Robert J Klein
Affiliation: The Rockefeller University
- RSEARCH: finding homologs of single structured RNA sequencesRobert J Klein
Howard Hughes Medical Institute and Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
BMC Bioinformatics 4:44. 2003..No programs have yet been published that allow searching a sequence database for homologs of a single RNA molecule on the basis of secondary structure...
- Noncoding RNA genes identified in AT-rich hyperthermophilesRobert J Klein
Howard Hughes Medical Institute and Department of Genetics, Washington University School of Medicine, Saint Louis, MO 63110, USA
Proc Natl Acad Sci U S A 99:7542-7. 2002..furiosus. Nine of the 30 new candidate genes predicted by these screens have been verified to produce discrete, apparently noncoding transcripts with sizes ranging from 97 to 277 nucleotides...
- Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degenerationSepideh Zareparsi
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA
Am J Hum Genet 77:149-53. 2005..39 (95% confidence interval 0.36-0.42) and the genotype relative risk to be 2.44 (95% confidence interval 2.08-2.83) for TC heterozygotes and 5.93 (95% confidence interval 4.33-8.02) for CC homozygotes...
- Power analysis for genome-wide association studiesRobert J Klein
Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
BMC Genet 8:58. 2007..To choose the proper sample size and genotyping platform for such studies, power calculations that take into account genetic model, tag SNP selection, and the population of interest are required...