LAWRENCE KIRSCHNER

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. doi request reprint The next generation of therapies for adrenocortical cancers
    Lawrence S Kirschner
    Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Trends Endocrinol Metab 23:343-50. 2012
  2. pmc PRKAR1A and the evolution of pituitary tumors
    Lawrence S Kirschner
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Mol Cell Endocrinol 326:3-7. 2010
  3. ncbi request reprint Emerging treatment strategies for adrenocortical carcinoma: a new hope
    Lawrence S Kirschner
    Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, and Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 91:14-21. 2006
  4. doi request reprint Use of mouse models to understand the molecular basis of tissue-specific tumorigenesis in the Carney complex
    L S Kirschner
    Division of Endocrinology, Diabetes and Metabolism and Human Cancer Genetics Program, The Ohio State University, 544 TMRF, 420 W 12th Ave, Columbus, OH 43210, USA
    J Intern Med 266:60-8. 2009
  5. doi request reprint Mouse models of altered protein kinase A signaling
    Lawrence S Kirschner
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The Ohio State University, 420 West 12th Avenue, TMRF 544, Columbus, Ohio 43210, USA
    Endocr Relat Cancer 16:773-93. 2009
  6. pmc Mouse models of endocrine tumours
    Georgette N Jones
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Best Pract Res Clin Endocrinol Metab 24:451-60. 2010
  7. doi request reprint Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis
    Zhirong Yin
    Department of Molecular Virology, Immunology, and Molecular Genetics, Ohio State University, Columbus, USA
    Circulation 117:1414-22. 2008
  8. pmc Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a
    Zhirong Yin
    Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, Ohio 43210, USA
    Mol Endocrinol 25:1786-93. 2011
  9. pmc Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition
    Kiran S Nadella
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, USA
    Cancer Res 68:2671-7. 2008
  10. pmc Mutation of Prkar1a causes osteoblast neoplasia driven by dysregulation of protein kinase A
    Emilia Pavel
    Department of Molecular Virology, Immunology, and Molecular Genetics, The Ohio State University, 420 West 12th Avenue, TMRF 546, Columbus, OH 43210, USA
    Mol Endocrinol 22:430-40. 2008

Research Grants

  1. ROLE OF THE CNC GENE IN DEVELOPMENT AND TUMORIGENESIS
    LAWRENCE KIRSCHNER; Fiscal Year: 2004
  2. Carney Complex: A Model for PKA-Mediated Tumorigenesis
    LAWRENCE KIRSCHNER; Fiscal Year: 2007

Collaborators

  • Mei Zhang
  • Matthew D Ringel
  • Constantine A Stratakis
  • Y S Cho-Chung
  • EVAN ABEL
  • Georgette N Jones
  • Zhirong Yin
  • Kiran S Nadella
  • Isabelle Bourdeau
  • Daphne R Pringle
  • Ludmila Matyakhina
  • William H Towns
  • Emilia Pavel
  • Leonardo M Porchia
  • Kurt J Griffin
  • Sotirios Stergiopoulos
  • Jerome Bertherat
  • Kimberly M Kelly
  • Parmeet K Manchanda
  • Anthony Trimboli
  • Philip F Binkley
  • Xiaoli Zhang
  • David Jarjoura
  • Kiran Nadella
  • Gustavo Leone
  • Allan V Espinosa
  • Motoo Shinohara
  • Ching Shih Chen
  • Motoyasu Saji
  • Yu Chieh Wang
  • Yunlong Zhang
  • Marcy Guerra
  • Samuel K Kulp
  • Elise Meoli
  • Audrey Robinson-White
  • Sonir R Antonini
  • Steven K Libutti
  • Andre Lacroix
  • Edward Claflin
  • Frank D Weinberg
  • Sara Lenherr
  • Dominique Lorang
  • Christine Gicquel
  • Fabiano Sandrini
  • Caroline Vincent-Dejean
  • Karine Perlemoine
  • Xavier Bertagna
  • Thalia Bei
  • Theocharis Papageorgiou
  • Lionel Groussin

