P Kermer

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. ncbi Insulin-like growth factor-I protects axotomized rat retinal ganglion cells from secondary death via PI3-K-dependent Akt phosphorylation and inhibition of caspase-3 In vivo
    P Kermer
    Department of Neurology, Medical School, University of Tubingen, 72076 Tubingen, Germany
    J Neurosci 20:2-8. 2000
  2. ncbi Caspase-9: involvement in secondary death of axotomized rat retinal ganglion cells in vivo
    P Kermer
    Department of Neurology, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Brain Res Mol Brain Res 85:144-50. 2000
  3. ncbi Transection of the optic nerve in rats: studying neuronal death and survival in vivo
    P Kermer
    The Burnham Institute, Program on Cell Death and Apoptosis Research, 10901 North Torrey Pines Road, San Diego, CA 92037, USA
    Brain Res Brain Res Protoc 7:255-60. 2001
  4. ncbi Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3'-kinase/protein kinase B signaling
    N Klocker
    Department of Neurology, University of Tubingen, 72076 Tubingen, Germany
    J Neurosci 20:6962-7. 2000
  5. ncbi Bifunctional apoptosis inhibitor (BAR) protects neurons from diverse cell death pathways
    W Roth
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Death Differ 10:1178-87. 2003
  6. ncbi Activation of caspase-3 in axotomized rat retinal ganglion cells in vivo
    P Kermer
    Dept of Neurology, Medical School, University of Tubingen, Germany
    FEBS Lett 453:361-4. 1999
  7. ncbi Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo
    J H Weishaupt
    Department of Neurology, University Hospital Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Neurobiol Dis 13:124-35. 2003
  8. ncbi Modulation of metabotropic glutamate receptors fails to prevent the loss of adult rat retinal ganglion cells following axotomy or N-methyl-D-aspartate lesion in vivo
    P Kermer
    Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Neurosci Lett 315:117-20. 2001
  9. ncbi Neuron-specific overexpression of the co-chaperone Bcl-2-associated athanogene-1 in superoxide dismutase 1(G93A)-transgenic mice
    G Rohde
    University of Gottingen, Department of Neurology, Robert Koch Str 40, 37075 Gottingen, Germany
    Neuroscience 157:844-9. 2008
  10. ncbi Bag1 is a regulator and marker of neuronal differentiation
    P Kermer
    The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 N Torrey Pines Road, La Jolla, California, CA 92037, USA
    Cell Death Differ 9:405-13. 2002

Collaborators

Detail Information

Publications12

  1. ncbi Insulin-like growth factor-I protects axotomized rat retinal ganglion cells from secondary death via PI3-K-dependent Akt phosphorylation and inhibition of caspase-3 In vivo
    P Kermer
    Department of Neurology, Medical School, University of Tubingen, 72076 Tubingen, Germany
    J Neurosci 20:2-8. 2000
    ..As expected, WM significantly reduced the neuroprotective effects of IGF-I. In summary, we show for the first time in vivo that IGF is neuroprotective via PI3-K-dependent Akt phosphorylation and by inhibition of caspase-3...
  2. ncbi Caspase-9: involvement in secondary death of axotomized rat retinal ganglion cells in vivo
    P Kermer
    Department of Neurology, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Brain Res Mol Brain Res 85:144-50. 2000
    ....
  3. ncbi Transection of the optic nerve in rats: studying neuronal death and survival in vivo
    P Kermer
    The Burnham Institute, Program on Cell Death and Apoptosis Research, 10901 North Torrey Pines Road, San Diego, CA 92037, USA
    Brain Res Brain Res Protoc 7:255-60. 2001
    ....
  4. ncbi Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3'-kinase/protein kinase B signaling
    N Klocker
    Department of Neurology, University of Tubingen, 72076 Tubingen, Germany
    J Neurosci 20:6962-7. 2000
    ..2000), it does not in the case of BDNF. Thus, we assume that BDNF does not depend on a single signal transduction pathway exerting its neuroprotective effects on lesioned CNS neurons...
  5. ncbi Bifunctional apoptosis inhibitor (BAR) protects neurons from diverse cell death pathways
    W Roth
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Death Differ 10:1178-87. 2003
    ..Taken together, the expression pattern and functional data suggest that the BAR protein is involved in the regulation of neuronal survival...
  6. ncbi Activation of caspase-3 in axotomized rat retinal ganglion cells in vivo
    P Kermer
    Dept of Neurology, Medical School, University of Tubingen, Germany
    FEBS Lett 453:361-4. 1999
    ..These data suggest caspase-3 as an important mediator of secondary retinal ganglion cell death following axotomy in vivo...
  7. ncbi Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo
    J H Weishaupt
    Department of Neurology, University Hospital Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Neurobiol Dis 13:124-35. 2003
    ..A late peak of caspase-8 activity and additive protective effects of caspase-8 and -9 inhibition on axotomized RGCs place caspase-8 in our model rather late in the apoptosis cascade, possibly after the onset of mitochondrial dysfunction...
  8. ncbi Modulation of metabotropic glutamate receptors fails to prevent the loss of adult rat retinal ganglion cells following axotomy or N-methyl-D-aspartate lesion in vivo
    P Kermer
    Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Neurosci Lett 315:117-20. 2001
    ..We conclude that activation/inactivation of retinal mGluRs does not play an important role for the initiation and execution of secondary RGC loss after ON transection and NMDA lesion in the adult rat...
  9. ncbi Neuron-specific overexpression of the co-chaperone Bcl-2-associated athanogene-1 in superoxide dismutase 1(G93A)-transgenic mice
    G Rohde
    University of Gottingen, Department of Neurology, Robert Koch Str 40, 37075 Gottingen, Germany
    Neuroscience 157:844-9. 2008
    ....
  10. ncbi Bag1 is a regulator and marker of neuronal differentiation
    P Kermer
    The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 N Torrey Pines Road, La Jolla, California, CA 92037, USA
    Cell Death Differ 9:405-13. 2002
    ..Taken together, these findings raise the possibility that the Bag1 protein is expressed early in neurogenesis in vivo and is capable of modulating neuronal cell survival and differentiation at least in part from a nuclear location...
  11. ncbi Both the neuronal and inducible isoforms contribute to upregulation of retinal nitric oxide synthase activity by brain-derived neurotrophic factor
    N Klocker
    Department of Neurology, University of Tubingen, 72076 Tubingen, Germany
    J Neurosci 19:8517-27. 1999
    ..These findings might be useful for developing pharmacological strategies to improve BDNF-mediated neuroprotection...
  12. ncbi Aggregopathy in neurodegenerative diseases: mechanisms and therapeutic implication
    C P Dohm
    Department of Neurology, University Hospital Gottingen, Gottingen, Germany
    Neurodegener Dis 5:321-38. 2008
    ..Furthermore, we will discuss current treatment strategies in these diseases targeting aggregate formation and concurrent neuronal cell death in these diseases...