M Kaul

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. pmc Molecular mechanisms of neuroinvasion by monocytes-macrophages in HIV-1 infection
    Gabriel Gras
    Institute of Emerging Diseases and Innovative Therapies, Division of Immuno Virology, CEA, 18 route du Panorama, F92265 Fontenay aux Roses, France
    Retrovirology 7:30. 2010
  2. pmc HIV's double strike at the brain: neuronal toxicity and compromised neurogenesis
    Marcus Kaul
    Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Front Biosci 13:2484-94. 2008
  3. ncbi request reprint Mechanisms of neuronal injury and death in HIV-1 associated dementia
    Marcus Kaul
    Center for Neuroscience and Aging Research, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Curr HIV Res 4:307-18. 2006
  4. ncbi request reprint HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection
    M Kaul
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Death Differ 14:296-305. 2007
  5. ncbi request reprint Experimental and potential future therapeutic approaches for HIV-1 associated dementia targeting receptors for chemokines, glutamate and erythropoietin
    M Kaul
    Center for Neuroscience and Aging Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neurotox Res 8:167-86. 2005
  6. ncbi request reprint Mechanisms of neuroimmunity and neurodegeneration associated with HIV-1 infection and AIDS
    Marcus Kaul
    Center for Neuroscience and Aging Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Neuroimmune Pharmacol 1:138-51. 2006
  7. pmc HIV-1 associated dementia: update on pathological mechanisms and therapeutic approaches
    Marcus Kaul
    Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Curr Opin Neurol 22:315-20. 2009
  8. ncbi request reprint HIV-1 infection and AIDS: consequences for the central nervous system
    M Kaul
    Center for Neuroscience and Aging Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Death Differ 12:878-92. 2005
  9. ncbi request reprint Pathways to neuronal injury and apoptosis in HIV-associated dementia
    M Kaul
    Center for Neuroscience and Aging Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 410:988-94. 2001
  10. doi request reprint HIV/gp120 decreases adult neural progenitor cell proliferation via checkpoint kinase-mediated cell-cycle withdrawal and G1 arrest
    Shu ichi Okamoto
    Center for Neuroscience, Stem Cells, and Aging, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Cell Stem Cell 1:230-6. 2007

Research Grants

  1. Chemokine Receptor Signaling in HIV Neuropathology
    Marcus Kaul; Fiscal Year: 2007
  2. Neuroprotection by IFN-beta in AIDS
    Marcus Kaul; Fiscal Year: 2010

