Research Topics
Genomes and Genes
| W JiangSummaryAffiliation: The Salk Institute Country: USA Publications
| Collaborators
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Detail Information
Publications
Corrected sequence of the mannitol (mtl) operon in Escherichia coliW Jiang
Department of Biochemistry and Nutrition, Virginia Polytechnic Institute and State University, Blacksburg 24061 0308
Mol Microbiol 4:2003-6. 1990....- Structure of the mouse metalloprotease meprin beta gene (Mep1b): alternative splicing in cancer cellsW Jiang
Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, PA 17033 0850, USA
Gene 248:77-87. 2000..This is the first gene structure that has been completed for meprin subunits from all species. The work elucidates molecular mechanisms that regulate differential expression of the Mep1b gene... - Fluorescence-based functional assay for Wnt/beta-catenin signaling activityL Zhou
The University of Chicago Medical Center, IL, USA
Biotechniques 33:1126-8, 1130, 1132 passim. 2002.... - Ultrastructural features of ichthyosis hystrix strongly resembling Lambert typeW H Wang
Department of Dermatology, Peking University Third Hospital, Haidian District, Beijing, China
Br J Dermatol 156:1027-31. 2007..The basic histopathological defects were not changed despite significant clinical improvement of the lesion... 
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6W Jiang
Molecular Biology and Virology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 96:6193-8. 1999....- Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replicationW Jiang
The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
EMBO J 18:5703-13. 1999..These results indicate that the HsCdc7-HsDbf4 kinase is directly involved in regulating the initiation of DNA replication by targeting MCM2 protein in mammalian cells... - PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesisW Jiang
Salk Institute, La Jolla, California 92037, USA
Mol Cell 2:877-85. 1998..Microinjection of anti-PRC1 antibodies into HeLa cells blocked cellular cleavage, but not nuclear division, indicating a functional role for PRC1 in the process of cytokinesis... - The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progressionN J Wells
Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California 92037, USA
J Cell Sci 112:3361-71. 1999.... - Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damageR Y Poon
Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Biol Chem 271:13283-91. 1996..It is likely that these underlying mechanisms that inactivate CDKs are similar for other kinds of DNA damage... - BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation siteH Ruffner
The Salk Institute, La Jolla, California 92037, USA
Mol Cell Biol 19:4843-54. 1999..These results suggest that the endogenous kinase activity is composed of CDK2-cyclin complexes, at least in part, concordant with the G1/S-specific increase in BRCA1 phosphorylation... - Identification and characterization of a human protein kinase related to budding yeast Cdc7pW Jiang
Molecular Biology and Virology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 94:14320-5. 1997..These results, together with the functions of Cdc7p in yeast, suggest that HsCdc7 may phosphorylate critical substrate(s) that regulate the G1/S phase transition and/or DNA replication in mammalian cells... - Transcriptional analysis of chromatin assembled with purified ACF and dNAP1 reveals that acetyl-CoA is required for preinitiation complex assemblyW Jiang
Section of Molecular Biology and Center for Molecular Genetics, University of California San Diego, La Jolla, California 92093 0347, USA
J Biol Chem 275:39819-22. 2000..These findings suggest that there is at least one key acetylation event that is needed to assemble a functional transcription preinitiation complex with a chromatin template... - Cdc2-mediated phosphorylation of the gap junction protein, connexin43, during mitosisM Y Kanemitsu
Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, San Diego, California 92186, USA
Cell Growth Differ 9:13-21. 1998..We conclude that phosphorylation of Cx43 by p34cdc2/cyclin B may contribute to the increased Cx43 phosphorylation and reduced gap junctional communication observed during mitosis... - Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complexD Lammer
Biology Department, Indiana University, Bloomington, Indiana, 47405 USA
