Research Topics
| Ron KerenSummaryAffiliation: The Children's Hospital of Philadelphia Country: USA Publications
Research Grants
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Detail Information
Publications
Prioritization of comparative effectiveness research topics in hospital pediatricsRon Keren
Division of General Pediatrics, Center for Pediatric Clinical Effectiveness, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Arch Pediatr Adolesc Med 166:1155-64. 2012..To use information about prevalence, cost, and variation in resource utilization to prioritize comparative effectiveness research topics in hospital pediatrics...
Consideration of social values in the establishment of accountable care organizations in the USARon Keren
Division of General Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
J Health Organ Manag 26:384-9. 2012..It assesses the importance of ACOs, defining and articulating the values that will underpin their strategic and clinical decision making...- A meta-analysis of randomized, controlled trials comparing short- and long-course antibiotic therapy for urinary tract infections in childrenRon Keren
Department of Medicine, Children s Hospital, Boston, Massachusetts, USA
Pediatrics 109:E70-0. 2002.... - Neurological and neuromuscular disease as a risk factor for respiratory failure in children hospitalized with influenza infectionRon Keren
Division of General Pediatrics, Pediatric Generalist Research Group, Department of Medicine, The Children s Hospital of Philadelphia, PA 19104, USA
JAMA 294:2188-94. 2005..Little is known about the relative contribution of each of these chronic medical conditions to the development of serious influenza-associated complications... 
Identifying newborns at risk of significant hyperbilirubinaemia: a comparison of two recommended approachesR Keren
Division of General Pediatrics, Pediatric Generalist Research Group, The Children s Hospital of Philadelphia, PA, USA
Arch Dis Child 90:415-21. 2005....- Visual assessment of jaundice in term and late preterm infantsR Keren
Division of General Pediatrics and the Center for Pediatric Clinical Effectiveness, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Arch Dis Child Fetal Neonatal Ed 94:F317-22. 2009..To determine the accuracy of predischarge visual assessment of jaundice for estimating bilirubin concentration and predicting risk of significant neonatal hyperbilirubinaemia... - Imaging and treatment strategies for children after first urinary tract infectionRon Keren
Center for Pediatric Clinical Effectiveness, The Children s Hospital of Philadelphia, and Department of Pediatrics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine 19104, USA
Curr Opin Pediatr 19:705-10. 2007..To highlight recent controversies regarding the rationale and effectiveness of imaging and treatment strategies for children who experience a first urinary tract infection... - A comparison of alternative risk-assessment strategies for predicting significant neonatal hyperbilirubinemia in term and near-term infantsRon Keren
Division of General Pediatrics, Center for Pediatric Clinical Effectiveness, Children s Hospital of Philadelphia, 3535 Market St, Philadelphia, PA 19104, USA
Pediatrics 121:e170-9. 2008..The purpose of this work was to compare the predictive accuracy of alternative risk-assessment strategies used to screen for the risk of significant neonatal hyperbilirubinemia... - Rationale and design issues of the Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) studyRon Keren
Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Pediatrics 122:S240-50. 2008.... - The generation gap: differences between children and adults pertinent to economic evaluations of health interventionsRon Keren
General Pediatrics, Pediatric Generalist Research Group, The Children s Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Pharmacoeconomics 22:71-81. 2004.... - Notifying emergency department patients of negative test results: pitfalls of passive communicationRon Keren
Department of Medicine, Children s Hospital, Boston, MA, USA
Pediatr Emerg Care 19:226-30. 2003..Thus, positive throat culture results are communicated actively and negative results are communicated passively. We sought to determine the effectiveness and safety of such a system... - Projected cost-effectiveness of statewide universal newborn hearing screeningRon Keren
Department of Medicine, Children s Hospital, Boston, Massachusetts, USA
Pediatrics 110:855-64. 2002.... - Direct medical cost of influenza-related hospitalizations in childrenRon Keren
Children s Hospital of Philadelphia, 3535 Market St, Room 1524, Philadelphia, PA 19104, USA
