Paul J Kenny

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Neurobiological evidence for hedonic allostasis associated with escalating cocaine use
    Serge H Ahmed
    Laboratoire de Neuropsychobiologie des Desadaptations, Universite de Bordeaux 2, CNRS UMR 5541, 146 rue Leo Saignat, Bordeaux 33076, France
    Nat Neurosci 5:625-6. 2002
  2. ncbi request reprint Brain reward systems and compulsive drug use
    Paul J Kenny
    Department of Biochemistry, The Scripps Research Institute, Jupiter, FL 33458, USA
    Trends Pharmacol Sci 28:135-41. 2007
  3. pmc Dopamine D2 receptors and striatopallidal transmission in addiction and obesity
    Paul J Kenny
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA
    Curr Opin Neurobiol 23:535-8. 2013
  4. pmc How can we begin to measure recovery?
    Karen Dodge
    Hanley Center, USA
    Subst Abuse Treat Prev Policy 5:31. 2010
  5. pmc NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala
    Paul J Kenny
    Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA
    Neuropsychopharmacology 34:266-81. 2009
  6. ncbi request reprint Conditioned withdrawal drives heroin consumption and decreases reward sensitivity
    Paul J Kenny
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 26:5894-900. 2006
  7. doi request reprint Common cellular and molecular mechanisms in obesity and drug addiction
    Paul J Kenny
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Florida, 130 Scripps Way, Jupiter, Florida 33458, USA
    Nat Rev Neurosci 12:638-51. 2011
  8. pmc Reward mechanisms in obesity: new insights and future directions
    Paul J Kenny
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA
    Neuron 69:664-79. 2011
  9. ncbi request reprint Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats
    P J Kenny
    The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Ann N Y Acad Sci 1003:415-8. 2003
  10. pmc Tobacco dependence, the insular cortex and the hypocretin connection
    Paul J Kenny
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA
    Pharmacol Biochem Behav 97:700-7. 2011

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Neurobiological evidence for hedonic allostasis associated with escalating cocaine use
    Serge H Ahmed
    Laboratoire de Neuropsychobiologie des Desadaptations, Universite de Bordeaux 2, CNRS UMR 5541, 146 rue Leo Saignat, Bordeaux 33076, France
    Nat Neurosci 5:625-6. 2002
    ....
  2. ncbi request reprint Brain reward systems and compulsive drug use
    Paul J Kenny
    Department of Biochemistry, The Scripps Research Institute, Jupiter, FL 33458, USA
    Trends Pharmacol Sci 28:135-41. 2007
    ..These findings provide a conceptual framework for improving our understanding of compulsive drug use, and might facilitate the development of novel therapeutics for substance abuse disorders...
  3. pmc Dopamine D2 receptors and striatopallidal transmission in addiction and obesity
    Paul J Kenny
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA
    Curr Opin Neurobiol 23:535-8. 2013
    ....
  4. pmc How can we begin to measure recovery?
    Karen Dodge
    Hanley Center, USA
    Subst Abuse Treat Prev Policy 5:31. 2010
    ..There is a lack of consensus in the addiction treatment literature regarding the definition of substance abuse "recovery"...
  5. pmc NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala
    Paul J Kenny
    Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA
    Neuropsychopharmacology 34:266-81. 2009
    ..Taken together, these data suggest that NMDA receptors, including those in the CeA and VTA, gate the magnitude and valence of the effects of nicotine on brain reward systems, thereby regulating motivation to consume the drug...
  6. ncbi request reprint Conditioned withdrawal drives heroin consumption and decreases reward sensitivity
    Paul J Kenny
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 26:5894-900. 2006
    ..Thus, conditioned stimuli predicting the onset of heroin withdrawal, and hence the reward deficits coupled with this state, may play a critical role in provoking craving and relapse in human opiate addicts...
