A J Hudspeth

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi How the ear's works work: mechanoelectrical transduction and amplification by hair cells
    A J Hudspeth
    Laboratory of Sensory Neuroscience and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY USA
    C R Biol 328:155-62. 2005
  2. pmc Transfer characteristics of the hair cell's afferent synapse
    Erica C Keen
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 103:5537-42. 2006
  3. pmc Making an effort to listen: mechanical amplification in the ear
    A J Hudspeth
    Laboratory of Sensory Neuroscience and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 59:530-45. 2008
  4. pmc A critique of the critical cochlea: Hopf--a bifurcation--is better than none
    A J Hudspeth
    The Rockefeller University, HHMI and Laboratory of Sensory Neuroscience, Campus Box 314, 1230 York Avenue, New York, NY 10065 6399, USA
    J Neurophysiol 104:1219-29. 2010
  5. pmc Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel beta 4 subunit
    H Hibino
    The Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:307-12. 2003
  6. pmc The spatial pattern of cochlear amplification
    Jonathan A N Fisher
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 76:989-97. 2012
  7. pmc Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear
    Yukako Asai
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 103:9069-74. 2006
  8. pmc Contribution of active hair-bundle motility to nonlinear amplification in the mammalian cochlea
    Fumiaki Nin
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:21076-80. 2012
  9. pmc Anomalous Brownian motion discloses viscoelasticity in the ear's mechanoelectrical-transduction apparatus
    Andrei S Kozlov
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:2896-901. 2012
  10. pmc Spontaneous oscillation by hair bundles of the bullfrog's sacculus
    Pascal Martin
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York 10021 6399, USA
    J Neurosci 23:4533-48. 2003

Collaborators

Detail Information

Publications63

  1. ncbi How the ear's works work: mechanoelectrical transduction and amplification by hair cells
    A J Hudspeth
    Laboratory of Sensory Neuroscience and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY USA
    C R Biol 328:155-62. 2005
    ..These three processes together explain many of the complex phenomena characteristic of the hearing process...
  2. pmc Transfer characteristics of the hair cell's afferent synapse
    Erica C Keen
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 103:5537-42. 2006
    ..This result implies that, for receptor potentials in the physiological range, the hair cell's synapse transmits information with high fidelity...
  3. pmc Making an effort to listen: mechanical amplification in the ear
    A J Hudspeth
    Laboratory of Sensory Neuroscience and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 59:530-45. 2008
    ....
  4. pmc A critique of the critical cochlea: Hopf--a bifurcation--is better than none
    A J Hudspeth
    The Rockefeller University, HHMI and Laboratory of Sensory Neuroscience, Campus Box 314, 1230 York Avenue, New York, NY 10065 6399, USA
    J Neurophysiol 104:1219-29. 2010
    ..Although this has not been realized, several valuable theories of cochlear function have achieved their success by incorporating critical oscillators...
  5. pmc Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel beta 4 subunit
    H Hibino
    The Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:307-12. 2003
    ..The beta(4c) subunit is therefore a multifunctional protein that not only constitutes a portion of the Ca(2+) channel but also regulates gene transcription...
  6. pmc The spatial pattern of cochlear amplification
    Jonathan A N Fisher
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 76:989-97. 2012
    ..These results reveal the locus of amplification in cochlear traveling waves and connect the characteristics of normal hearing to molecular forces...
  7. pmc Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear
    Yukako Asai
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 103:9069-74. 2006
    ..The resultant imbalance of Fgf8 and Sef signals then underlies the abnormal aural development observed in ru622...
  8. pmc Contribution of active hair-bundle motility to nonlinear amplification in the mammalian cochlea
    Fumiaki Nin
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:21076-80. 2012
    ..The results suggest that active hair-bundle motility plays a significant role in the amplification and compressive nonlinearity of the cochlea...
  9. pmc Anomalous Brownian motion discloses viscoelasticity in the ear's mechanoelectrical-transduction apparatus
    Andrei S Kozlov
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:2896-901. 2012
    ..We amend the canonical model and demonstrate several consequences of viscoelasticity for sensory coding...
