Affiliation: The University of Texas
Laumet G, Edralin J, Chiang A, Dantzer R, Heijnen C, Kavelaars A. Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling. Neuropsychopharmacology. 2018;43:2597-2605 pubmed publisher
..We propose that targeting the T lymphocyte/IL-10 resolution pathway could represent a novel approach to promote recovery from major depressive disorder. ..
Zhou W, Dantzer R, Budac D, Walker A, Mao Ying Q, Lee A, et al
. Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice. Brain Behav Immun. 2015;46:147-53 pubmed publisher
..Moreover, comorbidity of neuropathic pain and depression are only partially mediated by a common mechanism because mechanical hyperalgesia develops independently of Ido1. ..
Singhmar P, Huo X, Eijkelkamp N, Berciano S, Baameur F, Mei F, et al
. Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1. Proc Natl Acad Sci U S A. 2016;113:3036-41 pubmed publisher
..Importantly, using the Epac inhibitor ESI-09, we validate Epac1 as a potential therapeutic target for chronic pain. ..
Krukowski K, Eijkelkamp N, Laumet G, Hack C, Li Y, Dougherty P, et al
. CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain. J Neurosci. 2016;36:11074-11083 pubmed
..Clinically, peripheral blood CD8+ T-cell function and/or the capacity of individuals to produce IL-10 may represent biomarkers of risk for developing persistent peripheral neuropathy after completion of cancer treatment. ..
Laumet G, Zhou W, Dantzer R, Edralin J, Huo X, Budac D, et al
. Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain. Brain Behav Immun. 2017;66:94-102 pubmed publisher
..Inhibition of KMO may represent a promising target for treating depression. ..