TONY R HUNTER

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. ncbi request reprint The age of crosstalk: phosphorylation, ubiquitination, and beyond
    Tony Hunter
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Mol Cell 28:730-8. 2007
  2. pmc Why nature chose phosphate to modify proteins
    Tony Hunter
    Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Philos Trans R Soc Lond B Biol Sci 367:2513-6. 2012
  3. pmc PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture
    Gray W Pearson
    Molecular and Cell Biology Laboratory, Salk Institute, La Jolla, CA 92037, USA
    Breast Cancer Res 11:R29. 2009
  4. pmc Genic regions of a large salamander genome contain long introns and novel genes
    Jeramiah J Smith
    Department of Biology and Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40506, USA
    BMC Genomics 10:19. 2009
  5. pmc Microarray and cDNA sequence analysis of transcription during nerve-dependent limb regeneration
    James R Monaghan
    Department of Biology and Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40506, USA
    BMC Biol 7:1. 2009
  6. pmc Treatment for chronic myelogenous leukemia: the long road to imatinib
    Tony Hunter
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
    J Clin Invest 117:2036-43. 2007
  7. ncbi request reprint A not so brief history of the Oncogene Meeting and its cartoons
    T Hunter
    The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Oncogene 26:1260-7. 2007
  8. ncbi request reprint CaMKII structure--an elegant design
    Tony Hunter
    Molecular and Cell Biology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 123:765-7. 2005
  9. ncbi request reprint The discovery of tyrosine phosphorylation: it's all in the buffer!
    Tony Hunter
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Cell 116:S35-9, 1 p following S48. 2004
  10. ncbi request reprint Tyrosine phosphorylation in cell signaling and disease
    Tony Hunter
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Keio J Med 51:61-71. 2002

Collaborators

Detail Information

Publications72

  1. ncbi request reprint The age of crosstalk: phosphorylation, ubiquitination, and beyond
    Tony Hunter
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Mol Cell 28:730-8. 2007
    ..Particularly prominent are the multiple connections between phosphorylation and ubiquitination, which act either positively or negatively in both directions to regulate these processes...
  2. pmc Why nature chose phosphate to modify proteins
    Tony Hunter
    Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Philos Trans R Soc Lond B Biol Sci 367:2513-6. 2012
    ..In this manner, phosphorylation serves as a switch that allows signal transduction networks to transmit signals in response to extracellular stimuli...
  3. pmc PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture
    Gray W Pearson
    Molecular and Cell Biology Laboratory, Salk Institute, La Jolla, CA 92037, USA
    Breast Cancer Res 11:R29. 2009
    ..However, our limited understanding of the underlying molecular mechanisms of early-stage epithelial tumor growth has hampered the development of new forms treatment and preventative therapy...
  4. pmc Genic regions of a large salamander genome contain long introns and novel genes
    Jeramiah J Smith
    Department of Biology and Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40506, USA
    BMC Genomics 10:19. 2009
    ..Sixteen BAC clones from the Mexican axolotl (Ambystoma mexicanum: c-value = 32 x 10(9) bp) were isolated and sequenced to characterize the structure of genic regions...
  5. pmc Microarray and cDNA sequence analysis of transcription during nerve-dependent limb regeneration
    James R Monaghan
    Department of Biology and Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40506, USA
    BMC Biol 7:1. 2009
    ..Innervated (NR) and denervated (DL) forelimbs of Mexican axolotls were amputated and transcripts were sampled after 0, 5, and 14 days of regeneration...
  6. pmc Treatment for chronic myelogenous leukemia: the long road to imatinib
    Tony Hunter
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
    J Clin Invest 117:2036-43. 2007
    ....
  7. ncbi request reprint A not so brief history of the Oncogene Meeting and its cartoons
    T Hunter
    The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Oncogene 26:1260-7. 2007
  8. ncbi request reprint CaMKII structure--an elegant design
    Tony Hunter
    Molecular and Cell Biology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 123:765-7. 2005
    ..This study provides new mechanistic insights into the workings of this finely tuned molecular machine...
