, although Neurod1 and Math3 have evolved specialized functions for establishing amacrine cell fate, they are nevertheless capable of alternative functions when expressed in foreign environments...
  3. ncbi request reprint Two Otx proteins generated from multiple transcripts of a single gene in Strongylocentrotus purpuratus
    X Li
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Biol 187:253-66. 1997
    ..These results demonstrate that novel forms of Otx are produced in sea urchins by differential promoter utilization and alternative splicing. It may be that similar regulatory mechanisms lead to diverse forms of Otx in vertebrates...
  4. ncbi request reprint MyoD cannot compensate for the absence of myogenin during skeletal muscle differentiation in murine embryonic stem cells
    A Myer
    Department of Biochemistry and Molecular Biology and Graduate Program in Genes and Development, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
    Dev Biol 229:340-50. 2001
    ..Thus, despite their relatedness, myogenin's role in muscle formation is distinct from that of MyoD, and the distinction cannot be explained merely by differences in their expression properties...
  5. pmc Requirement for math5 in the development of retinal ganglion cells
    S W Wang
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 15:24-9. 2001
    ..These results imply that math5 is a proneural gene essential for RGC differentiation and that math5 acts upstream to activate brn-3b-dependent differentiation processes in RGCs...
  6. pmc Beta-catenin is essential for lamination but not neurogenesis in mouse retinal development
    Xueyao Fu
    Department of Biochemistry and Molecular Biology, Unit 1000, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Dev Biol 299:424-37. 2006
    ..The results further imply that retinal lamination and retinal cell differentiation are genetically separable processes...
  7. ncbi request reprint A gene network downstream of transcription factor Math5 regulates retinal progenitor cell competence and ganglion cell fate
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Dev Biol 280:467-81. 2005
    ..The identification of multiple roles for Math5 provides new insights into the gene network that defines progenitor cell competence in the embryonic retina...
  8. ncbi request reprint Involvement of Tcf/Lef in establishing cell types along the animal-vegetal axis of sea urchins
    L Huang
    Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Dev Genes Evol 210:73-81. 2000
    ..Our results suggest that SpTcf/Lef functions by interacting with beta-catenin to specify cell fates along the sea urchin animal-vegetal axis...
  9. ncbi request reprint Identification of a differentially expressed RNA helicase by gene trapping
    D S Wagner
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas, 77030, USA
    Biochem Biophys Res Commun 262:677-84. 1999
    ....
  10. ncbi request reprint Abnormal polarization and axon outgrowth in retinal ganglion cells lacking the POU-domain transcription factor Brn-3b
    S W Wang
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Mol Cell Neurosci 16:141-56. 2000
    ..Thus, Brn-3b appears to control the activity of genes that function in establishing RGC polarity, and without Brn-3b, RGCs cannot extend normal axons...
  11. pmc POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells
    L Gan
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Proc Natl Acad Sci U S A 93:3920-5. 1996
    ..In Brn-3b (-/-) mice other neurons within the retina and brain are minimally or not at all affected. These experiments indicate that Brn-3b plays an essential role in the development of specific ganglion cell types...
  12. ncbi request reprint Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth
    Steven W Wang
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Development 129:467-77. 2002
    ..Our results reveal a complex genetic relationship between Brn3b and Brn3c in regulating the retinal ganglion cell axon outgrowth...
  13. pmc A myogenic factor from sea urchin embryos capable of programming muscle differentiation in mammalian cells
    J M Venuti
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Proc Natl Acad Sci U S A 88:6219-23. 1991
    ..SUM-1 is an example of an invertebrate myogenic factor that is capable of functioning in mammalian cells...
  14. ncbi request reprint POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification
    L Gan
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA
    Dev Biol 210:469-80. 1999
    ..These results suggest that Brn-3b regulates the activity of genes whose products play essential roles in the formation of retinal ganglion cell axons...
  15. pmc Gene expression in the developing mouse retina by EST sequencing and microarray analysis
    X Mu
    Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    Nucleic Acids Res 29:4983-93. 2001
    ..The retinal EST database will be a valuable platform for gene expression profiling and a new source for gene discovery...
  16. pmc Epitope-tagging Math5 and Pou4f2: new tools to study retinal ganglion cell development in the mouse
    Xueyao Fu
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Dev Dyn 238:2309-17. 2009
    ..The epitope-tagged alleles provide new and useful tools for analyzing gene regulatory networks underlying RGC development...
