Research Topics
| Mahmood KhanSummaryAffiliation: The Ohio State University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Effect of oxygenation on stem-cell therapy for myocardial infarctionMahmood Khan
Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
Adv Exp Med Biol 701:175-81. 2011..05). In conclusion, the results suggested a beneficial effect of HBO administration on stem-cell therapy for MI...
Hyperbaric oxygenation enhances transplanted cell graft and functional recovery in the infarct heartMahmood Khan
Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
J Mol Cell Cardiol 47:275-87. 2009..Thus, HBO appears to be a potential and clinically-viable adjuvant treatment for myocardial stem-cell therapy...- Myocardial oxygenation and functional recovery in infarct rat hearts transplanted with mesenchymal stem cellsSimi M Chacko
Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, The Ohio State Univ, 420 W 12th Ave, Rm 114, Columbus, OH 43210, USA
Am J Physiol Heart Circ Physiol 296:H1263-73. 2009..The study established our ability to measure and correlate changes in myocardial tissue oxygenation with cardiac function in infarcted rat hearts treated with MSCs... - Cardioprotection by HO-4038, a novel verapamil derivative, targeted against ischemia and reperfusion-mediated acute myocardial infarctionIyyapu K Mohan
Davis Heart and Lung Research Institute, The Ohio State Univ, Columbus, OH 43210, USA
Am J Physiol Heart Circ Physiol 296:H140-51. 2009.... - Measurement of oxygenation at the site of stem cell therapy in a murine model of myocardial infarctionMahmood Khan
Center for Biomedical EPR Spectroscopy and Imaging, Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, 420 W 12th Ave, Columbus, OH 43210, USA
Adv Exp Med Biol 614:45-52. 2008..5 +/- 0.9 mmHg) compared to untreated hearts (pO2 = 1.6 +/- 0.7 mmHg). We have demonstrated, for the first time, the feasibility of monitoring pO2 in mouse hearts after stem cell therapy... - Trimetazidine, administered at the onset of reperfusion, ameliorates myocardial dysfunction and injury by activation of p38 mitogen-activated protein kinase and Akt signalingMahmood Khan
Division of Cardiovascular Medicine, Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
J Pharmacol Exp Ther 333:421-9. 2010..The study emphasizes the importance of administering TMZ before reflow to prevent reperfusion-mediated cardiac injury and dysfunction... - Pharmacological preconditioning of mesenchymal stem cells with trimetazidine (1-[2,3,4-trimethoxybenzyl]piperazine) protects hypoxic cells against oxidative stress and enhances recovery of myocardial function in infarcted heart through Bcl-2 expressionSheik Wisel
Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA
J Pharmacol Exp Ther 329:543-50. 2009..This study clearly demonstrated the potential benefits of pharmacological preconditioning of MSCs with TMZ for stem cell therapy for repairing myocardial ischemic damage... 
Skeletal myoblasts transplanted in the ischemic myocardium enhance in situ oxygenation and recovery of contractile functionMahmood Khan
Center for Biomedical Electron Paramagnetic Resonance Spectroscopy and Imaging, Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Am J Physiol Heart Circ Physiol 293:H2129-39. 2007..To our knowledge, this the first report detailing changes in in situ oxygenation in cell therapy. The increased myocardial Po(2) positively correlated with neoangiogenesis and cardiac function...- Sulfaphenazole protects heart against ischemia-reperfusion injury and cardiac dysfunction by overexpression of iNOS, leading to enhancement of nitric oxide bioavailability and tissue oxygenationMahmood Khan
Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Antioxid Redox Signal 11:725-38. 2009..The study established that SPZ attenuated myocardial I/R injury through overexpression of iNOS, leading to enhancement of nitric oxide bioavailability and tissue oxygenation... - Carvedilol enhances mesenchymal stem cell therapy for myocardial infarction via inhibition of caspase-3 expressionFatemat Hassan
Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
J Pharmacol Exp Ther 343:62-71. 2012..wt.) led to significant improvement in cardiac function, decreased fibrosis, and caspase-3 expression compared with the MI or MSC-alone groups... - Amelioration of doxorubicin-induced cardiotoxicity by an anticancer-antioxidant dual-function compound, HO-3867Alex Dayton
Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University, 420 W 12th Avenue, Columbus, OH 43210, USA
J Pharmacol Exp Ther 339:350-7. 2011..The study indicates that combination treatment of HO-3867 and DOX is a viable option for treatment of cancer with reduced cardiotoxic side effects... - Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiologyYoshinori Nishijima
