Mahesh Khatri

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. doi request reprint Influenza virus infects bone marrow mesenchymal stromal cells in vitro: implications for bone marrow transplantation
    Mahesh Khatri
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA
    Cell Transplant 22:461-8. 2013
  2. pmc Epithelial cells derived from swine bone marrow express stem cell markers and support influenza virus replication in vitro
    Mahesh Khatri
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA
    PLoS ONE 6:e29567. 2011
  3. doi request reprint Isolation and characterization of chicken lung mesenchymal stromal cells and their susceptibility to avian influenza virus
    Mahesh Khatri
    Department of Veterinary Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    Dev Comp Immunol 34:474-9. 2010
  4. pmc Differential modulation of cytokine, chemokine and Toll like receptor expression in chickens infected with classical and variant infectious bursal disease virus
    Abdul Rauf
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA
    Vet Res 42:85. 2011
  5. doi request reprint Susceptibility of chicken mesenchymal stem cells to infectious bursal disease virus
    Mahesh Khatri
    Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, 55108, USA
    J Virol Methods 160:197-9. 2009
  6. doi request reprint Isolation and differentiation of chicken mesenchymal stem cells from bone marrow
    Mahesh Khatri
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota 55108, USA
    Stem Cells Dev 18:1485-92. 2009
  7. doi request reprint Potential role of viral surface glycoproteins in the replication of H3N2 triple reassortant influenza A viruses in swine and turkeys
    Hadi M Yassine
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Ave, Wooster, OH 44691, USA
    Vet Microbiol 148:175-82. 2011
  8. doi request reprint Identification of swine H1N2/pandemic H1N1 reassortant influenza virus in pigs, United States
    Ahmed Ali
    Ohio State University, Food Animal Health Research Program, Ohio Agricultural Research and Development Center, 1680 Madison Avenue, Wooster, OH 44691, USA
    Vet Microbiol 158:60-8. 2012
  9. doi request reprint Protection against avian metapneumovirus subtype C in turkeys immunized via the respiratory tract with inactivated virus
    Ra Mi Cha
    Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Ave, St Paul, MN 55108, USA
    Vaccine 29:459-65. 2011
  10. doi request reprint Expression of perforin-granzyme pathway genes in the bursa of infectious bursal disease virus-infected chickens
    Abdul Rauf
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, United States
    Dev Comp Immunol 35:620-7. 2011

