John D Hulleman

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. doi request reprint A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion
    John D Hulleman
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA
    J Biomol Screen 18:647-58. 2013
  2. pmc Translational attenuation differentially alters the fate of disease-associated fibulin proteins
    John D Hulleman
    Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA
    FASEB J 26:4548-60. 2012
  3. pmc Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration
    John D Hulleman
    Departments of Chemistry and Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 22:4765-75. 2011

Detail Information

Publications3

  1. doi request reprint A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion
    John D Hulleman
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA
    J Biomol Screen 18:647-58. 2013
    ..The identified compounds could serve as tools for probing the etiology of fibulin-3-related diseases. ..
  2. pmc Translational attenuation differentially alters the fate of disease-associated fibulin proteins
    John D Hulleman
    Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA
    FASEB J 26:4548-60. 2012
    ..These data suggest that alteration of specific cellular signaling pathways and proteostasis network components can differentially influence fibulin fate, a hypothesis that could be exploited as a therapy for fibulin-related diseases...
  3. pmc Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration
    John D Hulleman
    Departments of Chemistry and Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 22:4765-75. 2011
    ..This study highlights the mechanisms underlying the inefficient secretion of R345W EFEMP1 and demonstrates that alteration of the proteostasis network may provide a strategy to alleviate or delay the onset of this macular dystrophy...