Pediatrics 118:e1321-7. 2006..Our goal was to determine the cost of influenza-related hospitalization in children with community-acquired laboratory-confirmed influenza and to identify predictors of high hospitalization costs... - Incidence, complications, and risk factors for prolonged stay in children hospitalized with community-acquired influenzaSusan E Coffin
Division of General Pediatrics, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
Pediatrics 119:740-8. 2007.... - Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR): background commentary of RIVUR investigatorsRussell W Chesney
University of Tennessee Health Science Center, Department of Pediatrics, Memphis, TN 38103, USA
Pediatrics 122:S233-9. 2008..Such recommendations should be evidence-based... - Use of antibiotics in children hospitalized with community-acquired, laboratory-confirmed influenzaJennifer J Wilkes
Division of Infectious Diseases, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Pediatr 154:447-9. 2009..A total of 333 of 729 (46%) patients received >2 days of treatment with antibacterial medications, of whom 36% did not have an apparent indication for therapy... - Corticosteroids may improve clinical outcomes during hospitalization for Henoch-Schönlein purpuraPamela F Weiss
Division of Rheumatology, Children s Hospital of Philadelphia, and Department of Pediatrics, Center for Clinical Epidemiology and Biostatistics, Leonard Davis Institute of Health Economics, University of Pennsylvania School of Medicine, Room 1539, North Campus, 3535 Market St, Philadelphia, PA 19104, USA
Pediatrics 126:674-81. 2010..To characterize the effect of corticosteroid exposure on clinical outcomes in children hospitalized with new-onset Henoch-Schönlein purpura (HSP)... - Neurologic complications in children hospitalized with influenza: characteristics, incidence, and risk factorsJason G Newland
Division of Infectious Diseases, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Pediatr 150:306-10. 2007..To determine the characteristics, incidence, and risk factors for influenza-related neurologic complications (INC)... - Oseltamivir shortens hospital stays of critically ill children hospitalized with seasonal influenza: a retrospective cohort studySusan E Coffin
Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Pediatr Infect Dis J 30:962-6. 2011..The effect of oseltamivir on outcomes of hospitalized children is unknown. The primary objective of this study was to determine whether oseltamivir improves outcomes of critically ill children hospitalized with influenza... - Enthesitis in an inception cohort of enthesitis-related arthritisPamela F Weiss
The Children s Hospital of Philadelphia, Pennsylvania, USA
Arthritis Care Res (Hoboken) 63:1307-12. 2011..To describe an enthesitis-related arthritis (ERA) inception cohort and determine which entheses and joints are most commonly affected... - Prolonged intravenous therapy versus early transition to oral antimicrobial therapy for acute osteomyelitis in childrenTheoklis Zaoutis
Division of Infectious Diseases, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, CHOP North, Suite 1527, Philadelphia, PA 19104, USA
Pediatrics 123:636-42. 2009..We sought to compare the effectiveness of early transition from intravenous to oral antimicrobial therapy versus prolonged intravenous antimicrobial therapy for the treatment of children with acute osteomyelitis... - Development of a score to predict clinical deterioration in hospitalized childrenChristopher P Bonafide
Division of General Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
J Hosp Med 7:345-9. 2012..Previous studies have evaluated vital sign-based early warning scores to detect deterioration that has already begun... - Variation in inpatient therapy and diagnostic evaluation of children with Henoch Schönlein purpuraPamela F Weiss
Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
J Pediatr 155:812-818.e1. 2009..To describe variation regarding inpatient therapy and evaluation of children with Henoch Schönlein purpura (HSP) admitted to children's hospitals across the United States... - Treatment with oseltamivir in children hospitalized with community-acquired, laboratory-confirmed influenza: review of five seasons and evaluation of an electronic reminderJennifer J Wilkes
Division of Infectious Diseases, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Hosp Med 4:171-8. 2009..When initiated within 48 hours of the onset of symptoms, oseltamivir has been shown to reduce severity and length of influenza illness. Few studies have evaluated the use of oseltamivir in patients hospitalized with influenza... - Patient volume and quality of care for young children hospitalized with acute gastroenteritisLisa McLeod
Department of Pediatrics, Children s Hospital of Philadelphia, PA 19104, USA