Collaborators

Detail Information

Publications23

  1. pmc Molecular mechanisms of neuroinvasion by monocytes-macrophages in HIV-1 infection
    Gabriel Gras
    Institute of Emerging Diseases and Innovative Therapies, Division of Immuno Virology, CEA, 18 route du Panorama, F92265 Fontenay aux Roses, France
    Retrovirology 7:30. 2010
    ..This review will summarize the recent data describing neuroinvasion by HIV with a focus on the molecular mechanisms involved...
  2. pmc HIV's double strike at the brain: neuronal toxicity and compromised neurogenesis
    Marcus Kaul
    Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Front Biosci 13:2484-94. 2008
    ..This article will review recently identified pathological mechanisms which potentially contribute to the development of neurocognitive impairment and dementia in association with HIV-1 infection...
  3. ncbi request reprint Mechanisms of neuronal injury and death in HIV-1 associated dementia
    Marcus Kaul
    Center for Neuroscience and Aging Research, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Curr HIV Res 4:307-18. 2006
    ..This article will review recently identified injurious mechanisms potentially contributing to neuronal death in association with HIV-1 disease and discuss recent and prospective approaches for therapy and prevention of HAD...
  4. ncbi request reprint HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection
    M Kaul
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Death Differ 14:296-305. 2007
    ..This finding suggests that CCR5 ligands can protect neurons at least, in part, by modulating CXCR4-mediated toxicity through heterologous desensitization...
  5. ncbi request reprint Experimental and potential future therapeutic approaches for HIV-1 associated dementia targeting receptors for chemokines, glutamate and erythropoietin
    M Kaul
    Center for Neuroscience and Aging Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neurotox Res 8:167-86. 2005
    ..This review will discuss experimental and potentially future therapeutic strategies based on recently uncovered pathologic mechanisms contributing to neuronal damage induced by HIV-1...
  6. ncbi request reprint Mechanisms of neuroimmunity and neurodegeneration associated with HIV-1 infection and AIDS
    Marcus Kaul
    Center for Neuroscience and Aging Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Neuroimmune Pharmacol 1:138-51. 2006
    ..This article addresses recently uncovered pathologic neuroimmune and degenerative mechanisms contributing to neuronal damage induced by HIV-1 and discusses experimental and potentially future therapeutic approaches...
  7. pmc HIV-1 associated dementia: update on pathological mechanisms and therapeutic approaches
    Marcus Kaul
    Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Curr Opin Neurol 22:315-20. 2009
    ..This review will discuss recent progress toward a better understanding of the pathogenesis and an improved design of therapies for HIV-associated neurocognitive disorders...
  8. ncbi request reprint HIV-1 infection and AIDS: consequences for the central nervous system
    M Kaul
    Center for Neuroscience and Aging Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Death Differ 12:878-92. 2005
    ..This review will discuss recently uncovered pathologic neuroimmune and degenerative mechanisms contributing to neuronal damage induced by HIV-1 and potential approaches for development of future therapeutic intervention...
  9. ncbi request reprint Pathways to neuronal injury and apoptosis in HIV-associated dementia
    M Kaul
    Center for Neuroscience and Aging Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 410:988-94. 2001
    ..Recent advances in understanding the signalling pathways mediating these events offer hope for therapeutic intervention...
  10. doi request reprint HIV/gp120 decreases adult neural progenitor cell proliferation via checkpoint kinase-mediated cell-cycle withdrawal and G1 arrest
    Shu ichi Okamoto
    Center for Neuroscience, Stem Cells, and Aging, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Cell Stem Cell 1:230-6. 2007
    ..Our findings define a molecular mechanism that compromises adult neurogenesis in this neurodegenerative disorder...
  11. pmc Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders
    Yeon Joo Kang
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Ann Neurol 68:342-52. 2010
    ..Here, we report that chronic treatment with erythropoietin (EPO) and insulin-like growth factor-I (IGF-I) protects against HIV/gp120-mediated neuronal damage in culture and in vivo...
  12. ncbi request reprint Human immunodeficiency virus-1/surface glycoprotein 120 induces apoptosis through RNA-activated protein kinase signaling in neurons
    Mehrdad Alirezaei
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 27:11047-55. 2007
    ..Together, these results identify PKR as a critical mediator of gp120 neurotoxicity, suggesting that activation of PKR contributes to the neuronal injury and cell death observed in HAD...
  13. ncbi request reprint Signaling pathways to neuronal damage and apoptosis in human immunodeficiency virus type 1-associated dementia: Chemokine receptors, excitotoxicity, and beyond
    Marcus Kaul
    The Burnham Institute, Center for Neuroscience and Aging Research, La Jolla, California 92037, USA
    J Neurovirol 10:97-101. 2004
    ..This article discusses recently identified pathways to neuronal damage triggered by HIV-1 and efforts aimed at development of applicable therapeutic intervention...
  14. pmc Molecular stages of rapid and uniform neuralization of human embryonic stem cells
    R Bajpai
    Neuroscience, Aging, and Stem Cell Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Cell Death Differ 16:807-25. 2009
    ..In conclusion, our study provides a framework for future analysis of molecular signaling during ESC neuralization...
  15. pmc Activation of p38 MAPK is required in monocytic and neuronal cells for HIV glycoprotein 120-induced neurotoxicity
    Kathryn E Medders
    Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Immunol 185:4883-95. 2010
    ..Thus, p38 MAPK signaling was critical, upon exposure to HIV gp120, for the neurotoxic phenotype of monocytic cells and subsequent toxin-initiated neuronal apoptosis...
  16. ncbi request reprint Erythropoietin protects cerebrocortical neurons from HIV-1/gp120-induced damage
    Murat Digicaylioglu
    Center for Neuroscience and Aging Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuroreport 15:761-3. 2004
    ..Here we show that EPO protects cerebrocortical neurons against apoptosis induced by HIV-1/gp120...
  17. pmc Alteration of Methamphetamine-induced stereotypic behaviour in transgenic mice expressing HIV-1 envelope protein gp120
    Amanda J Roberts
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N Torrey Pines Road, SV142 La Jolla, CA 92037, USA
    J Neurosci Methods 186:222-5. 2010
    ..Thus this experimental model system may be useful to further study the mechanistic interaction of both the viral envelope protein and the psychostimulant drug in behavioural alterations and neurodegenerative disease...
  18. pmc Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
    Shu ichi Okamoto
    Center for Neuroscience, Aging and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California, USA
    Nat Med 15:1407-13. 2009
    ..Our findings offer a rational therapeutic approach for protecting susceptible neurons in Huntington's disease...
  19. ncbi request reprint S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death
    Zezong Gu
    Center for Neuroscience and Aging, Program in Cell Adhesion and Extracellular Matrix Biology, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 297:1186-90. 2002
    ..These findings suggest a potential extracellular proteolysis pathway to neuronal cell death in which S-nitrosylation activates MMPs, and further oxidation results in a stable posttranslational modification with pathological activity...
  20. pmc Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: implications for major depressive disorder
    Erick T Tatro
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0603, USA
    Brain Res 1286:1-12. 2009
    ..We propose that immunophilins are modulators of the cortisol-HPA axis response to stress and related chronic brain disorders...
  21. ncbi request reprint BAG1 over-expression in brain protects against stroke
    Pawel Kermer
    Department of Neurology, University of Goettingen, Germany
    Brain Pathol 13:495-506. 2003
    ....
  22. ncbi request reprint Caspase cascades in human immunodeficiency virus-associated neurodegeneration
    Gwenn A Garden
    Department of Neurology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 22:4015-24. 2002
    ..These findings suggest that pharmacologic interventions aimed at the caspase enzyme pathways may be beneficial for the prevention or treatment of HAD...
  23. ncbi request reprint Neuronal apoptotic signaling pathways probed and intervened by synthetically and modularly modified (SMM) chemokines
    Won Tak Choi
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 282:7154-63. 2007
    ....

Research Grants5

  1. Chemokine Receptor Signaling in HIV Neuropathology
    Marcus Kaul; Fiscal Year: 2007
    ..Since signal transduction via p38 MAPK seems to be crucial to the neurotoxicity of gpl20 and SDF- 1, we will study the effect on this pathway of a dominant negative mutant of p38 and also of a constitutive activator of p38, MKK6b(E). ..
  2. Neuroprotection by IFN-beta in AIDS
    Marcus Kaul; Fiscal Year: 2010
    ....