Research Topics
| Mark Paul JohnsonSummaryAffiliation: The Children's Hospital of Philadelphia Country: USA Publications
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Detail Information
Publications
Fetal myelomeningocele repair: short-term clinical outcomesMark P Johnson
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadephia, PA 19104, USA
Am J Obstet Gynecol 189:482-7. 2003..The study was undertaken to evaluate short-term clinical outcomes with antenatal myelomeningocele (MMC) repair...- Maternal-fetal surgery for myelomeningocele: neurodevelopmental outcomes at 2 years of ageMark Paul Johnson
The Center for Fetal Diagnosis and Treatment, Philadelphia, PA 19104, USA
Am J Obstet Gynecol 194:1145-50; discussion 1150-2. 2006..This study was undertaken to examine short-term neurodevelopmental outcomes in children with myelomeningocele (MMC) who underwent in utero neurosurgical closure... 
The North American Fetal Therapy Network (NAFTNet): a new approach to collaborative research in fetal diagnosis and therapyMark Paul Johnson
Center for Fetal Diagnosis and Treatment, 5th Floor Wood Center, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
Semin Fetal Neonatal Med 15:52-7. 2010....- Sacrococcygeal teratoma: prenatal assessment, fetal intervention, and outcomeHolly L Hedrick
Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA 19104-4399, USA
J Pediatr Surg 39:430-8; discussion 430-8. 2004..Amnioreduction, cyst aspiration, and surgical debulking are potentially life-saving interventions... - Chorioamniotic membrane separation following open fetal surgery: pregnancy outcomeR Douglas Wilson
Department of Surgery, Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA
Fetal Diagn Ther 18:314-20. 2003..3) Delivery prior to 33 weeks gestation for MMC groups was 12/43 (28%) with 3 NND (7%). (4) Elective delivery at 36-37 weeks gestation was possible for 43% of the fetal surgery population... - Reproductive outcomes after pregnancy complicated by maternal-fetal surgeryR Douglas Wilson
Pediatric Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Am J Obstet Gynecol 191:1430-6. 2004..The uterine rupture rate is similar to the rupture rate after "classical" cesarean section (4%-9%)... - The EXIT procedure: experience and outcome in 31 casesSarah Bouchard
Division of Pediatric General, The Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
J Pediatr Surg 37:418-26. 2002.... - Abnormal umbilical cord Dopplers may predict impending demise in fetuses with sacrococcygeal teratoma. A report of 2 casesOluyinka O Olutoye
The Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
Fetal Diagn Ther 18:428-31. 2003..In such fetuses, depending on the gestational age, abnormalities in umbilical artery waveform should be considered indications for early delivery or in utero intervention to prevent fetal demise... - Abnormal umbilical cord Doppler sonograms may predict impending demise in fetuses with sacrococcygeal teratoma. A report of two casesOluyinka O Olutoye
Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pa. 19104, USA
Fetal Diagn Ther 19:35-9. 2004..In such fetuses, depending on the gestational age, abnormalities in umbilical artery waveform should be considered indications for early delivery or in utero intervention to prevent fetal demise... - Congenital high airway obstruction syndrome: natural history and managementFoong-Yen Lim
Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Surg 38:940-5. 2003..The EXIT procedure offers the potential for salvage of this otherwise lethal condition. Hydrops may be well tolerated prenatally for weeks with potential resolution if airway fistulization is present... - Liver position and lung-to-head ratio for prediction of extracorporeal membrane oxygenation and survival in isolated left congenital diaphragmatic herniaHolly L Hedrick
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA, USA
Am J Obstet Gynecol 197:422.e1-4. 2007..The purpose of this study was to determine the ability of liver position and lung-to-head ratio to predict outcome in isolated left congenital diaphragmatic hernia... - Antenatal diagnosis and management of congenital cystic adenomatoid malformationStephanie Mann
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Wood Center 5113, Philadelphia, PA 19104, USA
Semin Fetal Neonatal Med 12:477-81. 2007..Careful delivery planning by utilizing a multidisciplinary approach will optimize neonatal outcomes... - Predicting the severity of congenital high airway obstruction syndromeJessica L Roybal
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, PA 19104 4318, USA
J Pediatr Surg 45:1633-9. 2010..In our relatively large series of CHAOS patients, we have observed a spectrum of clinical severity. The aim of this study was to identify the prenatal characteristics of CHAOS predictive of a milder postnatal course... - Cystic adenomatoid malformation of the lung: review of genetics, prenatal diagnosis, and in utero treatmentR Douglas Wilson
Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4399, USA
Am J Med Genet A 140:151-5. 2006..In the appropriate situation, this maternal fetal surgery approach for CCAM is life-saving for the affected fetus with acceptable maternal morbidity risks in the present and future pregnancies... - Fetal thoracic and bladder shuntsStephanie Mann