  17. pmc Eomesodermin, a target gene of Pou4f2, is required for retinal ganglion cell and optic nerve development in the mouse
    Chai An Mao
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Development 135:271-80. 2008
    ..We conclude that Eomes is a crucial regulator positioned immediately downstream of Pou4f2 and is required for RGC differentiation and optic nerve development...
  18. pmc Retinal ganglion cell death and optic nerve degeneration by genetic ablation in adult mice
    Jang Hyeon Cho
    Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Exp Eye Res 88:542-52. 2009
    ..These events are hallmarks of progressive optic nerve degeneration observed in human retinal pathologies and demonstrate the validity of this model for use in developing stem cell therapies for replacing dead RGCs with healthy ones...
  19. ncbi request reprint Expression of a gene trap reporter construct in a subset of cells in embryonic sites of hematopoiesis: evidence for alternative rRNA production in hematopoietic cells
    D S Wagner
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas, 77030, USA
    Biochem Biophys Res Commun 250:674-81. 1998
    ..Our results suggest that there is a subset of hematopoietic stem cells, which when actively proliferating, express the SAbetageo reporter construct from RNA polymerase I transcription units...
  20. ncbi request reprint Temporal, spatial and tissue-specific expression of a myogenin-lacZ transgene targeted to the Hprt locus in mice
    J L Vivian
    University of Texas M D Anderson Cancer Center, Houston, USA
    Biotechniques 27:154-62. 1999
    ..This strategy, called targeted transgenesis, provides control for analyzing promoter sequences and for comparing various transgenes expressed by the same promoter...
  21. ncbi request reprint Similar myogenic functions for myogenin and MRF4 but not MyoD in differentiated murine embryonic stem cells
    V M Sumariwalla
    Department of Biochemistry and Molecular Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
    Genesis 30:239-49. 2001
    ..The results indicate that unlike MyoD, MRF4 plays a role similar to myogenin in skeletal muscle differentiation...
  22. ncbi request reprint Strongylocentrotus purpuratus transcription factor GATA-E binds to and represses transcription at an Otx-Goosecoid cis-regulatory element within the aboral ectoderm-specific spec2a enhancer
    Takae Kiyama
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Dev Biol 280:436-47. 2005
    ..Our results show that the recently evolved proximal element contributes to the repression of spec2a in endomesoderm and oral ectoderm territories...
  23. ncbi request reprint Discrete gene sets depend on POU domain transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Development 131:1197-210. 2004
    ..Our results demonstrate that a small but crucial fraction of the RGC transcriptome is dependent on Brn3b. The Brn3b-dependent gene sets therefore provide a unique molecular signature for the developing retina...
  24. ncbi request reprint Transcription of the Spec 1-like gene of Lytechinus is selectively inhibited in response to disruption of the extracellular matrix
    G M Wessel
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Development 106:355-65. 1989
    ..Thus, although the accumulation of many gene products occurred independently of the embryonic collagenous matrix, the accumulation of LpS1 and LvS1 appeared to be mediated by the ECM...
  25. ncbi request reprint A gene regulatory hierarchy for retinal ganglion cell specification and differentiation
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center, The University of Texas, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Semin Cell Dev Biol 15:115-23. 2004
    ..Future directions in RGC development will inevitably rely on combined genetic and genomics approaches...
  26. pmc Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development
    Chai An Mao
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX, 77030, USA
    Dev Biol 349:90-9. 2011
    ..Our results demonstrate an Atoh7-independent program for initial activation of RGC genes and suggest a novel role for REST in preventing premature expression in RPCs...
  27. ncbi request reprint Compensational regulation of bHLH transcription factors in the postnatal development of BETA2/NeuroD1-null retina
    Jang Hyeon Cho
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd Unit 1000, Houston, TX 77030, USA
    Mech Dev 124:543-50. 2007
    ..Our data suggest that compensatory and cross regulatory mechanisms exist among the bHLH factors during retinal development...
  28. ncbi request reprint Identification of an N-terminal transcriptional activation domain within Brn3b/POU4f2
    Suzanna E Martin
    Department of Biochemistry and Molecular Biology, Unit 117, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Differentiation 73:18-27. 2005
    ..The results demonstrate that Brn3b regulates gene expression through the action of a strong transcriptional activation domain within its N-terminal sequence...
