Research Topics
Genomes and Genes | TONY R HUNTERSummaryAffiliation: The Salk Institute Country: USA Publications
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Publications
Why nature chose phosphate to modify proteinsTony Hunter
Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Philos Trans R Soc Lond B Biol Sci 367:2513-6. 2012..In this manner, phosphorylation serves as a switch that allows signal transduction networks to transmit signals in response to extracellular stimuli...- PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architectureGray W Pearson
Molecular and Cell Biology Laboratory, Salk Institute, La Jolla, CA 92037, USA
Breast Cancer Res 11:R29. 2009..However, our limited understanding of the underlying molecular mechanisms of early-stage epithelial tumor growth has hampered the development of new forms treatment and preventative therapy... - Genic regions of a large salamander genome contain long introns and novel genesJeramiah J Smith
Department of Biology and Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40506, USA
BMC Genomics 10:19. 2009..Sixteen BAC clones from the Mexican axolotl (Ambystoma mexicanum: c-value = 32 x 10(9) bp) were isolated and sequenced to characterize the structure of genic regions... - Microarray and cDNA sequence analysis of transcription during nerve-dependent limb regenerationJames R Monaghan
Department of Biology and Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40506, USA
BMC Biol 7:1. 2009..Innervated (NR) and denervated (DL) forelimbs of Mexican axolotls were amputated and transcripts were sampled after 0, 5, and 14 days of regeneration... - Treatment for chronic myelogenous leukemia: the long road to imatinibTony Hunter
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
J Clin Invest 117:2036-43. 2007.... 
The age of crosstalk: phosphorylation, ubiquitination, and beyondTony Hunter
The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Mol Cell 28:730-8. 2007..Particularly prominent are the multiple connections between phosphorylation and ubiquitination, which act either positively or negatively in both directions to regulate these processes...- A not so brief history of the Oncogene Meeting and its cartoonsT Hunter
The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Oncogene 26:1260-7. 2007 - CaMKII structure--an elegant designTony Hunter
Molecular and Cell Biology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell 123:765-7. 2005..This study provides new mechanistic insights into the workings of this finely tuned molecular machine... - The discovery of tyrosine phosphorylation: it's all in the buffer!Tony Hunter
Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Cell 116:S35-9, 1 p following S48. 2004 - Tyrosine phosphorylation in cell signaling and diseaseTony Hunter
The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Keio J Med 51:61-71. 2002 - Tyrosine phosphorylation: thirty years and countingTony Hunter
The Salk Institute, La Jolla, CA 92037, USA
Curr Opin Cell Biol 21:140-6. 2009..The following is a brief personal reflection on some of the salient findings over the past 30 years that led to the development of tyrosine kinase inhibitors for disease therapy... - The protein kinases of budding yeast: six score and moreT Hunter
Salk Institute, La Jolla, CA 92037, USA
Trends Biochem Sci 22:18-22. 1997..As a consequence, we now know exactly how many protein kinases are encoded by the yeast genome, a number of considerable interest because of the importance of protein phosphorylation in the control of so many cellular processes... - p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21H Toyoshima
Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, California 92037
Cell 78:67-74. 1994..p27 is identical to p27Kip1, a cyclin-Cdk inhibitor present in TGF beta-treated cells. p27 has the hallmarks of a negative regulator of G1 progression and may mediate TGF beta-induced G1 arrest... - Activation of protein kinase C stimulates the dephosphorylation of natriuretic peptide receptor-B at a single serine residue: a possible mechanism of heterologous desensitizationL R Potter
Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Biol Chem 275:31099-106. 2000.... - Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycleN Watanabe
Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
EMBO J 14:1878-91. 1995..These results suggest that the activity of WEE1Hu is regulated by phosphorylation and proteolytic degradation, and that WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2... - Identification and characterization of the phosphorylation sites of the guanylyl cyclase-linked natriuretic peptide receptors A and BL R Potter
Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California, 92037, USA
