Aarif Y Khakoo

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. doi Therapy insight: Management of cardiovascular disease in patients with cancer and cardiac complications of cancer therapy
    Aarif Y Khakoo
    Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Nat Clin Pract Oncol 5:655-67. 2008
  2. pmc Cardiotoxicity due to cancer therapy
    Aarif Y Khakoo
    Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Tex Heart Inst J 38:253-6. 2011
  3. pmc Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
    Aarif Y Khakoo
    Laboratory of Molecular Biology, Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:1235-47. 2006
  4. doi Heart failure associated with sunitinib malate: a multitargeted receptor tyrosine kinase inhibitor
    Aarif Y Khakoo
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 112:2500-8. 2008
  5. pmc Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress
    Vishnu Chintalgattu
    Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 120:472-84. 2010
  6. doi Rare incidence of congestive heart failure in gastrointestinal stromal tumor and other sarcoma patients receiving imatinib mesylate
    Jonathan C Trent
    Department of Sarcoma Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 116:184-92. 2010
  7. doi MicroRNA-9 is an activation-induced regulator of PDGFR-beta expression in cardiomyocytes
    Jianhu Zhang
    Department of Cardiology, UT M D Anderson Cancer Center, USA
    J Mol Cell Cardiol 51:337-46. 2011
  8. pmc Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin/β-catenin signaling
    Shibani Pati
    Department of Surgery, University of Texas Health Sciences Center, Houston, TX, USA
    Stem Cells Dev 20:89-101. 2011
  9. doi Does the renin-angiotensin system participate in regulation of human vasculogenesis and angiogenesis?
    Aarif Y Khakoo
    The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 68:9112-5. 2008
  10. doi Molecular mechanisms of hypertension and heart failure due to antiangiogenic cancer therapies
    Meredith L Rees
    Department of Cardiology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1101, Houston, TX 77030, USA
    Heart Fail Clin 7:299-311. 2011