  29. pmc Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center and Graduate Training Program in Genes and Development, Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:6942-7. 2008
    ..They also reveal that identical RGC expression patterns are achieved by different combinations of divergent inputs from upstream transcription factors...
  30. ncbi request reprint Myogenin's functions do not overlap with those of MyoD or Myf-5 during mouse embryogenesis
    A Rawls
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Biol 172:37-50. 1995
    ..These results demonstrate that the functions of myogenin do not overlap with those of MyoD or Myf-5 and support the view that myogenin acts in a genetic pathway downstream of MyoD and Myf-5...
  31. ncbi request reprint Very early and transient vegetal-plate expression of SpKrox1, a Kr├╝ppel/Krox gene from Stronglyocentrotus purpuratus
    W Wang
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Mech Dev 60:185-95. 1996
    ..As the vegetal-plate cells invaginated into the blastopore, SpKrox1 expression was lost, suggesting that its role was not in endoderm differentiation per se but rather in the initial establishment of the vegetal plate...
  32. ncbi request reprint Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers
    M Sirito
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030
    Gene Expr 2:231-40. 1992
    ..This indicates that the conserved LR in human USF is not required for dimer formation, and influences only indirectly DNA-binding...
  33. ncbi request reprint Wild-type myoblasts rescue the ability of myogenin-null myoblasts to fuse in vivo
    A Myer
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Biol 185:127-38. 1997
    ..We propose that myogenin regulates the expression of one or more extracellular or cell surface proteins required to initiate the muscle differentiation program...
  34. ncbi request reprint Novel retinal genes discovered by mining the mouse embryonic RetinalExpress database
    Shuguang Liang
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Vis 10:773-86. 2004
    ....
  35. ncbi request reprint Creation of cis-regulatory elements during sea urchin evolution by co-option and optimization of a repetitive sequence adjacent to the spec2a gene
    Sandeep Dayal
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Dev Biol 273:436-53. 2004
    ..Our results indicated that a dynamic pattern of cis-regulatory element evolution exists for spec genes despite their conserved aboral ectoderm expression...
  36. ncbi request reprint SpGataE, a Strongylocentrotus purpuratus ortholog of mammalian Gata4/5/6: protein expression, interaction with putative target gene spec2a, and identification of friend of Gata factor SpFog1
    Takae Kiyama
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Unit 1000, 1515 Holcombe Boulevard, Houston, TX, 77030, USA
    Dev Genes Evol 217:651-63. 2007
    ..In addition to providing new information on Gata and Fog proteins in sea urchins, the anti-SpGataE antibody developed here should be a useful reagent for future analysis of SpGataE function...
  37. ncbi request reprint Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle
    Judith K Davie
    Department of Biochemistry and Molecular Biology, Unit 1000, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Dev Biol 311:650-64. 2007
    ..The results identify new target genes for myogenin and show that myogenin's target gene selectivity is not based solely on binding site sequences...
  38. ncbi request reprint Transient appearance of Strongylocentrotus purpuratus Otx in micromere nuclei: cytoplasmic retention of SpOtx possibly mediated through an alpha-actinin interaction
    C K Chuang
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Genet 19:231-7. 1996
    ..The transient appearance of SpOtx in micromere nuclei may be associated with the specification of micromere cell fate...
  39. ncbi request reprint A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation
    J L Vivian
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Dev Biol 208:44-55. 1999
    ....
  40. pmc Myogenin is required for late but not early aspects of myogenesis during mouse development
    J M Venuti
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    J Cell Biol 128:563-76. 1995
    ....
  41. ncbi request reprint Sea urchin USF: a helix-loop-helix protein active in embryonic ectoderm cells
    M T Kozlowski
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Dev Biol 148:625-30. 1991
    ..These data demonstrated that suUSF was responsible for the ectoderm-specific activity observed in sea urchin extracts...
  42. ncbi request reprint An orthodenticle-related protein from Strongylocentrotus purpuratus
    L Gan
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Dev Biol 167:517-28. 1995
    ..Our results suggest that SpOtx plays a role in the activation of the Spec2a gene and most likely has additional functions in the developing sea urchin embryo...