  7. doi request reprint Common cellular and molecular mechanisms in obesity and drug addiction
    Paul J Kenny
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Florida, 130 Scripps Way, Jupiter, Florida 33458, USA
    Nat Rev Neurosci 12:638-51. 2011
    ..Here, we review evidence suggesting that obesity and drug addiction may share common molecular, cellular and systems-level mechanisms...
  8. pmc Reward mechanisms in obesity: new insights and future directions
    Paul J Kenny
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA
    Neuron 69:664-79. 2011
    ..Also, emerging evidence suggesting that obesity and drug addiction may share common hedonic mechanisms will also be considered...
  9. ncbi request reprint Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats
    P J Kenny
    The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Ann N Y Acad Sci 1003:415-8. 2003
  10. pmc Tobacco dependence, the insular cortex and the hypocretin connection
    Paul J Kenny
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA
    Pharmacol Biochem Behav 97:700-7. 2011
    ..This latter finding may provide mechanistic insight into the apparent disruption of tobacco addiction reported in human smokers with stroke-associated damage to the insular cortex...
  11. ncbi request reprint Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats
    Paul J Kenny
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 179:247-54. 2005
    ..Evidence is accumulating that metabotropic glutamate 5 (mGlu5) receptors play an important role in regulating the reinforcing actions of drugs of abuse...
  12. pmc Striatal microRNA controls cocaine intake through CREB signalling
    Jonathan A Hollander
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA
    Nature 466:197-202. 2010
    ....
  13. pmc Insular hypocretin transmission regulates nicotine reward
    Jonathan A Hollander
    Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA
    Proc Natl Acad Sci U S A 105:19480-5. 2008
    ....
  14. pmc Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
    Paul M Johnson
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Scripps Florida, Jupiter, Florida, USA
    Nat Neurosci 13:635-41. 2010
    ..Common hedonic mechanisms may therefore underlie obesity and drug addiction...
  15. pmc MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212
    Heh In Im
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Scripps Florida, Jupiter, Florida, USA
    Nat Neurosci 13:1120-7. 2010
    ..These data suggest that homeostatic interactions between MeCP2 and miR-212 in dorsal striatum may be important in regulating vulnerability to cocaine addiction...
  16. ncbi request reprint Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats
    Paul J Kenny
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 306:1068-76. 2003
    ..Furthermore, it is likely that mGluII receptors generate this reward deficit, at least in part, by decreasing glutamate transmission at AMPA/kainate receptors...
  17. ncbi request reprint Prolonged nicotine exposure does not alter GABA(B) receptor-mediated regulation of brain reward function
    Neil E Paterson
    Department of Molecular and Integrative Neuroscience, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropharmacology 49:953-62. 2005
    ....
  18. pmc Decreased brain reward function during nicotine withdrawal in C57BL6 mice: evidence from intracranial self-stimulation (ICSS) studies
    Paul M Johnson
    Department of Molecular Therapeutics, The Scripps Research Institute, 5353 Parkside Drive, Jupiter, FL 33458, USA
    Pharmacol Biochem Behav 90:409-15. 2008
    ..Further, these findings highlight the potential utility of the ICSS procedure for assessing this important affective component of nicotine withdrawal in genetically modified mice...
  19. ncbi request reprint Nicotine self-administration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity
    Paul J Kenny
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 31:1203-11. 2006
    ....
  20. ncbi request reprint Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems
    Paul J Kenny
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037
    J Neurosci 25:6208-12. 2005
    ....
  21. ncbi request reprint Neurobiological mechanisms in the transition from drug use to drug dependence
    George F Koob
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neurosci Biobehav Rev 27:739-49. 2004
    ....
  22. ncbi request reprint Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats
    Paul J Kenny
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Neurosci 17:191-5. 2003
    ....
  23. pmc Habenular α5 nicotinic receptor subunit signalling controls nicotine intake
    Christie D Fowler
    Laboratory for Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Scripps Florida, Jupiter, Florida 33458, USA
    Nature 471:597-601. 2011
    ..Our findings indicate that nicotine activates the habenulo-interpeduncular pathway through α5-containing nAChRs, triggering an inhibitory motivational signal that acts to limit nicotine intake...
