Research Topics
Species | Jay D IamsSummaryAffiliation: The Ohio State University Country: USA Publications
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Detail Information
Publications
Cervical funneling: effect on gestational length and ultrasound-indicated cerclage in high-risk womenMelissa S Mancuso
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Alabama, Birmingham, AL, USA
Am J Obstet Gynecol 203:259.e1-5. 2010..The purpose of this study was to assess funnel type and pregnancy duration in women with previous spontaneous preterm birth and cervical length <25 mm...
The epidemiology of preterm birthJay D Iams
Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, 1654 Upham Drive, Columbus, OH 43210, USA
Clin Perinatol 30:651-64. 2003..The epidemiologic characteristics of women who deliver their infants before term birth are clues to the cause of this most important obstetric problem...
Primary, secondary, and tertiary interventions to reduce the morbidity and mortality of preterm birthJay D Iams
Department of Obstetrics and Gynecology, Ohio State University, Columbus, OH, USA
Lancet 371:164-75. 2008..Advances in primary and secondary care, following strategies used for other complex health problems, such as cervical cancer, will be needed to prevent prematurity-related illness in infants and children...
Does midtrimester cervical length ≥25 mm predict preterm birth in high-risk women?John Owen
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Alabama, Birmingham, AL, USA
Am J Obstet Gynecol 203:393.e1-5. 2010..We sought to assess pregnancy outcome along a continuum of cervical lengths (CLs) ≥25 mm...
Omega-3 fatty acid supplementation to prevent recurrent preterm birth: a randomized controlled trialMargaret Harper
Department of Obstetrics and Gynecology, Wake Forest University Health Sciences, Winston Salem, North Carolina27157, USA
Obstet Gynecol 115:234-42. 2010..To assess whether the addition of an omega-3 long-chain polyunsaturated fatty acid supplement would reduce preterm birth in women with at least one prior spontaneous preterm birth receiving 17alpha-hydroxyprogesterone caproate...
17-alpha-hydroxyprogesterone caproate for the prevention of preterm birth in women with prior preterm birth and a short cervical lengthVincenzo Berghella
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA
Am J Obstet Gynecol 202:351.e1-6. 2010..We sought to evaluate 17-alpha-hydroxyprogesterone caproate (17P) for prevention of preterm birth (PTB) in women with prior spontaneous PTB (SPTB) and cervical length (CL) <25 mm...
Gestational age at previous preterm birth does not affect cerclage efficacyDeborah A Wing
Department of Obstetrics and Gynecology, University of California, Irvine, Irvine, CA, USA
Am J Obstet Gynecol 203:377.e1-4. 2010..The purpose of this study was to evaluate the effect of earliest previous spontaneous preterm birth (SPTB) gestational age on cervical length, pregnancy duration, and ultrasound-indicated cerclage efficacy in a subsequent gestation...
The rate of cervical change and the phenotype of spontaneous preterm birthJay D Iams
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA
Am J Obstet Gynecol 205:130.e1-6. 2011..This classification does not include prior cervical change. We hypothesized that the rate of cervical shortening before preterm birth would not differ according to clinical presentation...
The effect of 17-alpha hydroxyprogesterone caproate on the risk of gestational diabetes in singleton or twin pregnanciesCynthia Gyamfi
Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY, USA
Am J Obstet Gynecol 201:392.e1-5. 2009..To compare the rates of gestational diabetes among women who received serial doses of 17-alpha hydroxyprogesterone caproate vs placebo...
Suture type and ultrasound-indicated cerclage efficacyVincenzo Berghella
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Matern Fetal Neonatal Med 25:2287-90. 2012..To assess whether type of suture material affects cerclage efficacy for preterm birth (PTB) prevention...
Failed labor induction: toward an objective diagnosisDwight J Rouse
Brown University, Warren Alpert Medical School, Department of Obstetrics and Gynecology, Providence, RI 02905, USA
Obstet Gynecol 117:267-72. 2011..To evaluate maternal and perinatal outcomes in women undergoing labor induction with an unfavorable cervix according to duration of oxytocin administration in the latent phase of labor after ruptured membranes...