  10. pmc Spontaneous oscillation by hair bundles of the bullfrog's sacculus
    Pascal Martin
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York 10021 6399, USA
    J Neurosci 23:4533-48. 2003
    ..These observations accord with a model in which oscillations arise from the interplay of the hair bundle's negative stiffness with the activity of adaptation motors and with Ca 2+-dependent relaxation of gating springs...
  11. pmc Ca2+ current-driven nonlinear amplification by the mammalian cochlea in vitro
    Dylan K Chan
    Laboratory of Sensory Neuroscience and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Neurosci 8:149-55. 2005
    ..These results suggest that the Ca(2+) current drives the cochlear active process, and they support the hypothesis that active hair-bundle motility underlies cochlear amplification...
  12. pmc Fast, automated implementation of temporally precise blind deconvolution of multiphasic excitatory postsynaptic currents
    Daniel Andor-Ardó
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 7:e38198. 2012
    ....
  13. pmc Radixin is a constituent of stereocilia in hair cells
    F Pataky
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:2601-6. 2004
    ..Labeling with anti-ezrin produced no signal in hair bundles. Radixin is thus a prominent constituent of stereocilia, where it may participate in anchoring the "pointed" ends of actin filaments to the membrane...
  14. pmc Transgenic labeling of hair cells in the zebrafish acousticolateralis system
    Brian M McDermott
    Laboratory of Sensory Neuroscience and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue New York, NY 10065, USA
    Gene Expr Patterns 10:113-8. 2010
    ..We additionally identified a transgenic line that offers variable labeling of supporting cells...
  15. pmc Mechanical responses of the organ of corti to acoustic and electrical stimulation in vitro
    Dylan K Chan
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York 10021 6399, USA
    Biophys J 89:4382-95. 2005
    ....
  16. pmc A nonsense mutation in the gene encoding a zebrafish myosin VI isoform causes defects in hair-cell mechanotransduction
    James A Kappler
    Howard Hughes Medical Institute, Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:13056-61. 2004
    ..The ru920 line therefore provides an animal model with which to study the role of class VI myosin proteins in mechanotransduction...
  17. pmc Hair-bundle movements elicited by transepithelial electrical stimulation of hair cells in the sacculus of the bullfrog
    D Bozovic
    The Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:958-63. 2003
    ..A model for electrically driven bundle motion that incorporates the negative stiffness of the hair bundle as well as its two mechanisms of motility captures the essential features of the measured responses...
  18. pmc The transmembrane inner ear (Tmie) protein is essential for normal hearing and balance in the zebrafish
    Michelle R Gleason
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:21347-52. 2009
    ..The mutant line therefore affords us an opportunity to investigate the role of the corresponding protein in mechanoelectrical transduction...
  19. pmc Specificity of afferent synapses onto plane-polarized hair cells in the posterior lateral line of the zebrafish
    Aaron Nagiel
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York 10065 6399, USA
    J Neurosci 28:8442-53. 2008
    ....
  20. pmc Frequency-selective exocytosis by ribbon synapses of hair cells in the bullfrog's amphibian papilla
    Suchit H Patel
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York 10065, USA
    J Neurosci 32:13433-8. 2012
    ..A model for synaptic release suggests that this gradient maintains the sharpness of tuning. We conclude that hair cells of the amphibian papilla use synaptic tuning as an additional mechanism for sharpening their frequency selectivity...
  21. pmc Coherent motion of stereocilia assures the concerted gating of hair-cell transduction channels
    Andrei S Kozlov
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Neurosci 10:87-92. 2007
    ..This feature assures the concerted gating of transduction channels that maximizes the sensitivity of mechanoelectrical transduction and enhances the hair bundle's capacity to amplify its inputs...
  22. pmc Activity-independent specification of synaptic targets in the posterior lateral line of the larval zebrafish
    Aaron Nagiel
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10065 6399, USA
    Proc Natl Acad Sci U S A 106:21948-53. 2009
    ....
  23. pmc Imaging electrical resonance in hair cells
    Jonathan A N Fisher
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065 6399, USA
    Proc Natl Acad Sci U S A 108:1651-6. 2011
    ..The stroboscopic imaging and analysis techniques described here present a general approach for studying subthreshold oscillations in electrically excitable cells...