  43. doi request reprint Myogenin regulates a distinct genetic program in adult muscle stem cells
    Eric Meadows
    Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Dev Biol 322:406-14. 2008
    ..Remarkably, these changes in gene expression were distinct from those found in Myog-null embryonic skeletal muscle, indicating that myogenin has separate functions during postnatal life...
  44. ncbi request reprint Ectoderm gene activation in sea urchin embryos mediated by the CCAAT-binding factor
    Xiaotao Li
    Department of Biochemistry and Molecular Biology, Box 117, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Differentiation 70:109-19. 2002
    ..In addition to its role in vertebrate cell growth and proliferation, our results indicate that CBF also functions at the early stages of germ layer formation, namely ectoderm differentiation...
  45. ncbi request reprint Loss of myogenin in postnatal life leads to normal skeletal muscle but reduced body size
    Jennifer R Knapp
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Development 133:601-10. 2006
    ....
  46. ncbi request reprint Retinal ganglion cell differentiation in cultured mouse retinal explants
    Steven W Wang
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Methods 28:448-56. 2002
    ....
  47. ncbi request reprint Regulation of retinal cone bipolar cell differentiation and photopic vision by the CVC homeobox gene Vsx1
    Akihira Ohtoshi
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Curr Biol 14:530-6. 2004
    ..Thus, Vsx1 is required for cone bipolar cell differentiation and regulates photopic vision perception...
  48. ncbi request reprint Multiple Otx binding sites required for expression of the Strongylocentrotus purpuratus Spec2a gene
    C A Mao
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Dev Biol 165:229-42. 1994
    ....
  49. ncbi request reprint Structure, expression, and transcriptional regulation of the Strongylocentrotus franciscanus spec gene family encoding intracellular calcium-binding proteins
    Jeffrey T Villinski
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 117, Houston 77030, USA
    Dev Genes Evol 215:410-22. 2005
    ..Our results show that the evolution of spec cis-regulatory elements is highly dynamic and that substantial alterations can occur when maintaining or grossly modifying gene expression patterns...
  50. pmc Canonical Wnt signaling functions in second heart field to promote right ventricular growth
    Di Ai
    Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:9319-24. 2007
    ..Our findings reveal that Wnt signaling plays a major positive role in promoting growth and diversification of SHF precursors into right ventricular and interventricular myocardium...
  51. ncbi request reprint Molecular patterning along the sea urchin animal-vegetal axis
    Bruce P Brandhorst
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
    Int Rev Cytol 213:183-232. 2002
    ..We also discuss how these systems may confer on the embryo its spectacular regulatory capacity to replace missing parts...
  52. pmc Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex
    Alessandro Sessa
    Molecular Neuropathology Laboratory, SCRI, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Neuron 60:56-69. 2008
    ..Together, these findings identify Tbr2 as a critical factor for the specification of IPCs during corticogenesis...
  53. ncbi request reprint Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages
    Athula H Wikramanayake
    Department of Zoology, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
    Genesis 39:194-205. 2004
    ..These results establish SpWnt8 as a critical component of the endomesoderm regulatory network in the sea urchin embryo...
  54. ncbi request reprint Ganglion cells are required for normal progenitor- cell proliferation but not cell-fate determination or patterning in the developing mouse retina
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology and Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Biol 15:525-30. 2005
    ..Intrinsic rather than extrinsic factors are likely to play the critical roles in determining retinal cell fate...
  55. ncbi request reprint Smooth muscle persists in the muscularis externa of developing and adult mouse esophagus
    Mark Rishniw
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, T4 018 VRT, Box 11, Ithaca, NY 14853, USA
    J Muscle Res Cell Motil 28:153-65. 2007
    ..Taken together, our results provide an alternative hypothesis regarding the fate of SM cells in the developing murine esophagus, which does not invoke apoptosis or transdifferentiation...
  56. pmc The genome of the sea urchin Strongylocentrotus purpuratus
    Erica Sodergren
    Science 314:941-52. 2006
    ..This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes...
  57. doi request reprint The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis
    Przemyslaw Sapieha
    Research Center of Centre Hospitalier Universitaire Sainte Justine, Department of Pediatrics, Universite de Montreal, Montreal, Quebec H3T 1C5, Canada
    Nat Med 14:1067-76. 2008
    ..These findings provide a new therapeutic target for modulating revascularization...