Detail Information

Publications17

  1. doi request reprint The next generation of therapies for adrenocortical cancers
    Lawrence S Kirschner
    Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Trends Endocrinol Metab 23:343-50. 2012
    ..Although convincing evidence for the effectiveness of targeted therapies is not currently available, these studies are in progress and should shift the prognosis of this disease in the years to come...
  2. pmc PRKAR1A and the evolution of pituitary tumors
    Lawrence S Kirschner
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Mol Cell Endocrinol 326:3-7. 2010
    ..These data indicate that complete loss of Prkar1a/PRKAR1A is able to cause pituitary tumors in mice and men. The pattern of tumors is likely related to the signaling pathways employed in specific pituitary cell types...
  3. ncbi request reprint Emerging treatment strategies for adrenocortical carcinoma: a new hope
    Lawrence S Kirschner
    Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, and Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 91:14-21. 2006
    ..Traditional cytotoxic chemotherapy for ACC has generally produced disappointing responses, implying the need for the new therapies for this disease...
  4. doi request reprint Use of mouse models to understand the molecular basis of tissue-specific tumorigenesis in the Carney complex
    L S Kirschner
    Division of Endocrinology, Diabetes and Metabolism and Human Cancer Genetics Program, The Ohio State University, 544 TMRF, 420 W 12th Ave, Columbus, OH 43210, USA
    J Intern Med 266:60-8. 2009
    ..This work confirms the role of Prkar1a as a tissue-specific tumour suppressor, and ongoing work is focused on identifying the key downstream signalling targets affected by dysregulation of PKA...
  5. doi request reprint Mouse models of altered protein kinase A signaling
    Lawrence S Kirschner
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The Ohio State University, 420 West 12th Avenue, TMRF 544, Columbus, Ohio 43210, USA
    Endocr Relat Cancer 16:773-93. 2009
    ..These data have led to a better understanding of both the complexity and the subtlety of PKA signaling, and point the way for future studies, which may help to modulate this pathway for therapeutic effect...
  6. pmc Mouse models of endocrine tumours
    Georgette N Jones
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Best Pract Res Clin Endocrinol Metab 24:451-60. 2010
    ....
  7. doi request reprint Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis
    Zhirong Yin
    Department of Molecular Virology, Immunology, and Molecular Genetics, Ohio State University, Columbus, USA
    Circulation 117:1414-22. 2008
    ..Mouse models of this genetic defect have been unsatisfactory because homozygote null animals die early in development and heterozygotes do not exhibit a cardiac phenotype...
  8. pmc Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a
    Zhirong Yin
    Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, Ohio 43210, USA
    Mol Endocrinol 25:1786-93. 2011
    ..These data suggest that both developmental and tumor phenotypes caused by Prkar1a mutation result from excess PKA activity due to PKA-Ca...
  9. pmc Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition
    Kiran S Nadella
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, USA
    Cancer Res 68:2671-7. 2008
    ..Finally, this down-regulation of vimentin was recapitulated in the adrenal nodules of CNC patients, confirming an unexpected and previously unrecognized role for PKA in MET...
  10. pmc Mutation of Prkar1a causes osteoblast neoplasia driven by dysregulation of protein kinase A
    Emilia Pavel
    Department of Molecular Virology, Immunology, and Molecular Genetics, The Ohio State University, 420 West 12th Avenue, TMRF 546, Columbus, OH 43210, USA
    Mol Endocrinol 22:430-40. 2008
    ..Tumor cells exhibited enhanced growth in response to PKA-stimulating agents, suggesting that tumorigenesis in osteoblast precursor cells is driven by effects directly mediated by the dysregulation of PKA...
  11. ncbi request reprint 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase
    Leonardo M Porchia
    Division of Endocrinology, Department of Medicine, the Ohio State University Colleges of Medicine and Pharmacy, Columbus, Ohio, USA
    Mol Pharmacol 72:1124-31. 2007
    ..In summary, OSU-03012 is a direct inhibitor of PAK, and inhibition of PAK, either directly or indirectly, may be involved in its biological effects in vitro...
  12. ncbi request reprint Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins
    Kiran S Nadella
    Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 65:10307-15. 2005
    ..Using this model, we provide the first direct genetic evidence that dysregulation of PKA promotes important steps in tumorigenesis, and that cyclin D1 is an essential target of PKA...
  13. ncbi request reprint Editorial: paradigms for adrenal cancer: think globally, act locally
    Lawrence S Kirschner
    J Clin Endocrinol Metab 91:4250-2. 2006
  14. ncbi request reprint Down-regulation of regulatory subunit type 1A of protein kinase A leads to endocrine and other tumors
    Kurt J Griffin
    Section on Genetics and Endocrinology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Cancer Res 64:8811-5. 2004
    ..This mouse provides a novel, useful tool for the investigation of cyclic AMP, RIalpha, and PKA functions and confirms the critical role of Prkar1a in tumorigenesis in endocrine and other tissues...
  15. ncbi request reprint Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators
    Isabelle Bourdeau
    Section on Endocrinology and Genetics, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 23:1575-85. 2004
    ..Several candidate genes that may be responsible for AIMAH formation and/or progression were also identified, suggesting pathways that affect the cell cycle, adhesion and transcription as possible mediators of adrenocortical hyperplasia...
  16. ncbi request reprint Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity
    Jerome Bertherat
    Department of Endocrinology, Institut Cochin, Institut National de la Sante et de la Recherche Medicale U567, CNRS UMR8104, Universite Paris V, Hopital Cochin, Paris 75014, France
    Cancer Res 63:5308-19. 2003
    ....
  17. ncbi request reprint Signaling pathways in adrenocortical cancer
    Lawrence S Kirschner
    Unit on Genetics and Endocrinology, DEB, NICHD, National Instutes of Health, Bethesda, Maryland 20892 1862, USA
    Ann N Y Acad Sci 968:222-39. 2002
    ....

Research Grants5

  1. ROLE OF THE CNC GENE IN DEVELOPMENT AND TUMORIGENESIS
    LAWRENCE KIRSCHNER; Fiscal Year: 2004
    ..The long-term goal of this project is to identify the role that the CNC gene product plays in the normal development of the endocrine and other systems, as well as the role that the mutated gene plays in tumorigenesis. ..
  2. Carney Complex: A Model for PKA-Mediated Tumorigenesis
    LAWRENCE KIRSCHNER; Fiscal Year: 2007
    ..abstract_text> ..