  24. pmc Molecular anatomy of the hair cell's ribbon synapse
    Revathy C Uthaiah
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York 10065, USA
    J Neurosci 30:12387-99. 2010
    ..Our results indicate that the ribbon synapses of hair cells display modifications to the presynaptic machinery that are associated with the high-fidelity transmission of acoustic signals to the brain...
  25. pmc Parvalbumin 3 is an abundant Ca2+ buffer in hair cells
    Stefan Heller
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    J Assoc Res Otolaryngol 3:488-98. 2002
    ..Parvalbumin 3 is therefore a significant mobile Ca2+ buffer, and perhaps the dominant buffer, in many types of hair cell. Moreover, parvalbumin 3 provides an early marker for developing hair cells in the frog, chicken, and zebrafish...
  26. pmc A search for factors specifying tonotopy implicates DNER in hair-cell development in the chick's cochlea
    Lukasz Kowalik
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, Campus Box 314, The Rockefeller University, 1230 York Avenue, New York, NY 10065 6399, USA
    Dev Biol 354:221-31. 2011
    ..Our results suggest a role for DNER and PTPζ in hair-cell development and possibly in the specification of tonotopy...
  27. pmc Comparison of a hair bundle's spontaneous oscillations with its response to mechanical stimulation reveals the underlying active process
    P Martin
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021-6399, USA
    Proc Natl Acad Sci U S A 98:14380-5. 2001
    ..This behavior, which is not generic for active oscillators, can be accommodated by a simple model that characterizes quantitatively the fluctuations of the spontaneous movements as well as the hair bundle's linear response function...
  28. pmc Putting ion channels to work: mechanoelectrical transduction, adaptation, and amplification by hair cells
    A J Hudspeth
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 97:11765-72. 2000
    ..Channels provide a feedback signal that controls the transducer's adaptation to large stimuli. Finally, transduction channels participate in an amplificatory process that sensitizes and sharpens hearing...
  29. pmc Hair cell-specific splicing of mRNA for the alpha1D subunit of voltage-gated Ca2+ channels in the chicken's cochlea
    R Kollmar
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 94:14889-93. 1997
    ..We propose that the alternative splicing of the alpha1D mRNA contributes to the unusual behavior of the hair cell's voltage-gated Ca2+ channels...
  30. ncbi Directional cell migration establishes the axes of planar polarity in the posterior lateral-line organ of the zebrafish
    Hernan Lopez-Schier
    Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Dev Cell 7:401-12. 2004
    ..We propose that the global orientation of hair cells relative to the body axes is established through an interaction between directional movement by primordial cells and the timing of neuromast maturation...
  31. pmc Relative stereociliary motion in a hair bundle opposes amplification at distortion frequencies
    Andrei S Kozlov
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY, USA
    J Physiol 590:301-8. 2012
    ..These results show that a hair bundle breaks into a highly dissipative serial arrangement of stereocilia at distortion frequencies, precluding their amplification...
  32. ncbi Dual contribution to amplification in the mammalian inner ear
    Tobias Reichenbach
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10065 6399, USA
    Phys Rev Lett 105:118102. 2010
    ..A recently proposed ratchet mechanism, in which hair-bundle forces do not feed back on the pressure wave, delineates the two effects. Our analytical calculations with a WKB approximation agree with numerical solutions...
  33. pmc Highly specific alternative splicing of transcripts encoding BK channels in the chicken's cochlea is a minor determinant of the tonotopic gradient
    Soledad Miranda-Rottmann
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065, USA
    Mol Cell Biol 30:3646-60. 2010
    ..Instead, a gradient in the expression of beta subunits slows BK channels toward the low-frequency apex of the cochlea...
  34. pmc Supernumerary neuromasts in the posterior lateral line of zebrafish lacking peripheral glia
    Hernan Lopez-Schier
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:1496-501. 2005
    ..Our results indicate that the development of these intercalary neuromasts occurs principally because of the absence of neural crest-derived peripheral glia, which evidently inhibit the assembly of interneuromast cells into neuromasts...
  35. pmc The structural and functional differentiation of hair cells in a lizard's basilar papilla suggests an operational principle of amniote cochleas
    M Eugenia Chiappe
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York 10065 6399, USA
    J Neurosci 27:11978-85. 2007
    ....
