Affiliation: The Children's Hospital of Philadelphia
- A trial comparing noninvasive ventilation strategies in preterm infantsHaresh Kirpalani
Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
N Engl J Med 369:611-20. 2013..To reduce the risk of bronchopulmonary dysplasia in extremely-low-birth-weight infants, clinicians attempt to minimize the use of endotracheal intubation by the early introduction of less invasive forms of positive airway pressure...
- Do transfusions cause necrotizing enterocolitis? The complementary role of randomized trials and observational studiesHaresh Kirpalani
Division of Neonatology, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104 4399, USA
Semin Perinatol 36:269-76. 2012..It is acknowledged that not all questions can be subject to a randomized evaluation, but argued that this particular association is amenable to such a test...
- Cooling for neonatal hypoxic ischemic encephalopathy: do we have the answer?Haresh Kirpalani
Department of Clinical Epidemiology, McMaster University, Hamilton, Ontario, Canada
Pediatrics 120:1126-30. 2007
- Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2)Matthias Briel
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
Trials 10:49. 2009..The aim of STOPIT-2 is to determine the magnitude and determinants of possible bias introduced by stopping RCTs early for benefit...
- Relationship between attrition and neurodevelopmental impairment rates in extremely preterm infants at 18 to 24 months: a systematic reviewUrsula Guillen
Division of Neonatology, The Children s Hospital of Philadelphia, PA 19104, USA
Arch Pediatr Adolesc Med 166:178-84. 2012..To assess the effect of loss to follow-up rates at 18 to 24 months on neurodevelopmental outcome statistics for infants of less than 1000 g birth weight or less than 28 weeks' gestational age...
- Economic evaluation alongside the Premature Infants in Need of Transfusion randomised controlled trialKaren L Kamholz
Division of Neonatology, Boston Medical Center, 771 Albany Street, Boston, MA 02118, USA
Arch Dis Child Fetal Neonatal Ed 97:F93-8. 2012..However, a post-hoc analysis expanding the definition of NDI to include borderline intellectual functioning (Mental Development Index (MDI) <85) found an improvement in outcomes in the group maintained at higher haemoglobin levels...
- Development and pretesting of a decision-aid to use when counseling parents facing imminent extreme premature deliveryUrsula Guillen
Division of Neonatology, Children s Hospital of Philadelphia, PA 19104, USA
J Pediatr 160:382-7. 2012..To develop and pretest a decision-aid to help parents facing extreme premature delivery during antenatal counseling regarding delivery room resuscitation...
- Evidence-based neonatal drug therapy for prevention of bronchopulmonary dysplasia in very-low-birth-weight infantsBarbara Schmidt
Department of Pediatrics, Children s Hospital of Philadelphia and The University of Pennsylvania, Philadelphia, PA 19104, USA
Neonatology 93:284-7. 2008..However, when given during the 2nd week of life to infants at high risk of BPD corticosteroids may have important short- and long-term benefits. These should be urgently confirmed or refuted in well-designed controlled trials...
- A clinical prediction model to stratify retinopathy of prematurity risk using postnatal weight gainGil Binenbaum
Division of Ophthalmology, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, 9 Main, Philadelphia, PA 19104, USA
Pediatrics 127:e607-14. 2011..Under current birth weight (BW) and gestational age (GA) screening criteria, <5% of infants examined in countries with advanced neonatal care require treatment...
- Positive end expiratory pressure for preterm infants requiring conventional mechanical ventilation for respiratory distress syndrome or bronchopulmonary dysplasiaNicolas Bamat
Pediatric Residency Program, Children s Hospital of Philadelphia, 34th Street and Civic CenterBoulevard, Philadelphia, Pennsylvania, 19104, USA
Cochrane Database Syst Rev 1:CD004500. 2012..An appropriate level of PEEP for neonates may also be best achieved by an individualized approach...
- A rational approach to red blood cell transfusion in the neonatal ICUMoira Crowley
Division of Neonatology, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Curr Opin Pediatr 22:151-7. 2010..There have been several recent randomized controlled trials collectively aimed at either the prevention or the management of anemia of prematurity. We aim to summarize evidence on prevention, management and long-term outcomes...
- Survival rates in extremely low birthweight infants depend on the denominator: avoiding potential for bias by specifying denominatorsUrsula Guillen
Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Am J Obstet Gynecol 205:329.e1-7. 2011..The objective of the study was to assess whether recent data reporting survival of preterm infants introduce a bias from the use of varying denominators...
- Use of antibiotics for the treatment of preterm parturition and prevention of neonatal morbidity: a metaanalysisCarolyn E Hutzal
Department of Pediatrics, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
Am J Obstet Gynecol 199:620.e1-8. 2008..We conducted a metaanalysis to determine whether antibiotics prolong pregnancy and reduce neonatal morbidity in preterm premature rupture of membranes (PPROM) and preterm labor (PTL) at 34 weeks or less...
- The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infantsHaresh Kirpalani
Pediatrics and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
J Pediatr 149:301-307. 2006..To determine whether extremely low birth weight infants (ELBW) transfused at lower hemoglobin thresholds versus higher thresholds have different rates of survival or morbidity at discharge...
- Quality of reporting of neonatal and infant trials in high-impact journalsSara B Demauro
Department of Pediatrics, Children s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Pediatrics 128:e639-44. 2011....
- Accuracy of tidal volume, compliance, and resistance measurements on neonatal ventilator displays: an in vitro assessmentSoraya Abbasi
Division of Neonatology, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA
Pediatr Crit Care Med 13:e262-8. 2012..To determine the accuracy of measures of respiratory mechanics derived from neonatal ventilators using an in vitro passive physical lung model to simulate newborn pulmonary conditions...
- Targeting inflammation to prevent bronchopulmonary dysplasia: can new insights be translated into therapies?Clyde J Wright
Division of Neonatology, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Pediatrics 128:111-26. 2011..In this review we highlight recent bench and clinical research aimed at understanding the role of inflammation in the pathogenesis of BPD. We also critically assess currently used therapies and promising developments in the field...
- Supporting bereaved parents: practical steps in providing compassionate perinatal and neonatal end-of-life care. A North American perspectiveConstance Williams
Division of Neonatology, Hospital for Sick Children, University of Toronto, Canada
Semin Fetal Neonatal Med 13:335-40. 2008..Challenges to providing comprehensive end-of-life care include care-giver comfort, consistency of care, cultural and legal barriers, and lack of adequate training...