Genomes and Genes


Annemieke Kavelaars


Affiliation: The University of Texas
Country: USA


  1. Laumet G, Edralin J, Chiang A, Dantzer R, Heijnen C, Kavelaars A. Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling. Neuropsychopharmacology. 2018;43:2597-2605 pubmed publisher
    ..We propose that targeting the T lymphocyte/IL-10 resolution pathway could represent a novel approach to promote recovery from major depressive disorder. ..
  2. Zhou W, Dantzer R, Budac D, Walker A, Mao Ying Q, Lee A, et al. Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice. Brain Behav Immun. 2015;46:147-53 pubmed publisher
    ..Moreover, comorbidity of neuropathic pain and depression are only partially mediated by a common mechanism because mechanical hyperalgesia develops independently of Ido1. ..
  3. Singhmar P, Huo X, Eijkelkamp N, Berciano S, Baameur F, Mei F, et al. Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1. Proc Natl Acad Sci U S A. 2016;113:3036-41 pubmed publisher
    ..Importantly, using the Epac inhibitor ESI-09, we validate Epac1 as a potential therapeutic target for chronic pain. ..
  4. Krukowski K, Eijkelkamp N, Laumet G, Hack C, Li Y, Dougherty P, et al. CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain. J Neurosci. 2016;36:11074-11083 pubmed
    ..Clinically, peripheral blood CD8+ T-cell function and/or the capacity of individuals to produce IL-10 may represent biomarkers of risk for developing persistent peripheral neuropathy after completion of cancer treatment. ..
  5. Laumet G, Zhou W, Dantzer R, Edralin J, Huo X, Budac D, et al. Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain. Brain Behav Immun. 2017;66:94-102 pubmed publisher
    ..Inhibition of KMO may represent a promising target for treating depression. ..