Methods 19:506-20. 1999..In this review, we give a detailed description of the phosphopeptide mapping techniques that were used to identify and characterize these sites and discuss the potential pitfalls that are associated with them... - The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligaseC A Joazeiro
The Salk Institute, Molecular Biology and Virology Laboratory, La Jolla, CA 92037, USA
Science 286:309-12. 1999..These results reveal an SH2-containing protein that functions as a ubiquitin-protein ligase and thus provide a distinct mechanism for substrate targeting in the ubiquitin system... - A human peptidyl-prolyl isomerase essential for regulation of mitosisK P Lu
Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California 92037, USA
Nature 380:544-7. 1996..Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity... - CBP/p300 interact with and function as transcriptional coactivators of BRCA1G M Pao
Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 97:1020-5. 2000..Immunocolocalization analyses suggest that BRCA1 and p300 associate in a cell cycle-dependent manner. Our results support a role for BRCA1 in transcription... - Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependentR Ranganathan
Structural Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Cell 89:875-86. 1997..This raises the possibility of phosphorylation-mediated control of Pin1-substrate interactions in cell cycle regulation... - C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survivalM Buck
Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Mol Cell 8:807-16. 2001..C/EBPbeta-/- and C/EBPbeta-Ala(217) stellate cells were rescued from apoptosis by the cell permeant KE(217)VD tetrapeptide or C/EBPbeta-Glu(217)... - Induction of growth arrest and cell death by overexpression of the cyclin-Cdk inhibitor p21 in hamster BHK21 cellsT Sekiguchi
Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California 92037, USA
Oncogene 16:369-80. 1998..Increased binding of p21 to PCNA and cyclin D1-Cdk4 was detected in induced cells. Overexpression of p21 led to cell death in BHK21 cells at 39.5 degrees C within 4 days... - MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substratesR Fukunaga
Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
EMBO J 16:1921-33. 1997..Together, these results indicate that MNK1 is a novel class of protein kinase that is activated through both the ERK and p38 MAP kinase signaling pathways... - An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathwayJ Moniakis
Section of Cell and Developmental Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0634, USA
Genes Dev 15:687-98. 2001..Consistent with such functions, SHK1 is localized at the plasma membrane/cortex, and we show that its SH2 domain is required for this localization and the proper function of SHK1... - Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclinR Y Poon
Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
Science 270:90-3. 1995..These results suggest that KAP binds to Cdk2 and dephosphorylates Thr160 when the associated cyclin subunit is degraded or dissociates... - Dependence of cyclin E-CDK2 kinase activity on cell anchorageF Fang
La Jolla Cancer Research Foundation, Cancer Center, CA 92037, USA
Science 271:499-502. 1996..Suppression of cyclin E-CDK2 activity may thus underlie the anchorage dependence of cell growth... - Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cellsG Orend
La Jolla Cancer Research Center, The Burnham Institute, California 92037, USA
Oncogene 16:2575-83. 1998.... - Structural basis for phosphoserine-proline recognition by group IV WW domainsM A Verdecia
Structural Biology Laboratory, University of California, San Diego, La Jolla, California 92093, USA
Nat Struct Biol 7:639-43. 2000..Ser. The lack of widespread conservation of the Arg and Ser residues responsible for P.Ser recognition in the WW domain family suggests that only a subset of WW domains can bind P.Ser-Pro in a similar fashion to that of Pin1... - Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiationR Y Poon
Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
Mol Biol Cell 6:1197-213. 1995..It is likely that a similar principle of redistribution of p27 is used by the cell in other instances of cell cycle arrest... - Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinasesD D Schlaepfer
Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
Mol Cell Biol 16:5623-33. 1996..In Src-transformed cells, this pathway may be constitutively activated as a result of FAK Tyr-925 phosphorylation in the absence of integrin stimulation... - BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation siteH Ruffner
The Salk Institute, La Jolla, California 92037, USA
