Fumitoshi Irie

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. ncbi request reprint [Roles of Eph receptors and the cell surface heparan sulfate proteoglycan syndecan-2 in dendritic spine morphogenesis]
    Yu Yamaguchi
    Neurobiology Program, Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Seikagaku 74:391-5. 2002
  2. ncbi request reprint EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP
    Fumitoshi Irie
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 5:1117-8. 2002
  3. pmc EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1
    Fumitoshi Irie
    Developmental Neurobiology Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Cell Biol 7:501-9. 2005
  4. pmc Heparan sulfate regulates ephrin-A3/EphA receptor signaling
    Fumitoshi Irie
    Sanford Children s Health Research Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:12307-12. 2008
  5. pmc Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects
    Yoshihiro Matsumoto
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Biol Chem 285:19227-34. 2010
  6. ncbi request reprint Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate
    Yoshihiro Matsumoto
    Developmental Neurobiology Program, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Neurosci 27:4342-50. 2007
  7. doi request reprint Roles of heparan sulfate in mammalian brain development current views based on the findings from Ext1 conditional knockout studies
    Yu Yamaguchi
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, California, USA
    Prog Mol Biol Transl Sci 93:133-52. 2010
  8. ncbi request reprint Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
    Keith K Murai
    The Burnham Institute, Neurobiology Program, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 6:153-60. 2003
  9. pmc A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostoses
    Kazu Matsumoto
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:10932-7. 2010
  10. pmc Autism-like socio-communicative deficits and stereotypies in mice lacking heparan sulfate
    Fumitoshi Irie
    Genetic Disease Program, Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 109:5052-6. 2012

Collaborators

Detail Information

Publications13

  1. ncbi request reprint [Roles of Eph receptors and the cell surface heparan sulfate proteoglycan syndecan-2 in dendritic spine morphogenesis]
    Yu Yamaguchi
    Neurobiology Program, Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Seikagaku 74:391-5. 2002
  2. ncbi request reprint EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP
    Fumitoshi Irie
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 5:1117-8. 2002
  3. pmc EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1
    Fumitoshi Irie
    Developmental Neurobiology Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Cell Biol 7:501-9. 2005
    ..Our results indicate that ephrinB-EphB signalling regulates clathrin-mediated endocytosis in various cellular contexts by influencing protein interactions and phosphoinositide turnover through tyrosine phosphorylation of synaptojanin 1...
  4. pmc Heparan sulfate regulates ephrin-A3/EphA receptor signaling
    Fumitoshi Irie
    Sanford Children s Health Research Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:12307-12. 2008
    ..These results show that heparan sulfate modulates ephrin/Eph signaling and suggest a physiological role for heparan sulfate proteoglycans in the regulation of ephrin-A3-dependent biological processes...
  5. pmc Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects
    Yoshihiro Matsumoto
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Biol Chem 285:19227-34. 2010
    ..Together, our results show that HS is essential for patterning of limb skeletal elements and that BMP signaling is one of the major targets for the regulatory role of HS in this developmental context...
  6. ncbi request reprint Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate
    Yoshihiro Matsumoto
    Developmental Neurobiology Program, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Neurosci 27:4342-50. 2007
    ..These results demonstrate that the expression of HS by commissural neurons is essential for these neurons to transduce netrin-1 signals, thus providing evidence for a cell-autonomous role of HS in netrin-1/DCC-mediated axon guidance...
  7. doi request reprint Roles of heparan sulfate in mammalian brain development current views based on the findings from Ext1 conditional knockout studies
    Yu Yamaguchi
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, California, USA
    Prog Mol Biol Transl Sci 93:133-52. 2010
    ..This chapter reviews the current understanding of the in vivo function of HS deduced from the phenotypes of conditional Ext1 knockout mice...
  8. ncbi request reprint Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
    Keith K Murai
    The Burnham Institute, Neurobiology Program, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 6:153-60. 2003
    ..Thus, our data support a model in which transient interactions between the ephrin-A3 ligand and the EphA4 receptor regulate the structure of excitatory synaptic connections through neuroglial cross-talk...
  9. pmc A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostoses
    Kazu Matsumoto
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:10932-7. 2010
    ..Because the observed osteochondromas in our mouse model do not arise from clonal growth of chondrocytes, they cannot be considered true neoplasms...
  10. pmc Autism-like socio-communicative deficits and stereotypies in mice lacking heparan sulfate
    Fumitoshi Irie
    Genetic Disease Program, Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 109:5052-6. 2012
    ..Our results demonstrate that heparan sulfate is critical for normal functioning of glutamatergic synapses and that its deficiency mediates socio-communicative deficits and stereotypies characteristic for autism...
  11. ncbi request reprint EPHB receptor signaling in dendritic spine development
    Fumitoshi Irie
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Front Biosci 9:1365-73. 2004
    ....
  12. ncbi request reprint Mammalian brain morphogenesis and midline axon guidance require heparan sulfate
    Masaru Inatani
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 302:1044-6. 2003
    ..Furthermore, the EXT1-null brain displayed severe guidance errors in major commissural tracts, revealing a pivotal role of HS in midline axon guidance. These findings demonstrate that HS is essential for mammalian brain development...
  13. pmc Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury
    Maryla Krajewska
    Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Rd La Jolla, CA 92037, USA
    Brain Res 1370:227-37. 2011
    ....