ALBERT J HUDSPETH

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc Hair-bundle movements elicited by transepithelial electrical stimulation of hair cells in the sacculus of the bullfrog
    D Bozovic
    The Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:958-63. 2003
  2. ncbi request reprint Mechanical amplification of stimuli by hair cells
    A Hudspeth
    Howard Hughes Medical Institute, Laboratory of Sensory Neuroscience, Box 314, The Rockefeller University, 1230 York Avenue, New York, New York 10021 6399, USA
    Curr Opin Neurobiol 7:480-6. 1997
  3. pmc Auditory neuroscience: development, transduction, and integration
    A J Hudspeth
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA 91125, USA
    Proc Natl Acad Sci U S A 97:11690-1. 2000
  4. pmc Putting ion channels to work: mechanoelectrical transduction, adaptation, and amplification by hair cells
    A J Hudspeth
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 97:11765-72. 2000
  5. ncbi request reprint Sensory systems
    A J Hudspeth
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10021 6399, USA
    Curr Opin Neurobiol 10:631-41. 2000
  6. ncbi request reprint How the ear's works work: mechanoelectrical transduction and amplification by hair cells
    A J Hudspeth
    Laboratory of Sensory Neuroscience and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY USA
    C R Biol 328:155-62. 2005
  7. pmc Coherent motion of stereocilia assures the concerted gating of hair-cell transduction channels
    Andrei S Kozlov
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Neurosci 10:87-92. 2007
  8. pmc Making an effort to listen: mechanical amplification in the ear
    A J Hudspeth
    Laboratory of Sensory Neuroscience and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 59:530-45. 2008
  9. pmc A critique of the critical cochlea: Hopf--a bifurcation--is better than none
    A J Hudspeth
    The Rockefeller University, HHMI and Laboratory of Sensory Neuroscience, Campus Box 314, 1230 York Avenue, New York, NY 10065 6399, USA
    J Neurophysiol 104:1219-29. 2010
  10. pmc Spontaneous oscillation by hair bundles of the bullfrog's sacculus
    Pascal Martin
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York 10021 6399, USA
    J Neurosci 23:4533-48. 2003

Research Grants

  1. TRANSDUCTION MECHANISM OF HAIR CELLS
    ALBERT HUDSPETH; Fiscal Year: 2007
  2. ION CHANNELS AND DEVELOPMENT OF HAIR CELLS
    ALBERT HUDSPETH; Fiscal Year: 2002

Collaborators

  • Hernan Lopez-Schier
  • Masakazu Konishi
  • Brian M McDermott
  • ROGER G O'NEIL
  • N Logothetis
  • Dylan K Chan
  • H Hibino
  • P Martin
  • Catherine J Starr
  • James A Kappler
  • Daniel Andor-Ardó
  • Marcelo O Magnasco
  • Revathy C Uthaiah
  • Oreste Piro
  • Tobias Reichenbach
  • Michael Gelfand
  • R Pironkova
  • D Bozovic
  • Michelle R Gleason
  • Andrei S Kozlov
  • S Heller
  • Erica C Keen
  • Loïc Le Goff
  • F Pataky
  • Richard Kollmar
  • Pascal Martin
  • F Lesage
  • O Onwumere
  • Stefan Heller
  • Y Choe
  • W Liedtke
  • Aaron Nagiel
  • Sophie Jamet
  • Maria Vologodskaia
  • Thomas Risler
  • Dolores Bozovic
  • K P Rosenblatt
  • P Charnet
  • M Rousset
  • M Vologodskaia
  • Charlotte S Denis
  • Andrea M Bell
  • Yong Choe
  • C S Denis
  • A Sali
  • M A Martí-Renom
  • J M Friedman
  • A M Bell
  • Z Javed
  • C A Sheane
  • Z P Sun

