Jean Pierre J Issa

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. doi request reprint Epigenetics.
    Jean Pierre Issa
    Department of Leukemia, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    FEBS Lett 585:1993. 2011
  2. pmc LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability
    Marcos R H Estecio
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 2:e399. 2007
  3. ncbi request reprint The epigenetics of colorectal cancer
    J P Issa
    University of Texas at M D Anderson Cancer Center, Houston 77030, USA
    Ann N Y Acad Sci 910:140-53; discussion 153-5. 2000
  4. pmc Targeting DNA methylation
    Jean Pierre J Issa
    Department of Leukemia and Center for Cancer Epigenetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 15:3938-46. 2009
  5. ncbi request reprint Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel
    Lanlan Shen
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:11335-43. 2007
  6. ncbi request reprint DNA methylation patterns at relapse in adult acute lymphocytic leukemia
    Guillermo Garcia-Manero
    Department of Leukemia, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Clin Cancer Res 8:1897-903. 2002
  7. pmc Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters
    Lanlan Shen
    Department of Leukemia, The University of Texas at M D Anderson Cancer Center, Houston, Texas, USA
    PLoS Genet 3:2023-36. 2007
  8. ncbi request reprint Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers
    Emile M Youssef
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 64:2411-7. 2004
  9. ncbi request reprint RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis
    Yanis A Boumber
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA
    Cancer Res 67:1997-2005. 2007
  10. ncbi request reprint Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias
    Kazuo Konishi
    Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Gastroenterology 132:1254-60. 2007

Collaborators

Detail Information

Publications104 found, 100 shown here

  1. doi request reprint Epigenetics.
    Jean Pierre Issa
    Department of Leukemia, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    FEBS Lett 585:1993. 2011
  2. pmc LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability
    Marcos R H Estecio
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 2:e399. 2007
    ..This study was performed to determine the relationship between DNA hypomethylation, hypermethylation and microsatellite instability in cancer...
  3. ncbi request reprint The epigenetics of colorectal cancer
    J P Issa
    University of Texas at M D Anderson Cancer Center, Houston 77030, USA
    Ann N Y Acad Sci 910:140-53; discussion 153-5. 2000
    ..Thus, the integration of epigenetic and genetic information provides a more complete molecular understanding of colorectal cancer and may have implications for the diagnosis, prognosis, and treatment of patients affected by this disease...
  4. pmc Targeting DNA methylation
    Jean Pierre J Issa
    Department of Leukemia and Center for Cancer Epigenetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 15:3938-46. 2009
    ..But the idea of stably changing gene expression in vivo has transformative potential in cancer therapy and beyond...
  5. ncbi request reprint Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel
    Lanlan Shen
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:11335-43. 2007
    ..Our results confirm that epigenetic profiles are useful in identifying molecular mediators for cancer drug sensitivity (pharmaco-epigenomics)...
  6. ncbi request reprint DNA methylation patterns at relapse in adult acute lymphocytic leukemia
    Guillermo Garcia-Manero
    Department of Leukemia, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Clin Cancer Res 8:1897-903. 2002
    ..To study the role of DNA methylation in relapse mechanisms in acute lymphocytic leukemia (ALL), we have compared the methylation status of five genes at the time of initial presentation and at first relapse in 25 adult patients with ALL...
  7. pmc Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters
    Lanlan Shen
    Department of Leukemia, The University of Texas at M D Anderson Cancer Center, Houston, Texas, USA
    PLoS Genet 3:2023-36. 2007
    ....
  8. ncbi request reprint Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers
    Emile M Youssef
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 64:2411-7. 2004
    ..These findings indicate that silencing of TIG1 promoter by hypermethylation is common in human cancers and may contribute to the loss of retinoic acid responsiveness in some neoplastic cells...
  9. ncbi request reprint RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis
    Yanis A Boumber
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA
    Cancer Res 67:1997-2005. 2007
    ..In MDS, RIL methylation is a marker of adverse prognosis independent of chromosome 5 and 7 deletions. Our data suggest that RIL is a good candidate TSG silenced by hypermethylation in cancer...
  10. ncbi request reprint Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias
    Kazuo Konishi
    Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Gastroenterology 132:1254-60. 2007
    ..Whether this translates into hypermethylation in UC-associated cancers (UC-Cs) is not known...