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Semin Fetal Neonatal Med 15:28-33. 2010.... - Severe pulmonary hypoplasia associated with giant cervical teratomasKenneth W Liechty
Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Surg 41:230-3. 2006..Despite obtaining airway control, a subset of these patients will die because of pulmonary hypoplasia. When counseling patients with large cervical masses it is important to discuss potential pulmonary hypoplasia in these patients... - The twin-twin transfusion syndrome: spectrum of cardiovascular abnormality and development of a cardiovascular score to assess severity of diseaseJack Rychik
Fetal Heart Program, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Am J Obstet Gynecol 197:392.e1-8. 2007..Current means of grading twin-twin transfusion syndrome does not characterize cardiovascular aspects adequately. We sought to develop a score that describes the magnitude of cardiovascular severity in twin-twin transfusion syndrome... - Congenital pulmonary lymphangiectasis sequence: a rare, heterogeneous, and lethal etiology for prenatal pleural effusionR Douglas Wilson
The Center for Fetal Diagnosis and Treatment, Department of Surgery at The Children s Hospital of Philadelphia University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4399, USA
Prenat Diagn 26:1058-61. 2006..Autopsy-identified CPL... - In utero meconium passage in fetuses and newborns with myelomeningoceleEnrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
J Neurosurg Pediatr 3:141-6. 2009..The authors retrospectively investigated whether midgestational fetal myelomeningocele (fMMC) repair alters intrauterine meconium exposure... - Does a myelomeningocele sac compared to no sac result in decreased postnatal leg function following maternal fetal surgery for spina bifida aperta?R Douglas Wilson
Department of Surgery and Obstetrics and Gynecology, Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4399, USA
Fetal Diagn Ther 22:348-51. 2007..A fetus with large sac S1 myelomeningocele (MMC) but bilateral talipes prompted the question, 'Does the presence or size of an MMC sac affect postnatal leg function?'.. - Sacrococcygeal teratomas: prenatal surveillance, growth and pregnancy outcomeR Douglas Wilson
Fetal Heart Program, The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Fetal Diagn Ther 25:15-20. 2009..Prenatal surveillance and growth characteristics are evaluated in a cohort of fetuses with sacrococcygeal teratomas (SCT) as part of risk assessment... - A randomized trial of prenatal versus postnatal repair of myelomeningoceleN Scott Adzick
Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
N Engl J Med 364:993-1004. 2011..Prenatal repair of myelomeningocele, the most common form of spina bifida, may result in better neurologic function than repair deferred until after delivery. We compared outcomes of in utero repair with standard postnatal repair... - The ex utero intrapartum therapy procedure for high-risk fetal lung lesionsHolly L Hedrick
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
J Pediatr Surg 40:1038-43; discussion 1044. 2005..Indications for the ex utero intrapartum therapy (EXIT) procedure have expanded to include any fetal anomaly in which resuscitation of the neonate may be compromised... - Thoracoamniotic shunts: fetal treatment of pleural effusions and congenital cystic adenomatoid malformationsR Douglas Wilson
Department of Surgery, Center for Fetal Diagnosis and Treatment at the Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104 4399, USA
Fetal Diagn Ther 19:413-20. 2004.... - Right congenital diaphragmatic hernia: Prenatal assessment and outcomeHolly L Hedrick
Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA 19104-4399, USA
J Pediatr Surg 39:319-23; discussion 319-23. 2004.... - Fetoscopic surgeryTimothy M Crombleholme
Center for Fetal Diagnosis and Treatment at the Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
Clin Obstet Gynecol 46:76-91. 2003 - Acute cardiovascular effects of fetal surgery in the humanJack Rychik
Center for Fetal Diagnosis and Treatment and the Fetal Heart Program, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
Circulation 110:1549-56. 2004..The indications for fetal surgery continue to expand, yet little is known about the acute sequelae of fetal surgery on the human cardiovascular system... - Prenatal ultrasound guided percutaneous shunts for obstructive uropathy and thoracic diseaseR Douglas Wilson
The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
Semin Pediatr Surg 12:182-9. 2003..Thoracoamniotic shunt and thoracocentesis pregnancy loss risks for pleural effusion (PE) and macrocystic adenomatoid malformation of the lung (CCAM) are 5% and 0.5% to 1.0%, respectively... - Fetal surgery for myelomeningoceleLeslie N Sutton
Division of Neurosurgery, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19087, USA
Childs Nerv Syst 19:587-91. 2003..TRIAL: The upcoming trial represents one of the few times that the pediatric neurosurgical community has come together to test a new procedure... - Congenital abdominal wall defects: an updateR Douglas Wilson
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104 4399, USA
