K H Kirsch

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi CMS: an adapter molecule involved in cytoskeletal rearrangements
    K H Kirsch
    Laboratory of Molecular Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:6211-6. 1999
  2. ncbi The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction
    K H Kirsch
    Laboratory of Molecular Oncology, The Rockefeller University, New York, NY 10021, USA
    J Biol Chem 276:4957-63. 2001
  3. ncbi Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor
    M M Georgescu
    Laboratory of Molecular Oncology, The Rockefeller University, New York, New York 10021, USA
    Cancer Res 60:7033-8. 2000
  4. ncbi Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB
    M M Georgescu
    Laboratory of Molecular Oncology, The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 19:1171-81. 1999
  5. ncbi Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II
    A Zvara
    Laboratory of Molecular Oncology, The Rockefeller University, New York, NY 10021, USA
    Oncogene 20:951-61. 2001
  6. ncbi The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region
    M M Georgescu
    Laboratory of Molecular Oncology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:10182-7. 1999
  7. ncbi Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G
    K H Kirsch
    Laboratory of Molecular Oncology, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 273:25673-9. 1998
  8. ncbi Mader: a novel nuclear protein over expressed in human melanomas
    K H Kirsch
    Institute for Immunology, University of Munich, Germany
    Oncogene 12:963-71. 1996

Collaborators

Detail Information

Publications8

  1. ncbi CMS: an adapter molecule involved in cytoskeletal rearrangements
    K H Kirsch
    Laboratory of Molecular Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:6211-6. 1999
    ..We observed a diffuse distribution of actin in small dots and less actin fiber formation. Altogether, these features suggest that CMS functions as a scaffolding molecule with a specialized role in regulation of the actin cytoskeleton...
  2. ncbi The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction
    K H Kirsch
    Laboratory of Molecular Oncology, The Rockefeller University, New York, NY 10021, USA
    J Biol Chem 276:4957-63. 2001
    ....
  3. ncbi Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor
    M M Georgescu
    Laboratory of Molecular Oncology, The Rockefeller University, New York, New York 10021, USA
    Cancer Res 60:7033-8. 2000
    ..These data support a double role for PTEN C2 domain in protein stability and in productive orientation of the catalytic site...
  4. ncbi Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB
    M M Georgescu
    Laboratory of Molecular Oncology, The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 19:1171-81. 1999
    ..Consistent with this notion, apoptosis induced by IL-3 withdrawal was strongly prevented by CDMer but not by the F867 mutant receptor...
  5. ncbi Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II
    A Zvara
    Laboratory of Molecular Oncology, The Rockefeller University, New York, NY 10021, USA
    Oncogene 20:951-61. 2001
    ....
  6. ncbi The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region
    M M Georgescu
    Laboratory of Molecular Oncology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:10182-7. 1999
    ..We also propose that the molecular conformational changes induced by these mutations constitute the mechanism for PTEN inactivation...
  7. ncbi Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G
    K H Kirsch
    Laboratory of Molecular Oncology, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 273:25673-9. 1998
    ..Cas shows structural characteristics of a docking molecule and may serve to bring C3G to specific compartments within the cell...
  8. ncbi Mader: a novel nuclear protein over expressed in human melanomas
    K H Kirsch
    Institute for Immunology, University of Munich, Germany
    Oncogene 12:963-71. 1996
    ..The fact that only one of six benign melanocytic nevi examined showed evidence of Mader expression suggests that over-expression of Mader protein may be associated with the malignant transformation of melanocytes...