  11. pmc High-throughput methylation profiling by MCA coupled to CpG island microarray
    Marcos R H Estecio
    Department of Leukemia, UT M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genome Res 17:1529-36. 2007
    ..In summary, MCAM is a suitable technique to discover methylated genes and to profile methylation changes in clinical samples in a high-throughput fashion...
  12. pmc Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia
    Jaroslav Jelinek
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e22110. 2011
    ..Finally, DNA methylation of PDLIM4 may help identify a subset of CML patients that would benefit from treatment with Src/Abl inhibitors...
  13. ncbi request reprint Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas
    Sang Geol Kim
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Gastroenterology 124:1300-10. 2003
    ..Carcinomas of the extrahepatic bile ducts, ampulla of Vater, and duodenum are uncommon, and their epigenetic and genetic alterations are not well characterized...
  14. pmc CpG island methylation in aberrant crypt foci of the colorectum
    Annie On On Chan
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    Am J Pathol 160:1823-30. 2002
    ....
  15. pmc Chromatin remodeling is required for gene reactivation after decitabine-mediated DNA hypomethylation
    Jiali Si
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, TX, USA
    Cancer Res 70:6968-77. 2010
    ..Our findings suggest that gene expression is the key in optimizing DAC treatment strategies in the clinic...
  16. pmc DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis
    Kazuo Konishi
    Department of Leukemia, Division of Cancer Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e27889. 2011
    ..The contribution of DNA methylation to the metastatic process in colorectal cancers (CRCs) is unclear...
  17. ncbi request reprint Imatinib mesylate for Philadelphia chromosome-positive, chronic-phase myeloid leukemia after failure of interferon-alpha: follow-up results
    Hagop M Kantarjian
    Departments of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 8:2177-87. 2002
    ..We identified pretreatment and treatment-associated factors that were associated with higher major cytogenetic response rates and with improved survival...
  18. pmc A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
    Allen S Yang
    Department of Leukemia, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Nucleic Acids Res 32:e38. 2004
    ..This method can be used as a surrogate marker of genome-wide methylation changes. In addition, it is less labor intensive and requires less DNA than previous methods of assessing global DNA methylation...
  19. doi request reprint Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
    Yutaka Kondo
    Department of Leukemia, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Nat Genet 40:741-50. 2008
    ..These data establish EZH2-mediated H3K27triM as a mechanism of tumor-suppressor gene silencing in cancer that is potentially independent of promoter DNA methylation...
  20. pmc DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes
    Lanlan Shen
    Department of Leukemia and Biostatistics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 28:605-13. 2010
    ..Epigenetic therapy using decitabine, a DNA hypomethylating agent, is clinically effective for the treatment of MDS. Therefore, we investigated the association between DNA methylation and clinical outcome in MDS...
  21. ncbi request reprint Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies
    Jean Pierre J Issa
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 103:1635-40. 2004
    ..There was no correlation between P15 methylation at baseline or after therapy and response to decitabine. We conclude that decitabine is effective in myeloid malignancies, and low doses are as or more effective than higher doses...
  22. ncbi request reprint Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate
    Jean Pierre J Issa
    Department of Leukemia and Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 23:3948-56. 2005
    ..To determine the activity of decitabine, a DNA methylation inhibitor, in imatinib-refractory or intolerant chronic myelogenous leukemia...
  23. ncbi request reprint Silencing of bidirectional promoters by DNA methylation in tumorigenesis
    Jingmin Shu
    Department of Leukemia, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 66:5077-84. 2006
    ....
  24. ncbi request reprint PML-RARalpha and AML1-ETO translocations are rarely associated with methylation of the RARbeta2 promoter
    Yoko Tabe
    Section of Molecular Hematology and Therapy, Department of Blood and Marrow Transplantation, The University of Texas M D Anderson Cancer Center, 1400 Holcombe Boulevard, Unit 448, Houston, TX 77030, USA
    Ann Hematol 85:689-704. 2006
    ..These results demonstrate that oncogenic PML-RARalpha and AML1-ETO translocations are rarely associated with RARbeta2 promoter methylation in primary AML samples...
  25. ncbi request reprint Age-related DNA methylation changes in normal human prostate tissues
    Bernard Kwabi-Addo
    Department of Pathology, Baylor College of Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 13:3796-802. 2007
    ..We examined the extent of gene methylation in pathologically normal human prostate as a function of age...