  24. pmc Molecular, cellular, and structural mechanisms of cocaine addiction: a key role for microRNAs
    Sietse Jonkman
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Florida, Jupiter, FL 33458, USA
    Neuropsychopharmacology 38:198-211. 2013
    ....
  25. pmc Intravenous nicotine self-administration and cue-induced reinstatement in mice: effects of nicotine dose, rate of drug infusion and prior instrumental training
    Christie D Fowler
    Department of Molecular Therapeutics, The Scripps Research Institute Scripps Florida, Jupiter, FL 33458, USA
    Neuropharmacology 61:687-98. 2011
    ..These data demonstrate that nicotine is an effective reinforcer in mice and establish conditions under which the drug is reliably self-administered by mice...
  26. pmc MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function
    Brooke H Miller
    Department of Molecular Therapeutics, The Scripps Research Institute Scripps Florida, Jupiter, FL 33458, USA
    Proc Natl Acad Sci U S A 109:3125-30. 2012
    ..Our data suggest miR-132 dysregulation and subsequent abnormal expression of miR-132 target genes contribute to the neurodevelopmental and neuromorphological pathologies present in schizophrenia...
  27. pmc Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior
    Luis M Tuesta
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Scripps Florida, Jupiter, FL 33458, USA
    Biochem Pharmacol 82:984-95. 2011
    ..The aim of the present review is to discuss recent preclinical findings concerning the identity of the nAChR subtypes that regulate self-administration of nicotine and other drugs of abuse...
  28. ncbi request reprint Conditioned facilitation of brain reward function after repeated cocaine administration
    Paul J Kenny
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Behav Neurosci 117:1103-7. 2003
    ..These data demonstrate that cocaine-predictive conditioned stimuli induce a conditioned facilitation of brain reward function...
  29. pmc Patterns of responding differentiate intravenous nicotine self-administration from responding for a visual stimulus in C57BL/6J mice
    Candice Contet
    Department of Psychiatry, Mail Code 0603, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Psychopharmacology (Berl) 212:283-99. 2010
    ..Testing genetically engineered mice in a reliable nicotine self-administration procedure could provide important insights into the molecular mechanisms underlying nicotine reinforcement...
  30. pmc MicroRNAs in neuronal function and dysfunction
    Heh In Im
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Scripps Florida, Jupiter, FL 33458, USA
    Trends Neurosci 35:325-34. 2012
    ..A better understanding of how miRNAs influence the development of neuropsychiatric disorders may reveal fundamental insights into the causes of these devastating illnesses and offer novel targets for therapeutic development...
  31. pmc Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists
    Rong Jiang
    Department of Molecular Therapeutics, and Translational Research Institute, The Scripps Research Institute, Scripps Florida, 130 Scripps Way 2A1, Jupiter, FL 33458, USA
    Bioorg Med Chem Lett 22:3890-4. 2012
    ..Compounds were profiled in vivo for plasma and brain levels in order to identify candidates suitable for efficacy in a model of drug addiction...
  32. pmc Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice
    Christie D Fowler
    Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, USA
    Behav Pharmacol 19:461-84. 2008
    ..Thus, we also briefly review data generated from genetically modified mice to support a role for discrete nAChR subunits in anxiety disorders, depression, and schizophrenia...
  33. doi request reprint Synthesis and activity of substituted heteroaromatics as positive allosteric modulators for α4β2α5 nicotinic acetylcholine receptors
    Zhuang Jin
    Department of Molecular Therapeutics and Translational Research Institute, The Scripps Research Institute, Scripps Florida, 130 Scripps Way A2A, Jupiter, FL 33458, USA
    Bioorg Med Chem Lett 24:674-8. 2014
    ....
