Mozaffarul Islam

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. doi RhoC regulates cancer stem cells in head and neck squamous cell carcinoma by overexpressing IL-6 and phosphorylation of STAT3
    Mozaffarul Islam
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
    PLoS ONE 9:e88527. 2014
  2. doi Down regulation of RhoC by microRNA-138 results in de-activation of FAK, Src and Erk(1/2) signaling pathway in head and neck squamous cell carcinoma
    Mozaffarul Islam
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Wexner Medical Center, Columbus, OH, USA Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University, Wexner Medical Center, Columbus, OH, USA Electronic address
    Oral Oncol 50:448-56. 2014
  3. doi Atorvastatin inhibits RhoC function and limits head and neck cancer metastasis
    Mozaffarul Islam
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA
    Oral Oncol 49:778-86. 2013
  4. pmc RhoC expression and head and neck cancer metastasis
    Mozaffarul Islam
    Department of Otolaryngology Head and Neck Surgery, Ohio State University, Columbus, OH 43210, USA
    Mol Cancer Res 7:1771-80. 2009
  5. ncbi Tetrathiomolybdate promotes tumor necrosis and prevents distant metastases by suppressing angiogenesis in head and neck cancer
    Basil Hassouneh
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, 1500 East Medical Centre Drive, 1904 Taubman Center, Ann Arbor, MI 48109, USA
    Mol Cancer Ther 6:1039-45. 2007
  6. pmc Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis
    Pawan Kumar
    Department of Otolaryngology Head and Neck Surgery and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
    Mol Cancer 9:206. 2010
  7. ncbi The effect of tetrathiomolybdate on cytokine expression, angiogenesis, and tumor growth in squamous cell carcinoma of the head and neck
    Theodoros N Teknos
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, MI 48103, USA
    Arch Otolaryngol Head Neck Surg 131:204-11. 2005
  8. ncbi Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma
    Benjamin Marcus
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48103, USA
    Cancer 101:2779-87. 2004

Collaborators

  • Sofia D Merajver
  • Quintin Pan
  • Pawan Kumar
  • Theodoros N Teknos
  • Benjamin Marcus
  • Basil Hassouneh
  • Supriti Paul
  • Thomas Nagel
  • Curtis D Vandenberg
  • Michael Carron
  • Aaron M Abarbanell
  • Douglas A Arenberg
  • Jacques E Nor
  • Shannon L Carskadon
  • Cecelia E Schmalbach
  • Douglas B Chepeha
  • Douglas Arenberg
  • Rork Kuick
  • Samir Hanash
  • Celina Kleer
  • Julia Lee

Detail Information

Publications8

  1. doi RhoC regulates cancer stem cells in head and neck squamous cell carcinoma by overexpressing IL-6 and phosphorylation of STAT3
    Mozaffarul Islam
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
    PLoS ONE 9:e88527. 2014
    ..These findings suggest that RhoC may be a novel target for HNSCC therapy. ..
  2. doi Down regulation of RhoC by microRNA-138 results in de-activation of FAK, Src and Erk(1/2) signaling pathway in head and neck squamous cell carcinoma
    Mozaffarul Islam
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Wexner Medical Center, Columbus, OH, USA Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University, Wexner Medical Center, Columbus, OH, USA Electronic address
    Oral Oncol 50:448-56. 2014
    ..We hypothesize that miR-138 can inhibit the function of RhoC and consequently the activation of downstream target molecules involve in the signaling cascade. For this reason we investigated the role of miR-138 in HNSCC...
  3. doi Atorvastatin inhibits RhoC function and limits head and neck cancer metastasis
    Mozaffarul Islam
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA
    Oral Oncol 49:778-86. 2013
    ..Given that RhoC is a key oncogene involved in metastasis, we hypothesized Atorvastatin can reduce head and neck metastasis by inhibiting RhoC activity...
  4. pmc RhoC expression and head and neck cancer metastasis
    Mozaffarul Islam
    Department of Otolaryngology Head and Neck Surgery, Ohio State University, Columbus, OH 43210, USA
    Mol Cancer Res 7:1771-80. 2009
    ..These findings suggest that RhoC warrants further investigation to delineate its robustness as a novel potentially therapeutic target...
  5. ncbi Tetrathiomolybdate promotes tumor necrosis and prevents distant metastases by suppressing angiogenesis in head and neck cancer
    Basil Hassouneh
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, 1500 East Medical Centre Drive, 1904 Taubman Center, Ann Arbor, MI 48109, USA
    Mol Cancer Ther 6:1039-45. 2007
    ..Taken together, these results show that tetrathiomolybdate can act long-term as a suppressor of vascularity and inhibit the growth of metastasis in this model of HNSCC...
  6. pmc Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis
    Pawan Kumar
    Department of Otolaryngology Head and Neck Surgery and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
    Mol Cancer 9:206. 2010
    ..However, very little is known about the effect of TM on tumor cell function and tumor metastasis. In this study, we explored the mechanisms underlying TM-mediated inhibition of tumor metastasis...
  7. ncbi The effect of tetrathiomolybdate on cytokine expression, angiogenesis, and tumor growth in squamous cell carcinoma of the head and neck
    Theodoros N Teknos
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, MI 48103, USA
    Arch Otolaryngol Head Neck Surg 131:204-11. 2005
    ..To assess the effect of tetrathiomolybdate on cytokine expression, angiogenesis, and tumor growth rate in human squamous cell carcinoma (SCC)...
  8. ncbi Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma
    Benjamin Marcus
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48103, USA
    Cancer 101:2779-87. 2004
    ..The authors hypothesized that tumor-associated macrophages contribute to HNSCC aggressiveness, and the objective of the current study was to prove this hypothesis using mRNA expression analysis and a large cohort of clinical specimens...