Arch Pediatr Adolesc Med 165:857-63. 2011..To explore the relationship between the volume of children admitted to the hospital with acute gastroenteritis and adherence to recommended quality indicators... - Valuing children's health: a comparison of cost-utility analyses for adult and paediatric health interventions in the USJoseph A Ladapo
Harvard Medical School and Harvard Graduate School of Arts and Sciences, Boston, Massachusetts, USA
Pharmacoeconomics 25:817-28. 2007.... - Recurrent urinary tract infections in children: risk factors and association with prophylactic antimicrobialsPatrick H Conway
Robert Wood Johnson Clinical Scholars Program, University of Pennsylvania, Philadelphia, PA 19104, USA
JAMA 298:179-86. 2007..The evidence regarding risk factors for recurrent urinary tract infection (UTI) and the risks and benefits of antimicrobial prophylaxis in children is scant... - Diagnosis and management of hyperbilirubinemia in the term neonate: for a safer first weekVinod K Bhutani
Department of Pediatrics, University of Pennsylvania School of Medicine, 800 Spruce Street, Philadelphia, PA 19107, USA
Pediatr Clin North Am 51:843-61, vii. 2004..We should also provide focused universal education emphasizing adequate lactational nutrition, to decrease severe hyperbilirubinemia and thus prevent kernicterus... - Beyond statistical prediction: qualitative evaluation of the mechanisms by which pediatric early warning scores impact patient safetyChristopher P Bonafide
Division of General Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania Center for Pediatric Clinical Effectiveness, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania
J Hosp Med 8:248-53. 2013..Despite marginal predictive accuracy in retrospective datasets and a paucity of studies prospectively evaluating their clinical effectiveness, pediatric EWSs are commonly used... - Racial differences in antibiotic prescribing by primary care pediatriciansJeffrey S Gerber
Division of Infectious Diseases, The Children s Hospital of Philadelphia, 3535 Market St, Ste 1518, Philadelphia, PA 19104
Pediatrics 131:677-84. 2013..To determine whether racial differences exist in antibiotic prescribing among children treated by the same clinician... - Previous antimicrobial exposure is associated with drug-resistant urinary tract infections in childrenAmanda A Paschke
Children s Hospital of Philadelphia, Division of Infectious Diseases, 3615 Civic Center Blvd, ARC 1202, Philadelphia, PA 19104, USA
Pediatrics 125:664-72. 2010..The aim of this study was to evaluate the impact of previous antimicrobial exposure on the development of antimicrobial resistance in children with their first urinary tract infection (UTI)... - Medications associated with clinical deterioration in hospitalized childrenEmily J Huang
Division of General Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania
J Hosp Med 8:254-60. 2013..Surveillance tools using electronic health record data help identify children at risk of deterioration. Existing early warning scores primarily include vital signs, but may benefit from the incorporation of medications... - Development of heart and respiratory rate percentile curves for hospitalized childrenChristopher P Bonafide
MSCE, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, Suite 12NW80, Philadelphia, PA 19104
Pediatrics 131:e1150-7. 2013..To develop and validate heart and respiratory rate percentile curves for hospitalized children and compare their vital sign distributions to textbook reference ranges and pediatric early warning score (EWS) parameters... - Evaluation of a novel method for grading heart murmur intensityRon Keren
Division of General Pediatrics, Pediatric Generalist Research Group, Children s Hospital of Philadelphia, 3535 Market Street, Philadelphia, PA 19104, USA
Arch Pediatr Adolesc Med 159:329-34. 2005..To determine if heart murmur intensity grading performance can be improved using the heart sounds as an internal reference... - Public spending on elders and children: the gap is growingSusmita Pati
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA
LDI Issue Brief 10:1-4. 2004..This Issue Brief evaluates trends in social welfare spending for children and the elderly from 1980 to 2000, and the relationship of national economic trends to public spending patterns... - Complications of central venous catheters used for the treatment of acute hematogenous osteomyelitisRebecca Ruebner
Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Pediatrics 117:1210-5. 2006..Clinical trials are needed to evaluate the safety and efficacy of oral antibiotic therapy after a short course of IV therapy as an alternative to prolonged IV therapy... - Measuring health preferences for use in cost-utility and cost-benefit analyses of interventions in children: theoretical and methodological considerationsLisa A Prosser
Center for Child Health Care Studies, Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