  26. pmc Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
    Lanlan Shen
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030
    Proc Natl Acad Sci U S A 104:18654-9. 2007
    ..Together, our integrated genetic and epigenetic analysis reveals that colon cancers correspond to three molecularly distinct subclasses of disease...
  27. pmc Mechanisms of resistance to decitabine in the myelodysplastic syndrome
    Taichun Qin
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e23372. 2011
    ..Therefore, we investigated mechanisms of primary and secondary resistance to DAC in MDS...
  28. pmc SINE retrotransposons cause epigenetic reprogramming of adjacent gene promoters
    Marcos R H Estecio
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cancer Res 10:1332-42. 2012
    ..In summary, our work supports the concept that SINE repeats interfere negatively with gene expression and that their presence near gene promoters is counter-selected, except when the promoter is protected by an insulator element...
  29. pmc Concordant CpG island methylation in hyperplastic polyposis
    Annie On On Chan
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4095, USA
    Am J Pathol 160:529-36. 2002
    ..The hypermethylator phenotype is related to patient-specific factors, such as carcinogenic exposure or genetic predisposition...
  30. ncbi request reprint Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation
    Satoshi Fujii
    Department of Experimental Therapeutics, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Hum Mol Genet 12:1791-800. 2003
    ....
  31. pmc Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation
    Yutaka Kondo
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:7398-403. 2004
    ..This unbiased approach confirms the tight coupling between DNA methylation and histone modifications in cancer and could be used to probe gene silencing in nonneoplastic conditions as well...
  32. ncbi request reprint MGMT promoter methylation and field defect in sporadic colorectal cancer
    Lanlan Shen
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 97:1330-8. 2005
    ..The DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) is frequently methylated in colorectal cancer. We hypothesized that MGMT methylation could be one of the mediators of field cancerization in the colon mucosa...
  33. pmc DNA methylation does not stably lock gene expression but instead serves as a molecular mark for gene silencing memory
    Noel J M Raynal
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Cancer Res 72:1170-81. 2012
    ..These findings define chromatin as an important druggable target for cancer epigenetic therapy and suggest that removal of DNA methylation signals is required to achieve long-term gene reactivation...
  34. pmc The epigenome of AML stem and progenitor cells
    Jumpei Yamazaki
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Epigenetics 8:92-104. 2013
    ..Our data indicates that histone modifications but not promoter DNA methylation are involved in switches from CSCs to non-CSCs in AML...
  35. doi request reprint Epigenetic mechanisms in AML - a target for therapy
    Yasuhiro Oki
    Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Cancer Treat Res 145:19-40. 2010
    ..Recent clinical studies have shown the relative safety and efficacy of such epigenetic therapies...
  36. doi request reprint Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation
    Weiwei Feng
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer 112:1489-502. 2008
    ..Two imprinted genes, paternally expressed 3 (PEG3) and aplasia Ras homologue member I (ARHI), are the most frequently down-regulated in ovarian cancers on gene expression arrays...
  37. pmc Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island
    Yan Zhang
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Nucleic Acids Res 40:7257-68. 2012
    ....
  38. ncbi request reprint DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia
    Guillermo Garcia-Manero
    Departments of Leukemia, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 8:2217-24. 2002
    ..Aberrant methylation of promoter-associated CpG islands is an epigenetic oncogenic mechanism. The objective of this study was to define the methylation characteristics of patients with acute lymphocytic leukemia (ALL)...
  39. ncbi request reprint Methylation and regulation of expression of different retinoic acid receptor beta isoforms in human colon cancer
    Emile M Youssef
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 3:82-6. 2004
    ....
  40. ncbi request reprint Epigenetic changes in colorectal cancer
    Yutaka Kondo
    Department of Leukemia, University of Texas at M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Metastasis Rev 23:29-39. 2004
    ..Understanding epigenetic alterations as a driving force in neoplasia opens new fields of research in epidemiology, risk assessment, and treatment in CRCs...
  41. ncbi request reprint Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome
    Andres O Soriano
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 110:2302-8. 2007
    ..VPA blood levels were higher in responders (P < .005). In conclusion, the combination studied is safe and has significant clinical activity. This clinical trial was registered at www.clinicaltrials.gov as no. NCT00326170...
  42. pmc Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome
    Jia Xu
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    BMC Cancer 12:243. 2012
    ..To determine the impact of methylation on clinical outcome, we have conducted a larger study with breast cancers for which time to first recurrence and overall survival are known...