Mol Cell Biol 19:4843-54. 1999..These results suggest that the endogenous kinase activity is composed of CDK2-cyclin complexes, at least in part, concordant with the G1/S-specific increase in BRCA1 phosphorylation... - Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alphaM Buck
Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
EMBO J 20:6712-23. 2001..Treatment of TNF-alpha mice with antioxidants or NOS inhibitors prevented phosphorylation of C/EBPbeta on Ser239 and its nuclear export, and rescued the abnormal albumin gene expression... - Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangementM A Verdecia
Structural Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Nat Struct Biol 7:602-8. 2000.... - Convergence of MAP kinase pathways on the ternary complex factor Sap-1aR Janknecht
Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
EMBO J 16:1620-7. 1997..However, signaling from p38 MAP kinase to Sap-1a or from Sap-1a to the basal transcription machinery does not occur in all cell types nor at promoters other than the c-fos SRE, which may ensure the specificity of signaling... - Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteinsD D Schlaepfer
Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
Mol Cell Biol 17:1702-13. 1997..These results show that there are additional FN-stimulated pathways to ERK2 that do not involve Grb2 binding to FAK... - The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progressionN J Wells
Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California 92037, USA
J Cell Sci 112:3361-71. 1999.... - DFak56 is a novel Drosophila melanogaster focal adhesion kinaseR H Palmer
Salk Institute, Molecular Biology and Virology Laboratory, La Jolla, California 92037 1099, USA
J Biol Chem 274:35621-9. 1999..Our results imply a role for DFak56 in adhesion-dependent signaling pathways in vivo during D. melanogaster development... - The APC11 RING-H2 finger mediates E2-dependent ubiquitinationJ D Leverson
Molecular Biology and Virology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Mol Biol Cell 11:2315-25. 2000..We suggest that Apc11p is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo... - Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1W H Biggs
The Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093 0660, USA
Proc Natl Acad Sci U S A 96:7421-6. 1999..These results indicate that phosphorylation by PKB/Akt negatively regulates FKHR1 by promoting export from the nucleus... - The PDGF receptor phosphorylates Tyr 138 in the c-Src SH3 domain in vivo reducing peptide ligand bindingM A Broome
Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California 92037, USA
Oncogene 14:17-34. 1997..However, Tyr 138 phosphorylation was found to diminish SH3 domain peptide ligand binding ability in vitro... - Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damageR Y Poon
Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Biol Chem 271:13283-91. 1996..It is likely that these underlying mechanisms that inactivate CDKs are similar for other kinds of DNA damage... - atpk1, a novel ribosomal protein kinase gene from Arabidopsis. I. Isolation, characterization, and expressionS H Zhang
Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037
J Biol Chem 269:17586-92. 1994..The first intron of atpk1 functions as an enhancer in atpk1 expression... - The receptor-like protein-tyrosine phosphatase, RPTP alpha, is phosphorylated by protein kinase C on two serines close to the inner face of the plasma membraneS Tracy
Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, California 92037, USA
J Biol Chem 270:10587-94. 1995..Our results suggest that activation of PKC by cytokines modulates RPTP alpha function in several different ways... - Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerizationA M Bilwes
Structural Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Nature 382:555-9. 1996.... - Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivoJ den Hertog
Salk Institute, Molecular Biology and Virology Laboratory, La Jolla, CA 92037
EMBO J 13:3020-32. 1994..Our results suggest a role for RPTP alpha in attenuation of GRB2-mediated signaling... - Identification of functional domains in the neuronal Cdk5 activator proteinR Y Poon
Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Biol Chem 272:5703-8. 1997..Residues approximately 150-200 of p35 were sufficient for binding to Cdk5, but residues approximately 279-291 were needed in addition for activation of Cdk5 in vitro... - A mouse cdc25 homolog is differentially and developmentally expressedA Kakizuka
Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037