Collaborators

Detail Information

Publications17

  1. doi Therapy insight: Management of cardiovascular disease in patients with cancer and cardiac complications of cancer therapy
    Aarif Y Khakoo
    Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Nat Clin Pract Oncol 5:655-67. 2008
    ..In this Review, we discuss management strategies for cardiovascular disease in patients with cancer, focusing on the prevention and treatment of congestive heart failure and myocardial infarction...
  2. pmc Cardiotoxicity due to cancer therapy
    Aarif Y Khakoo
    Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Tex Heart Inst J 38:253-6. 2011
    ..They might also provide novel insights into the pathogenesis of non-cancer-therapy–induced human heart disease...
  3. pmc Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
    Aarif Y Khakoo
    Laboratory of Molecular Biology, Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:1235-47. 2006
    ....
  4. doi Heart failure associated with sunitinib malate: a multitargeted receptor tyrosine kinase inhibitor
    Aarif Y Khakoo
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 112:2500-8. 2008
    ..This report describes the development of heart failure in cancer patients who received this novel agent...
  5. pmc Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress
    Vishnu Chintalgattu
    Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 120:472-84. 2010
    ..Furthermore, our findings may provide insights into the mechanism of cardiotoxicity due to anticancer PDGFR inhibitors...
  6. doi Rare incidence of congestive heart failure in gastrointestinal stromal tumor and other sarcoma patients receiving imatinib mesylate
    Jonathan C Trent
    Department of Sarcoma Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 116:184-92. 2010
    ....
  7. doi MicroRNA-9 is an activation-induced regulator of PDGFR-beta expression in cardiomyocytes
    Jianhu Zhang
    Department of Cardiology, UT M D Anderson Cancer Center, USA
    J Mol Cell Cardiol 51:337-46. 2011
    ..This article is part of a Special Issue entitled 'Possible Editorial'...
  8. pmc Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin/β-catenin signaling
    Shibani Pati
    Department of Surgery, University of Texas Health Sciences Center, Houston, TX, USA
    Stem Cells Dev 20:89-101. 2011
    ..Further, our results suggest that the mediator(s) of these vascular protective effects is a secreted factor(s) released as a result of direct MSC-EC interaction...
  9. doi Does the renin-angiotensin system participate in regulation of human vasculogenesis and angiogenesis?
    Aarif Y Khakoo
    The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 68:9112-5. 2008
    ..If proven correct, this hypothesis carries many implications for the medical practices of cardiology, oncology, and neonatology...
  10. doi Molecular mechanisms of hypertension and heart failure due to antiangiogenic cancer therapies
    Meredith L Rees
    Department of Cardiology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1101, Houston, TX 77030, USA
    Heart Fail Clin 7:299-311. 2011
    ....
  11. pmc Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β
    Christina L Papke
    Department of Internal Medicine, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 6 100, Houston, TX 77030, USA
    Hum Mol Genet 22:3123-37. 2013
    ..Loss of α-SMA leads to SMC hyperplasia in vivo and in vitro through a mechanism involving FAK, p53 and Pdgfr-β, supporting the hypothesis that SMC hyperplasia contributes to occlusive lesions in patients with ACTA2 missense mutations. ..
  12. doi Reducing the toxicity of cancer therapy: recognizing needs, taking action
    Charles S Cleeland
    Department of Symptom Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1450, Houston, TX 77030, USA
    Nat Rev Clin Oncol 9:471-8. 2012
    ..With an emphasis on coordinating multidisciplinary efforts, this panel has presented a strategy to increase funding for the field and develop a coherent research agenda...
  13. ncbi Cardiovascular effects of tyrosine kinase inhibitors used for gastrointestinal stromal tumors
    Vishnu Chintalgattu
    Department of Cardiology, University of Texas, M D Anderson Cancer Center, Institute of Biosciences and Technology, Room 718, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
    Hematol Oncol Clin North Am 23:97-107, viii-ix. 2009
    ..In this review, the authors discuss what is known regarding the cardiovascular effects of TKIs used in the treatment of GISTs...
  14. ncbi Endothelial progenitor cells
    Aarif Y Khakoo
    National Institutes of Health, National Heart, Lung, and Blood Institute, Cardiovascular Branch, Laboratory of Molecular Biology, Bethesda, Maryland 21284, USA
    Annu Rev Med 56:79-101. 2005
    ..We review experimental results obtained from both animal studies and recent clinical trials that suggest this cell type may have tremendous therapeutic potential for a wide range of human diseases...
  15. ncbi Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI
    Ali S Arbab
    Laboratory of Diagnostic Radiology Research, National Institutes of Health, Building 10, Room no B1N256, Bethesda, MD 20892, USA
    Blood 104:1217-23. 2004
    ..94 +/- 1.86 pg for MSCs with 100% of cells labeled. Cell labeling using these agents should facilitate the translation of this method to clinical trials for evaluation of trafficking of infused or transplanted cells by MRI...
  16. ncbi Reversible cardiomyopathy caused by administration of interferon alpha
    Aarif Y Khakoo
    Division of Cardiology, Johns Hopkins University, Baltimore, MD 21287, USA
    Nat Clin Pract Cardiovasc Med 2:53-7. 2005
    ..Physical examination findings were consistent with congestive heart failure. Laboratory studies were notable for hypothyroidism. Echocardiography revealed severe, global left-ventricular dysfunction...
  17. ncbi Labeling of cells with ferumoxides-protamine sulfate complexes does not inhibit function or differentiation capacity of hematopoietic or mesenchymal stem cells
    Ali S Arbab
    Radiology Research, Henry Ford Health System, Detroit, MI 48202, USA
    NMR Biomed 18:553-9. 2005
    ..These data increase confidence that MRI studies of FePro-labeled HSC or MSC will provide an accurate representation of in vivo trafficking of unlabeled cells...