JOSEPH KISSIL

Summary

Affiliation: The Wistar Institute
Country: USA

Publications

  1. pmc The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
    C Zhou
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Oncogene 32:903-9. 2013
  2. ncbi request reprint Requirement for Rac1 in a K-ras induced lung cancer in the mouse
    Joseph L Kissil
    Program in Molecular Oncogenesis, The Wistar Institute, Philadelphia, PA 19104, USA
    Cancer Res 67:8089-94. 2007
  3. pmc Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice
    Angélica M Santos
    The Wistar Institute, Philadelphia, Pennsylvania, USA
    J Clin Invest 119:3613-25. 2009
  4. pmc Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancer
    Chunling Yi
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 25:10052-9. 2005
  5. pmc Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma
    Linda Hanlon
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, 3601Spruce Street, Philadelphia, PA 19104, USA
    Cancer Res 70:4280-6. 2010
  6. pmc WT1: a weak spot in KRAS-induced transformation
    Silvia Licciulli
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 120:3804-7. 2010
  7. ncbi request reprint New tools for dissecting RON receptor tyrosine kinase oncogenic signaling
    Joseph L Kissil
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA
    Cancer Biol Ther 5:1187-8. 2006
  8. pmc Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2
    Chunling Yi
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 68:7932-7. 2008
  9. ncbi request reprint Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1
    Joseph L Kissil
    Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cell 12:841-9. 2003
  10. pmc Protein 4.1B suppresses prostate cancer progression and metastasis
    Sunny Y Wong
    Howard Hughes Medical Institute, Massachusetts Institute of Technology Center for Cancer Research, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:12784-9. 2007

Research Grants

  1. The NF2 gene: elucidation of tumor suppressor function
    JOSEPH KISSIL; Fiscal Year: 2004
  2. The Role of RAC1 in Cancer
    JOSEPH KISSIL; Fiscal Year: 2009
  3. The Role of RAC1 in Cancer
    JOSEPH KISSIL; Fiscal Year: 2010

Collaborators

  • Al Charest
  • DAVID TUVESON
  • Anil Rustgi
  • Joseph McCarty
  • Victor L J Tybulewicz
  • Ellen Pure
  • Angélica M Santos
  • Chunling Yi
  • C Zhou
  • Linda Hanlon
  • Silvia Licciulli
  • Sunny Y Wong
  • Roderick T Bronson
  • Kristen C Johnson
  • Q Liu
  • S M Albelda
  • A Vachani
  • J L Avila
  • M Cho
  • L C Showe
  • P Jiang
  • A V Kossenkov
  • S Licciulli
  • S Troutman
  • Fenella Long
  • Anthony J Capobianco
  • Francesca Ratti
  • Scott Troutman
  • Megan Allen
  • Renee M Demarest
  • Volkan Adsay
  • Fred Radtke
  • Ben Z Stanger
  • Jacqueline L Avila
  • Erik W Wilker
  • Anat Stemmer-Rachamimov
  • Michael B Yaffe
  • Steven S Shen
  • Marc Barry
  • Herbert Haack
  • Denise Crowley
  • Charles A Whittaker
  • Richard O Hynes
  • Scott A Troutman
  • Matthew S Eckman
  • Tyler Jacks
  • Jessica L Fry

Detail Information

Publications11

  1. pmc The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
    C Zhou
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Oncogene 32:903-9. 2013
    ..Given the partially overlapping spectrum of downstream effectors regulated by Rac1 and Rac1b, our findings further delineate the signaling pathways downstream of Rac1 that are required for K-ras driven tumorigenesis...
  2. ncbi request reprint Requirement for Rac1 in a K-ras induced lung cancer in the mouse
    Joseph L Kissil
    Program in Molecular Oncogenesis, The Wistar Institute, Philadelphia, PA 19104, USA
    Cancer Res 67:8089-94. 2007
    ..These data show a specific requirement for Rac1 function in cells expressing oncogenic K-ras...
  3. pmc Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice
    Angélica M Santos
    The Wistar Institute, Philadelphia, Pennsylvania, USA
    J Clin Invest 119:3613-25. 2009
    ..These data provide proof of principle that targeting stromal cell-mediated modifications of the tumor microenvironment may be an effective approach to treating epithelial-derived solid tumors...
  4. pmc Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancer
    Chunling Yi
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 25:10052-9. 2005
    ..These findings indicate that the 4.1B gene is not required for normal development and that 4.1B/Dal-1 does not function as a tumor suppressor gene...
  5. pmc Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma
    Linda Hanlon
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, 3601Spruce Street, Philadelphia, PA 19104, USA
    Cancer Res 70:4280-6. 2010
    ..Unexpectedly, the loss of Notch1 in this model resulted in increased tumor incidence and progression, implying that Notch1 can function as a tumor suppressor gene in PDAC...
  6. pmc WT1: a weak spot in KRAS-induced transformation
    Silvia Licciulli
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 120:3804-7. 2010
    ..These findings are of significant interest given previous studies suggesting that the ability of oncogenic Kras to induce senescence versus proliferation depends on its levels of expression...
  7. ncbi request reprint New tools for dissecting RON receptor tyrosine kinase oncogenic signaling
    Joseph L Kissil
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA
    Cancer Biol Ther 5:1187-8. 2006
  8. pmc Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2
    Chunling Yi
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 68:7932-7. 2008
    ..In addition, the finding that the shRNA-mediated Pak1 suppression was silenced rapidly by methylation raises questions about the future application of such technologies for the treatment of diseases such as cancer...
  9. ncbi request reprint Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1
    Joseph L Kissil
    Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cell 12:841-9. 2003
    ..This link provides a possible mechanism for the effect of loss of merlin expression in tumorigenesis...
  10. pmc Protein 4.1B suppresses prostate cancer progression and metastasis
    Sunny Y Wong
    Howard Hughes Medical Institute, Massachusetts Institute of Technology Center for Cancer Research, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:12784-9. 2007
    ..1B as a negative regulator of cancer progression to metastatic disease...
  11. ncbi request reprint Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene
    Kristen C Johnson
    Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, MA 02139, USA
    Oncogene 21:5990-7. 2002
    ..Finally, fibroblasts that express this mutant Nf2 allele form tumors when injected into nude mice...

Research Grants4

  1. The NF2 gene: elucidation of tumor suppressor function
    JOSEPH KISSIL; Fiscal Year: 2004
    ..This should lead to a better understanding of merlin function in normal cells and the consequences of its loss in tumor development. Such information will directly assist in the search for effective therapies. ..
  2. The Role of RAC1 in Cancer
    JOSEPH KISSIL; Fiscal Year: 2009
    ..Given the prevalence of Ras mutations in human cancer these finds could potentially have an impact on a broad spectrum of cancers. ..
  3. The Role of RAC1 in Cancer
    JOSEPH KISSIL; Fiscal Year: 2010
    ..Given the prevalence of Ras mutations in human cancer these finds could potentially have an impact on a broad spectrum of cancers. ..