Mahmood Khan

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Mesenchymal stem cells for cardiac regeneration: translation to bedside reality
    Mohammad T Elnakish
    Department of Physiology and Cell Biology, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
    Stem Cells Int 2012:646038. 2012
  2. ncbi request reprint Effect of pulmonary-generated reactive oxygen species on left-ventricular dysfunction associated with cardio-pulmonary ischemia-reperfusion injury
    Mahmood Khan
    Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, 420 West 12th Ave, Room 116, Columbus, OH, 43210, USA
    Cell Biochem Biophys 67:275-80. 2013
  3. pmc Hyperbaric oxygenation enhances transplanted cell graft and functional recovery in the infarct heart
    Mahmood Khan
    Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Mol Cell Cardiol 47:275-87. 2009
  4. doi request reprint Effect of oxygenation on stem-cell therapy for myocardial infarction
    Mahmood Khan
    Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Adv Exp Med Biol 701:175-81. 2011
  5. pmc Myocardial oxygenation and functional recovery in infarct rat hearts transplanted with mesenchymal stem cells
    Simi M Chacko
    Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, The Ohio State Univ, 420 W 12th Ave, Rm 114, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 296:H1263-73. 2009
  6. pmc Cardioprotection by HO-4038, a novel verapamil derivative, targeted against ischemia and reperfusion-mediated acute myocardial infarction
    Iyyapu K Mohan
    Davis Heart and Lung Research Institute, The Ohio State Univ, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 296:H140-51. 2009
  7. doi request reprint Measurement of oxygenation at the site of stem cell therapy in a murine model of myocardial infarction
    Mahmood Khan
    Center for Biomedical EPR Spectroscopy and Imaging, Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, 420 W 12th Ave, Columbus, OH 43210, USA
    Adv Exp Med Biol 614:45-52. 2008
  8. pmc Trimetazidine, administered at the onset of reperfusion, ameliorates myocardial dysfunction and injury by activation of p38 mitogen-activated protein kinase and Akt signaling
    Mahmood Khan
    Division of Cardiovascular Medicine, Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    J Pharmacol Exp Ther 333:421-9. 2010
  9. pmc Sulfaphenazole protects heart against ischemia-reperfusion injury and cardiac dysfunction by overexpression of iNOS, leading to enhancement of nitric oxide bioavailability and tissue oxygenation
    Mahmood Khan
    Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Antioxid Redox Signal 11:725-38. 2009
  10. pmc Pharmacological preconditioning of mesenchymal stem cells with trimetazidine (1-[2,3,4-trimethoxybenzyl]piperazine) protects hypoxic cells against oxidative stress and enhances recovery of myocardial function in infarcted heart through Bcl-2 expression
    Sheik Wisel
    Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA
    J Pharmacol Exp Ther 329:543-50. 2009

Collaborators

Detail Information

Publications44

  1. pmc Mesenchymal stem cells for cardiac regeneration: translation to bedside reality
    Mohammad T Elnakish
    Department of Physiology and Cell Biology, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
    Stem Cells Int 2012:646038. 2012
    ..In this paper, we focus on the therapeutic applications of MSCs and their transition from the experimental benchside to the clinical bedside...
  2. ncbi request reprint Effect of pulmonary-generated reactive oxygen species on left-ventricular dysfunction associated with cardio-pulmonary ischemia-reperfusion injury
    Mahmood Khan
    Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, 420 West 12th Ave, Room 116, Columbus, OH, 43210, USA
    Cell Biochem Biophys 67:275-80. 2013
    ....
  3. pmc Hyperbaric oxygenation enhances transplanted cell graft and functional recovery in the infarct heart
    Mahmood Khan
    Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Mol Cell Cardiol 47:275-87. 2009
    ..Thus, HBO appears to be a potential and clinically-viable adjuvant treatment for myocardial stem-cell therapy...
  4. doi request reprint Effect of oxygenation on stem-cell therapy for myocardial infarction
    Mahmood Khan
    Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Adv Exp Med Biol 701:175-81. 2011
    ..05). In conclusion, the results suggested a beneficial effect of HBO administration on stem-cell therapy for MI...