Genes Dev 6:578-90. 1992..We suggest that the expression and accumulation of the cdc25 mitotic inducer may play a critical role in the regulation of mouse development... - Isolation and characterization of the Pin1/Ess1p homologue in Schizosaccharomyces pombeH K Huang
Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
J Cell Sci 114:3779-88. 2001..Our genetic data also suggest that Pin1p might function as a positive regulator of Cdc25p and Wee1p... - Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1B H Jiang
Department of Molecular and Experimental Medicine, BCC239, The Scripps Research Institute, La Jolla, California 92037, USA
Cell Growth Differ 12:363-9. 2001..Vascular endothelial growth factor reporter gene activity was also inhibited by expression of a dominant negative PI3K construct and by the tumor suppressor PTEN... - The budding yeast HRR25 gene product is a casein kinase I isoformA J DeMaggio
Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, CA 92037
Proc Natl Acad Sci U S A 89:7008-12. 1992..The identity between Hrr25p and bovine CKI suggests that Hrr25p is a yeast isoform of the CKI family and that CKIs may play a role in regulating DNA metabolism... - The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cellsK P Lu
Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, California 92037, USA
Prog Cell Cycle Res 1:187-205. 1995..Thus, NIMA may represent a new essential eukaryotic cell cycle regulator, although its homologues in other species are yet to be identified... - Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinaseD M Friedrichsen
Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Plant Physiol 123:1247-56. 2000..Therefore, we conclude that BRI1 is a ubiquitously expressed leucine-rich repeat receptor that plays a role in BR signaling through Ser/Thr phosphorylation... - Biochemistry. Ubiquitination--more than two to tangoC A Joazeiro
Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, CA 92037, USA
Science 289:2061-2. 2000..In their Perspective, Joazeiro and Hunter discuss new structural findings that reveal the part played by an E3 called c-Cbl in this ubiquitinating process... - D-type cyclin expression is decreased and p21 and p27 CDK inhibitor expression is increased when tsBN462 CCG1/TAFII250 mutant cells arrest in G1 at the restrictive temperatureT Sekiguchi
Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, CA 92037, USA
Genes Cells 1:687-705. 1996..5 degrees C, due to a point mutation in the CCG1/TAFII250 gene, which encodes a component of the general transcription factor TFIID... - Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation eventsD D Schlaepfer
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Mol Cell Biol 18:2571-85. 1998.... - Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertilityP Blume-Jensen
Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California, USA
Nat Genet 24:157-62. 2000..It provides the first in vivo model for male sterility caused by a discrete signalling pathway defect affecting early germ cells... - Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alphaM Buck
Salk Institute for Biological Studies, La Jolla, California 92037, USA
Mol Cell 4:1087-92. 1999..Thus, a site-specific phosphorylation of the transcription factor C/EBP beta is critical for hepatocyte proliferation induced by TGF alpha and other stimuli that activate RSK... - Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6W Jiang
Molecular Biology and Virology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 96:6193-8. 1999.... - A constitutively "phosphorylated" guanylyl cyclase-linked atrial natriuretic peptide receptor mutant is resistant to desensitizationL R Potter
Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Mol Biol Cell 10:1811-20. 1999..These data provide the first direct test of the requirement for dephosphorylation in guanylyl cyclase desensitization and they indicate that it is an essential component of this process... - Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alphaG Jiang
Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Nature 401:606-10. 1999..Our results suggest that RPTPalpha activity can in principle be negatively regulated by dimerization in vivo... - Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replicationW Jiang
The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
EMBO J 18:5703-13. 1999..These results indicate that the HsCdc7-HsDbf4 kinase is directly involved in regulating the initiation of DNA replication by targeting MCM2 protein in mammalian cells... - Phosphorylation and spindle pole body localization of the Cdc15p mitotic regulatory protein kinase in budding yeastS Xu
Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla 92037, USA