  9. ncbi request reprint The discovery of tyrosine phosphorylation: it's all in the buffer!
    Tony Hunter
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Cell 116:S35-9, 1 p following S48. 2004
  10. ncbi request reprint Tyrosine phosphorylation in cell signaling and disease
    Tony Hunter
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Keio J Med 51:61-71. 2002
  11. pmc Tyrosine phosphorylation: thirty years and counting
    Tony Hunter
    The Salk Institute, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 21:140-6. 2009
    ..The following is a brief personal reflection on some of the salient findings over the past 30 years that led to the development of tyrosine kinase inhibitors for disease therapy...
  12. ncbi request reprint The protein kinases of budding yeast: six score and more
    T Hunter
    Salk Institute, La Jolla, CA 92037, USA
    Trends Biochem Sci 22:18-22. 1997
    ..As a consequence, we now know exactly how many protein kinases are encoded by the yeast genome, a number of considerable interest because of the importance of protein phosphorylation in the control of so many cellular processes...
  13. ncbi request reprint p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
    H Toyoshima
    Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, California 92037
    Cell 78:67-74. 1994
    ..p27 is identical to p27Kip1, a cyclin-Cdk inhibitor present in TGF beta-treated cells. p27 has the hallmarks of a negative regulator of G1 progression and may mediate TGF beta-induced G1 arrest...
  14. ncbi request reprint Activation of protein kinase C stimulates the dephosphorylation of natriuretic peptide receptor-B at a single serine residue: a possible mechanism of heterologous desensitization
    L R Potter
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Biol Chem 275:31099-106. 2000
    ....
  15. pmc Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle
    N Watanabe
    Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    EMBO J 14:1878-91. 1995
    ..These results suggest that the activity of WEE1Hu is regulated by phosphorylation and proteolytic degradation, and that WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2...
  16. ncbi request reprint Identification and characterization of the phosphorylation sites of the guanylyl cyclase-linked natriuretic peptide receptors A and B
    L R Potter
    Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California, 92037, USA
    Methods 19:506-20. 1999
    ..In this review, we give a detailed description of the phosphopeptide mapping techniques that were used to identify and characterize these sites and discuss the potential pitfalls that are associated with them...
  17. ncbi request reprint The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
    C A Joazeiro
    The Salk Institute, Molecular Biology and Virology Laboratory, La Jolla, CA 92037, USA
    Science 286:309-12. 1999
    ..These results reveal an SH2-containing protein that functions as a ubiquitin-protein ligase and thus provide a distinct mechanism for substrate targeting in the ubiquitin system...
  18. ncbi request reprint A human peptidyl-prolyl isomerase essential for regulation of mitosis
    K P Lu
    Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Nature 380:544-7. 1996
    ..Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity...
  19. pmc CBP/p300 interact with and function as transcriptional coactivators of BRCA1
    G M Pao
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 97:1020-5. 2000
    ..Immunocolocalization analyses suggest that BRCA1 and p300 associate in a cell cycle-dependent manner. Our results support a role for BRCA1 in transcription...
  20. ncbi request reprint Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent
    R Ranganathan
    Structural Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Cell 89:875-86. 1997
    ..This raises the possibility of phosphorylation-mediated control of Pin1-substrate interactions in cell cycle regulation...
  21. ncbi request reprint C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival
    M Buck
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Mol Cell 8:807-16. 2001
    ..C/EBPbeta-/- and C/EBPbeta-Ala(217) stellate cells were rescued from apoptosis by the cell permeant KE(217)VD tetrapeptide or C/EBPbeta-Glu(217)...
  22. ncbi request reprint Induction of growth arrest and cell death by overexpression of the cyclin-Cdk inhibitor p21 in hamster BHK21 cells
    T Sekiguchi
    Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Oncogene 16:369-80. 1998
    ..Increased binding of p21 to PCNA and cyclin D1-Cdk4 was detected in induced cells. Overexpression of p21 led to cell death in BHK21 cells at 39.5 degrees C within 4 days...