  5. pmc Myocardial oxygenation and functional recovery in infarct rat hearts transplanted with mesenchymal stem cells
    Simi M Chacko
    Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, The Ohio State Univ, 420 W 12th Ave, Rm 114, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 296:H1263-73. 2009
    ..The study established our ability to measure and correlate changes in myocardial tissue oxygenation with cardiac function in infarcted rat hearts treated with MSCs...
  6. pmc Cardioprotection by HO-4038, a novel verapamil derivative, targeted against ischemia and reperfusion-mediated acute myocardial infarction
    Iyyapu K Mohan
    Davis Heart and Lung Research Institute, The Ohio State Univ, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 296:H140-51. 2009
    ....
  7. doi request reprint Measurement of oxygenation at the site of stem cell therapy in a murine model of myocardial infarction
    Mahmood Khan
    Center for Biomedical EPR Spectroscopy and Imaging, Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, 420 W 12th Ave, Columbus, OH 43210, USA
    Adv Exp Med Biol 614:45-52. 2008
    ..5 +/- 0.9 mmHg) compared to untreated hearts (pO2 = 1.6 +/- 0.7 mmHg). We have demonstrated, for the first time, the feasibility of monitoring pO2 in mouse hearts after stem cell therapy...
  8. pmc Trimetazidine, administered at the onset of reperfusion, ameliorates myocardial dysfunction and injury by activation of p38 mitogen-activated protein kinase and Akt signaling
    Mahmood Khan
    Division of Cardiovascular Medicine, Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    J Pharmacol Exp Ther 333:421-9. 2010
    ..The study emphasizes the importance of administering TMZ before reflow to prevent reperfusion-mediated cardiac injury and dysfunction...
  9. pmc Sulfaphenazole protects heart against ischemia-reperfusion injury and cardiac dysfunction by overexpression of iNOS, leading to enhancement of nitric oxide bioavailability and tissue oxygenation
    Mahmood Khan
    Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Antioxid Redox Signal 11:725-38. 2009
    ..The study established that SPZ attenuated myocardial I/R injury through overexpression of iNOS, leading to enhancement of nitric oxide bioavailability and tissue oxygenation...
  10. pmc Pharmacological preconditioning of mesenchymal stem cells with trimetazidine (1-[2,3,4-trimethoxybenzyl]piperazine) protects hypoxic cells against oxidative stress and enhances recovery of myocardial function in infarcted heart through Bcl-2 expression
    Sheik Wisel
    Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA
    J Pharmacol Exp Ther 329:543-50. 2009
    ..This study clearly demonstrated the potential benefits of pharmacological preconditioning of MSCs with TMZ for stem cell therapy for repairing myocardial ischemic damage...
  11. ncbi request reprint N-hydroxy-pyrroline modification of verapamil exhibits antioxidant protection of the heart against ischemia/reperfusion-induced cardiac dysfunction without compromising its calcium antagonistic activity
    Rajarsi Mandal
    Davis Heart and Lung Research Institute, Ohio State University, 420 West 12th Avenue, Room 114, Columbus, OH 43210, USA
    J Pharmacol Exp Ther 323:119-27. 2007
    ..This can be attributed to the combined benefits of the pyrroline moiety (antioxidant) and the parent verapamil component (antiarrhythmic) in the protection of the heart from I/R-induced injury...
  12. ncbi request reprint Skeletal myoblasts transplanted in the ischemic myocardium enhance in situ oxygenation and recovery of contractile function
    Mahmood Khan
    Center for Biomedical Electron Paramagnetic Resonance Spectroscopy and Imaging, Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Am J Physiol Heart Circ Physiol 293:H2129-39. 2007
    ..To our knowledge, this the first report detailing changes in in situ oxygenation in cell therapy. The increased myocardial Po(2) positively correlated with neoangiogenesis and cardiac function...
  13. pmc Amelioration of doxorubicin-induced cardiotoxicity by an anticancer-antioxidant dual-function compound, HO-3867
    Alex Dayton
    Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University, 420 W 12th Avenue, Columbus, OH 43210, USA
    J Pharmacol Exp Ther 339:350-7. 2011
    ..The study indicates that combination treatment of HO-3867 and DOX is a viable option for treatment of cancer with reduced cardiotoxic side effects...
