Shuji Kishi

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Embryonic senescence and laminopathies in a progeroid zebrafish model
    Eriko Koshimizu
    Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e17688. 2011
  2. doi request reprint Using zebrafish models to explore genetic and epigenetic impacts on evolutionary developmental origins of aging
    Shuji Kishi
    Department of Metabolism and Aging, The Scripps Research Institute, Scripps Florida, Jupiter, Fla Electronic address
    Transl Res 163:123-35. 2014
  3. pmc Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates--a mini-review
    Shuji Kishi
    Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL 33458, USA
    Gerontology 55:430-41. 2009
  4. doi request reprint The search for evolutionary developmental origins of aging in zebrafish: a novel intersection of developmental and senescence biology in the zebrafish model system
    Shuji Kishi
    Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL 33458, USA
    Birth Defects Res C Embryo Today 93:229-48. 2011
  5. pmc A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis
    Shintaro Imamura
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 3:e3364. 2008
  6. pmc The identification of zebrafish mutants showing alterations in senescence-associated biomarkers
    Shuji Kishi
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000152. 2008
  7. ncbi request reprint Differential effects of genotoxic stress on both concurrent body growth and gradual senescence in the adult zebrafish
    Stephanie B Tsai
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA
    Aging Cell 6:209-24. 2007
  8. pmc Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3
    Samuel Sidi
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 133:864-77. 2008
  9. ncbi request reprint Functional aging and gradual senescence in zebrafish
    Shuji Kishi
    Department of Cancer Biology, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115 6084, USA
    Ann N Y Acad Sci 1019:521-6. 2004
  10. pmc The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity
    Jun Ichi Hanai
    Renal Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Invest 117:3940-51. 2007

Collaborators

Detail Information

Publications16

  1. pmc Embryonic senescence and laminopathies in a progeroid zebrafish model
    Eriko Koshimizu
    Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e17688. 2011
    ..Zebrafish show an array of senescence symptoms resembling those in humans, which can be targeted to specific aging pathways conserved in vertebrates. However, no zebrafish models bearing human premature senescence currently exist...
  2. doi request reprint Using zebrafish models to explore genetic and epigenetic impacts on evolutionary developmental origins of aging
    Shuji Kishi
    Department of Metabolism and Aging, The Scripps Research Institute, Scripps Florida, Jupiter, Fla Electronic address
    Transl Res 163:123-35. 2014
    ....
  3. pmc Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates--a mini-review
    Shuji Kishi
    Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL 33458, USA
    Gerontology 55:430-41. 2009
    ....
  4. doi request reprint The search for evolutionary developmental origins of aging in zebrafish: a novel intersection of developmental and senescence biology in the zebrafish model system
    Shuji Kishi
    Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL 33458, USA
    Birth Defects Res C Embryo Today 93:229-48. 2011
    ....
  5. pmc A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis
    Shintaro Imamura
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 3:e3364. 2008
    ..The data also provide insights into a non-canonical pathway by which TERT functions to modulate specification of hematopoietic stem/progenitor cells during vertebrate development. (276 words)...
  6. pmc The identification of zebrafish mutants showing alterations in senescence-associated biomarkers
    Shuji Kishi
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000152. 2008
    ..Our current strategy of mutant screening for a senescence-associated biomarker in zebrafish embryos may thus prove to be a useful new tool for the genetic dissection of vertebrate stress response and senescence mechanisms...
  7. ncbi request reprint Differential effects of genotoxic stress on both concurrent body growth and gradual senescence in the adult zebrafish
    Stephanie B Tsai
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA
    Aging Cell 6:209-24. 2007
    ..Moreover, our present findings indicate that genotoxic DNA damage may play a role as a rate-limiting factor during the induction of senescence, but not in the inhibition of continuous, density-dependent growth in adult zebrafish...
  8. pmc Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3
    Samuel Sidi
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 133:864-77. 2008
    ..The evolutionarily conserved "Chk1-suppressed" pathway defines a novel apoptotic process, whose responsiveness to Chk1 inhibitors and insensitivity to p53 and BCL2 alterations have important implications for cancer therapy...
  9. ncbi request reprint Functional aging and gradual senescence in zebrafish
    Shuji Kishi
    Department of Cancer Biology, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115 6084, USA
    Ann N Y Acad Sci 1019:521-6. 2004
    ....
  10. pmc The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity
    Jun Ichi Hanai
    Renal Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Invest 117:3940-51. 2007
    ..Collectively, our human, animal, and in vitro findings shed light on the molecular mechanism of statin-induced myopathy and suggest that atrogin-1 may be a critical mediator of the muscle damage induced by statins...
  11. pmc Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling
    Mathew Sajish
    The Skaggs Institute for Chemical Biology, Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA
    Nat Chem Biol 8:547-54. 2012
    ..These and further results suggest an unexpected evolutionary expansion of the protein synthesis apparatus to a nuclear role that links major signaling pathways...
  12. ncbi request reprint The zebrafish as a vertebrate model of functional aging and very gradual senescence
    Shuji Kishi
    Department of Cancer Biology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115 6084, USA
    Exp Gerontol 38:777-86. 2003
    ....
  13. ncbi request reprint Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency
    Tomoyuki Sasaki
    Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, Florida, United States of America
    PLoS Genet 10:e1004409. 2014
    ..Thus, these results provide evidence that Spns1 operates during autophagy and senescence differentially with Beclin 1 and p53. ..
  14. ncbi request reprint Molecular cloning and functional characterization of zebrafish ATM
    Shintaro Imamura
    Department of Cancer Biology, Dana Farber Cancer Institute, and Department of Pathology, Harvard Medical School, 44 Binney Street, Boston, MA 02115 6084, USA
    Int J Biochem Cell Biol 37:1105-16. 2005
    ..We demonstrated that this knockdown of zATM caused abnormal development upon ionizing radiation-induced DNA damage. Our data suggest that the ATM gene is structurally and functionally conserved in vertebrates from zebrafish to human...
  15. pmc Unique domain appended to vertebrate tRNA synthetase is essential for vascular development
    Xiaoling Xu
    Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Commun 3:681. 2012
    ....
  16. pmc Molecular and chemical genetic approaches to developmental origins of aging and disease in zebrafish
    Tomoyuki Sasaki
    Department of Metabolism and Aging, The Scripps Research Institute, USA
    Biochim Biophys Acta 1832:1362-70. 2013
    ..This article is part of a Special Issue entitled: Animal Models of Disease...