Jean P Hubble
Affiliation: The Ohio State University
- Association study of Parkin gene polymorphisms with idiopathic Parkinson diseaseSofia A Oliveira
Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC
Arch Neurol 60:975-80. 2003..However, previous case-control studies have reported conflicting results regarding the role of more common Parkin polymorphisms as susceptibility alleles for idiopathic PD...
- Long-term studies of dopamine agonistsJean P Hubble
Department of Neurology, Ohio State University, Columbus, OH, USA
Neurology 58:S42-50. 2002..The extension phase of the long-term study comparing pramipexole with levodopa is ongoing, and follow-up information may help to establish the value of this treatment strategy...
- Pharmacokinetic-pharmacodynamic crossover comparison of two levodopa extension strategiesPeter A LeWitt
Department of Neurology, Henry Ford Hospital and Wayne State University School of Medicine, Detroit, Michigan, USA
Mov Disord 24:1319-24. 2009..803), and "on state with nontroublesome dyskinesia" was 18% for CLE and 7% for CL-CR (P = 0.03). Despite less "off" time with CLE, both formulations demonstrated similar mean PK values and marked intersubject PK variability...
- Randomized trial of the adenosine A(2A) receptor antagonist istradefylline in advanced PDRobert A Hauser
Department of Neurology, University of South Florida, and Tampa General Healthcare, 33606, USA
Neurology 61:297-303. 2003..To evaluate the safety and efficacy of the adenosine A(2A) receptor antagonist istradefylline (KW-6002) in patients with levodopa-treated Parkinson's disease (PD) with both motor fluctuations and peak-dose dyskinesias...
- Long-term evaluation of deep brain stimulation of the thalamusRajesh Pahwa
Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
J Neurosurg 104:506-12. 2006..The aim of this study was to evaluate the long-term safety and efficacy of DBS of the ventralis intermedius nucleus (VIM) of the thalamus for PD and ET...
- PARK3 influences age at onset in Parkinson disease: a genome scan in the GenePD studyAnita L Destefano
Department of Neurology, Boston University Schools of Medicine and of Public Health, Boston, MA 02118, USA
Am J Hum Genet 70:1089-95. 2002....
- Assessment of sleepiness and unintended sleep in Parkinson's disease patients taking dopamine agonistsThomas Roth
Henry Ford Hospital, Sleep Disorders and Research Center, Clara Ford Pavilion, 3rd Floor, 2799 West Grand Boulevard CFP 3, Detroit, MI 48202, USA
Sleep Med 4:275-80. 2003....
- Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson diseaseYi Ju Li
Department of Medicine, Center for Human Genetics, Institute for Genome Science and Policy, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
Hum Mol Genet 12:3259-67. 2003..This is provocative given reports of the possible role of inflammation in these two neurodegenerative disorders...
- Parkin mutations and susceptibility alleles in late-onset Parkinson's diseaseSofia A Oliveira
Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
Ann Neurol 53:624-9. 2003..These findings suggest that mutations in Parkin contribute to the common form of PD and that heterozygous mutations, especially those lying in exon 7, act as susceptibility alleles for late-onset form of Parkinson disease...
- Mitochondrial polymorphisms significantly reduce the risk of Parkinson diseaseJoelle M van der Walt
Department of Medicine, and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
Am J Hum Genet 72:804-11. 2003..45; 95% CI 0.22-0.93; P=.03). Our results suggest that ND3 is an important factor in PD susceptibility among white individuals and could help explain the role of complex I in PD expression...
- Age at onset in two common neurodegenerative diseases is genetically controlledYi Ju Li
Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
Am J Hum Genet 70:985-93. 2002..62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases...