FRAZ AHMED ISMAT

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi request reprint Coronary anatomy in congenitally corrected transposition of the great arteries
    Fraz A Ismat
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, PA 19104, USA
    Int J Cardiol 86:207-16. 2002
  2. pmc The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice
    Fraz A Ismat
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 116:2378-84. 2006
  3. pmc Right aortic arch and coarctation: a rare association
    Fraz A Ismat
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Congenit Heart Dis 1:217-23. 2006
  4. pmc Nf1 has an essential role in endothelial cells
    Aaron D Gitler
    Department of Medicine, Cardiology Division, University of Pennsylvania Health System, 954 BRB II III, 421 Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 33:75-9. 2003
  5. ncbi request reprint NF1 regulates a Ras-dependent vascular smooth muscle proliferative injury response
    Junwang Xu
    Department of Cell and Developmental Biology and Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA
    Circulation 116:2148-56. 2007
  6. pmc Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction
    Junwang Xu
    Department of Cell and Developmental Biology and the Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Circ Res 105:304-11. 2009
  7. pmc Homeobox protein Hop functions in the adult cardiac conduction system
    Fraz A Ismat
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Circ Res 96:898-903. 2005

Research Grants

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Coronary anatomy in congenitally corrected transposition of the great arteries
    Fraz A Ismat
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, PA 19104, USA
    Int J Cardiol 86:207-16. 2002
    ..g. typical congenitally corrected transposition of the great arteries, has made delineation of the coronary artery anatomy in these hearts important. Previous studies have suggested a consistently inverted coronary arterial pattern...
  2. pmc The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice
    Fraz A Ismat
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 116:2378-84. 2006
    ....
  3. pmc Right aortic arch and coarctation: a rare association
    Fraz A Ismat
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Congenit Heart Dis 1:217-23. 2006
    ..Understand anatomical and clinical correlatives to coarctation in right aortic arch...
  4. pmc Nf1 has an essential role in endothelial cells
    Aaron D Gitler
    Department of Medicine, Cardiology Division, University of Pennsylvania Health System, 954 BRB II III, 421 Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 33:75-9. 2003
    ..These results establish a new and essential role for Nf1 in endothelial cells and confirm the requirement for neurofibromin in the neural crest...
  5. ncbi request reprint NF1 regulates a Ras-dependent vascular smooth muscle proliferative injury response
    Junwang Xu
    Department of Cell and Developmental Biology and Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA
    Circulation 116:2148-56. 2007
    ..In animal models, endothelial expression of the disease gene, NF1, is critical for normal heart development. However, the pathogeneses of the more common vascular disorders are not well characterized...
  6. pmc Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction
    Junwang Xu
    Department of Cell and Developmental Biology and the Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Circ Res 105:304-11. 2009
    ..In animal models, endothelial and smooth muscle expression of the disease gene is critical for normal heart development and the prevention of vascular disease, respectively...
  7. pmc Homeobox protein Hop functions in the adult cardiac conduction system
    Fraz A Ismat
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Circ Res 96:898-903. 2005
    ..Our results suggest that Hop functions in the adult CCS and demonstrate conservation of molecular hierarchies between embryonic myocardium and the specialized conduction tissue of the mature heart...

Research Grants2

  1. Neurofibromin, Ras & NFAT in Cardiovascular Development
    FRAZ ISMAT; Fiscal Year: 2007
    ..Together this training program will prepare me for independent investigation, lead to a better understanding of cardiovascular abnormalities in neurofibromatosis, and address fundamental issues of cardiovascular development. ..