  23. pmc MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates
    R Fukunaga
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    EMBO J 16:1921-33. 1997
    ..Together, these results indicate that MNK1 is a novel class of protein kinase that is activated through both the ERK and p38 MAP kinase signaling pathways...
  24. pmc An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway
    J Moniakis
    Section of Cell and Developmental Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0634, USA
    Genes Dev 15:687-98. 2001
    ..Consistent with such functions, SHK1 is localized at the plasma membrane/cortex, and we show that its SH2 domain is required for this localization and the proper function of SHK1...
  25. ncbi request reprint Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin
    R Y Poon
    Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
    Science 270:90-3. 1995
    ..These results suggest that KAP binds to Cdk2 and dephosphorylates Thr160 when the associated cyclin subunit is degraded or dissociates...
  26. ncbi request reprint Dependence of cyclin E-CDK2 kinase activity on cell anchorage
    F Fang
    La Jolla Cancer Research Foundation, Cancer Center, CA 92037, USA
    Science 271:499-502. 1996
    ..Suppression of cyclin E-CDK2 activity may thus underlie the anchorage dependence of cell growth...
  27. ncbi request reprint Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells
    G Orend
    La Jolla Cancer Research Center, The Burnham Institute, California 92037, USA
    Oncogene 16:2575-83. 1998
    ....
  28. ncbi request reprint Structural basis for phosphoserine-proline recognition by group IV WW domains
    M A Verdecia
    Structural Biology Laboratory, University of California, San Diego, La Jolla, California 92093, USA
    Nat Struct Biol 7:639-43. 2000
    ..Ser. The lack of widespread conservation of the Arg and Ser residues responsible for P.Ser recognition in the WW domain family suggests that only a subset of WW domains can bind P.Ser-Pro in a similar fashion to that of Pin1...
  29. pmc Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation
    R Y Poon
    Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
    Mol Biol Cell 6:1197-213. 1995
    ..It is likely that a similar principle of redistribution of p27 is used by the cell in other instances of cell cycle arrest...
  30. pmc Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases
    D D Schlaepfer
    Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Cell Biol 16:5623-33. 1996
    ..In Src-transformed cells, this pathway may be constitutively activated as a result of FAK Tyr-925 phosphorylation in the absence of integrin stimulation...
  31. pmc BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site
    H Ruffner
    The Salk Institute, La Jolla, California 92037, USA
    Mol Cell Biol 19:4843-54. 1999
    ..These results suggest that the endogenous kinase activity is composed of CDK2-cyclin complexes, at least in part, concordant with the G1/S-specific increase in BRCA1 phosphorylation...
  32. pmc Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha
    M Buck
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    EMBO J 20:6712-23. 2001
    ..Treatment of TNF-alpha mice with antioxidants or NOS inhibitors prevented phosphorylation of C/EBPbeta on Ser239 and its nuclear export, and rescued the abnormal albumin gene expression...
  33. ncbi request reprint Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement
    M A Verdecia
    Structural Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Struct Biol 7:602-8. 2000
    ....
  34. pmc Convergence of MAP kinase pathways on the ternary complex factor Sap-1a
    R Janknecht
    Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    EMBO J 16:1620-7. 1997
    ..However, signaling from p38 MAP kinase to Sap-1a or from Sap-1a to the basal transcription machinery does not occur in all cell types nor at promoters other than the c-fos SRE, which may ensure the specificity of signaling...
  35. pmc Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins
    D D Schlaepfer
    Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Cell Biol 17:1702-13. 1997
    ..These results show that there are additional FN-stimulated pathways to ERK2 that do not involve Grb2 binding to FAK...
  36. ncbi request reprint The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression
    N J Wells
    Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    J Cell Sci 112:3361-71. 1999
    ....
  37. pmc DFak56 is a novel Drosophila melanogaster focal adhesion kinase
    R H Palmer
    Salk Institute, Molecular Biology and Virology Laboratory, La Jolla, California 92037 1099, USA
    J Biol Chem 274:35621-9. 1999
    ..Our results imply a role for DFak56 in adhesion-dependent signaling pathways in vivo during D. melanogaster development...
