Shih Jen Hwang

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Germline p53 mutations in a cohort with childhood sarcoma: sex differences in cancer risk
    Shih Jen Hwang
    Section of Clinical Cancer Genetics, Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Hum Genet 72:975-83. 2003
  2. ncbi request reprint Lung cancer risk in germline p53 mutation carriers: association between an inherited cancer predisposition, cigarette smoking, and cancer risk
    Shih Jen Hwang
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, TX 77030, Houston, USA
    Hum Genet 113:238-43. 2003
  3. pmc Individual-specific liability groups in genetic linkage, with applications to kindreds with Li-Fraumeni syndrome
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Hum Genet 70:813-7. 2002
  4. ncbi request reprint Generation or birth cohort effect on cancer risk in Li-Fraumeni syndrome
    Barry W Brown
    Department of Biomathematics, Unit 237, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA
    Hum Genet 118:489-98. 2005
  5. ncbi request reprint The postmortem sociomedical interview: uncertainty in confirming infectious disease risks of young tattooed donors
    Mary Keirnan Scardino
    Lions Eye Bank of Texas, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Cornea 21:798-802. 2002
  6. ncbi request reprint Pachymetry of donor corneas: effect of ethnicity and gender on central corneal thickness
    Christopher L Hanna
    Lions Eye Bank of Texas, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USA
    Cornea 23:701-3. 2004
  7. ncbi request reprint A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
    Gareth L Bond
    Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    Cell 119:591-602. 2004
  8. pmc Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies
    Anna Kottgen
    Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
    BMC Med Genet 9:49. 2008
  9. pmc Chronic kidney disease as a predictor of cardiovascular disease (from the Framingham Heart Study)
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Bethesda, MD, USA
    Am J Cardiol 102:47-53. 2008
  10. pmc Overweight, obesity, and the development of stage 3 CKD: the Framingham Heart Study
    Meredith C Foster
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Am J Kidney Dis 52:39-48. 2008

Collaborators

Detail Information

Publications19

  1. pmc Germline p53 mutations in a cohort with childhood sarcoma: sex differences in cancer risk
    Shih Jen Hwang
    Section of Clinical Cancer Genetics, Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Hum Genet 72:975-83. 2003
    ..These results quantitatively illustrated the spectrum of cancer risk in germline p53 mutation carriers and will provide valuable reference for the evaluation and treatment of patients with cancer...
  2. ncbi request reprint Lung cancer risk in germline p53 mutation carriers: association between an inherited cancer predisposition, cigarette smoking, and cancer risk
    Shih Jen Hwang
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, TX 77030, Houston, USA
    Hum Genet 113:238-43. 2003
    ..This finding could be useful in designing strategies for early detection and treatment of lung and smoking-related cancers in individuals with this inherited cancer predisposition...
  3. pmc Individual-specific liability groups in genetic linkage, with applications to kindreds with Li-Fraumeni syndrome
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Hum Genet 70:813-7. 2002
    ..Application of our method to these families yielded significantly higher LOD scores and more-accurate recombination fractions than did analysis that did not account for individual-specific covariate information...
  4. ncbi request reprint Generation or birth cohort effect on cancer risk in Li-Fraumeni syndrome
    Barry W Brown
    Department of Biomathematics, Unit 237, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA
    Hum Genet 118:489-98. 2005
    ..The apparent lack of increase in incidence in noncarriers argues against a cohort effect explaining the increase in carriers...
  5. ncbi request reprint The postmortem sociomedical interview: uncertainty in confirming infectious disease risks of young tattooed donors
    Mary Keirnan Scardino
    Lions Eye Bank of Texas, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Cornea 21:798-802. 2002
    ....
  6. ncbi request reprint Pachymetry of donor corneas: effect of ethnicity and gender on central corneal thickness
    Christopher L Hanna
    Lions Eye Bank of Texas, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USA
    Cornea 23:701-3. 2004
    ..To examine demographic differences associated with the central corneal thickness (CCT) of donor corneas and to investigate whether these differences confirmed previous clinical studies...
  7. ncbi request reprint A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
    Gareth L Bond
    Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    Cell 119:591-602. 2004
    ..In humans, SNP309 is shown to associate with accelerated tumor formation in both hereditary and sporadic cancers. A model is proposed whereby SNP309 serves as a rate-limiting event in carcinogenesis...
  8. pmc Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies
    Anna Kottgen
    Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
    BMC Med Genet 9:49. 2008
    ..The study of 70,987 single nucleotide polymorphisms (SNPs) in 1,010 FHS participants provides a list of SNPs showing the strongest associations with renal traits which need to be verified in independent study samples...
  9. pmc Chronic kidney disease as a predictor of cardiovascular disease (from the Framingham Heart Study)
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Bethesda, MD, USA
    Am J Cardiol 102:47-53. 2008
    ..004 for interaction). Stage 3b CKD was associated with CVD, but was not a CVD risk equivalent. In conclusion, CVD risk in the setting of CKD is higher in the setting of low high-density lipoprotein cholesterol...
  10. pmc Overweight, obesity, and the development of stage 3 CKD: the Framingham Heart Study
    Meredith C Foster
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Am J Kidney Dis 52:39-48. 2008
    ..Prior research yielded conflicting results about the magnitude of the association between body mass index (BMI) and chronic kidney disease (CKD)...
  11. pmc Parental obesity and offspring serum alanine and aspartate aminotransferase levels: the Framingham heart study
    Rohit Loomba
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
    Gastroenterology 134:953-9. 2008
    ..We sought to examine the relations between parental obesity and the serum ALT and AST levels among offspring in a community-based sample...
  12. pmc A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study
    Joanne M Murabito
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S6. 2007
    ..Breast and prostate cancer are two commonly diagnosed cancers in the United States. Prior work suggests that cancer causing genes and cancer susceptibility genes can be identified...
  13. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
    ..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes...
  14. pmc Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study
    Christopher J O'Donnell
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S4. 2007
    ..We conducted a genome-wide association study (GWAS) for SCA measurements in the community-based Framingham Heart Study...
  15. pmc Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
    Daniel Levy
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S3. 2007
    ..Increased arterial stiffness is a key factor in the pathogenesis of systolic hypertension and cardiovascular disease. Substantial heritability of blood-pressure (BP) and arterial-stiffness suggests important genetic contributions...
  16. pmc A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study
    Shih Jen Hwang
    National Heart Lung and Blood Institutes, Bethesda, MD, USA
    BMC Med Genet 8:S10. 2007
    ..Many endocrine conditions have strong familial components. We tested for association between the Affymetrix GeneChip Human Mapping 100K single nucleotide polymorphism (SNP) set and measures of kidney function and endocrine traits...
  17. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  18. ncbi request reprint Parental occurrence of premature cardiovascular disease predicts increased coronary artery and abdominal aortic calcification in the Framingham Offspring and Third Generation cohorts
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:1473-81. 2007
    ..We related validated parental premature CVD with the subclinical measures of coronary artery (CAC) and abdominal aortic (AAC) calcification in the community...
  19. pmc TCF7L2 variants associate with CKD progression and renal function in population-based cohorts
    Anna Kottgen
    Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Soc Nephrol 19:1989-99. 2008
    ..In conclusion, several population-based samples suggest that variants in the TCF7L2 gene are associated with reduced kidney function or CKD progression, overall and specifically among participants without diabetes...