Association of fetal inflammation and coagulation pathway gene polymorphisms with neurodevelopmental delay at age 2 yearsErin A S Clark
Department of Obstetrics and Gynecology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
Am J Obstet Gynecol 203:83.e1-83.e10. 2010..The purpose of this study was to evaluate the association between fetal inflammation and coagulation gene single-nucleotide polymorphisms (SNPs) and neurodevelopmental delay at age 2 years...
Care for women with prior preterm birthJay D Iams
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The Ohio State University Medical Center, Columbus, OH
Am J Obstet Gynecol 203:89-100. 2010..Interventions including smoking cessation, eradication of asymptomatic bacteriuria, progestational agents, and cervical cerclage can reduce the risk of recurrent preterm birth when employed appropriately...
Cytokine gene polymorphisms and length of gestationMargaret Harper
Department of Obstetrics and Gynecology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
Obstet Gynecol 117:125-30. 2011..To estimate whether there is an association between length of gestation and gene polymorphisms that effect transcription of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), or interleukin-1β (IL-1β)...
Epstein-Barr virus reactivation during pregnancy and postpartum: effects of race and racial discriminationLisa M Christian
Department of Psychiatry, The Ohio State University Medical Center, Columbus, OH, USA
Brain Behav Immun 26:1280-7. 2012..This study examined associations of EBV virus capsid antigen immunoglobulin G (VCA IgG) with gestational stage, race, and racial discrimination in women during pregnancy and postpartum...
Second-stage labor duration in nulliparous women: relationship to maternal and perinatal outcomesDwight J Rouse
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA
Am J Obstet Gynecol 201:357.e1-7. 2009..The purpose of this study was to assess maternal and perinatal outcomes as a function of second-stage labor duration...
First-trimester prediction of preeclampsia in nulliparous women at low riskLeslie Myatt
Department of Obstetrics and Gynecology of the University of Cincinnati, Cincinnati, OH, USA
Obstet Gynecol 119:1234-42. 2012..To identify clinical characteristics and biochemical markers in first-trimester samples that would possibly predict the subsequent development of preeclampsia...
A trial of 17 alpha-hydroxyprogesterone caproate to prevent prematurity in twinsDwight J Rouse
Department of Obstetrics and Gynecology, Center for Women s Reproductive Health, University of Alabama at Birmingham, Birmingham 35249 7333, USA
N Engl J Med 357:454-61. 2007..In singleton gestations, 17 alpha-hydroxyprogesterone caproate (17P) has been shown to reduce the rate of recurrent preterm birth. This study was undertaken to evaluate whether 17P would reduce the rate of preterm birth in twin gestations...
Depressive symptoms predict exaggerated inflammatory responses to an in vivo immune challenge among pregnant womenLisa M Christian
Department of Psychiatry, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
Brain Behav Immun 24:49-53. 2010..The current study was designed to test the hypothesis that depressive symptoms would predict an exaggerated proinflammatory response to an in vivo antigen challenge, influenza virus vaccination, among pregnant women...
Multicenter randomized trial of cerclage for preterm birth prevention in high-risk women with shortened midtrimester cervical lengthJohn Owen
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35249 7333, USA
Am J Obstet Gynecol 201:375.e1-8. 2009..The objective of the study was to assess cerclage to prevent recurrent preterm birth in women with short cervix...
Is sonographic assessment of the cervix necessary and helpful?Joel D Larma
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, The Ohio State University, Columbus, Ohio, USA
Clin Obstet Gynecol 55:324-35. 2012....
Nomenclature for pregnancy outcomes: time for a changeRobert M Silver
Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
Obstet Gynecol 118:1402-8. 2011..In this article, we propose a more useful nomenclature for pregnancy loss and preterm births that is informative and is based on developmental periods in gestation and shared pathophysiology...
Epidemiology and causes of preterm birthRobert L Goldenberg
Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
Lancet 371:75-84. 2008..A short cervical length and a raised cervical-vaginal fetal fibronectin concentration are the strongest predictors of spontaneous preterm birth...