  43. pmc JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia
    Jaroslav Jelinek
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Blood 106:3370-3. 2005
    ..We conclude that the JAK2 1849G>T mutation is common in Ph(-) MPD but not critical for transformation to the acute phase of these diseases and that it is generally rare in aggressive leukemias...
  44. pmc Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling
    Woonbok Chung
    Department of Leukemia, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 3:e2079. 2008
    ..Our data identify new targets of transcriptional silencing in cancer, and provide new biomarkers that could be useful in screening for prostate cancer and other cancers...
  45. pmc Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties
    Joseph H Taube
    1 Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 2 Metastasis Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 3 Center for Stem Cells and Developmental Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Sci Rep 3:2687. 2013
    ..Our data suggest that restoring miR-203 expression levels may inhibit metastasis and combat deregulated Wnt signaling. ..
  46. ncbi request reprint Comment on "Chromosomal instability and tumors promoted by DNA hypomethylation" and "Induction of tumors in nice by genomic hypomethylation"
    Allen S Yang
    Department of Leukemia, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Science 302:1153; author reply 1153. 2003
  47. pmc Correlation between CpG methylation profiles and hormone receptor status in breast cancers
    Weiwei Feng
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Breast Cancer Res 9:R57. 2007
    ..The present study was undertaken to determine whether methylation of a set of growth-suppressor genes would correlate to the expression of estrogen receptors (ERs) and progesterone receptors (PRs)...
  48. pmc Induction of hypomethylation and molecular response after decitabine therapy in patients with chronic myelomonocytic leukemia
    Yasuhiro Oki
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 111:2382-4. 2008
    ..Our data suggest a predominantly noncytotoxic mechanism of action for decitabine, leading to altered biology of the neoplastic clone and/or normal cells. This trial was registered at www.ClinicalTrials.gov as #NCT00067808...
  49. ncbi request reprint Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia
    Lanlan Shen
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 101:4131-6. 2003
    ..02). Our results indicate that p57KIP2 is frequently methylated in adult patients with ALL, and that inactivation of a pathway composed of p73, p15, and p57KIP2 predicts for poor prognosis in Ph-negative patients...
  50. ncbi request reprint Targeting aberrant chromatin structure in colorectal carcinomas
    Kazuo Konishi
    Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer J 13:49-55. 2007
    ..Drugs that inhibit DNA methylation and histone deacetylation are in use in the clinic and should be tested in colorectal malignancy...
  51. pmc Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer
    Marcos R H Estecio
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Genome Res 20:1369-82. 2010
    ....
  52. ncbi request reprint P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53
    Lanlan Shen
    Department of Leukemia, The University of Texas at M D Anderson Cancer Center, Houston, Texas 77030, USA
    Gastroenterology 124:626-33. 2003
    ..The p14 (ARF) gene on chromosome 9p is deleted and/or silenced by hypermethylation in a subset of human malignancies. There is evidence suggesting that p14 suppresses tumorigenicity by stabilizing the p53 protein...
  53. ncbi request reprint Effect of cytarabine and decitabine in combination in human leukemic cell lines
    Taichun Qin
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:4225-32. 2007
    ..5-Aza-2'-deoxycytidine (DAC) is a cytosine analogue that inhibits DNA methylation and also has activity in myeloid leukemia. Therefore, we investigated combining these two drugs in human leukemia cell lines in vitro...
  54. ncbi request reprint DNA methylation and environmental exposures in human hepatocellular carcinoma
    Lanlan Shen
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    J Natl Cancer Inst 94:755-61. 2002
    ..To determine whether CIMP is associated with the development of hepatocellular carcinoma (HCC) and with exposure to environmental agents, we examined the methylation status of CpG islands in HCCs from countries with various HCC risks...
  55. ncbi request reprint Enrichment for histone H3 lysine 9 methylation at Alu repeats in human cells
    Yutaka Kondo
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 278:27658-62. 2003
    ..Thus H3-Lys9 methylation is enriched at human repetitive elements, particularly Alu elements, and may play a role in the suppression of recombination by these elements...
  56. ncbi request reprint Differential methylation status of tumor-associated genes in head and neck squamous carcinoma: incidence and potential implications
    Shin ichiro Maruya
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 10:3825-30. 2004
    ..Concurrent methylation analysis of multiple, functionally distinct genes may provide important information on their differential alterations and potential association in head and neck squamous carcinogenesis...