  38. pmc The APC11 RING-H2 finger mediates E2-dependent ubiquitination
    J D Leverson
    Molecular Biology and Virology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Mol Biol Cell 11:2315-25. 2000
    ..We suggest that Apc11p is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo...
  39. pmc Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
    W H Biggs
    The Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093 0660, USA
    Proc Natl Acad Sci U S A 96:7421-6. 1999
    ..These results indicate that phosphorylation by PKB/Akt negatively regulates FKHR1 by promoting export from the nucleus...
  40. ncbi request reprint The PDGF receptor phosphorylates Tyr 138 in the c-Src SH3 domain in vivo reducing peptide ligand binding
    M A Broome
    Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Oncogene 14:17-34. 1997
    ..However, Tyr 138 phosphorylation was found to diminish SH3 domain peptide ligand binding ability in vitro...
  41. ncbi request reprint Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage
    R Y Poon
    Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Biol Chem 271:13283-91. 1996
    ..It is likely that these underlying mechanisms that inactivate CDKs are similar for other kinds of DNA damage...
  42. ncbi request reprint atpk1, a novel ribosomal protein kinase gene from Arabidopsis. I. Isolation, characterization, and expression
    S H Zhang
    Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037
    J Biol Chem 269:17586-92. 1994
    ..The first intron of atpk1 functions as an enhancer in atpk1 expression...
  43. ncbi request reprint The receptor-like protein-tyrosine phosphatase, RPTP alpha, is phosphorylated by protein kinase C on two serines close to the inner face of the plasma membrane
    S Tracy
    Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, California 92037, USA
    J Biol Chem 270:10587-94. 1995
    ..Our results suggest that activation of PKC by cytokines modulates RPTP alpha function in several different ways...
  44. ncbi request reprint Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization
    A M Bilwes
    Structural Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 382:555-9. 1996
    ....
  45. pmc Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo
    J den Hertog
    Salk Institute, Molecular Biology and Virology Laboratory, La Jolla, CA 92037
    EMBO J 13:3020-32. 1994
    ..Our results suggest a role for RPTP alpha in attenuation of GRB2-mediated signaling...
  46. ncbi request reprint Identification of functional domains in the neuronal Cdk5 activator protein
    R Y Poon
    Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Biol Chem 272:5703-8. 1997
    ..Residues approximately 150-200 of p35 were sufficient for binding to Cdk5, but residues approximately 279-291 were needed in addition for activation of Cdk5 in vitro...
  47. ncbi request reprint A mouse cdc25 homolog is differentially and developmentally expressed
    A Kakizuka
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037
    Genes Dev 6:578-90. 1992
    ..We suggest that the expression and accumulation of the cdc25 mitotic inducer may play a critical role in the regulation of mouse development...
  48. ncbi request reprint Isolation and characterization of the Pin1/Ess1p homologue in Schizosaccharomyces pombe
    H K Huang
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    J Cell Sci 114:3779-88. 2001
    ..Our genetic data also suggest that Pin1p might function as a positive regulator of Cdc25p and Wee1p...
  49. ncbi request reprint Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1
    B H Jiang
    Department of Molecular and Experimental Medicine, BCC239, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell Growth Differ 12:363-9. 2001
    ..Vascular endothelial growth factor reporter gene activity was also inhibited by expression of a dominant negative PI3K construct and by the tumor suppressor PTEN...
  50. pmc The budding yeast HRR25 gene product is a casein kinase I isoform
    A J DeMaggio
    Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 89:7008-12. 1992
    ..The identity between Hrr25p and bovine CKI suggests that Hrr25p is a yeast isoform of the CKI family and that CKIs may play a role in regulating DNA metabolism...
  51. ncbi request reprint The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells
    K P Lu
    Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, California 92037, USA
    Prog Cell Cycle Res 1:187-205. 1995
    ..Thus, NIMA may represent a new essential eukaryotic cell cycle regulator, although its homologues in other species are yet to be identified...