Proteomic identification of serum peptides predicting subsequent spontaneous preterm birthM Sean Esplin
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, 84132, USA
Am J Obstet Gynecol 204:391.e1-8. 2011..We sought to identify serum markers of subsequent spontaneous preterm birth (SPTB) in asymptomatic women prior to labor...
Cervical length measurement and cervical cerclage to prevent preterm birthMarvin Williams
Division of Maternal Fetal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Clin Obstet Gynecol 47:775-83; discussion 881-2. 2004
Inflammatory responses to trivalent influenza virus vaccine among pregnant womenLisa M Christian
Department of Psychiatry, The Ohio State University Medical Center, Columbus, OH 43210, United States
Vaccine 29:8982-7. 2011..Given the clinical and empirical justifications, the current study examined the magnitude, time course, and variance in inflammatory responses following seasonal influenza virus vaccination among pregnant women...
The effect of treatment with 17 alpha-hydroxyprogesterone caproate on changes in cervical length over timeCeleste P Durnwald
Department of Obstetrics and Gynecology, College of Medicine, The Ohio State University, Columbus, OH, USA
Am J Obstet Gynecol 201:410.e1-5. 2009....
Spontaneous late preterm births: what can be done to improve outcomes?Jay D Iams
Ohio Perinatal Quality Collaborative, The Ohio State University Medical Center, Columbus, OH, USA
Semin Perinatol 35:309-13. 2011..This article summarizes the factors contributing to late spontaneous preterm birth and offers suggestions to improve care for these mothers and infants...
A prospective masked observational study of uterine contraction frequency in twinsRoger B Newman
Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC, USA
Am J Obstet Gynecol 195:1564-70. 2006..Neither maximum am or pm contraction frequency predicted spontaneous preterm birth less than 35 weeks' gestation in twin pregnancies...
Nuclear factor-kappa B localization and function within intrauterine tissues from term and preterm labor and cultured fetal membranesSonali Vora
Laboratory of Perinatal Research, Department of Obstetrics and Gynecology, College of Medicine, The Ohio State University, Columbus, OH, USA
Reprod Biol Endocrinol 8:8. 2010....
What we have here is a failure to communicate: obstacles to optimal care for preterm birthJay D Iams
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The Ohio State University Medical Center, Columbus, OH 43210 1267, USA
Clin Perinatol 38:517-28. 2011..This article asserts that miscommunication between the specialties, fostered by separate definitions, metrics, and outcomes, is an impediment to optimal care. Solutions are suggested for improving communication and outcomes...
Goals and strategies for prevention of preterm birth: an obstetric perspectiveChristopher T Lang
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, The Ohio State University College of Medicine, Columbus, OH 43210, USA
Pediatr Clin North Am 56:537-63, Table of Contents. 2009..This review from a prenatal perspective confirms those concerns and describes the risks and opportunities that may attend efforts to improve the health of fetuses, newborns, and infants. Fetal and live-born outcomes are included...
The relationship between resolution of asymptomatic bacterial vaginosis and spontaneous preterm birth in fetal fibronectin-positive womenIsrael Hendler
Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Am J Obstet Gynecol 197:488.e1-5. 2007..The purpose of this study was to determine the impact of persistent bacterial vaginosis (BV) on the occurrence of spontaneous preterm birth (SPB) in women who test positive for fetal fibronectin...
The association of chronic endometritis with preterm birthEric J Knudtson
Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH, USA
Am J Obstet Gynecol 196:337.e1-4. 2007..The purpose of this study was to determine whether chronic endometritis (CE) that is diagnosed by endometrial biopsy is associated with preterm birth at <37 weeks of gestation...
Depressive symptoms are associated with elevated serum proinflammatory cytokines among pregnant womenLisa M Christian
Department of Psychiatry, The Ohio State University Medical Center, 1670 Upham Drive, Columbus, OH 43210, USA
Brain Behav Immun 23:750-4. 2009..These data are consistent with the contention that depressive symptoms may contribute to negative perinatal outcomes via inflammatory pathways...
