Research Topics
Genomes and Genes | Yukio KawaharaSummaryAffiliation: The Wistar Institute Country: USA Publications
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Publications
Human spinal motoneurons express low relative abundance of GluR2 mRNA: an implication for excitotoxicity in ALSYukio Kawahara
Department of Neurology, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo, Japan
J Neurochem 85:680-9. 2003..However, the low relative abundance of GluR2 might provide spinal motoneurons with conditions that are easily affected by changes of AMPA receptor properties including deficient GluR2 mRNA editing in ALS...- Excitotoxicity and ALS: what is unique about the AMPA receptors expressed on spinal motor neurons?Yukio Kawahara
The Wistar Institute, Philadelphia, PA 19104, USA
Amyotroph Lateral Scler Other Motor Neuron Disord 6:131-44. 2005..This review focuses on recent progress on the molecular dynamics of AMPA receptors and discusses the pathophysiology of selective motor neuron death mediated by AMPA receptors in individuals affected with sporadic ALS... 
Redirection of silencing targets by adenosine-to-inosine editing of miRNAsYukio Kawahara
Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
Science 315:1137-40. 2007....- RNA editing of the microRNA-151 precursor blocks cleavage by the Dicer-TRBP complexYukio Kawahara
The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
EMBO Rep 8:763-9. 2007..Our results indicate that A --> I conversion at two specific positions of the pre-miRNA foldback structure can affect its interaction with the Dicer-TRBP complex, showing a new regulatory role of A --> I RNA editing in miRNA biogenesis... - Extensive adenosine-to-inosine editing detected in Alu repeats of antisense RNAs reveals scarcity of sense-antisense duplex formationYukio Kawahara
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
FEBS Lett 580:2301-5. 2006..Our findings imply that sense and antisense RNAs form two separate intramolecular double-stranded RNAs consisting of inversely oriented Alu repeats, but rarely form intermolecular duplexes... - Functional relevance of serotonin 2C receptor mRNA editing in antidepressant- and anxiety-like behaviorsCedric Mombereau
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Neuropharmacology 59:468-73. 2010..These data constitute the first in vivo demonstration of a role for 5-HT(2C)R mRNA editing in anxiety- and depression-related behaviors... - [MicroRNAs in neurobiology]Yukio Kawahara
Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Brain Nerve 60:1437-44. 2008..Finally, the possible connection between microRNA dysfunction and neurological diseases, and future implications for diagnosis, and treatment of defects in human brain development and neurodegenerative diseases are discussed... - Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat massYukio Kawahara
The Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 28:12834-44. 2008..Our results highlight the importance of regulated 5-HT(2C)R mRNA editing, because dysregulation could result in the pathological consequences such as growth retardation seen in VGV mice... - Frequency and fate of microRNA editing in human brainYukio Kawahara
The Wistar Institute
Nucleic Acids Res 36:5270-80. 2008..Our studies predict that approximately 16% of human pri-miRNAs are subject to A-->I editing and, thus, miRNA editing could have a large impact on the miRNA-mediated gene silencing... - A-to-I RNA editing and human diseaseStefan Maas
Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
RNA Biol 3:1-9. 2006..Here we review the recent knowledge on where disturbances in A-to-I RNA editing have been correlated with human disease phenotypes... - Slow and selective death of spinal motor neurons in vivo by intrathecal infusion of kainic acid: implications for AMPA receptor-mediated excitotoxicity in ALSHui Sun
Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
J Neurochem 98:782-91. 2006..e. calcium-permeable) AMPA receptors. This rat model may be useful in investigating ALS etiology... - Underediting of GluR2 mRNA, a neuronal death inducing molecular change in sporadic ALS, does not occur in motor neurons in ALS1 or SBMAYukio Kawahara
Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Neurosci Res 54:11-4. 2006..It seems likely that the death cascade is different among the dying motor neurons in sporadic ALS, familial ALS with mutant SOD1 and SBMA... - [AMPA receptor-mediated neuronal death and amyotrophic lateral sclerosis]Takuto Hideyama
Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
No To Shinkei 57:585-98. 2005 - Deficient RNA editing of GluR2 and neuronal death in amyotropic lateral sclerosisShin Kwak
Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655 Tokyo, Japan
J Mol Med (Berl) 83:110-20. 2005..The restoration of this enzyme activity in ALS motor neurons may open the novel strategy for specific ALS therapy... - Glutamate receptors: RNA editing and death of motor neuronsYukio Kawahara
Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Nature 427:801. 2004.... - Low editing efficiency of GluR2 mRNA is associated with a low relative abundance of ADAR2 mRNA in white matter of normal human brainYukio Kawahara
Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Eur J Neurosci 18:23-33. 2003..These results suggest that Q/R site of GluRs editing is regulated in a regional, and hence presumably cell-specific, manner and that the GluR2 Q/R site editing is critically regulated by ADAR2 in human brain... - Expression profile of AMPA receptor subunit mRNA in single adult rat brain and spinal cord neurons in situHui Sun
Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Neurosci Res 52:228-34. 2005..The unique AMPA receptor expression profile of motoneurons may render them selectively vulnerable to AMPA receptor-mediated excitotoxicity... - GluR4c, an alternative splicing isoform of GluR4, is abundantly expressed in the adult human brainYukio Kawahara
Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 8655, Japan
Brain Res Mol Brain Res 127:150-5. 2004..The GluR4 subunit may play a pivotal role in regulating channel properties as well as trafficking of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors in the adult human brain... - Regulation of glutamate receptor RNA editing and ADAR mRNA expression in developing human normal and Down's syndrome brainsYukio Kawahara
Department of Neurology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan
Brain Res Dev Brain Res 148:151-5. 2004..ADAR2 mRNA was not overexpressed in the brains of Down's syndrome subjects, nor was there any evidence of changes in the RNA editing efficiency of their GluRs... - Novel splice variants of human ADAR2 mRNA: skipping of the exon encoding the dsRNA-binding domains, and multiple C-terminal splice sitesYukio Kawahara
Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Gene 363:193-201. 2005..Among them, variants containing the long C-terminus are translated in human brains in situ, implying that alternative splicing in the 3' UTR of ADAR2 might regulate translational efficiency and mRNA stability in vivo...