Donghee Kim

Summary

Affiliation: The Chicago Medical School
Country: USA

Publications

  1. ncbi TASK-5, a new member of the tandem-pore K(+) channel family
    D Kim
    Department of Physiology and Biophysics, Finch University of Health Sciences Chicago Medical School, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
    Biochem Biophys Res Commun 284:923-30. 2001
  2. ncbi Localization of TREK-2 K+ channel domains that regulate channel kinetics and sensitivity to pressure, fatty acids and pHi
    Y Kim
    Department of Physiology and Biophysics, Finch University of Health Sciences, The Chicago Medical School, IL 60064, USA
    Pflugers Arch 442:952-60. 2001
  3. ncbi Fatty acid-sensitive two-pore domain K+ channels
    Donghee Kim
    Department of Physiology and Biophysics, Finch University of Health Sciences The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Trends Pharmacol Sci 24:648-54. 2003
  4. pmc Control of the single channel conductance of K2P10.1 (TREK-2) by the amino-terminus: role of alternative translation initiation
    Dina Simkin
    Department of Physiology and Biophysics, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    J Physiol 586:5651-63. 2008
  5. ncbi Functional expression of TREK-2 in insulin-secreting MIN6 cells
    Dawon Kang
    Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Biochem Biophys Res Commun 323:323-31. 2004
  6. ncbi Functional expression of TRESK-2, a new member of the tandem-pore K+ channel family
    Dawon Kang
    Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    J Biol Chem 279:28063-70. 2004
  7. pmc Characterization of an ATP-sensitive K(+) channel in rat carotid body glomus cells
    Donghee Kim
    Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, United States
    Respir Physiol Neurobiol 177:247-55. 2011
  8. pmc Properties of single two-pore domain TREK-2 channels expressed in mammalian cells
    Dawon Kang
    Department of Physiology and Biophysics, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    J Physiol 583:57-69. 2007
  9. pmc Functional expression of TASK-1/TASK-3 heteromers in cerebellar granule cells
    Dawon Kang
    Department of Physiology and Biophysics, Finch University of Health Sciences The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    J Physiol 554:64-77. 2004
  10. pmc Heteromeric TASK-1/TASK-3 is the major oxygen-sensitive background K+ channel in rat carotid body glomus cells
    Donghee Kim
    Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    J Physiol 587:2963-75. 2009