Are women with recurrent spontaneous preterm births different from those without such history?Brian M Mercer
Department of Reproductive Biology, Case Western Reserve University, Cleveland, OH, USA
Am J Obstet Gynecol 194:1176-84; discussion 1184-5. 2006....
Metaanalysis vs large clinical trials: which should guide our management?Christina M Scifres
Department of Obstetrics and Gynecology, Washington University in St Louis School of Medicine, St Louis, MO, USA
Am J Obstet Gynecol 200:484.e1-5. 2009..We conclude that, when available, large randomized clinical trials should be used to guide clinical practice...
Rates of recurrent preterm birth by obstetrical history and cervical lengthCeleste P Durnwald
Division of Maternal Fetal Medicine, The Ohio State University, Columbus, OH, USA
Am J Obstet Gynecol 193:1170-4. 2005..Women with 2 prior preterm births and a cervix greater than 35 mm were at low risk for subsequent preterm birth less than 35 weeks...
Plasma CRH measurement at 16 to 20 weeks' gestation does not predict preterm delivery in women at high-risk for preterm deliveryBaha Sibai
Department of Obstetrics and Gynecology, University of Cincinnati School of Medicine, Cincinnati, OH 45267, USA
Am J Obstet Gynecol 193:1181-6. 2005..The purpose of this study was to examine the utility of a single second-trimester plasma corticotropin-releasing hormone measurement as a marker for preterm delivery in women at high risk for preterm delivery...
Prediction and early detection of preterm laborJay D Iams
Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio, USA
Obstet Gynecol 101:402-12. 2003..Current use of cervical length and fetal fibronectin in pregnancy is limited to situations where a negative result can avoid unnecessary interventions...
Vaginal sonography and cervical incompetenceJohn Owen
Maternal-Fetal Medicine Divisions, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, USA
Am J Obstet Gynecol 188:586-96. 2003..We believe that women with a prior early spontaneous preterm birth and shortened midtrimester cervical length represent an ideal population for the conduct of a randomized trial of cerclage, which is currently underway...
Endometrial endotoxin, assisted reproductive technology, and preterm birthJay D Iams
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio 43210-1228, USA
Fertil Steril 82:793-4. 2004..as an explanation for reduced fertility...
Frequency of uterine contractions in asymptomatic pregnant women with or without a short cervix on transvaginal ultrasound scanVincenzo Berghella
Departments of Obstetrics and Gynecology at Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, USA
Am J Obstet Gynecol 191:1253-6. 2004....
Progesterone for prevention of recurrent preterm birth: impact of gestational age at previous deliveryCatherine Y Spong
National Institute of Child Health and Human Development, Bethesda, MD, USA
Am J Obstet Gynecol 193:1127-31. 2005..CONCLUSION: 17-OHP caproate therapy given to prevent recurrent PTB is associated with a prolongation of pregnancy overall, and especially for women with a previous spontaneous PTB at <34 weeks...
The Preterm Prediction Study: association between maternal body mass index and spontaneous and indicated preterm birthIsrael Hendler
National Institute of Child Health and Human Development, Maternal Fetal Medicine Units Network, National Institutes of Health, Bethesda, MD, USA
Am J Obstet Gynecol 192:882-6. 2005..The purpose of this study was to evaluate the relationship between prepregnancy maternal body mass index and spontaneous preterm birth and indicated preterm birth...
Steering Committee of the Eunice Kennedy Shriver National Institute of Child Health and Human Development's (NICHD) Maternal-Fetal Medicine Units NetworkRobert Goldenberg
Am J Obstet Gynecol 199:e14-5. 2008
A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsyDwight J Rouse
University of Alabama at Birmingham, Birmingham, USA
N Engl J Med 359:895-905. 2008..Research suggests that fetal exposure to magnesium sulfate before preterm birth might reduce the risk of cerebral palsy...
Transdermal nitroglycerin for preterm laborJay D Iams
Am J Obstet Gynecol 196:4. 2007