Pharmacoeconomics 25:713-26. 2007.... - Perioperative antibiotic use for spinal surgery procedures in US children's hospitalsLisa M McLeod
Department of General Pediatrics, Center for Pediatric Clinical Effectiveness, Children s Hospital of Philadelphia, Philadelphia, PA, USA
Spine (Phila Pa 1976) 38:609-16. 2013..Retrospective cohort study using the Pediatric Health Information System database... - Development of a pragmatic measure for evaluating and optimizing rapid response systemsChristopher P Bonafide
Division of General Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Pediatrics 129:e874-81. 2012..We aimed to develop a valid, pragmatic measure for evaluating and optimizing RRSs over shorter periods of time... - Disparities in the evaluation and diagnosis of abuse among infants with traumatic brain injuryJoanne N Wood
General Pediatrics, Children s Hospital of Philadelphia, Department of Biostatistics, University of Pennsylvania School of Medicine, 3535 Market Street, Room 1517, Philadelphia, PA 19104, USA
Pediatrics 126:408-14. 2010..To evaluate in a national database the association of race and socioeconomic status with radiographic evaluation and subsequent diagnosis of child abuse after traumatic brain injury (TBI) in infants... - Does simulation improve patient safety? Self-efficacy, competence, operational performance, and patient safetyAkira Nishisaki
Division of Critical Care, Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
Anesthesiol Clin 25:225-36. 2007..Even so, confidence is growing in the validity of medical simulation as the training tool of the future. The use of medical simulation will continue to grow in the context of multidisciplinary team training for patient safety... - Flu-related hospitalization in childrenRon Keren
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
LDI Issue Brief 12:1-4. 2006..These findings should help inform clinicians and policymakers in prioritizing their efforts to implement the new recommendations... - National Institute of Child Health and Human Development (NICHD) conference on kernicterus: a population perspective on prevention of kernicterusR Heather Palmer
The Center for Quality of Care Research and Education, Harvard School of Public Health, Boston, MA 02115, USA
J Perinatol 24:723-5. 2004..Lastly, discovering how to motivate change in existing practices can provide the guidance needed to prevent kernicterus in the US... - Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer diseaseHao Li
GlaxoSmithKline, Research Triangle Park, North Carolina, USA
Arch Neurol 65:45-53. 2008..To identify single-nucleotide polymorphisms (SNPs) associated with risk and age at onset of Alzheimer disease (AD) in a genomewide association study of 469 438 SNPs... - Vesicoureteral reflux: the RIVUR study and the way forwardSaul P Greenfield
J Urol 179:405-7. 2008 - ICD-9 codes for identifying influenza hospitalizations in childrenRon Keren
Emerg Infect Dis 12:1603-4. 2006 - Comparison of alternative diagnostic approaches for managing appendicitis in children: the effect of disease prevalence and spectrumDaniel Swarr
Pediatrics 114:513-4. 2004 - Generational differences in U.S. public spending, 1980-2000Susmita Pati
Children's Hospital of Philadelphia, USA
Health Aff (Millwood) 23:131-41. 2004..Unlike spending for programs for the elderly, spending for children's programs suffered during recessions. Public discussion about the current imbalance in public spending is needed...
Research Grants
- Clinical Trial of Prophylactic Antibiotics for Children with Vesicoureteral RefluRon Keren; Fiscal Year: 2007..Relevance: The trial has the potential to substantially impact the diagnostic work-up and management for the tens of thousands of children in the US who develop UTIs each year ..
- Prediciting Severe Neonatal HyperbilirubinemiaRon Keren; Fiscal Year: 2007The overall goal of this research career development award is to promote the development of Dr. Ron Keren as an independent patient-oriented clinical researcher. To achieve this goal, Dr...
- Risk factors for renal scarring in children after urinary tract infectionRon Keren; Fiscal Year: 2009..PROJECT NARRATIVE Understanding which children are at the greatest risk of renal scarring after a UTI will allow clinicians to provide more targeted therapies and interventions to prevent this adverse outcome. ..
- Risk factors for renal scarring in children after urinary tract infectionRon Keren; Fiscal Year: 2010..PROJECT NARRATIVE Understanding which children are at the greatest risk of renal scarring after a UTI will allow clinicians to provide more targeted therapies and interventions to prevent this adverse outcome. ..
- PHIS+: Augmenting the Pediatric Health Information System with Clinical DataRon Keren; Fiscal Year: 2010....