  57. ncbi request reprint Regulation of RARbeta1 expression in head and neck cancer cells by cell density-dependent chromatin remodeling
    Emile M Youssef
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer Biol Ther 3:1002-6. 2004
    ..These findings reveal that the expression of RARbeta1 is regulated by cell density through changes in histone acetylation...
  58. pmc Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy
    Lanlan Shen
    The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:6093-8. 2007
    ..We sought to determine the prognostic significance of CIMP in advanced colorectal cancer patients treated with 5-fluorouracil (5-FU) in an Eastern Cooperative Oncology Group clinical trial...
  59. pmc Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma
    Yutaka Suehiro
    Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 14:2560-9. 2008
    ....
  60. pmc Widespread and tissue specific age-related DNA methylation changes in mice
    Shinji Maegawa
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genome Res 20:332-40. 2010
    ..We conclude that epigenetic deregulation is a common feature of aging in mammals...
  61. pmc Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer
    Yoshiyuki Watanabe
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e23320. 2011
    ..Mutations in MLL3 were found in a whole genome analysis of colorectal cancer but have not been confirmed by a separate study...
  62. pmc Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer
    Yutaka Kondo
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Mol Cell Biol 23:206-15. 2003
    ..Our results suggest that reduced H3 Lys-4 methylation and increased H3 Lys-9 methylation play a critical role in the maintenance of promoter DNA methylation-associated gene silencing in colorectal cancer...
  63. ncbi request reprint Phase II study of low-dose decitabine in combination with imatinib mesylate in patients with accelerated or myeloid blastic phase of chronic myelogenous leukemia
    Yasuhiro Oki
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 109:899-906. 2007
    ..A Phase II study was performed on low-dose decitabine, a DNA methyltransferase inhibitor, in combination with imatinib in patients with CML in accelerated phase (AP) and myeloid blastic phase (BP)...
  64. pmc BRAF mutations in aberrant crypt foci and hyperplastic polyposis
    Robyn Beach
    Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030 4095, USA
    Am J Pathol 166:1069-75. 2005
    ..Our study shows that BRAF mutation status is heterogeneous among patients with multiple/large HPs and/or hyperplastic polyposis, suggesting differences in pathogenesis of HPs that indicate subsets within this phenotype...
  65. ncbi request reprint Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia
    Guillermo Garcia-Manero
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 97:695-702. 2003
    ..This epigenetic modification has been associated with gene silencing, malignant transformation, and aging. It is not known whether there are epigenetic differences between pediatric patients and adult patients with ALL...
  66. ncbi request reprint DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia
    Allen S Yang
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 66:5495-503. 2006
    ..In conclusion, we show dose-dependent hypomethylation after decitabine at low doses. Increasing the dose, which has been shown previously to result in a reduced response rate, was not accompanied by further hypomethylation...
  67. ncbi request reprint Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors)
    In Seon Choi
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Mod Pathol 20:802-10. 2007
    ....
  68. ncbi request reprint Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer
    Marsha L Frazier
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:4805-8. 2003
    ..Patients with methylation at all four loci were 14 times more likely to have a family history of cancer than patients with methylation at none of the four loci. These findings suggest that there may be a genetic component to CIMP in CRC...
  69. pmc Sensitive and specific detection of early gastric cancer with DNA methylation analysis of gastric washes
    Yoshiyuki Watanabe
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Gastroenterology 136:2149-58. 2009
    ..We hypothesized that methylation analysis of DNA recovered from gastric washes could be used to detect gastric cancer...
  70. ncbi request reprint CpG island methylation profiling in human melanoma cell lines
    Carmen S Tellez
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Melanoma Res 19:146-55. 2009
    ..We conclude that aberrant hypermethylation, is frequent in melanoma cell lines, directly correlated with global DNA methylation, and independent of BRAF and NRAS mutations...
  71. ncbi request reprint Treatment of philadelphia chromosome-positive, accelerated-phase chronic myelogenous leukemia with imatinib mesylate
    Hagop M Kantarjian
    Departments of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 8:2167-76. 2002
    ..Imatinib mesylate, a specific Bcr-Abl tyrosine kinase inhibitor, has shown encouraging activity in chronic myelogenous leukemia (CML)...