  52. pmc Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase
    D M Friedrichsen
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Plant Physiol 123:1247-56. 2000
    ..Therefore, we conclude that BRI1 is a ubiquitously expressed leucine-rich repeat receptor that plays a role in BR signaling through Ser/Thr phosphorylation...
  53. ncbi request reprint Biochemistry. Ubiquitination--more than two to tango
    C A Joazeiro
    Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, CA 92037, USA
    Science 289:2061-2. 2000
    ..In their Perspective, Joazeiro and Hunter discuss new structural findings that reveal the part played by an E3 called c-Cbl in this ubiquitinating process...
  54. ncbi request reprint D-type cyclin expression is decreased and p21 and p27 CDK inhibitor expression is increased when tsBN462 CCG1/TAFII250 mutant cells arrest in G1 at the restrictive temperature
    T Sekiguchi
    Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, CA 92037, USA
    Genes Cells 1:687-705. 1996
    ..5 degrees C, due to a point mutation in the CCG1/TAFII250 gene, which encodes a component of the general transcription factor TFIID...
  55. pmc Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events
    D D Schlaepfer
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Cell Biol 18:2571-85. 1998
    ....
  56. ncbi request reprint Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility
    P Blume-Jensen
    Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California, USA
    Nat Genet 24:157-62. 2000
    ..It provides the first in vivo model for male sterility caused by a discrete signalling pathway defect affecting early germ cells...
  57. ncbi request reprint Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha
    M Buck
    Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Cell 4:1087-92. 1999
    ..Thus, a site-specific phosphorylation of the transcription factor C/EBP beta is critical for hepatocyte proliferation induced by TGF alpha and other stimuli that activate RSK...
  58. pmc Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
    W Jiang
    Molecular Biology and Virology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 96:6193-8. 1999
    ....
  59. pmc A constitutively "phosphorylated" guanylyl cyclase-linked atrial natriuretic peptide receptor mutant is resistant to desensitization
    L R Potter
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Biol Cell 10:1811-20. 1999
    ..These data provide the first direct test of the requirement for dephosphorylation in guanylyl cyclase desensitization and they indicate that it is an essential component of this process...
  60. ncbi request reprint Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha
    G Jiang
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 401:606-10. 1999
    ..Our results suggest that RPTPalpha activity can in principle be negatively regulated by dimerization in vivo...
  61. pmc Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication
    W Jiang
    The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    EMBO J 18:5703-13. 1999
    ..These results indicate that the HsCdc7-HsDbf4 kinase is directly involved in regulating the initiation of DNA replication by targeting MCM2 protein in mammalian cells...
  62. ncbi request reprint Phosphorylation and spindle pole body localization of the Cdc15p mitotic regulatory protein kinase in budding yeast
    S Xu
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla 92037, USA
    Curr Biol 10:329-32. 2000
    ..At the end of telophase, a portion of Cdc15p is located at the mother-bud neck, suggesting a possible role for Cdc15p in cytokinesis...
  63. ncbi request reprint Determination of phosphorylation sites in peptides and proteins employing a volatile Edman reagent
    W H Fischer
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, California 92037, USA
    J Protein Chem 16:329-34. 1997
    ..The protocol was employed to identify the site of phosphorylation in phosphoserine- and phosphotyrosine-containing peptides...
  64. ncbi request reprint Identification and characterization of the major phosphorylation sites of the B-type natriuretic peptide receptor
    L R Potter
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Biol Chem 273:15533-9. 1998
    ..These data indicate that phosphorylation of the kinase homology domain is a critical event in the regulation of NPR-B...
  65. ncbi request reprint Inhibition of c-Abl tyrosine kinase activity by filamentous actin
    P J Woodring
    Salk Institute, La Jolla, California 92037 1099, USA
    J Biol Chem 276:27104-10. 2001
    ..Taken together, the data suggest that F-actin is an inhibitor of the c-Abl tyrosine kinase and that this inhibition contributes in part to the reduced Abl kinase activity in detached cells...