  34. ncbi request reprint The ups and downs of addiction: role of metabotropic glutamate receptors
    Paul J Kenny
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Pharmacol Sci 25:265-72. 2004
    ..These findings increase our understanding of the pathological processes that are associated with the development of drug addiction, and might ultimately lead to new therapies for the treatment of this disorder...
  35. pmc Methylation, memory and addiction
    Purva Bali
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Florida, Jupiter, FL, USA
    Epigenetics 6:671-4. 2011
    ..Emerging evidence now suggests that DNA methylation plays a central role in these processes, likely by directly influencing the expression of genes involved in synaptic plasticity...
  36. pmc MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction
    Jannet Kocerha
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
    Proc Natl Acad Sci U S A 106:3507-12. 2009
    ..Taken together, these data support an integral role for miR-219 in the expression of behavioral aberrations associated with NMDA receptor hypofunction...
  37. pmc Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence
    Jonathan A Hollander
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter FL, USA
    Front Behav Neurosci 6:47. 2012
    ....
  38. doi request reprint Utility of genetically modified mice for understanding the neurobiology of substance use disorders
    Christie D Fowler
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute, Scripps, Florida, Jupiter, FL 33458, USA
    Hum Genet 131:941-57. 2012
    ....
  39. pmc Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability
    Christie D Fowler
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA
    Neuropharmacology 76:533-44. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'. ..
  40. pmc Development of novel pharmacotherapeutics for tobacco dependence: progress and future directions
    Dympna Harmey
    Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA
    Nicotine Tob Res 14:1300-18. 2012
    ..Hence, there is a pressing need to develop safer and more efficacious smoking cessation medications...
  41. pmc MicroRNAs and Drug Addiction
    Purva Bali
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Florida Jupiter, FL, USA Laboratory of Behavioral and Molecular Neuroscience, Department of Neuroscience, The Scripps Research Institute Florida Jupiter, FL, USA
    Front Genet 4:43. 2013
    ..These findings highlight the unique role for miRNAs in simultaneously controlling multiple signaling cascades implicated in addiction...
  42. pmc Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
    Benjamin Boutrel
    Center for Psychiatric Neuroscience and Service Universitaire de Psychiatrie de l Enfant et de l Adolescent, Centre Hospitalier Universitaire Vaudois Département de Psychiatrie, University of Lausanne, Prilly, Switzerland
    Proc Natl Acad Sci U S A 102:19168-73. 2005
    ..These findings reveal a previously unidentified role for hypocretins in driving drug seeking through activation of stress pathways in the brain...

Research Grants11

  1. Development of Orexin-1 Receptor Antagonists to Prevent Drug Relapse
    Paul Kenny; Fiscal Year: 2007
    ..Such an integrated multidisciplinary research plan will capitalize on the unique drug discovery capabilities at Scripps Florida, and promises to yield novel therapeutic entities for the prevention of relapse in human addicts. ..
  2. Mechanisms of nicotine reinforcement in mice
    Paul Kenny; Fiscal Year: 2007
    ..These studies promise to yield significant new insights into the neurobiological mechanisms of nicotine addiction, with relevance for the treatment of the tobacco habit in human smokers. ..
  3. Role of MicroRNAs in the Mechanisms of Drug Dependence
    CLAES ROBERT WAHLESTEDT; Fiscal Year: 2010
    ..The proposed work has the potential to aid in the development of completely novel therapeutics. ..
  4. Mechanisms of nicotine reinforcement in mice
    Paul J Kenny; Fiscal Year: 2010
    ..These studies promise to yield significant new insights into the neurobiological mechanisms of nicotine addiction, with relevance for the treatment of the tobacco habit in human smokers. ..
  5. Development of Orexin-1 Receptor Antagonists to Prevent Drug Relapse
    Paul J Kenny; Fiscal Year: 2010
    ..Such an integrated multidisciplinary research plan will capitalize on the unique drug discovery capabilities at Scripps Florida, and promises to yield novel therapeutic entities for the prevention of relapse in human addicts. ..