Curr Biol 10:329-32. 2000..At the end of telophase, a portion of Cdc15p is located at the mother-bud neck, suggesting a possible role for Cdc15p in cytokinesis... - Determination of phosphorylation sites in peptides and proteins employing a volatile Edman reagentW H Fischer
Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, California 92037, USA
J Protein Chem 16:329-34. 1997..The protocol was employed to identify the site of phosphorylation in phosphoserine- and phosphotyrosine-containing peptides... - Identification and characterization of the major phosphorylation sites of the B-type natriuretic peptide receptorL R Potter
Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Biol Chem 273:15533-9. 1998..These data indicate that phosphorylation of the kinase homology domain is a critical event in the regulation of NPR-B... - Inhibition of c-Abl tyrosine kinase activity by filamentous actinP J Woodring
Salk Institute, La Jolla, California 92037 1099, USA
J Biol Chem 276:27104-10. 2001..Taken together, the data suggest that F-actin is an inhibitor of the c-Abl tyrosine kinase and that this inhibition contributes in part to the reduced Abl kinase activity in detached cells... - Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injuryT Herdegen
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0636, USA
J Neurosci 18:5124-35. 1998..These results demonstrate that lasting c-Jun S73 phosphorylation and JNK activity are part of neuronal stress response after neurodegenerative disorders in the adult mammalian brain with Fas-ligand as a putative apoptotic effector... - Oncogenic kinase signallingP Blume-Jensen
The Salk Institute, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Nature 411:355-65. 2001.... - The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136P Blume-Jensen
Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, California 92037, USA
Curr Biol 8:779-82. 1998..Such a mechanism may account for how deregulated PI 3-kinase activity and naturally occurring gain-of-function point mutants of Kit/SCF-R lead to cellular transformation and fatal malignancies in man... - Phosphorylation of the kinase homology domain is essential for activation of the A-type natriuretic peptide receptorL R Potter
Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Mol Cell Biol 18:2164-72. 1998..We conclude that phosphorylation of the KHD is absolutely required for hormone-dependent activation of NPR-A... - TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300R Janknecht
Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California 92037 USA
Genes Dev 12:2114-9. 1998..Thus, CBP/p300 are important components of activin/TGF-beta signaling and may mediate the antioncogenic functions of Smad2 and Smad4... - Identification and characterization of a human protein kinase related to budding yeast Cdc7pW Jiang
Molecular Biology and Virology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 94:14320-5. 1997..These results, together with the functions of Cdc7p in yeast, suggest that HsCdc7 may phosphorylate critical substrate(s) that regulate the G1/S phase transition and/or DNA replication in mammalian cells... - Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivityH Ruffner
The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 98:5134-9. 2001..Furthermore, we propose that the analysis of the Ub ligase activity of RING-domain mutations identified in patients may constitute an assay to predict predisposition to cancer...
Research Grants
- SOMATIC CELL CYCLE REGULATION BY PHOSPHORYLATIONTony Hunter; Fiscal Year: 2007..abstract_text> ..
- Checkpoint Kinase Chk1 in Cancer Biology and TherapyTony Hunter; Fiscal Year: 2007....
- SIGNAL TRANSDUCTION BY TYROSINE PHOSPHORYLATIONTony Hunter; Fiscal Year: 2007..abstract_text> ..
- Checkpoint Kinase Chk1 in Cancer Biology and TherapyTony Hunter; Fiscal Year: 2009....
- SOMATIC CELL CYCLE REGULATION BY PHOSPHORYLATIONTony Hunter; Fiscal Year: 2009..Since many cancer therapeutics kill cancer cells by eliciting DNA damage, our studies will also provide insights into the sensitivity of cancer cells to these agents, and suggest ways to improve their use. ..
- Checkpoint Kinase Chk1 in Cancer Biology and TherapyTONY R HUNTER; Fiscal Year: 2010....
- SOMATIC CELL CYCLE REGULATION BY PHOSPHORYLATIONTONY R HUNTER; Fiscal Year: 2010..Since many cancer therapeutics kill cancer cells by eliciting DNA damage, our studies will also provide insights into the sensitivity of cancer cells to these agents, and suggest ways to improve their use. ..
- SOMATIC CELL CYCLE REGULATION BY PHOSPHORYLATIONTony Hunter; Fiscal Year: 2003..Perturbation of cell cycle control is a hallmark of cancer cells, and these studies will contribute to our understanding of mechanisms of oncogenesis. ..
- SIGNAL TRANSDUCTION BY TYROSINE PHOSPHORYLATIONTONY R HUNTER; Fiscal Year: 2010....