  66. ncbi request reprint Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury
    T Herdegen
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0636, USA
    J Neurosci 18:5124-35. 1998
    ..These results demonstrate that lasting c-Jun S73 phosphorylation and JNK activity are part of neuronal stress response after neurodegenerative disorders in the adult mammalian brain with Fas-ligand as a putative apoptotic effector...
  67. ncbi request reprint Oncogenic kinase signalling
    P Blume-Jensen
    The Salk Institute, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 411:355-65. 2001
    ....
  68. ncbi request reprint The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136
    P Blume-Jensen
    Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, California 92037, USA
    Curr Biol 8:779-82. 1998
    ..Such a mechanism may account for how deregulated PI 3-kinase activity and naturally occurring gain-of-function point mutants of Kit/SCF-R lead to cellular transformation and fatal malignancies in man...
  69. pmc Phosphorylation of the kinase homology domain is essential for activation of the A-type natriuretic peptide receptor
    L R Potter
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Cell Biol 18:2164-72. 1998
    ..We conclude that phosphorylation of the KHD is absolutely required for hormone-dependent activation of NPR-A...
  70. pmc TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300
    R Janknecht
    Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California 92037 USA
    Genes Dev 12:2114-9. 1998
    ..Thus, CBP/p300 are important components of activin/TGF-beta signaling and may mediate the antioncogenic functions of Smad2 and Smad4...
  71. pmc Identification and characterization of a human protein kinase related to budding yeast Cdc7p
    W Jiang
    Molecular Biology and Virology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 94:14320-5. 1997
    ..These results, together with the functions of Cdc7p in yeast, suggest that HsCdc7 may phosphorylate critical substrate(s) that regulate the G1/S phase transition and/or DNA replication in mammalian cells...
  72. pmc Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity
    H Ruffner
    The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:5134-9. 2001
    ..Furthermore, we propose that the analysis of the Ub ligase activity of RING-domain mutations identified in patients may constitute an assay to predict predisposition to cancer...

Research Grants28

  1. SOMATIC CELL CYCLE REGULATION BY PHOSPHORYLATION
    Tony Hunter; Fiscal Year: 2007
    ..abstract_text> ..
  2. Checkpoint Kinase Chk1 in Cancer Biology and Therapy
    Tony Hunter; Fiscal Year: 2007
    ....
  3. SIGNAL TRANSDUCTION BY TYROSINE PHOSPHORYLATION
    Tony Hunter; Fiscal Year: 2007
    ..abstract_text> ..
  4. Checkpoint Kinase Chk1 in Cancer Biology and Therapy
    Tony Hunter; Fiscal Year: 2009
    ....
  5. SOMATIC CELL CYCLE REGULATION BY PHOSPHORYLATION
    Tony Hunter; Fiscal Year: 2009
    ..Since many cancer therapeutics kill cancer cells by eliciting DNA damage, our studies will also provide insights into the sensitivity of cancer cells to these agents, and suggest ways to improve their use. ..
  6. Checkpoint Kinase Chk1 in Cancer Biology and Therapy
    TONY R HUNTER; Fiscal Year: 2010
    ....
  7. SOMATIC CELL CYCLE REGULATION BY PHOSPHORYLATION
    TONY R HUNTER; Fiscal Year: 2010
    ..Since many cancer therapeutics kill cancer cells by eliciting DNA damage, our studies will also provide insights into the sensitivity of cancer cells to these agents, and suggest ways to improve their use. ..
  8. SOMATIC CELL CYCLE REGULATION BY PHOSPHORYLATION
    Tony Hunter; Fiscal Year: 2003
    ..Perturbation of cell cycle control is a hallmark of cancer cells, and these studies will contribute to our understanding of mechanisms of oncogenesis. ..
  9. SIGNAL TRANSDUCTION BY TYROSINE PHOSPHORYLATION
    TONY R HUNTER; Fiscal Year: 2010
    ....