Genes Dev 12:914-26. 1998..Consistent with this model, both enr2delta and an allele of Cdc53p that is not Rub1p modified, render cells sensitive to alterations in the levels of Cdc4p, Cdc34p, and Cdc53p... - Four distinct regions in the auxiliary domain of heterogeneous nuclear ribonucleoprotein C-related proteinsW Jiang
Department of Biochemistry and Molecular Biology H171, Pennsylvania State University College of Medicine, Hershey 17033, USA
Biochim Biophys Acta 1399:229-33. 1998..The C-terminal region is more divergent between hnRNP C and Raly. Signature sequences and possible functions are proposed for the different regions of the hnRNP C proteins... - Sequence of a second gene encoding bovine submaxillary mucin: implication for mucin heterogeneity and cloningW Jiang
Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, 17033, USA
Biochem Biophys Res Commun 251:550-6. 1998..In addition, this work raises several important issues in mucin cloning such as assembling sequences from seemingly overlapping clones and deducing consensus sequences for nearly identical tandem repeats... - Correct regulation of the septation initiation network in Schizosaccharomyces pombe requires the activities of par1 and par2W Jiang
Department of Biology, Syracuse University, Syracuse, New York 13244, USA
Genetics 158:1413-29. 2001..On the basis of our epistasis analyses and cytological studies, we concluded that par genes normally negatively regulate SIN at or upstream of cdc7, ensuring that multiple rounds of septation do not occur... - Signature sequences for the galectin-4 subfamilyW Jiang
Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey 17033, USA
IUBMB Life 48:601-5. 1999..The two peptide motifs are proposed here as the signature sequences to identify new members of the galectin-4 subfamily... - Isolation and characterization of par1(+) and par2(+): two Schizosaccharomyces pombe genes encoding B' subunits of protein phosphatase 2AW Jiang
Department of Biology, Syracuse University, Syracuse, New York 13244, USA
Genetics 154:1025-38. 2000..cerevisiae homolog Rts1p. Thus, while Schizosaccharomyces pombe is more similar to higher eukaryotes with respect to its complement of B'-encoding genes, the function of those proteins is conserved relative to that of Rts1p... - Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteinsY Yao
Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Exp Cell Res 257:22-32. 2000..2-12, a locus that is amplified in several types of human cancer. These results suggest that DIP1 may be involved in the control of gene expression and differentiation, but its precise function remains to be determined... - Loss of a protein phosphatase 2A regulatory subunit (Cdc55p) elicits improper regulation of Swe1p degradationH Yang
Department of Biology, Syracuse University, Syracuse, New York 13244, USA
Mol Cell Biol 20:8143-56. 2000..We also present evidence indicating that, in cdc55-null cells, misregulated PP2A phosphatase activity is the cause of both the ectopic stabilization of Swe1p and the production of the morphologically abnormal phenotype... - Molecular mechanisms associated with Se-allylselenocysteine regulation of cell proliferation and apoptosisW Jiang
Center for Nutrition in the Prevention of Disease, AMC Cancer Research Center, Lakewood, CO 80214, USA
Cancer Lett 162:167-73. 2001..Collectively, the results demonstrate for the first time that ASC is able to cause an immediate response in the expression of cell cycle regulatory proteins that favor an arrest in proliferation and an augmentation in apoptosis... - Identification of a novel allele at the human NAT1 acetyltransferase locusM A Doll
Department of Pharmacology and Toxicology, University of North Dakota School of Medicine and Health Sciences, Grand Forks 58202 9037, USA
Biochem Biophys Res Commun 233:584-91. 1997.... - Correlation of the exon/intron organization to the secondary structures of the protease domain of mouse meprin alpha subunitW Jiang
Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey 17033, USA
Gene 189:65-71. 1997..The relationship between gene and protein structures within the astacin family provide novel information on the evolution of this family in relation to other gene families... - Two-hybrid interaction of a human UBC9 homolog with centromere proteins of Saccharomyces cerevisiaeW Jiang
Myco Pharmaceuticals Inc, Cambridge, MA 02139, USA