Detail Information

Publications33

  1. pmc Hair-bundle movements elicited by transepithelial electrical stimulation of hair cells in the sacculus of the bullfrog
    D Bozovic
    The Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:958-63. 2003
    ..A model for electrically driven bundle motion that incorporates the negative stiffness of the hair bundle as well as its two mechanisms of motility captures the essential features of the measured responses...
  2. ncbi request reprint Mechanical amplification of stimuli by hair cells
    A Hudspeth
    Howard Hughes Medical Institute, Laboratory of Sensory Neuroscience, Box 314, The Rockefeller University, 1230 York Avenue, New York, New York 10021 6399, USA
    Curr Opin Neurobiol 7:480-6. 1997
    ....
  3. pmc Auditory neuroscience: development, transduction, and integration
    A J Hudspeth
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA 91125, USA
    Proc Natl Acad Sci U S A 97:11690-1. 2000
    ....
  4. pmc Putting ion channels to work: mechanoelectrical transduction, adaptation, and amplification by hair cells
    A J Hudspeth
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 97:11765-72. 2000
    ..Channels provide a feedback signal that controls the transducer's adaptation to large stimuli. Finally, transduction channels participate in an amplificatory process that sensitizes and sharpens hearing...
  5. ncbi request reprint Sensory systems
    A J Hudspeth
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10021 6399, USA
    Curr Opin Neurobiol 10:631-41. 2000
    ..In future research, the last approach is likely to form a bridge between the large body of electrophysiological knowledge acquired in animal experiments and that currently being obtained in human imaging research...
  6. ncbi request reprint How the ear's works work: mechanoelectrical transduction and amplification by hair cells
    A J Hudspeth
    Laboratory of Sensory Neuroscience and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY USA
    C R Biol 328:155-62. 2005
    ..These three processes together explain many of the complex phenomena characteristic of the hearing process...
  7. pmc Coherent motion of stereocilia assures the concerted gating of hair-cell transduction channels
    Andrei S Kozlov
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Neurosci 10:87-92. 2007
    ..This feature assures the concerted gating of transduction channels that maximizes the sensitivity of mechanoelectrical transduction and enhances the hair bundle's capacity to amplify its inputs...
  8. pmc Making an effort to listen: mechanical amplification in the ear
    A J Hudspeth
    Laboratory of Sensory Neuroscience and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 59:530-45. 2008
    ....
  9. pmc A critique of the critical cochlea: Hopf--a bifurcation--is better than none
    A J Hudspeth
    The Rockefeller University, HHMI and Laboratory of Sensory Neuroscience, Campus Box 314, 1230 York Avenue, New York, NY 10065 6399, USA
    J Neurophysiol 104:1219-29. 2010
    ..Although this has not been realized, several valuable theories of cochlear function have achieved their success by incorporating critical oscillators...
  10. pmc Spontaneous oscillation by hair bundles of the bullfrog's sacculus
    Pascal Martin
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York 10021 6399, USA
    J Neurosci 23:4533-48. 2003
    ..These observations accord with a model in which oscillations arise from the interplay of the hair bundle's negative stiffness with the activity of adaptation motors and with Ca 2+-dependent relaxation of gating springs...
  11. pmc Ca2+ current-driven nonlinear amplification by the mammalian cochlea in vitro
    Dylan K Chan
    Laboratory of Sensory Neuroscience and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Neurosci 8:149-55. 2005
    ..These results suggest that the Ca(2+) current drives the cochlear active process, and they support the hypothesis that active hair-bundle motility underlies cochlear amplification...
  12. pmc A ratchet mechanism for amplification in low-frequency mammalian hearing
    Tobias Reichenbach
    Laboratory of Sensory Neuroscience, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065 6399, USA
    Proc Natl Acad Sci U S A 107:4973-8. 2010
    ..The ratchet mechanism constitutes a general design principle for implementing mechanical amplification in engineering applications...
  13. pmc Parvalbumin 3 is an abundant Ca2+ buffer in hair cells
    Stefan Heller
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    J Assoc Res Otolaryngol 3:488-98. 2002
    ..Parvalbumin 3 is therefore a significant mobile Ca2+ buffer, and perhaps the dominant buffer, in many types of hair cell. Moreover, parvalbumin 3 provides an early marker for developing hair cells in the frog, chicken, and zebrafish...
  14. pmc Mechanical responses of the organ of corti to acoustic and electrical stimulation in vitro
    Dylan K Chan
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York 10021 6399, USA
    Biophys J 89:4382-95. 2005
    ....
  15. pmc Comparison of a hair bundle's spontaneous oscillations with its response to mechanical stimulation reveals the underlying active process
    P Martin
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021-6399, USA
    Proc Natl Acad Sci U S A 98:14380-5. 2001
    ..This behavior, which is not generic for active oscillators, can be accommodated by a simple model that characterizes quantitatively the fluctuations of the spontaneous movements as well as the hair bundle's linear response function...
  16. pmc Adaptive shift in the domain of negative stiffness during spontaneous oscillation by hair bundles from the internal ear
    Loïc Le Goff
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 102:16996-7001. 2005
    ..The results are in accordance with the idea that adaptation underlies spontaneous hair-bundle oscillation, and therefore powers the active process that also amplifies and tunes the hair cell's mechanical responsiveness...
  17. pmc Radixin is a constituent of stereocilia in hair cells
    F Pataky
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:2601-6. 2004
    ..Labeling with anti-ezrin produced no signal in hair bundles. Radixin is thus a prominent constituent of stereocilia, where it may participate in anchoring the "pointed" ends of actin filaments to the membrane...