College of Pharmacy, The Ohio State University, 500 W 12th Avenue, Columbus, OH 43210, USA
Cardiovasc Res 91:71-9. 2011..Chronic canine heart failure reduces atrial action potential duration and atrial refractoriness. We hypothesized that inducible nitric oxide synthase 2 (NOS2) contributes to atrial oxidative stress and electrophysiologic alterations... - N-hydroxy-pyrroline modification of verapamil exhibits antioxidant protection of the heart against ischemia/reperfusion-induced cardiac dysfunction without compromising its calcium antagonistic activityRajarsi Mandal
Davis Heart and Lung Research Institute, Ohio State University, 420 West 12th Avenue, Room 114, Columbus, OH 43210, USA
J Pharmacol Exp Ther 323:119-27. 2007..This can be attributed to the combined benefits of the pyrroline moiety (antioxidant) and the parent verapamil component (antiarrhythmic) in the protection of the heart from I/R-induced injury... - Oxygenation inhibits ovarian tumor growth by downregulating STAT3 and cyclin-D1 expressionsKaruppaiyah Selvendiran
Department of Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, USA
Cancer Biol Ther 10:386-90. 2010..Hyperoxia appears to inhibit STAT3 activation, which is a key step in the ovarian tumor progression. The study may have important implications for the treatment of ovarian cancer in the clinic... - Oxygen cycling in conjunction with stem cell transplantation induces NOS3 expression leading to attenuation of fibrosis and improved cardiac functionMahmood Khan
Division of Cardiovascular Medicine, Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, 43210, USA
Cardiovasc Res 93:89-99. 2012..The goal of the present study was to evaluate the effect of supplemental oxygenation on cell engraftment and functional recovery in a rat model... - Cardioprotection by sulfaphenazole, a cytochrome p450 inhibitor: mitigation of ischemia-reperfusion injury by scavenging of reactive oxygen speciesMahmood Khan
Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
J Pharmacol Exp Ther 323:813-21. 2007.... - Oxygen and oxygenation in stem-cell therapy for myocardial infarctionMahmood Khan
Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
Life Sci 87:269-74. 2010..The results obtained from these studies have demonstrated the importance of tissue oxygen in the application of stem-cell therapy to treat ischemic heart tissues. These results have been summarized in this review article... - Pulmonary hypertension secondary to left-heart failure involves peroxynitrite-induced downregulation of PTEN in the lungYazhini Ravi
Ohio State University, Columbus, OH 43210, USA
Hypertension 61:593-601. 2013..In conclusion, peroxynitrite and peroxynitrite-mediated PTEN inactivation seem to be key mediators of lung microvascular remodeling associated with PH secondary to LHF... - Chronic heart failure and the substrate for atrial fibrillationArun Sridhar
Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
Cardiovasc Res 84:227-36. 2009..We sought to define the underlying mechanisms for atrial fibrillation (AF) during chronic heart failure (HF)... - Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cellsSimi M Chacko
Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Am J Physiol Cell Physiol 299:C1562-70. 2010..These results could provide further insights into optimal preparation of MSCs which would greatly influence the effectiveness of cell therapy in vivo... - Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosisMohammad T Elnakish
Department of Anesthesiology, and Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States of America
PLoS ONE 7:e42500. 2012..Targeting Rac signaling could represent valuable therapeutic strategy not only in saving the failing myocardium but also to prevent this transition process... - Labeling of skeletal myoblasts with a novel oxygen-sensing spin probe for noninvasive monitoring of in situ oxygenation and cell therapy in heartSheik Wisel
Center for Biomedical Electron Paramagnetic Resonance Spectroscopy and Imaging, Division of Cardiothoracic Surgery, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
Am J Physiol Heart Circ Physiol 292:H1254-61. 2007..In conclusion, labeling of SM cells with the oxygen-sensing spin probe offers a unique opportunity for the noninvasive monitoring of transplanted cells as well as in situ tissue Po(2) in infarcted mouse hearts... - Cardiac remodeling caused by transgenic overexpression of a corn Rac geneMohammad T Elnakish
Department of Anesthesiology, The Ohio State University, Columbus, Ohio, USA
Am J Physiol Heart Circ Physiol 301:H868-80. 2011.... - Oxygen-sensitive outcomes and gene expression in acute ischemic strokeCameron Rink
Department of Surgery, The Ohio State University Medical Center, 473 W 12th Avenue, Columbus, OH 43210, USA
J Cereb Blood Flow Metab 30:1275-87. 2010..The findings provide key information relevant to understanding oxygen-dependent molecular mechanisms in the AIS-affected brain... - Role of oxygen in postischemic myocardial injuryVijay Kumar Kutala
Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
Antioxid Redox Signal 9:1193-206. 2007..In this review, we discuss the role of oxygenation during reperfusion and subsequent biochemical and pathologic alterations in reperfused myocardium and recovery of heart function... - Stem cell transplantation as a therapy for cardiac fibrosisMohammad T Elnakish
Dorothy M Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA
J Pathol 229:347-54. 2013..Therefore, the main focus of this review is to discuss the impact of different types of stem cells on cardiac fibrosis and associated cardiac remodelling in a variety of experimental models of heart failure, particularly MI... - Crataegus oxycantha extract attenuates apoptotic incidence in myocardial ischemia-reperfusion injury by regulating Akt and HIF-1 signaling pathwaysKesavan S Jayachandran
Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
J Cardiovasc Pharmacol 56:526-31. 2010..The results suggested that COC extract attenuated apoptotic incidence in the experimental myocardial ischemia-reperfusion model by regulating Akt and HIF-1 signaling pathways... - Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct modelHiranmoy Das
The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA
PLoS ONE 4:e7325. 2009..Therapeutic potential was evaluated in a rat model of myocardial infarction using nanofiber-expanded human cord blood derived hematopoietic stem cells (CD133+/CD34+) genetically modified with VEGF plus PDGF genes (VIP)... - Prevention of postischemic myocardial reperfusion injury by the combined treatment of NCX-4016 and TempolVijay Kumar Kutala
Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, and Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
J Cardiovasc Pharmacol 48:79-87. 2006..In conclusion, NCX-4016 in combination with Tempol demonstrated significant cardioprotection and, thus, may offer a novel therapeutic strategy to prevent I/R-mediated myocardial injury... - Role of heat shock factor-1 activation in the doxorubicin-induced heart failure in miceKaushik Vedam
Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA
Am J Physiol Heart Circ Physiol 298:H1832-41. 2010..From these results we propose a novel mechanism for Dox-induced heart failure: increased expression of Hsp25 because of oxidant-induced activation of HSF-1 transactivates p53 to increase Bax levels, which leads to heart failure... - Myeloid-derived suppressor cell inhibition of the IFN response in tumor-bearing miceBethany L Mundy-Bosse
Department of Integrated Biomedical Sciences, The Ohio State University, Columbus, OH, USA
Cancer Res 71:5101-10. 2011..These data suggest that nitric oxide produced by MDSC can lead to reduced IFN responsiveness in immune cells... - Granulocyte macrophage colony-stimulating factor inhibits breast cancer growth and metastasis by invoking an anti-angiogenic program in tumor-educated macrophagesTim D Eubank
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
Cancer Res 69:2133-40. 2009..In situ hybridization and flow cytometry identified macrophages as the primary source of sVEGFR-1. These data suggest that GM-CSF can re-educate macrophages to reduce angiogenesis and metastases in murine breast cancer... - Injectable, rapid gelling and highly flexible hydrogel composites as growth factor and cell carriersFeng Wang
Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA
Acta Biomater 6:1978-91. 2010..These injectable and rapid gelling hydrogel composites demonstrated attractive properties for serving as growth factor and cell carriers for cardiovascular tissue engineering applications... - Mesenchymal stem cells for cardiac regeneration: translation to bedside realityMohammad T Elnakish
Department of Physiology and Cell Biology, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
Stem Cells Int 2012:646038. 2012..In this paper, we focus on the therapeutic applications of MSCs and their transition from the experimental benchside to the clinical bedside... - Attenuation of myocardial ischemia-reperfusion injury by trimetazidine derivatives functionalized with antioxidant propertiesVijay Kumar Kutala
Davis Heart and Lung Research Institute, The Ohio State University, 420 W. 12th Ave, Room 114, Columbus, OH 43210, USA
J Pharmacol Exp Ther 317:921-8. 2006..The protective effect of the TMZ derivatives could be due to the combined effects of antioxidant and anti-ischemic activities as well as enhanced pro-survival Akt activity...