Aaron Johnson

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Ordered ATP hydrolysis in the gamma complex clamp loader AAA+ machine
    Aaron Johnson
    Howard Hughes Medical Institute and The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 278:14406-13. 2003
  2. ncbi request reprint In vivo magnetic resonance imaging of immune cells in the central nervous system with superparamagnetic antibodies
    Istvan Pirko
    Department of Neurology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    FASEB J 18:179-82. 2004
  3. ncbi request reprint Cellular DNA replicases: components and dynamics at the replication fork
    Aaron Johnson
    Howard Hughes Medical Institute, New York City, New York 10021 6399, USA
    Annu Rev Biochem 74:283-315. 2005
  4. ncbi request reprint DNA ligase: getting a grip to seal the deal
    Aaron Johnson
    The Rockefeller University 1230 York Avenue, Box 228, New York, New York 10021 6399, USA
    Curr Biol 15:R90-2. 2005
  5. ncbi request reprint Characterization of a triple DNA polymerase replisome
    Peter McInerney
    Laboratory of DNA Replication, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Mol Cell 27:527-38. 2007
  6. ncbi request reprint The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading
    Aaron Johnson
    Laboratory of DNA Replication, Howard Hughes Medical Institute and Rockefeller University, New York, New York 10021, USA
    J Biol Chem 281:35531-43. 2006
  7. ncbi request reprint Fluorescence measurements on the E.coli DNA polymerase clamp loader: implications for conformational changes during ATP and clamp binding
    Eric R Goedken
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA
    J Mol Biol 336:1047-59. 2004
  8. ncbi request reprint Mechanism of loading the Escherichia coli DNA polymerase III sliding clamp: II. Uncoupling the beta and DNA binding activities of the gamma complex
    Anita K Snyder
    Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32610 0245, USA
    J Biol Chem 279:4386-93. 2004
  9. ncbi request reprint Mechanism of proliferating cell nuclear antigen clamp opening by replication factor C
    Nina Y Yao
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Biol Chem 281:17528-39. 2006
  10. pmc Motion of a DNA sliding clamp observed by single molecule fluorescence spectroscopy
    Ted A Laurence
    Lawrence Livermore National Laboratory, California 94550, USA
    J Biol Chem 283:22895-906. 2008

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Ordered ATP hydrolysis in the gamma complex clamp loader AAA+ machine
    Aaron Johnson
    Howard Hughes Medical Institute and The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 278:14406-13. 2003
    ..Implications of these results to clamp loaders of other systems are discussed...
  2. ncbi request reprint In vivo magnetic resonance imaging of immune cells in the central nervous system with superparamagnetic antibodies
    Istvan Pirko
    Department of Neurology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    FASEB J 18:179-82. 2004
    ..Because superparamagnetic antibodies similar to those used in the study are approved for human use, the in vivo MRI technique we have described could be developed for human use...
  3. ncbi request reprint Cellular DNA replicases: components and dynamics at the replication fork
    Aaron Johnson
    Howard Hughes Medical Institute, New York City, New York 10021 6399, USA
    Annu Rev Biochem 74:283-315. 2005
    ..Twin polymerases and clamps coordinate their actions with a clamp loader and yet other proteins to form a replisome machine that advances the replication fork...
  4. ncbi request reprint DNA ligase: getting a grip to seal the deal
    Aaron Johnson
    The Rockefeller University 1230 York Avenue, Box 228, New York, New York 10021 6399, USA
    Curr Biol 15:R90-2. 2005
    ..The elegant structure explains how ligase attains fidelity for the sealing operation...
  5. ncbi request reprint Characterization of a triple DNA polymerase replisome
    Peter McInerney
    Laboratory of DNA Replication, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Mol Cell 27:527-38. 2007
    ..We propose that two polymerases can function on the lagging strand and that the third DNA polymerase can act as a reserve enzyme to overcome certain types of obstacles to the replication fork...
  6. ncbi request reprint The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading
    Aaron Johnson
    Laboratory of DNA Replication, Howard Hughes Medical Institute and Rockefeller University, New York, New York 10021, USA
    J Biol Chem 281:35531-43. 2006
    ..PCNA closure severs contact to RFC subunits D and E (RFC2 and RFC5), and the gamma-phosphate sensor of ATP site C is switched off, resulting in low affinity of RFC for DNA and ejection of RFC from the site of PCNA loading...
  7. ncbi request reprint Fluorescence measurements on the E.coli DNA polymerase clamp loader: implications for conformational changes during ATP and clamp binding
    Eric R Goedken
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA
    J Mol Biol 336:1047-59. 2004
    ....
  8. ncbi request reprint Mechanism of loading the Escherichia coli DNA polymerase III sliding clamp: II. Uncoupling the beta and DNA binding activities of the gamma complex
    Anita K Snyder
    Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32610 0245, USA
    J Biol Chem 279:4386-93. 2004
    ..Additionally, these results show that the "arginine fingers" play a structural role in facilitating the formation of a conformation that has high affinity for beta and DNA...
  9. ncbi request reprint Mechanism of proliferating cell nuclear antigen clamp opening by replication factor C
    Nina Y Yao
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Biol Chem 281:17528-39. 2006
    ..Interestingly, the Rad.RFC DNA damage checkpoint clamp loader unloads PCNA clamps from DNA. We propose that Rad.RFC may clear PCNA from DNA to facilitate shutdown of replication in the face of DNA damage...
  10. pmc Motion of a DNA sliding clamp observed by single molecule fluorescence spectroscopy
    Ted A Laurence
    Lawrence Livermore National Laboratory, California 94550, USA
    J Biol Chem 283:22895-906. 2008
    ..These results may imply that the clamp not only acts to hold the polymerase on the DNA but also prevents excessive drifting along the DNA...