  18. pmc Interactions between hair cells shape spontaneous otoacoustic emissions in a model of the tokay gecko's cochlea
    Michael Gelfand
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 5:e11116. 2010
    ..Hair cells, the sensory receptors of the inner ear, are known to provide the energy for such emissions; it is unclear, though, how ensembles of such cells collude to power observable emissions...
  19. pmc A two-step mechanism underlies the planar polarization of regenerating sensory hair cells
    Hernan Lopez-Schier
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 103:18615-20. 2006
    ..This mechanism may represent a general principle governing the long-term maintenance of planar cell polarity in remodeling epithelia...
  20. pmc Analysis and functional evaluation of the hair-cell transcriptome
    Brian M McDermott
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 104:11820-5. 2007
    ..Moreover, a search for candidate genes that underlie heritable deafness identified a human ortholog of a zebrafish hair-cell gene whose map location is bracketed by the markers of a deafness locus...
  21. pmc The transmembrane inner ear (Tmie) protein is essential for normal hearing and balance in the zebrafish
    Michelle R Gleason
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:21347-52. 2009
    ..The mutant line therefore affords us an opportunity to investigate the role of the corresponding protein in mechanoelectrical transduction...
  22. pmc Modeling the resonant release of synaptic transmitter by hair cells as an example of biological oscillators with cooperative steps
    Daniel Andor-Ardó
    Laboratory of Sensory Neuroscience, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY, 100656399, USA
    Proc Natl Acad Sci U S A 107:2019-24. 2010
    ..It is thus possible to connect multiquantal release with frequency selectivity through the mechanism of cooperativity...
  23. pmc Transfer characteristics of the hair cell's afferent synapse
    Erica C Keen
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 103:5537-42. 2006
    ..This result implies that, for receptor potentials in the physiological range, the hair cell's synapse transmits information with high fidelity...
  24. ncbi request reprint Directional cell migration establishes the axes of planar polarity in the posterior lateral-line organ of the zebrafish
    Hernan Lopez-Schier
    Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Dev Cell 7:401-12. 2004
    ..We propose that the global orientation of hair cells relative to the body axes is established through an interaction between directional movement by primordial cells and the timing of neuromast maturation...
  25. ncbi request reprint Distribution of Ca2+-activated K+ channel isoforms along the tonotopic gradient of the chicken's cochlea
    K P Rosenblatt
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York 10021 6399, USA
    Neuron 19:1061-75. 1997
    ..Heterologously expressed cSlo variants differed in their sensitivities to Ca2+ and voltage, suggesting that the distinct spatial distributions of cSlo variants help determine the tonotopic map...
  26. pmc Molecular markers for cell types of the inner ear and candidate genes for hearing disorders
    S Heller
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 95:11400-5. 1998
    ..This group also includes proteins expressed in two unique cell types of the inner ear, homogene cells and cells of the tegmentum vasculosum...
  27. pmc Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor
    W Liedtke
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    Cell 103:525-35. 2000
    ..The channel also occurs in other neurosensory cells, including inner-ear hair cells, sensory neurons, and Merkel cells...
  28. pmc Compressive nonlinearity in the hair bundle's active response to mechanical stimulation
    P Martin
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021-6399, USA
    Proc Natl Acad Sci U S A 98:14386-91. 2001
    ..This scaling behavior, also found in the response of the mammalian basilar membrane to sound, signals the operation of an amplificatory process at the brink of an oscillatory instability, a Hopf bifurcation...
  29. pmc RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels
    H Hibino
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 34:411-23. 2002
    ....
  30. pmc Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel beta 4 subunit
    H Hibino
    The Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:307-12. 2003
    ..The beta(4c) subunit is therefore a multifunctional protein that not only constitutes a portion of the Ca(2+) channel but also regulates gene transcription...
  31. pmc Mutation of the zebrafish choroideremia gene encoding Rab escort protein 1 devastates hair cells
    Catherine J Starr
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:2572-7. 2004
    ..The degenerative phenotype resulting from a null mutation in the zebrafish gene indicates that hair cells and retinal cells require Rab escort protein 1 for survival...
  32. pmc A nonsense mutation in the gene encoding a zebrafish myosin VI isoform causes defects in hair-cell mechanotransduction
    James A Kappler
    Howard Hughes Medical Institute, Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:13056-61. 2004
    ..The ru920 line therefore provides an animal model with which to study the role of class VI myosin proteins in mechanotransduction...
  33. pmc Molecular anatomy of the hair cell's ribbon synapse
    Revathy C Uthaiah
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York 10065, USA
    J Neurosci 30:12387-99. 2010
    ..Our results indicate that the ribbon synapses of hair cells display modifications to the presynaptic machinery that are associated with the high-fidelity transmission of acoustic signals to the brain...

Research Grants2

  1. TRANSDUCTION MECHANISM OF HAIR CELLS
    ALBERT HUDSPETH; Fiscal Year: 2007
    ..This investigation should provide insight into the biochemical basis for specifying the identity of individual hair cells and may suggest effective techniques for fostering their regeneration. ..
  2. ION CHANNELS AND DEVELOPMENT OF HAIR CELLS
    ALBERT HUDSPETH; Fiscal Year: 2002
    ..These studies should provide information useful in promoting the survival, repair, and eventual replacement of hair cells in the human internal ear. ..