Mol Gen Genet 251:153-60. 1996..We also provide further in vivo evidence that Mck1p, a protein kinase, is specifically associated with the centromere proteins Cbf2p and Cbf5p, which were previously shown to interact in vitro... - Overexpression of the yeast MCK1 protein kinase suppresses conditional mutations in centromere-binding protein genes CBF2 and CBF5W Jiang
Department of Biology, University of California, Santa Barbara 93106
Mol Gen Genet 246:360-6. 1995..This phosphorylation occurs on both serine and threonine residues in Cbf2p... - Molecular cloning of TPAR1, a gene whose expression is repressed by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)W Jiang
Columbia Presbyterian Cancer Center, Columbia University, New York, New York 10032
Exp Cell Res 215:284-93. 1994..Further studies are required to determine whether it plays a negative role in controlling cell proliferation and tumorigenesis... - Cloning, expression, and chromosomal localization of the mouse meprin beta subunitC M Gorbea
Department of Biological Chemistry, Pennsylvania State University College of Medicine, Hershey 17033
J Biol Chem 268:21035-43. 1993.... - Sequence of bovine carbonic anhydrase VI: potential recognition sites for N-acetylgalactosaminyltransferaseW Jiang
Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey 17033, USA
Biochem J 318:291-6. 1996..Comparison of these sequences with sheep and human CA VI sequences indicates that distinct glycoforms of CA VI could exist in submaxillary gland from different species... - Two novel heterozygous mutations in COL7A1 in a Chinese patient with recessive dystrophic epidermolysis bullosa of Hallopeau-Siemens typeW Jiang
Department of Dermatology, Peking University First Hospital, Beijing 10034, China
Br J Dermatol 152:1357-9. 2005 - Subcellular distribution and cytokine- and chemokine-regulated secretion of leukolysin/MT6-MMP/MMP-25 in neutrophilsT Kang
Departments of Pharmacology and Neurosciences, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA
J Biol Chem 276:21960-8. 2001..These results not only establish leukolysin as the first neutrophil-specific MT-MMP but also implicate it as a cytokine/chemokine-regulated effector during innate immune responses or tissue injury... - Cortical neurogenesis in adult rats after transient middle cerebral artery occlusionW Jiang
Departments of Public Health and Clinical Medicine, Medicine, ,
Stroke 32:1201-7. 2001..CONCLUSIONS: This study suggests that new neurons can be generated in the cerebral cortex of adult rats after transient focal cerebral ischemia. Cortical neurogenesis may be a potential pathway for brain repair after stroke... - Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acidW Szeto
Department of Molecular Oncology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Cancer Res 61:4197-205. 2001..The data support a model in which Wnt-1 signaling synergizes with retinoids to activate retinoic acid receptor-gamma-responsive genes in human cancers... 
Identification of a novel HLA-A allele, HLA-A*9216W Jiang
The Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Department of Genetics and Developmental Biology, Southeast University Medical School, Nanjing, Jiangsu, China
Tissue Antigens 71:479-80. 2008..The new human leukocyte antigen (HLA)-A*9216 differs from A*02010101 by a nonsynonymous nucleotide change at condon 76 (GTG>CTG)...- Electron cryomicroscopy and bioinformatics suggest protein fold models for rice dwarf virusZ H Zhou
Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, Houston, Texas 77030, USA
Nat Struct Biol 8:868-73. 2001..Symmetry mismatch between the two shells results in nonequivalent, yet specific, interactions that contribute to the stability of this large macromolecular machine... - Cyclooxygenase-2 inhibition: effects on tumour growth, cell cycling and lymphangiogenesis in a xenograft model of breast cancerN L P Barnes
Department of Academic Surgery, South Manchester University Hospital, Research and Education Building 2nd Floor, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK
Br J Cancer 96:575-82. 2007..Cyclooxygenase-2 inhibition decreases tumour growth, and may potentially decrease recurrence, by inactivating AKT and decreasing lymphangiogenesis... - Tetracycline-regulated gene expression mediated by a novel chimeric repressor that recruits histone deacetylases in mammalian cellsW Jiang
Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois 60637, USA
J Biol Chem 276:45168-74. 2001..Therefore, this novel chimeric repressor provides an effective means for more tightly regulated gene expression, and the simplified inducible system may be used for a broad range of basic and clinical studies... - Angiotensin II type 1 receptor modulation of L-type calcium currents in guinea-pig ventricular cellsX Yang