  72. ncbi request reprint Methylated CpG island amplification for methylation analysis and cloning differentially methylated sequences
    Minoru Toyota
    Graduate School of Biomedical Sciences, MD Anderson Cancer Center, Houston, TX, USA
    Methods Mol Biol 200:101-10. 2002
  73. ncbi request reprint Decitabine--bedside to bench
    Yasuhiro Oki
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Crit Rev Oncol Hematol 61:140-52. 2007
    ..Herein, we summarize the results of recent clinical trials of decitabine in hematologic malignancies, and review the translational research into decitabine's mechanism of clinical activity...
  74. ncbi request reprint Optimizing annealing temperature overcomes bias in bisulfite PCR methylation analysis
    Lanlan Shen
    Department of Leukemia, M D Anderson Cancer Center, Houston, TX 77030, USA
    Biotechniques 42:48, 50, 52 passim. 2007
  75. ncbi request reprint Review: recent clinical trials in epigenetic therapy
    Yasuhiro Oki
    Department of Leukemia, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 428, Houston, TX, 77030, USA
    Rev Recent Clin Trials 1:169-82. 2006
    ..No agent in this class has been studied in a phase III trial, but several agents have been or are being studied in phase II trials. Further research is needed to determine the appropriate patient selection and dosing schedules...
  76. ncbi request reprint Mitoxantrone: a hypomethylating agent?
    Allen S Yang
    Department of Leukemia, University of Texas at M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 2:264-5. 2003
  77. pmc Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia
    Jumpei Yamazaki
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Epigenetics 7:201-7. 2012
    ..0% and 9.8%, respectively) (p = 0.016). Thus, TET2 mutations affect global methylation in CMML but most of the changes are likely to be outside gene promoters...
  78. ncbi request reprint Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study
    Hagop Kantarjian
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:1794-803. 2006
    ..Decitabine indirectly depletes methylcytosine and causes hypomethylation of target gene promoters...
  79. ncbi request reprint DNA methylation as a therapeutic target in cancer
    Jean Pierre J Issa
    University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 13:1634-7. 2007
    ..These drugs have now been approved for clinical use in the United States in the treatment of myelodysplastic syndrome, thus opening the floodgate for a whole new approach to cancer therapy--epigenetic therapy...
  80. ncbi request reprint PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL
    Yoko Tabe
    Section of Molecular Hematology and Therapy, Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Cancer Biol Ther 6:1967-77. 2007
    ..In summary, these results provide rationale for the combined targeting of RAR and PPARgamma nuclear receptors in the therapy of APL...
  81. pmc Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse
    Heike Kroeger
    Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Blood 112:1366-73. 2008
    ..0% to 15.2% (median 10.6%) genes in relapse (P < .001). Our data suggest that DNA methylation is involved in AML progression and provide a rationale for the use of epigenetic agents in remission maintenance...
  82. pmc Mechanisms of resistance to 5-aza-2'-deoxycytidine in human cancer cell lines
    Taichun Qin
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, USA
    Blood 113:659-67. 2009
    ..DAC induced DNA breaks as evidenced by H2AX phosphorylation and increased homologous recombination rates by 7- to 10-fold. These results suggest that in vitro resistance to DAC can be explained by insufficient incorporation into DNA...
  83. doi request reprint Hypomethylation of long interspersed nuclear element-1 in hepatocellular carcinomas
    Mi Jung Kim
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 22:442-9. 2009
    ..In hepatocellular carcinomas, hypermethylation of CpG islands, and CpG island methylator phenotype status seems to correlate with levels of long interspersed nuclear element-1 hypomethylation...
  84. doi request reprint Cancer epigenetics
    Rodolphe Taby
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    CA Cancer J Clin 60:376-92. 2010
    ..The success of this approach in hematopoietic malignancies validates the importance of epigenetic alterations in cancer, not only at the therapeutic level but also with regard to prevention, diagnosis, risk stratification, and prognosis...
  85. ncbi request reprint Decitabine dosing schedules
    Hagop M Kantarjian
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Semin Hematol 42:S17-22. 2005
    ..Even with all the information we have learned, there is still a need to determine the optimal dosing schedule and the development of alternative dosing forms...
  86. ncbi request reprint Epigenetic changes in estrogen receptor beta gene in atherosclerotic cardiovascular tissues and in-vitro vascular senescence
    Jei Kim
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Biochim Biophys Acta 1772:72-80. 2007
    ..We suggest that focal epigenetic changes in estrogen receptor beta contribute to the development of atherosclerosis and vascular aging...