Collaborators

Detail Information

Publications24

  1. doi request reprint Influenza virus infects bone marrow mesenchymal stromal cells in vitro: implications for bone marrow transplantation
    Mahesh Khatri
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA
    Cell Transplant 22:461-8. 2013
    ..The data also suggest that transplantation of bone marrow MSCs from influenza virus-infected donors may transmit infection to recipients. Also, MSCs may get infected if infused into a patient with an ongoing influenza virus infection...
  2. pmc Epithelial cells derived from swine bone marrow express stem cell markers and support influenza virus replication in vitro
    Mahesh Khatri
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA
    PLoS ONE 6:e29567. 2011
    ....
  3. doi request reprint Isolation and characterization of chicken lung mesenchymal stromal cells and their susceptibility to avian influenza virus
    Mahesh Khatri
    Department of Veterinary Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    Dev Comp Immunol 34:474-9. 2010
    ..Further characterization of lung MSCs in chicken and other mammalian species may help in understanding the pathogenesis of infectious and non-infectious lung diseases and the mechanisms of lung injury repair...
  4. pmc Differential modulation of cytokine, chemokine and Toll like receptor expression in chickens infected with classical and variant infectious bursal disease virus
    Abdul Rauf
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA
    Vet Res 42:85. 2011
    ..These findings demonstrate the critical differences in bursal lesions, infiltration of T cells, expression of cytokines, chemokines and TLRs in the bursa of cIBDV-and vIBDV-infected chickens...
  5. doi request reprint Susceptibility of chicken mesenchymal stem cells to infectious bursal disease virus
    Mahesh Khatri
    Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, 55108, USA
    J Virol Methods 160:197-9. 2009
    ..The finding that IBDV can replicate in mesenchymal stem cells provides new information on the susceptible target cell population within the host and contributes to the understanding of the pathogenic potential of the virus...
  6. doi request reprint Isolation and differentiation of chicken mesenchymal stem cells from bone marrow
    Mahesh Khatri
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota 55108, USA
    Stem Cells Dev 18:1485-92. 2009
    ....
  7. doi request reprint Potential role of viral surface glycoproteins in the replication of H3N2 triple reassortant influenza A viruses in swine and turkeys
    Hadi M Yassine
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Ave, Wooster, OH 44691, USA
    Vet Microbiol 148:175-82. 2011
    ..Such findings further highlight the polygenic nature of influenza virus pathogenesis...
  8. doi request reprint Identification of swine H1N2/pandemic H1N1 reassortant influenza virus in pigs, United States
    Ahmed Ali
    Ohio State University, Food Animal Health Research Program, Ohio Agricultural Research and Development Center, 1680 Madison Avenue, Wooster, OH 44691, USA
    Vet Microbiol 158:60-8. 2012
    ..S. and their impact on both swine production and public health...
  9. doi request reprint Protection against avian metapneumovirus subtype C in turkeys immunized via the respiratory tract with inactivated virus
    Ra Mi Cha
    Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Ave, St Paul, MN 55108, USA
    Vaccine 29:459-65. 2011
    ..05). These results showed that inactivated aMPV/C administered by the respiratory route induced protective immunity against pathogenic virus challenge...
  10. doi request reprint Expression of perforin-granzyme pathway genes in the bursa of infectious bursal disease virus-infected chickens
    Abdul Rauf
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, United States
    Dev Comp Immunol 35:620-7. 2011
    ..The findings of this study highlight the mechanisms of IBD pathogenesis and the role of cytotoxic T cells in the clearance of virus-infected cells...
  11. pmc Oct4+ stem/progenitor swine lung epithelial cells are targets for influenza virus replication
    Mahesh Khatri
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA
    J Virol 86:6427-33. 2012
    ..These observations suggest the possible involvement of lung stem/progenitor cells in influenza virus infection...
  12. ncbi request reprint Replication of infectious bursal disease virus in macrophages and altered tropism of progeny virus
    Mahesh Khatri
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Vet Immunol Immunopathol 117:106-15. 2007
    ..mcIBDV and mvIBDV were immunogenic and generated antibody responses and provided 100% protection against cIBDV...
  13. doi request reprint Pathogenic and immunogenic responses in turkeys following in ovo exposure to avian metapneumovirus subtype C
    Ra Mi Cha
    Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Ave, St Paul, MN 55108, USA
    Vet Immunol Immunopathol 140:30-6. 2011
    ..Turkeys hatching from virus-exposed eggs had aMPV/C-specific IgG in the serum and the lachrymal fluid. At 3 week of age, in ovo immunized turkeys were protected against a challenge with pathogenic aMPV/C...
  14. pmc Swine influenza H1N1 virus induces acute inflammatory immune responses in pig lungs: a potential animal model for human H1N1 influenza virus
    Mahesh Khatri
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA
    J Virol 84:11210-8. 2010
    ....
  15. doi request reprint Response of embryonic chicken lymphoid cells to infectious bursal disease virus
    Mahesh Khatri
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Vet Immunol Immunopathol 127:316-24. 2009
    ..Relatively modest response of the embryo to aIBDV is significant because in ovo vaccination with aIBDV-type viruses and several other non-pathogenic viruses result in protective immunity that is well pronounced at hatch...
  16. doi request reprint Functional invariant NKT cells in pig lungs regulate the airway hyperreactivity: a potential animal model
    Gourapura J Renukaradhya
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Department of Veterinary Preventive Medicine, The Ohio State University, 1680 Madison Ave, Wooster, OH 44691, USA
    J Clin Immunol 31:228-39. 2011
    ..Thus, baby pigs may serve as a useful animal model to study iNKT cell-mediated AHR caused by various environmental and microbial CD1d-specific glycolipid antigens...
  17. ncbi request reprint Infectious bursal disease virus infection induces macrophage activation via p38 MAPK and NF-kappaB pathways
    Mahesh Khatri
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, 55108, USA
    Virus Res 118:70-7. 2006
    ..The increased production of NO, IL-8 and COX-2 by macrophages may contribute to bursa inflammatory responses commonly seen during the acute IBDV infection...
  18. pmc Respiratory proteins contribute differentially to Campylobacter jejuni's survival and in vitro interaction with hosts' intestinal cells
    Issmat I Kassem
    Department of Veterinary Preventive Medicine, Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691, USA
    BMC Microbiol 12:258. 2012
    ..42°C) and oxygen (microaerobic, ambient, and oxygen-limited/anaerobic) conditions and ii- its interactions with intestinal epithelial cells from disparate hosts (human vs. chickens)...
  19. pmc Characterization of an H3N2 triple reassortant influenza virus with a mutation at the receptor binding domain (D190A) that occurred upon virus transmission from turkeys to pigs
    Hadi M Yassine
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Ave, Wooster, OH 44691, USA
    Virol J 7:258. 2010
    ..Antisera raised against the parental virus reacted equally to both homologous and heterlogous viruses, however, antisera raised against the mutant virus showed 4-8 folds lower reactivity to the parental virus...
  20. doi request reprint Detection of influenza viral gene in European starlings and experimental infection
    Zhuoming Qin
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691, USA
    Influenza Other Respi Viruses 5:268-75. 2011
    ..However, starlings have been one of the neglected land-based wild bird species for influenza surveillance...
  21. doi request reprint IFN-gamma upregulation and protection by macrophage-adapted infectious bursal disease virus
    Mahesh Khatri
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    Vaccine 26:4740-6. 2008
    ..These data indicated that adaptation of IBDV to macrophages enhanced the ability of the virus to induce cell-mediated immune response in chickens...
  22. ncbi request reprint B-cell infiltration in the respiratory mucosa of turkeys exposed to subtype C avian metapneumovirus
    Ra Mi Cha
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    Avian Dis 51:764-70. 2007
    ..These results suggest, for the first time, the possible involvement of local mucosal immunoglobulins in the pathogenesis of aMPV in turkeys...
  23. ncbi request reprint Infection and activation of bursal macrophages by virulent infectious bursal disease virus
    Mahesh Khatri
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    Virus Res 113:44-50. 2005
    ..These data suggested that B cells may not be the sole targets for the virus; macrophages and possibly other cells may serve as host for IBDV...
  24. pmc Horizontal gene transfer of a ColV plasmid has resulted in a dominant avian clonal type of Salmonella enterica serovar Kentucky
    Timothy J Johnson
    Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, Minnesota, United States of America
    PLoS ONE 5:e15524. 2010
    ..Thus, the potential for horizontal gene transfer of virulence and fitness factors to Salmonella from other enteric bacteria exists in poultry, representing a potential human health hazard...