Collaborators

Detail Information

Publications33

  1. ncbi TASK-5, a new member of the tandem-pore K(+) channel family
    D Kim
    Department of Physiology and Biophysics, Finch University of Health Sciences Chicago Medical School, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
    Biochem Biophys Res Commun 284:923-30. 2001
    ..Exchange of C-termini of TASK-3 and TASK-5 failed to generate whole-cell currents. Thus, TASK-5 is a new member of the tandem-pore K(+) channel family but does not produce a functional plasma membrane K(+) current by itself...
  2. ncbi Localization of TREK-2 K+ channel domains that regulate channel kinetics and sensitivity to pressure, fatty acids and pHi
    Y Kim
    Department of Physiology and Biophysics, Finch University of Health Sciences, The Chicago Medical School, IL 60064, USA
    Pflugers Arch 442:952-60. 2001
    ..Thus, the C-terminus endows TREK-2 with unique channel kinetics and the ability to be gated by free fatty acids and low pHi, and with increased mechanosensitivity...
  3. ncbi Fatty acid-sensitive two-pore domain K+ channels
    Donghee Kim
    Department of Physiology and Biophysics, Finch University of Health Sciences The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Trends Pharmacol Sci 24:648-54. 2003
    ..The unique properties of K(FA) channels indicate that they are well suited to sensing various types of stress that occur in the cell...
  4. pmc Control of the single channel conductance of K2P10.1 (TREK-2) by the amino-terminus: role of alternative translation initiation
    Dina Simkin
    Department of Physiology and Biophysics, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    J Physiol 586:5651-63. 2008
    ....
  5. ncbi Functional expression of TREK-2 in insulin-secreting MIN6 cells
    Dawon Kang
    Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Biochem Biophys Res Commun 323:323-31. 2004
    ..8). Arachidonic acid increased Ba2+-sensitive whole-cell current in MIN6 cell. These results suggest that TREK-2 contributes to the background K+ conductance in MIN6 cells, and may regulate depolarization-induced secretion of insulin...
  6. ncbi Functional expression of TRESK-2, a new member of the tandem-pore K+ channel family
    Dawon Kang
    Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    J Biol Chem 279:28063-70. 2004
    ..These results show that TRESK-2 is a functional member of the K(2P) channel family and contributes to the background K+ conductance in many types of cells...
  7. pmc Characterization of an ATP-sensitive K(+) channel in rat carotid body glomus cells
    Donghee Kim
    Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, United States
    Respir Physiol Neurobiol 177:247-55. 2011
    ..These results show that an ATP-sensitive K(+) channel is expressed in the plasma membrane of CB cells, but is not activated by short-term metabolic inhibition. The functional relevance of the 72-pS channel remains to be determined...
  8. pmc Properties of single two-pore domain TREK-2 channels expressed in mammalian cells
    Dawon Kang
    Department of Physiology and Biophysics, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    J Physiol 583:57-69. 2007
    ..This represents a novel mechanism by which receptor agonists modulate the function of a K+ channel to alter cell excitability...
  9. pmc Functional expression of TASK-1/TASK-3 heteromers in cerebellar granule cells
    Dawon Kang
    Department of Physiology and Biophysics, Finch University of Health Sciences The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    J Physiol 554:64-77. 2004
    ..These electrophysiological studies show that native 38 pS K+ channels of the TASK family in cultured CG neurones consist of both homomeric TASK-3 and heteromeric TASK-1/TASK-3...
  10. pmc Heteromeric TASK-1/TASK-3 is the major oxygen-sensitive background K+ channel in rat carotid body glomus cells
    Donghee Kim
    Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    J Physiol 587:2963-75. 2009
    ..These results show that TASK-1, TASK-1/3 and TASK-3 are all functionally expressed in isolated CB cells, and that the TASK-1/3 heteromer provides the major part of the oxygen-sensitive TASK-like background K+ conductance...
  11. ncbi Mechanism of inhibition of TREK-2 (K2P10.1) by the Gq-coupled M3 muscarinic receptor
    Dawon Kang
    Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    Am J Physiol Cell Physiol 291:C649-56. 2006
    ..These results suggest that the agonist-induced inhibition of TREK-2 via M(3) receptor occurs primarily via PKC-mediated phosphorylation...
  12. ncbi Single-channel properties and pH sensitivity of two-pore domain K+ channels of the TALK family
    Dawon Kang
    Department of Physiology and Biophysics, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Biochem Biophys Res Commun 315:836-44. 2004
    ..The effect of pH changes was mainly on the opening frequency. Thus, members of the TALK family expressed in native tissues may be identified based on their single-channel kinetics and pHo sensitivity...
  13. ncbi TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons
    Dawon Kang
    Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Am J Physiol Cell Physiol 291:C138-46. 2006
    ..As TREKs and TRESK are targets of modulation by receptor agonists, they are likely to play an active role in the regulation of excitability in DRG neurons...
  14. pmc Changes in oxygen sensitivity of TASK in carotid body glomus cells during early postnatal development
    Donghee Kim
    Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science 3333 Green Bay Rd, North Chicago, IL 60064, United States
    Respir Physiol Neurobiol 177:228-35. 2011
    ..These results support the hypothesis that postnatal carotid body functional maturation is due, at least in part, to changes in the sensitivity of TASK to the hypoxic signals generated in glomus cells...
  15. ncbi Requirement of a soluble intracellular factor for activation of transient receptor potential A1 by pungent chemicals: role of inorganic polyphosphates
    Donghee Kim
    Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci 27:6500-9. 2007
    ..These results show that TRPA1 requires an intracellular factor to adopt a functional conformation that is sensitive to pungent chemicals and suggest that polyphosphates may partly act as such a factor...
  16. pmc Background and tandem-pore potassium channels in magnocellular neurosecretory cells of the rat supraoptic nucleus
    Jaehee Han
    Department of Physiology and Biophysics, Finch University of Health Sciences The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    J Physiol 546:625-39. 2003