  87. pmc DNA methylation predicts recurrence from resected stage III proximal colon cancer
    Joong Bae Ahn
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 117:1847-54. 2011
    ..The role of this classification in predicting recurrence and disease-free survival (DFS) in resected stage III CRC was evaluated...
  88. pmc Detection of bladder cancer using novel DNA methylation biomarkers in urine sediments
    Woonbok Chung
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 20:1483-91. 2011
    ..Bladder cancer (BCa) remains a lethal malignancy that can be cured if detected early. DNA hypermethylation is a common epigenetic abnormality in cancer that may serve as a marker of disease activity...
  89. pmc Tumor-associated methylation of the putative tumor suppressor AJAP1 gene and association between decreased AJAP1 expression and shorter survival in patients with glioma
    David Cogdell
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Chin J Cancer 30:247-53. 2011
    ..Thus, both genetic (gene deletion) and epigenetic alterations (promoter methylation) are likely mechanisms that inactivate the putative tumor suppressor AJAP1 in gliomas, which contributes to poor prognosis...
  90. ncbi request reprint Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia
    Hagop Kantarjian
    Department of Leukemia, MD Anderson Cancer Center, 1515 Holcombe Blvd, Box 428, Houston, TX 77030, USA
    Blood 109:52-7. 2007
    ..We conclude that a low-dose, dose-intensity schedule of decitabine optimizes epigenetic modulation and clinical responses in MDS...
  91. ncbi request reprint Epigenetic control of PRV-1 expression on neutrophils
    Jaroslav Jelinek
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Exp Hematol 35:1677-83. 2007
    ..We investigated whether DNA methylation of the PRV-1 gene has a role in regulation of transcription and expression of the PRV-1 protein...
  92. ncbi request reprint Epigenetics in cancer: what's the future?
    Yanis Boumber
    Hematology Oncology Fellowship Program, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Oncology (Williston Park) 25:220-6, 228. 2011
    ..In this review, we focus on recent clinical and translational data in the epigenetics field that have potential in cancer therapy...
  93. ncbi request reprint Accelerated age-related CpG island methylation in ulcerative colitis
    J P Issa
    University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 61:3573-7. 2001
    ....
  94. pmc CpG island methylation in colorectal adenomas
    A Rashid
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    Am J Pathol 159:1129-35. 2001
    ..Methylation is distinct from microsatellite instability and develops in individual adenomas rather than resulting from a field defect in an individual patient...
  95. pmc Dnmt3a is essential for hematopoietic stem cell differentiation
    Grant A Challen
    Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, Texas, USA
    Nat Genet 44:23-31. 2011
    ..These data establish Dnmt3a as a critical participant in the epigenetic silencing of HSC regulatory genes, thereby enabling efficient differentiation...
  96. pmc Concordant DNA methylation in synchronous colorectal carcinomas
    Kazuo Konishi
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 2:814-22. 2009
    ..Screening for and secondary prevention of colon cancer should take this fact into account...
  97. pmc Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees
    Astrid Spannhoff
    Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Park Road 1C, Smithville, Texas 78957, USA
    EMBO Rep 12:238-43. 2011
    ..Furthermore, 10HDA can reactivate the expression of epigenetically silenced genes in mammalian cells. Thus, the epigenetic regulation of queen-bee development is probably driven, in part, by HDACi activity in royal jelly...
  98. doi request reprint Methylated CpG Island Amplification and Microarray (MCAM) for High-Throughput Analysis of DNA Methylation
    Marcos R H Estecio
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    CSH Protoc 2008:pdb.prot4974. 2008
    ..Subsequently, a comparative hybridization of reference and test samples (typically normal and tumor DNA specimens) is done on a microarray platform...
  99. ncbi request reprint Decitabine in chronic leukemias
    Jean Pierre J Issa
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Semin Hematol 42:S43-9. 2005
    ....
  100. doi request reprint Histone deacetylase inhibitors as anti-neoplastic agents
    Nicolas Batty
    Department of Leukemia, MD Anderson Cancer Center, Unit 428, Houston, TX 77030, USA
    Cancer Lett 280:192-200. 2009
    ..In this review, we focus on recent basic and clinical data that highlight the anti-neoplastic role of HDACIs...
  101. doi request reprint Time to think outside the (genetic) box
    Jean Pierre J Issa
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 428, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 4:6-8. 2011
    ..Here, we discuss the implications of this work in terms of the etiology, risk, and potential prevention of cancer...