DANA LEANNE JONES

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. ncbi request reprint Aging and the germ line: where mortality and immortality meet
    D Leanne Jones
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, San Diego, CA 92037, USA
    Stem Cell Rev 3:192-200. 2007
  2. pmc Efficiency of spermatogonial dedifferentiation during aging
    Chihunt Wong
    Laboratory of Genetics, The Salk Institute for Biological Studies, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e33635. 2012
  3. doi request reprint Walk the (germ) line
    D Leanne Jones
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell Metab 10:78-9. 2009
  4. ncbi request reprint No place like home: anatomy and function of the stem cell niche
    D Leanne Jones
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Nat Rev Mol Cell Biol 9:11-21. 2008
  5. ncbi request reprint Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis
    Monica Boyle
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell Stem Cell 1:470-8. 2007
  6. pmc Stem cells and the niche: a dynamic duo
    Justin Voog
    Laboratory of Genetics, The Salk Institute for Biological Studies, University of California, San Diego, La Jolla, CA 92037, USA
    Cell Stem Cell 6:103-15. 2010
  7. ncbi request reprint Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome
    Yukiko M Yamashita
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Science 301:1547-50. 2003
  8. pmc Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B
    Eileen L Beall
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA
    Genes Dev 21:904-19. 2007
  9. ncbi request reprint Signaling in stem cell niches: lessons from the Drosophila germline
    Yukiko M Yamashita
    Department of Development Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Sci 118:665-72. 2005
  10. pmc A misexpression screen reveals effects of bag-of-marbles and TGF beta class signaling on the Drosophila male germ-line stem cell lineage
    Cordula Schulz
    Department of Developmental Biology, Stanford University School of Medicine, California 94305 5329, USA
    Genetics 167:707-23. 2004

Collaborators

  • Amy J Wagers
  • M Tatar
  • Thomas Flatt
  • Yukiko M Yamashita
  • Chihunt Wong
  • Margaret T Fuller
  • Cordula Schulz
  • Justin Voog
  • Niels Geijsen
  • Eileen L Beall
  • Monica Boyle
  • Michael Rocha
  • Salli I Tazuke
  • Cricket G Wood
  • Peter W Lewis
  • Michael R Botchan
  • Maren Bell
  • Luiz C Pantalena-Filho
  • Amy A Kiger

Detail Information

Publications13

  1. ncbi request reprint Aging and the germ line: where mortality and immortality meet
    D Leanne Jones
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, San Diego, CA 92037, USA
    Stem Cell Rev 3:192-200. 2007
    ....
  2. pmc Efficiency of spermatogonial dedifferentiation during aging
    Chihunt Wong
    Laboratory of Genetics, The Salk Institute for Biological Studies, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e33635. 2012
    ..However, the average number of male GSCs decreases with age, suggesting that stem cell replacement may become compromised in older flies...
  3. doi request reprint Walk the (germ) line
    D Leanne Jones
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell Metab 10:78-9. 2009
    ..In a recent paper, Curran et al. (2009) explore the possibility that some features of germ cells, including enhanced genomic stability, can be acquired by the soma as a mechanism to increase longevity...
  4. ncbi request reprint No place like home: anatomy and function of the stem cell niche
    D Leanne Jones
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Nat Rev Mol Cell Biol 9:11-21. 2008
    ....
  5. ncbi request reprint Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis
    Monica Boyle
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell Stem Cell 1:470-8. 2007
    ..Therefore, our data indicate that age-related changes within stem cell niches may be a significant contributing factor to reduced tissue homeostasis and regeneration in older individuals...
  6. pmc Stem cells and the niche: a dynamic duo
    Justin Voog
    Laboratory of Genetics, The Salk Institute for Biological Studies, University of California, San Diego, La Jolla, CA 92037, USA
    Cell Stem Cell 6:103-15. 2010
    ..Additional work in the identification of genetic factors that regulate the formation, activity, and size of stem cell niches will facilitate incorporation of the niche into stem cell-based therapies and regenerative medicine...
  7. ncbi request reprint Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome
    Yukiko M Yamashita
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Science 301:1547-50. 2003
    ....
  8. pmc Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B
    Eileen L Beall
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA
    Genes Dev 21:904-19. 2007
    ..Together, these data demonstrate that MMB serves diverse roles in different developmental pathways, and members of MMB can be found in alternative, noninteracting complexes in different cell types...
  9. ncbi request reprint Signaling in stem cell niches: lessons from the Drosophila germline
    Yukiko M Yamashita
    Department of Development Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Sci 118:665-72. 2005
    ..Recent results describing stem cell niches in other adult stem cells, including hematopoietic and neural stem cells, have demonstrated that the features characteristic of stem cell niches in Drosophila gonads might be conserved...
  10. pmc A misexpression screen reveals effects of bag-of-marbles and TGF beta class signaling on the Drosophila male germ-line stem cell lineage
    Cordula Schulz
    Department of Developmental Biology, Stanford University School of Medicine, California 94305 5329, USA
    Genetics 167:707-23. 2004
    ..In addition, forced activation of the TGF beta signal transduction pathway in germ cells inhibits the transition from the spermatogonial mitotic amplification program to spermatocyte differentiation...
  11. pmc Drosophila germ-line modulation of insulin signaling and lifespan
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 105:6368-73. 2008
    ..These results suggest that signals from the gonad regulate lifespan and modulate insulin sensitivity in the fly and that the gonadal regulation of aging is evolutionarily conserved...
  12. doi request reprint Seminal discoveries in regenerative medicine: contributions of the male germ line to understanding pluripotency
    Niels Geijsen
    Harvard Medical School, Massachusetts General Hospital, Center for Regenerative Medicine and Technology, Boston, MA 02114, USA
    Hum Mol Genet 17:R16-22. 2008
    ....
  13. ncbi request reprint Signaling from germ cells mediated by the rhomboid homolog stet organizes encapsulation by somatic support cells
    Cordula Schulz
    Departments of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Development 129:4523-34. 2002
    ..The micro-environment provided by the surrounding somatic cells may, in turn, regulate differentiation of the germ cells they enclose...

Research Grants6

  1. A Stem Cell Niche to Support Proliferation and Maintenance of Human Germ Cells
    Dana Jones; Fiscal Year: 2006
    ..This project proposes to develop conditions to continually grow and manipulate one type of stem cell, human germ cells, in the lab. ..
  2. Characterization of Age-related Changes in Stem Cell Behavior
    DANA LEANNE JONES; Fiscal Year: 2010
    ....
  3. Characterization of Age-related Changes in Stem Cell Behavior
    Dana Jones; Fiscal Year: 2009
    ....