    ..Various physiological and pathophysiological conditions may modulate these K(+) channels and regulate the excitability of MNCs...
  17. ncbi Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1
    Jaehee Han
    Department of Physiology and Biophysics, Finch University of Health Sciences Chicago Medical School, 3333 Green Bay Rd, North Chicago, IL 60064, USA
    Am J Physiol Cell Physiol 285:C529-38. 2003
    ..16 and 7.21, respectively. These results indicate that at least two functional TALK-1 variants are present and may serve as background K+ currents in certain cells of the human pancreas...
  18. pmc Modulation of K2P3.1 (TASK-1), K2P9.1 (TASK-3), and TASK-1/3 heteromer by reactive oxygen species
    Justin R Papreck
    Department of Physiology and Biophysics, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Pflugers Arch 464:471-80. 2012
    ..These findings show that ROS do not support or inhibit TASK and BK activity and therefore are unlikely to be the hypoxic signal that causes cell excitation via inhibition of these K(+) channels...
  19. pmc Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate
    Donghee Kim
    Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, IL 60064, USA
    Am J Physiol Cell Physiol 295:C92-9. 2008
    ..These results show that PIP2 inhibits TRPA1 and reduces the sensitivity of TRPA1 to AITC...
  20. ncbi Functional expression of TREK-2 K+ channel in cultured rat brain astrocytes
    Carmen Gnatenco
    Department of Physiology and Biophysics, Finch University of Health Sciences The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    Brain Res 931:56-67. 2002
    ..Our results show that TREK-2 is functionally expressed in cortical astrocytes in culture, and suggest that TREK-2 may be involved in K+ homeostasis of astrocytes during pathological states...
  21. pmc Species differences and molecular determinant of TRPA1 cold sensitivity
    Jun Chen
    Neuroscience and Early Discovery, Building AP9 1125, North Waukegan Road, North Chicago, Illinois 60064 6125, USA
    Nat Commun 4:2501. 2013
    ..This residue difference also underlies the species-specific effects of menthol. Together, our findings identify the species-specific cold activation of TRPA1 and reveal a molecular determinant of cold-sensitive gating. ..
  22. pmc Effects of modulators of AMP-activated protein kinase on TASK-1/3 and intracellular Ca(2+) concentration in rat carotid body glomus cells
    Donghee Kim
    Department of Physiology and Biophysics, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, United States Electronic address
    Respir Physiol Neurobiol 195:19-26. 2014
    ..Our results suggest that AMPK does not affect TASK activity and is not involved in hypoxia-induced elevation of intracellular [Ca(2+)] in isolated rat carotid body glomus cells. ..
  23. doi K(+) channels in O(2) sensing and postnatal development of carotid body glomus cell response to hypoxia
    Donghee Kim
    Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, United States
    Respir Physiol Neurobiol 185:44-56. 2013
    ....
  24. pmc THIK-1 (K2P13.1) is a small-conductance background K(+) channel in rat trigeminal ganglion neurons
    Dawon Kang
    Department of Physiology and Biophysics, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL, 60064, USA
    Pflugers Arch 466:1289-300. 2014
    ..These results show that THIK-1 is functionally expressed in TG neurons and contributes to the background K(+) conductance...
  25. ncbi Increase in cytosolic Ca2+ produced by hypoxia and other depolarizing stimuli activates a non-selective cation channel in chemoreceptor cells of rat carotid body
    Dawon Kang
    Department of Physiology and Biophysics, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    J Physiol 592:1975-92. 2014
    ..Our results suggest that inhibition of K(+) efflux and stimulation of Na(+) influx both contribute to the depolarization of glomus cells during moderate to severe hypoxia. ..
  26. ncbi Physiology and pharmacology of two-pore domain potassium channels
    Donghee Kim
    Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Curr Pharm Des 11:2717-36. 2005
    ..Therefore, K2P channels could become potentially important therapeutic targets for the treatment of various pathological conditions...
  27. ncbi Choice of the adequate detection time for the accurate evaluation of the efficiency of siRNA-induced gene silencing
    Inho Choi
    Laboratory of Immunology, Transplantation Research Institute and Clinical Research Institute, Seoul National University Hospital, Seoul 110 744, Republic of Korea
    J Biotechnol 120:251-61. 2005
    ....
  28. pmc Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK
    Dawon Kang
    Department of Physiology, Gyeongsang National University School of Medicine, Jinju, Korea
    J Physiol 564:103-16. 2005
    ....
  29. pmc Properties and modulation of the G protein-coupled K+ channel in rat cerebellar granule neurons: ATP versus phosphatidylinositol 4,5-bisphosphate
    Jaehee Han
    Department of Physiology, Gyeonsang National University School of Medicine, Chinju, Korea
    J Physiol 550:693-706. 2003
    ..Our results also show that intracellular ATP modulates GIRK via pathways different from that of PIP2 in CG neurons...
  30. pmc Characterization of four types of background potassium channels in rat cerebellar granule neurons
    Jaehee Han
    Department of Physiology, Gyeongsang National University School of Medicine, Chinju, Korea
    J Physiol 542:431-44. 2002
    ..Our results also show that the high sensitivity of I(K,SO) to extracellular pH comes from the high sensitivity of Type 2 (TASK-3) and Type 4 K+ channels...
  31. pmc Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1
    Lillian Cruz-Orengo
    Washington University Pain Center, Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63130, USA
    Mol Pain 4:30. 2008
    ..Acrid, electrophilic chemicals including cinnamaldehyde (CA) and allyl isothiocyanate (AITC), derivatives of cinnamon and mustard oil respectively, activate thermoTRP member TRPA1 via direct modification of channel cysteine residues...
  32. ncbi MHC expression in a human adult stem cell line and its down-regulation by hCMV US gene transfection
    Jae Young Kim
    Xenotransplantation Research Center, Seoul National University Hospital, Seoul 110 744, South Korea
    Int J Biochem Cell Biol 37:69-78. 2005
    ..In addition, viral stealth mechanisms can be exploited for stem cell transplantation...
  33. ncbi International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels
    Steve A N Goldstein
    Department of Pediatrics and Institute for Molecular Pediatric Sciences, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Pharmacol Rev 57:527-40. 2005