  14. ncbi request reprint Dysregulation of PTEN in cardiopulmonary vascular remodeling induced by pulmonary hypertension
    Yazhini Ravi
    Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA
    Cell Biochem Biophys 67:363-72. 2013
    ..The study, for the first time, established that PTEN plays a key role in the progression of pulmonary hypertension. The findings may have potential for the treatment of pulmonary hypertension using PTEN as a target. ..
  15. pmc Cardioprotection by sulfaphenazole, a cytochrome p450 inhibitor: mitigation of ischemia-reperfusion injury by scavenging of reactive oxygen species
    Mahmood Khan
    Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
    J Pharmacol Exp Ther 323:813-21. 2007
    ....
  16. pmc Carvedilol enhances mesenchymal stem cell therapy for myocardial infarction via inhibition of caspase-3 expression
    Fatemat Hassan
    Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Pharmacol Exp Ther 343:62-71. 2012
    ..wt.) led to significant improvement in cardiac function, decreased fibrosis, and caspase-3 expression compared with the MI or MSC-alone groups...
  17. pmc Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology
    Yoshinori Nishijima
    College of Pharmacy, The Ohio State University, 500 W 12th Avenue, Columbus, OH 43210, USA
    Cardiovasc Res 91:71-9. 2011
    ..Chronic canine heart failure reduces atrial action potential duration and atrial refractoriness. We hypothesized that inducible nitric oxide synthase 2 (NOS2) contributes to atrial oxidative stress and electrophysiologic alterations...
  18. ncbi request reprint Oxygenation inhibits ovarian tumor growth by downregulating STAT3 and cyclin-D1 expressions
    Karuppaiyah Selvendiran
    Department of Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, USA
    Cancer Biol Ther 10:386-90. 2010
    ..Hyperoxia appears to inhibit STAT3 activation, which is a key step in the ovarian tumor progression. The study may have important implications for the treatment of ovarian cancer in the clinic...
  19. pmc Pulmonary hypertension secondary to left-heart failure involves peroxynitrite-induced downregulation of PTEN in the lung
    Yazhini Ravi
    Ohio State University, Columbus, OH 43210, USA
    Hypertension 61:593-601. 2013
    ..In conclusion, peroxynitrite and peroxynitrite-mediated PTEN inactivation seem to be key mediators of lung microvascular remodeling associated with PH secondary to LHF...
  20. doi request reprint Myocardial Rac1 exhibits partial involvement in thyroxin-induced cardiomyocyte hypertrophy and its inhibition is not sufficient to improve cardiac dysfunction or contractile abnormalities in mouse papillary muscles
    Mohammad T Elnakish
    Department of Physiology and Cell Biology, Dorothy M Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43201, USA
    J Cardiovasc Pharmacol 61:536-44. 2013
    ..We also provide the first mechanistic evidence for the partial involvement of Rac1 activation in T4-induced cardiomyocyte hypertrophy and reveal a putative role for Rac1 in the development of T4-induced hypertension...
  21. pmc Oxygen cycling in conjunction with stem cell transplantation induces NOS3 expression leading to attenuation of fibrosis and improved cardiac function
    Mahmood Khan
    Division of Cardiovascular Medicine, Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, 43210, USA
    Cardiovasc Res 93:89-99. 2012
    ..The goal of the present study was to evaluate the effect of supplemental oxygenation on cell engraftment and functional recovery in a rat model...
  22. pmc Oxygen and oxygenation in stem-cell therapy for myocardial infarction
    Mahmood Khan
    Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Life Sci 87:269-74. 2010
    ..The results obtained from these studies have demonstrated the importance of tissue oxygen in the application of stem-cell therapy to treat ischemic heart tissues. These results have been summarized in this review article...
  23. ncbi request reprint Labeling of skeletal myoblasts with a novel oxygen-sensing spin probe for noninvasive monitoring of in situ oxygenation and cell therapy in heart
    Sheik Wisel
    Center for Biomedical Electron Paramagnetic Resonance Spectroscopy and Imaging, Division of Cardiothoracic Surgery, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 292:H1254-61. 2007
    ..In conclusion, labeling of SM cells with the oxygen-sensing spin probe offers a unique opportunity for the noninvasive monitoring of transplanted cells as well as in situ tissue Po(2) in infarcted mouse hearts...