Department of Cardiology, First Affiliated Hospital, Suzhou University, Suzhou 215006, China
Chin Med J (Engl) 114:577-82. 2001..CONCLUSION: Ang II stimulates ICa,L in guinea-pig ventricular cells by binding to AT1 through a transduction pathway involving protein kinase C... - Increased efficiency of cloning large DNA fragments using a lower copy number plasmidT Feng
The University of Chicago Medical Center, IL 60637, USA
Biotechniques 32:992, 994, 996 passim. 2002 - Birt-Hogg-Dubé gene mutations in human endometrial carcinomas with microsatellite instabilityH Fujii
Department of Pathology II, Juntendo University School of Medicine, Tokyo, 113 8421 Japan
J Pathol 209:328-35. 2006..However, its mutational frequency is lower than that of BAX, and BHD mutation tends to occur during neoplastic progression after the acquisition of mutations in another MSI target gene, BAX... - MoeA, an enzyme in the molybdopterin synthesis pathway, is required for rifamycin SV production in Amycolatopsis mediterranei U32W Wang
Laboratory of Molecular Microbiology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, P.R. China
Appl Microbiol Biotechnol 60:139-46. 2002..mediterranei, and that the nitrogen assimilation pathway involved in nitrate reductase is the major pathway for the genesis of the amide nitrogen atom in the rifamycin SV molecule... - Implantation of BM cells transfected with phVEGF165 enhances functional improvement of the infarcted heartH-X Xu
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China
Cytotherapy 6:204-11. 2004..05). CONCLUSIONS: Implantation of BM-MNCs transfected with phVEGF165 can increase the number of implanted cells surviving, and enhance the impaired cardiac function after AMI... - Characterization of SSU and LSU rRNA genes of three Trypanosoma (Herpetosoma) grosi isolates maintained in Mongolian jirdsH Sato
Department of Parasitology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
Parasitology 130:157-67. 2005.... - Expression of penicillin G acylase from the cloned pac gene of Escherichia coli ATCC11105. Effects of pacR and temperatureM Dai
Department of Microbiology, Institute of Plant Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China
Eur J Biochem 268:1298-303. 2001..Our investigations confirmed the hypothesis of pacR-mediated PAA induction for PGA expression and clarified the inhibitory effect of high temperature upon the post-translational processing of the PGA precursor polypeptide... - Analysis and expression of the Borrelia burgdorferi P/Gau fla gene: identification of heterogeneity with the B31 strainB J Luft
Department of Medicine, SUNY, Stony Brook
FEMS Microbiol Lett 72:63-7. 1992..burgdorferi, has been expressed in Escherichia coli using a pET7HIS.2 expression system. These peptides may be of great value for the development of sensitive and specific recombinant-based serological assays... - KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor geneG S Wu
Nat Genet 17:141-3. 1997 - Complete growth inhibition of Escherichia coli by ribosome trapping with truncated cspA mRNA at low temperatureW Jiang
Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Genes Cells 1:965-76. 1996..CspA, the major cold-shock protein of Escherichia coli, is transiently induced upon temperature downshift and considered to play an important role in low-temperature adaptation... - Activation of protein kinase C in human uterine smooth muscle induces connexin-43 gene transcription through an AP-1 site in the promoter sequenceE Geimonen
Department of Obstetrics, Gynecology and Reproductive Medicine, School of Medicine, State University of New York, Stony Brook, New York 11794 8091, USA
J Biol Chem 271:23667-74. 1996..This work provides evidence that transcription of the human connexin-43 gene is induced through protein kinase C activation in uterine smooth muscle cells, and that the induction involves up-regulation and activation of c-Jun and c-Fos... - Bovine submaxillary mucin contains multiple domains and tandemly repeated non-identical sequencesW Jiang
Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Biochem J 331:193-9. 1998..In contrast, two peptide sequences of ovine submaxillary mucin are highly similar (86% and 65% identical respectively) to the corresponding sequences in domain V of BSM... - The role of the 5'-end untranslated region of the mRNA for CspA, the major cold-shock protein of Escherichia coli, in cold-shock adaptationW Jiang
Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA
J Bacteriol 178:4919-25. 1996..CspA appears to promote either directly or indirectly the repressor function... - The alpha subunit of meprin A. Molecular cloning and sequencing, differential expression in inbred mouse strains, and evidence for divergent evolution of the alpha and beta subunitsW Jiang
Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061 0308
J Biol Chem 267:9185-93. 1992..These data indicate that alpha and beta are closely related products of divergent evolution... - A novel meprin beta' mRNA in mouse embryonal and human colon carcinoma cellsJ M Dietrich
Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey 17033, USA
J Biol Chem 271:2271-8. 1996..Expression of the two isoforms may be regulated differentially depending on cell type and/or differentiation state of the cell... - A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 geneP L Tavormina
Department of Biological Chemistry, University of California, Irvine, CA, USA
Am J Hum Genet 64:722-31. 1999.... - Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cellsE Dumermuth
Institute of Biochemistry and Molecular Biology, University of Berne, Switzerland
FEBS Lett 335:367-75. 1993..In addition, complex glycosylated forms were detected in the culture medium, suggesting that the enzyme is secreted after proteolytic removal of the membrane anchor... - Crystal structure of CspA, the major cold shock protein of Escherichia coliH Schindelin
Forschungsgruppe Kristallographie, Max Delbruck Centrum fur Molekulare Medizin, Berlin, Germany
Proc Natl Acad Sci U S A 91:5119-23. 1994..Due to the high homology of the bacterial cold shock proteins with the Y-box factors, E. coli CspA and B. subtilis CspB define a structural framework for the common cold shock domain... - Family of the major cold-shock protein, CspA (CS7.4), of Escherichia coli, whose members show a high sequence similarity with the eukaryotic Y-box binding proteinsS J Lee
Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854
Mol Microbiol 11:833-9. 1994..A similar cold-shock induction to cspA was observed for cspB but not cspC and cspD. These results indicate that E. coli has a family of the cspA gene, some of which are induced by cold shock... - The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processingW Jiang
Laboratory of Molecular Immunology, Rockefeller University, New York, New York 10021, USA
Nature 375:151-5. 1995..Thus DEC-205 is a novel endocytic receptor that can be used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to a specialized antigen-processing compartment... - Variation among cell types in the signaling pathways by which IGF-I stimulates specific cellular responsesT Petley
Biology Department, Syracuse University, NY, USA
Horm Metab Res 31:70-6. 1999..Thus, it seems that there are no simple generalizations that can be used to forecast the signaling pathway that will be involved in any response to the IGFs... - Tissue-specific expression and chromosomal localization of the alpha subunit of mouse meprin AW Jiang
Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061 0308
J Biol Chem 268:10380-5. 1993..The localization of this allele to Mep-1, the gene previously found to regulate the expression of meprin A activity in mice, supports the proposal that Mep-1 is the structural gene for the alpha subunit... - Structure and expression of the human MEP1A gene encoding the alpha subunit of metalloendopeptidase meprin AW Jiang
Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Arch Biochem Biophys 379:183-7. 2000..The elucidated gene structure and tissue-specific expression of the MEP1A gene set the stage for investigating regulation and function of the gene and related sequences in the human genome... - Human fructose-1,6-bisphosphatase gene (FBP1): exon-intron organization, localization to chromosome bands 9q22.2-q22.3, and mutation screening in subjects with fructose-1,6-bisphosphatase deficiencyM R El-Maghrabi
Department of Physiology and Biophysics, State University of New York, Stony Brook 11794, USA
Genomics 27:520-5. 1995.... - Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor geneJ Zuo
Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
Nature 388:769-73. 1997..Thus the activation of apoptotic neuronal death in Lurcher mice may provide a physiologically relevant model for excitotoxic cell death...