Research Topics
| Matthew KesicSummaryAffiliation: The Ohio State University Country: USA Publications
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Detail Information
Publications
Human T-cell leukemia virus type 2 post-transcriptional control protein p28 is required for viral infectivity and persistence in vivoBrenda Yamamoto
Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA
Retrovirology 5:38. 2008....
Phosphorylation regulates human T-cell leukemia virus type 1 Rex functionMatthew Kesic
Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA
Retrovirology 6:105. 2009..HTLV-1 Rex (Rex-1) is a phosphoprotein and general protein kinase inhibition correlates with reduced function. Therefore, it has been proposed that Rex-1 function may be regulated through site-specific phosphorylation...
Human T-cell leukemia virus type 2 Rex carboxy terminus is an inhibitory/stability domain that regulates Rex functional activity and viral replicationLi Xie
Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Rd, Columbus, OH 43210, USA
J Virol 83:5232-43. 2009..The ability of this domain to modulate viral replication likely plays a key role in the infectious spread of the virus and in virus-induced cellular proliferation...
Kinetic analysis of human T-cell leukemia virus type 1 gene expression in cell culture and infected animalsMin Li
Departments of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
J Virol 83:3788-97. 2009....
Site-specific phosphorylation regulates human T-cell leukemia virus type 2 Rex function in vivoMatthew Kesic
Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
J Virol 83:8859-68. 2009..Overall, this work is the first to completely map the phosphorylation sites in Rex-2 and provides important insight into the phosphorylation continuum that tightly regulates Rex-2 structure, cellular localization, and function...
Human T lymphotropic virus type 1 regulatory and accessory gene transcript expression and export are not rex dependentMin Li
Center for Retrovirus Research, The Ohio State University, Columbus, USA
AIDS Res Hum Retroviruses 28:405-10. 2012..This is consistent with the conclusion that viral mRNAs that contain the cis-acting repressive sequence (CRS) and/or a fully functional splice donor site require a Rex/RxRE interaction for efficient cytoplasmic expression...
Human T-lymphotropic virus type 1 p30 interacts with REGgamma and modulates ATM (ataxia telangiectasia mutated) to promote cell survivalRajaneesh Anupam
Center for Retrovirus Research, Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 286:7661-8. 2011..On the basis of our findings, we propose that HTLV-1 p30 interacts with ATM and REGγ to increase viral spread by facilitating cell survival...