  24. ncbi request reprint Attenuation of myocardial ischemia-reperfusion injury by trimetazidine derivatives functionalized with antioxidant properties
    Vijay Kumar Kutala
    Davis Heart and Lung Research Institute, The Ohio State University, 420 W 12th Ave, Room 114, Columbus, OH 43210, USA
    J Pharmacol Exp Ther 317:921-8. 2006
    ..The protective effect of the TMZ derivatives could be due to the combined effects of antioxidant and anti-ischemic activities as well as enhanced pro-survival Akt activity...
  25. pmc Chronic heart failure and the substrate for atrial fibrillation
    Arun Sridhar
    Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
    Cardiovasc Res 84:227-36. 2009
    ..We sought to define the underlying mechanisms for atrial fibrillation (AF) during chronic heart failure (HF)...
  26. pmc Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cells
    Simi M Chacko
    Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Am J Physiol Cell Physiol 299:C1562-70. 2010
    ..These results could provide further insights into optimal preparation of MSCs which would greatly influence the effectiveness of cell therapy in vivo...
  27. ncbi request reprint Role of oxygen in postischemic myocardial injury
    Vijay Kumar Kutala
    Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    Antioxid Redox Signal 9:1193-206. 2007
    ..In this review, we discuss the role of oxygenation during reperfusion and subsequent biochemical and pathologic alterations in reperfused myocardium and recovery of heart function...
  28. pmc Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis
    Mohammad T Elnakish
    Department of Anesthesiology, and Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 7:e42500. 2012
    ..Targeting Rac signaling could represent valuable therapeutic strategy not only in saving the failing myocardium but also to prevent this transition process...
  29. pmc p53's choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys(118) acetylation
    Rajan Gogna
    Dorothy M Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH, USA
    EMBO Mol Med 5:1662-83. 2013
    ..Understanding this novel oxygen-p53 survival pathway will open new avenues in cardioprotection molecular therapy...
  30. doi request reprint Cardiac remodeling caused by transgenic overexpression of a corn Rac gene
    Mohammad T Elnakish
    Department of Anesthesiology, The Ohio State University, Columbus, Ohio, USA
    Am J Physiol Heart Circ Physiol 301:H868-80. 2011
    ....
  31. ncbi request reprint C-phycocyanin ameliorates doxorubicin-induced oxidative stress and apoptosis in adult rat cardiomyocytes
    Mahmood Khan
    Center for Biomedical EPR Spectroscopy and Imaging, Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Cardiovasc Pharmacol 47:9-20. 2006
    ..This study further supports the crucial role of the antioxidant nature of C-phycocyanin in its cardioprotection against doxorubicin-induced oxidative stress and apoptosis...
  32. pmc Oxygen-sensitive outcomes and gene expression in acute ischemic stroke
    Cameron Rink
    Department of Surgery, The Ohio State University Medical Center, 473 W 12th Avenue, Columbus, OH 43210, USA
    J Cereb Blood Flow Metab 30:1275-87. 2010
    ..The findings provide key information relevant to understanding oxygen-dependent molecular mechanisms in the AIS-affected brain...
  33. pmc Role of heat shock factor-1 activation in the doxorubicin-induced heart failure in mice
    Kaushik Vedam
    Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA
    Am J Physiol Heart Circ Physiol 298:H1832-41. 2010
    ..From these results we propose a novel mechanism for Dox-induced heart failure: increased expression of Hsp25 because of oxidant-induced activation of HSF-1 transactivates p53 to increase Bax levels, which leads to heart failure...
  34. doi request reprint Emerging role of oxidative stress in metabolic syndrome and cardiovascular diseases: important role of Rac/NADPH oxidase
    Mohammad T Elnakish
    Dorothy M Davis Heart and Lung Research Institute, Ohio State University Wexner Medical Center, Columbus, OH, USA Department of Physiology and Cell Biology, Ohio State University Wexner Medical Center, Columbus, OH, USA
    J Pathol 231:290-300. 2013
    ..Therefore, the main goal of this review is to give a brief outline about the important role of the Rac1-NOX axis in the pathophysiology of both metabolic syndrome and cardiovascular disease...