  36. pmc Effects of cochlear loading on the motility of active outer hair cells
    Dáibhid O Maoiléidigh
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 110:5474-9. 2013
    ..The results suggest that somatic motility evolved to enhance a preexisting amplifier based on active hair-bundle motility, thus allowing mammals to hear high-frequency sounds...
  37. pmc Mutation of the zebrafish choroideremia gene encoding Rab escort protein 1 devastates hair cells
    Catherine J Starr
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:2572-7. 2004
    ..The degenerative phenotype resulting from a null mutation in the zebrafish gene indicates that hair cells and retinal cells require Rab escort protein 1 for survival...
  38. pmc Modeling the resonant release of synaptic transmitter by hair cells as an example of biological oscillators with cooperative steps
    Daniel Andor-Ardó
    Laboratory of Sensory Neuroscience, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY, 100656399, USA
    Proc Natl Acad Sci U S A 107:2019-24. 2010
    ..It is thus possible to connect multiquantal release with frequency selectivity through the mechanism of cooperativity...
  39. pmc Association of beta-catenin with the alpha-subunit of neuronal large-conductance Ca2+-activated K+ channels
    F Lesage
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:671-5. 2004
    ..beta-Catenin may therefore provide a physical link between the two types of channels at the presynaptic active zone...
  40. pmc Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor
    W Liedtke
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    Cell 103:525-35. 2000
    ..The channel also occurs in other neurosensory cells, including inner-ear hair cells, sensory neurons, and Merkel cells...
  41. pmc A two-step mechanism underlies the planar polarization of regenerating sensory hair cells
    Hernan Lopez-Schier
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 103:18615-20. 2006
    ..This mechanism may represent a general principle governing the long-term maintenance of planar cell polarity in remodeling epithelia...
  42. pmc Interactions between hair cells shape spontaneous otoacoustic emissions in a model of the tokay gecko's cochlea
    Michael Gelfand
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 5:e11116. 2010
    ..Hair cells, the sensory receptors of the inner ear, are known to provide the energy for such emissions; it is unclear, though, how ensembles of such cells collude to power observable emissions...
  43. pmc Discrimination of low-frequency tones employs temporal fine structure
    Tobias Reichenbach
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY, USA
    PLoS ONE 7:e45579. 2012
    ..No such effect appears for higher carrier frequencies at which temporal information is not available in the central auditory system...
  44. pmc Waves on Reissner's membrane: a mechanism for the propagation of otoacoustic emissions from the cochlea
    Tobias Reichenbach
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065 6399, USA
    Cell Rep 1:374-84. 2012
    ..The results are in accord with the theory and thus support a role for Reissner's membrane in otoacoustic emissions...
  45. pmc Expression and phylogeny of claudins in vertebrate primordia
    R Kollmar
    Laboratory of Sensory Neuroscience and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 98:10196-201. 2001
    ..We propose that tight junctions not only form barriers in mature epithelia, but also participate in vertebrate morphogenesis...
  46. pmc Analysis and functional evaluation of the hair-cell transcriptome
    Brian M McDermott
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 104:11820-5. 2007
    ..Moreover, a search for candidate genes that underlie heritable deafness identified a human ortholog of a zebrafish hair-cell gene whose map location is bracketed by the markers of a deafness locus...
  47. pmc Molecular markers for cell types of the inner ear and candidate genes for hearing disorders
    S Heller
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 95:11400-5. 1998
    ..This group also includes proteins expressed in two unique cell types of the inner ear, homogene cells and cells of the tegmentum vasculosum...
  48. pmc Forces between clustered stereocilia minimize friction in the ear on a subnanometre scale
    Andrei S Kozlov
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 474:376-9. 2011
    ....
  49. pmc Compressive nonlinearity in the hair bundle's active response to mechanical stimulation
    P Martin
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021-6399, USA
    Proc Natl Acad Sci U S A 98:14386-91. 2001
    ..This scaling behavior, also found in the response of the mammalian basilar membrane to sound, signals the operation of an amplificatory process at the brink of an oscillatory instability, a Hopf bifurcation...
  50. ncbi Sensory systems
    A J Hudspeth
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10021 6399, USA
    Curr Opin Neurobiol 10:631-41. 2000
    ..In future research, the last approach is likely to form a bridge between the large body of electrophysiological knowledge acquired in animal experiments and that currently being obtained in human imaging research...