Fetal Diagn Ther 19:385-98. 2004..To review published peer-reviewed literature regarding abdominal wall defects including gastroschisis and omphalocele... - Outcomes after postnatal resection of prenatally diagnosed asymptomatic cystic lung lesionsANTHONY Y TSAI
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Surg 43:513-7. 2008..On the other hand, malignant degeneration, pneumonia, and pneumothorax are known consequences of cystic lung lesions. This study aims to assess the safety of resection for asymptomatic lung lesions that were diagnosed before birth... - Lower extremity neuromotor function and short-term ambulatory potential following in utero myelomeningocele surgeryEnrico Danzer
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fetal Diagn Ther 25:47-53. 2009..To evaluate lower extremity neuromotor function (LENF) and short-term ambulatory potential following fetal myelomeningocele (fMMC) closure... - OEIS sequence--a rare congenital anomaly with prenatal evaluation and postnatal outcome in six casesEleonor Tiblad
Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Prenat Diagn 28:141-7. 2008..To describe the outcome of children prenatally diagnosed with omphalocele, exstrophy of the cloaca, imperforate anus and spinal defects (OEIS)... - Postnatal chest wall deformities after fetal thoracoamniotic shunting for congenital cystic adenomatoid malformationAziz M Merchant
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, and Department of Surgery and Obstetrics Gynecology, University of Pennsylvania, Philadelphia, PA 19104 4399, USA
Fetal Diagn Ther 22:435-9. 2007..Large macrocystic congenital cystic adenomatoid malformations (CCAMs) can be treated with thoracoamniotic (TA) shunting to reduce CCAM volume. Two CCAM fetuses treated with TA shunt had postnatal radiographic rib deformities... - Fetal tracheal occlusion for severe congenital diaphragmatic hernia in humans: a morphometric study of lung parenchyma and muscularization of pulmonary arteriolesEnrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
J Pediatr Surg 43:1767-75. 2008..The aim of this study is to examine structure of lung parenchyma (Pp) and muscularization of pulmonary arterioles (PAs) in human fetuses that underwent tracheal occlusion (TO) therapy for severe congenital diaphragmatic hernia (CDH)... - Long-term outcomes in children treated by prenatal vesicoamniotic shunting for lower urinary tract obstructionJean-Marc Biard
Center for Fetal Diagnosis and Treatment, at The Children's Hospital of Philadelphia, and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4399, USA
Obstet Gynecol 106:503-8. 2005..Although one third of the surviving babies required dialysis and transplantation, the majority have acceptable renal and bladder function and report satisfactory quality of life. LEVEL OF EVIDENCE: III... - Magnetic resonance imaging of fetal urinomaJoel C Hutcheson
Department of Surgery, Division of Pediatric Urology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Urology 60:697. 2002..We report the case of a baby girl with a urinoma diagnosed by fetal magnetic resonance imaging and discuss the significance of this radiologic finding... - Reproductive outcomes in subsequent pregnancies after a pregnancy complicated by open maternal-fetal surgery (1996-2007)R Douglas Wilson
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA, USA
Am J Obstet Gynecol 203:209.e1-6. 2010..The reproductive and gynecologic outcomes for women after the pregnancy complicated by open maternal-fetal surgery (OMFS) were evaluated... - Diagnosis and characterization of fetal sacrococcygeal teratoma with prenatal MRIEnrico Danzer
The Center for Fetal Diagnosis and Treatment, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104-4399, USA
AJR Am J Roentgenol 187:W350-6. 2006..The additional anatomic resolution provided by MRI resulted in more accurate prenatal counseling and improved preoperative planning for surgical resection... - Fetal head biometry assessed by fetal magnetic resonance imaging following in utero myelomeningocele repairEnrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fetal Diagn Ther 22:1-6. 2007..To examine the impact of fetal myelomeningocele (MMC) repair on fetal head biometry and cerebrospinal fluid (CSF) spaces assessed by magnetic resonance imaging (MR) studies... - Preschool neurodevelopmental outcome of children following fetal myelomeningocele closureEnrico Danzer
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Obstet Gynecol 202:450.e1-9. 2010..We sought to investigate the preschool neurodevelopmental outcomes of children following fetal myelomeningocele (fMMC) surgery... - Intradural inclusion cysts following in utero closure of myelomeningocele: clinical implications and follow-up findingsEnrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Neurosurg Pediatr 2:406-13. 2008..The goal in this study was to evaluate the incidence and clinical implications of the development of cutaneously derived intradural inclusion cysts (ICs) following fetal myelomeningocele (fMMC) closure... - Utility of fetal muscle biopsy for diagnosis of nemaline myopathyStefanie B Kasperski
The Center for Fetal Diagnosis and Treatment at the Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
Fetal Diagn Ther 24:400-4. 2008..To report and discuss prenatal diagnosis of nemaline myopathy (NM) using fetal muscle biopsy... - History of fetal diagnosis and therapy: Children's Hospital of Philadelphia experienceHolly L Hedrick
Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, and Department of Surgery and Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fetal Diagn Ther 18:65-82. 2003..Outcomes have been improved through carefully planned and coordinated perinatal management. In some cases of life-threatening or severely debilitating defects, prenatal surgery has been offered... - Prenatal course and postnatal management of peripheral bronchial atresia: association with congenital cystic adenomatoid malformation of the lungWilliam H Peranteau
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fetal Diagn Ther 24:190-6. 2008.... - Prenatal diagnosis and management of mainstem bronchial atresiaSundeep G Keswani
Center for Fetal Diagnosis and Treatment, The Chhildren's Hospital of Philadelphia, Philadelphia, PA 19104, USA
Fetal Diagn Ther 20:74-8. 2005..Post-mortem findings in both cases confirmed the presence of an atretic mainstem bronchus with massive enlargement of the lung. Bronchial atresia involving the mainstem bronchus is associated with a poor prognosis... - The natural history of prenatally diagnosed conjoined twinsTippi C MacKenzie
Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
J Pediatr Surg 37:303-9. 2002..CONCLUSIONS: Advances in prenatal diagnosis allow detailed, accurate evaluations of conjoined twins. Careful prenatal studies may uncover cases in which emergent separation at birth is lifesaving... - Effect of maternal betamethasone administration on prenatal congenital cystic adenomatoid malformation growth and fetal survivalWilliam H Peranteau
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fetal Diagn Ther 22:365-71. 2007..To evaluate the effect of prenatal steroid treatment on the growth of congenital cystic adenomatoid malformations (CCAM) and survival in affected fetuses not amenable to other percutaneous ultrasound-guided prenatal interventions... - Management of fetal mediastinal teratomaAziz M Merchant
Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA
J Pediatr Surg 40:228-31. 2005..CONCLUSIONS: Massive fetal mediastinal teratoma can result in fetal or neonatal mortality by a variety of mechanisms. Optimal prenatal and perinatal management is required to salvage fetuses compromised by this lesion... - Impact of continuous intraoperative monitoring on outcomes in open fetal surgerySundeep G Keswani
Center for Fetal Diagnosis and Treatment and Fetal Heart Program at the Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
Fetal Diagn Ther 20:316-20. 2005..CONCLUSION: Continuous intraoperative fetal monitoring provides real time assessment of fetal hemodynamics which results in changes in intraoperative management. The overall outcomes in these critically ill fetuses have been improved... - Fetal lower urinary tract obstructionSerena Wu
General Surgery, The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Clin Perinatol 36:377-90, x. 2009..Although shunting has improved survival, long-term morbidities remain a significant challenge... 
Haploidentical in utero hematopoietic cell transplantation improves phenotype and can induce tolerance for postnatal same-donor transplants in the canine leukocyte adhesion deficiency modelWilliam H Peranteau
Center for Fetal Research, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Biol Blood Marrow Transplant 15:293-305. 2009....- In utero limb salvage: fetoscopic release of amniotic bands for threatened limb amputationSundeep G Keswani
The Center for Fetal Diagnosis and Treatment, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
J Pediatr Surg 38:848-51. 2003..There were no perioperative complications. In select patients with isolated extremity ABS, early fetoscopic release may prevent amputation and allow improved limb development... - Fetal posterior fossa volume: assessment with MR imagingSara C Chen
Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, USA
Radiology 238:997-1003. 2006..16 for all fetuses) at preliminary analysis. No correlation between APFV and FL could be found. CONCLUSION: The normal fetal PFV growth curve generated in this study may have potential as a model for clinical application... - Prenatal ultrasonographic gastrointestinal abnormalities in fetuses with gastroschisis do not correlate with postnatal outcomesAndrea T Badillo
The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Surg 43:647-53. 2008..The purpose of this study was to correlate prenatal identification of additional gastrointestinal sonographic abnormalities with postnatal clinical outcome... - The Wayne State experienceMark I Evans
Department of Obstetrics and Gynecology, MCP Hahnemann University, Philadelphia, PA 19102, USA
Fetal Diagn Ther 17:321-30. 2002 - Pregnancy outcomes following bipolar umbilical cord cauterization for selective termination in complicated monochorionic multiple gestationsJohn G Ilagan
Center for Fetal Diagnosis and Treatment at the Children s Hospital of Philadelphia, Department of Surgery and Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Fetal Diagn Ther 23:153-8. 2008..To review pregnancy and childhood outcomes following selective termination by ultrasound guided bipolar umbilical cord cauterization (UCC) in complicated monochorionic multifetal pregnancies...