  35. doi request reprint Stem cell transplantation as a therapy for cardiac fibrosis
    Mohammad T Elnakish
    Dorothy M Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA
    J Pathol 229:347-54. 2013
    ..Therefore, the main focus of this review is to discuss the impact of different types of stem cells on cardiac fibrosis and associated cardiac remodelling in a variety of experimental models of heart failure, particularly MI...
  36. doi request reprint Crataegus oxycantha extract attenuates apoptotic incidence in myocardial ischemia-reperfusion injury by regulating Akt and HIF-1 signaling pathways
    Kesavan S Jayachandran
    Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
    J Cardiovasc Pharmacol 56:526-31. 2010
    ..The results suggested that COC extract attenuated apoptotic incidence in the experimental myocardial ischemia-reperfusion model by regulating Akt and HIF-1 signaling pathways...
  37. pmc Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model
    Hiranmoy Das
    The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA
    PLoS ONE 4:e7325. 2009
    ..Therapeutic potential was evaluated in a rat model of myocardial infarction using nanofiber-expanded human cord blood derived hematopoietic stem cells (CD133+/CD34+) genetically modified with VEGF plus PDGF genes (VIP)...
  38. ncbi request reprint Prevention of postischemic myocardial reperfusion injury by the combined treatment of NCX-4016 and Tempol
    Vijay Kumar Kutala
    Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, and Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
    J Cardiovasc Pharmacol 48:79-87. 2006
    ..In conclusion, NCX-4016 in combination with Tempol demonstrated significant cardioprotection and, thus, may offer a novel therapeutic strategy to prevent I/R-mediated myocardial injury...
  39. pmc Noninvasive monitoring of small intestinal oxygen in a rat model of chronic mesenteric ischemia
    Elaine M Fisher
    School of Nursing, The University of Akron, Akron, OH, 44325, USA
    Cell Biochem Biophys 67:451-9. 2013
    ..Tracking pO2 in conditions that produce chronic mesenteric ischemia will contribute to our understanding of intestinal tissue oxygenation and how changes impact symptom evolution and the trajectory of chronic disease...
  40. pmc Granulocyte macrophage colony-stimulating factor inhibits breast cancer growth and metastasis by invoking an anti-angiogenic program in tumor-educated macrophages
    Tim D Eubank
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 69:2133-40. 2009
    ..In situ hybridization and flow cytometry identified macrophages as the primary source of sVEGFR-1. These data suggest that GM-CSF can re-educate macrophages to reduce angiogenesis and metastases in murine breast cancer...
  41. pmc Myeloid-derived suppressor cell inhibition of the IFN response in tumor-bearing mice
    Bethany L Mundy-Bosse
    Department of Integrated Biomedical Sciences, The Ohio State University, Columbus, OH, USA
    Cancer Res 71:5101-10. 2011
    ..These data suggest that nitric oxide produced by MDSC can lead to reduced IFN responsiveness in immune cells...
  42. pmc Sivelestat attenuates myocardial reperfusion injury during brief low flow postischemic infusion
    Sverre E Aune
    Department of Emergency Medicine, The Davis Heart Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
    Oxid Med Cell Longev 2013:279847. 2013
    ..Taken together, these results indicate that sivelestat infusion during postischemic low flow reduces infarct size and preserves vasoreactivity in association with decreased ROS formation and the preservation of nitric oxide...
  43. doi request reprint Injectable, rapid gelling and highly flexible hydrogel composites as growth factor and cell carriers
    Feng Wang
    Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA
    Acta Biomater 6:1978-91. 2010
    ..These injectable and rapid gelling hydrogel composites demonstrated attractive properties for serving as growth factor and cell carriers for cardiovascular tissue engineering applications...
  44. ncbi request reprint C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signaling
    Mahmood Khan
    Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 290:H2136-45. 2006
    ..Overall, these results for the first time showed that PC attenuated I/R-induced cardiac dysfunction through its antioxidant and antiapoptotic actions and modulation of p38 MAPK and ERK1/2...