  51. pmc A ratchet mechanism for amplification in low-frequency mammalian hearing
    Tobias Reichenbach
    Laboratory of Sensory Neuroscience, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065 6399, USA
    Proc Natl Acad Sci U S A 107:4973-8. 2010
    ..The ratchet mechanism constitutes a general design principle for implementing mechanical amplification in engineering applications...
  52. pmc Rearrangements between differentiating hair cells coordinate planar polarity and the establishment of mirror symmetry in lateral-line neuromasts
    Ivana Mirkovic
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Biol Open 1:498-505. 2012
    ..Manipulation of Vangl2 expression or of Notch signaling results in a uniform hair-cell polarity, indicating that rearrangements refine neuromast polarity with respect to the body axes...
  53. pmc The diverse effects of mechanical loading on active hair bundles
    Dáibhid O Maoiléidigh
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065 6399, USA
    Proc Natl Acad Sci U S A 109:1943-8. 2012
    ..The predictions stemming from this description provide insight into the operation of hair bundles in a variety of contexts...
  54. pmc Divalent counterions tether membrane-bound carbohydrates to promote the cohesion of auditory hair bundles
    Adria C Leboeuf
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York, USA
    Biophys J 101:1316-25. 2011
    ..The forces between stereocilia produced chaotic stick-slip behavior. These results indicate that counterion-mediated interactions in the glycocalyx contribute to the stereociliary coherence that is essential for hearing...
  55. pmc RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels
    H Hibino
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 34:411-23. 2002
    ....
  56. pmc Predominance of the alpha1D subunit in L-type voltage-gated Ca2+ channels of hair cells in the chicken's cochlea
    R Kollmar
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 94:14883-8. 1997
    ..We conclude that most, if not all, voltage-gated Ca2+ channels in hair cells contain an alpha1D subunit. Furthermore, we propose that the alpha1D subunit plays a hitherto undocumented role at tonic synapses...
  57. pmc Adaptive shift in the domain of negative stiffness during spontaneous oscillation by hair bundles from the internal ear
    Loïc Le Goff
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 102:16996-7001. 2005
    ..The results are in accordance with the idea that adaptation underlies spontaneous hair-bundle oscillation, and therefore powers the active process that also amplifies and tunes the hair cell's mechanical responsiveness...
  58. ncbi Distribution of Ca2+-activated K+ channel isoforms along the tonotopic gradient of the chicken's cochlea
    K P Rosenblatt
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York 10021 6399, USA
    Neuron 19:1061-75. 1997
    ..Heterologously expressed cSlo variants differed in their sensitivities to Ca2+ and voltage, suggesting that the distinct spatial distributions of cSlo variants help determine the tonotopic map...
  59. pmc Efferent control of the electrical and mechanical properties of hair cells in the bullfrog's sacculus
    Manuel Castellano-Muñoz
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 5:e13777. 2010
    ..The sensitivity of mechanoelectrical transduction is modulated by the efferent pathway, whose activity usually reduces the responsiveness of hair cells. The basis of this effect remains unknown...
  60. pmc Auditory neuroscience: development, transduction, and integration
    A J Hudspeth
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA 91125, USA
    Proc Natl Acad Sci U S A 97:11690-1. 2000
    ....
  61. ncbi Unidirectional mechanical amplification as a design principle for an active microphone
    Tobias Reichenbach
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10065 6399, USA
    Phys Rev Lett 106:158701. 2011
    ..We show that amplification improves the microphone's threshold for detecting weak signals and that unidirectionality prevents distortion...
  62. pmc A hydrodynamic sensory antenna used by killifish for nocturnal hunting
    Jason S Schwarz
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065, USA
    J Exp Biol 214:1857-66. 2011
    ..On the basis of electrophysiological, hydrodynamic and behavioral evidence, we propose that the ridges constitute a hydrodynamic antenna for the cephalic lateral line...
  63. ncbi Expression patterns of the RGS9-1 anchoring protein R9AP in the chicken and mouse suggest multiple roles in the nervous system
    Gabor Keresztes
    Department of Otolaryngology and Program in Neuroscience, Harvard Medical School, Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Mol Cell Neurosci 24:687-95. 2003
    ..GTPase-activating proteins to specific membranous compartments...