Yi Wen Huang

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development
    Martín A Rivas
    Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental IBYME, CONICET, Vuelta de Obligado 2490, C1428ADN Buenos Aires, Argentina
    Breast Cancer Res 14:R77. 2012
  2. pmc Profiling DNA methylomes from microarray to genome-scale sequencing
    Yi Wei Huang
    The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA
    Technol Cancer Res Treat 9:139-47. 2010
  3. pmc An overview of epigenetics and chemoprevention
    Yi Wen Huang
    Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, United States
    FEBS Lett 585:2129-36. 2011
  4. pmc Preprocessing differential methylation hybridization microarray data
    Shuying Sun
    Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, 44106, USA
    BioData Min 4:13. 2011
  5. pmc A modulated empirical Bayes model for identifying topological and temporal estrogen receptor α regulatory networks in breast cancer
    Changyu Shen
    Center for Computational Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    BMC Syst Biol 5:67. 2011
  6. pmc Identifying hypermethylated CpG islands using a quantile regression model
    Shuying Sun
    Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA
    BMC Bioinformatics 12:54. 2011
  7. ncbi request reprint Conjugated linoleic acid (CLA) up-regulates the estrogen-regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells
    Li Shu Wang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:27-34. 2006
  8. ncbi request reprint Induction of apoptosis by (-)-gossypol-enriched cottonseed oil in human breast cancer cells
    Weiping Ye
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Int J Mol Med 26:113-9. 2010
  9. ncbi request reprint Effects of serum on (-)-gossypol-suppressed growth in human prostate cancer cells
    Yi Wen Huang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:3613-20. 2006
  10. ncbi request reprint Keratinocyte growth factor (KGF) induces tamoxifen (Tam) resistance in human breast cancer MCF-7 cells
    Hsiang Lin Chang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:1773-84. 2006

Collaborators

Detail Information

Publications31

  1. pmc Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development
    Martín A Rivas
    Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental IBYME, CONICET, Vuelta de Obligado 2490, C1428ADN Buenos Aires, Argentina
    Breast Cancer Res 14:R77. 2012
    ..The role of miRNA in progestin-induced breast cancer is poorly explored. In this study we explored progestin modulation of miRNA expression in mammary tumorigenesis...
  2. pmc Profiling DNA methylomes from microarray to genome-scale sequencing
    Yi Wei Huang
    The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA
    Technol Cancer Res Treat 9:139-47. 2010
    ..With advances on next-generation sequencing technologies, it is now possible to globally map the DNA cytosine methylation at single-base resolution, providing new insights into the regulation and dynamics of DNA methylation in genomes...
  3. pmc An overview of epigenetics and chemoprevention
    Yi Wen Huang
    Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, United States
    FEBS Lett 585:2129-36. 2011
    ..Uncovering the human epigenome can lead us to better understand the dynamics of DNA methylation in disease progression which can further assist in cancer prevention...
  4. pmc Preprocessing differential methylation hybridization microarray data
    Shuying Sun
    Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, 44106, USA
    BioData Min 4:13. 2011
    ..abstract:..
  5. pmc A modulated empirical Bayes model for identifying topological and temporal estrogen receptor α regulatory networks in breast cancer
    Changyu Shen
    Center for Computational Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    BMC Syst Biol 5:67. 2011
    ..Dynamic gene expression changes have been shown to characterize the breast cancer cell response to estrogens, the every molecular mechanism of which is still not well understood...
  6. pmc Identifying hypermethylated CpG islands using a quantile regression model
    Shuying Sun
    Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA
    BMC Bioinformatics 12:54. 2011
    ..However, we were unsure whether 75% was the best quantile level for identifying hypermethylated CGIs. In this paper, we attempt to determine which quantile level should be used to identify hypermethylated CGIs and their associated genes...
  7. ncbi request reprint Conjugated linoleic acid (CLA) up-regulates the estrogen-regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells
    Li Shu Wang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:27-34. 2006
    ..Our previous results indicated that estradiol-17beta (E2)-induced suppression of PTPgamma may play a role in mammary tumorigenesis...
  8. ncbi request reprint Induction of apoptosis by (-)-gossypol-enriched cottonseed oil in human breast cancer cells
    Weiping Ye
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Int J Mol Med 26:113-9. 2010
    ..It might be possible for (-)-GPCSO to be developed as a novel chemotherapeutic agent for breast cancer patients...
  9. ncbi request reprint Effects of serum on (-)-gossypol-suppressed growth in human prostate cancer cells
    Yi Wen Huang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:3613-20. 2006
    ..Here, the effect of bovine serum albumin (BSA) and dextran-coated charcoal-treated fetal bovine serum (DCC-FBS)-containing medium on the ability of (-)-gossypol to inhibit the growth of human prostate cancer cells was studied...
  10. ncbi request reprint Keratinocyte growth factor (KGF) induces tamoxifen (Tam) resistance in human breast cancer MCF-7 cells
    Hsiang Lin Chang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:1773-84. 2006
    ..In the present study, ER-alpha, two estrogen-regulated genes, PR and PTPgamma, KGF and their relationship with endocrine resistance in human breast cancer cells were investigated...
  11. ncbi request reprint Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil
    Weiping Ye
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210 1092, USA
    Anticancer Res 27:107-16. 2007
    ....
  12. ncbi request reprint Effects of human breast stromal cells on conjugated linoleic acid (CLA) modulated vascular endothelial growth factor-A (VEGF-A) expression in MCF-7 cells
    Li Shu Wang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 25:4061-8. 2005
    ..Our previous results indicated that CLA induced suppression of VEGF-A in MCF-7 cells, which may be one of CLA's anticancer mechanisms...
  13. ncbi request reprint Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells
    Sherry T Shu
    Laboratory of Reproductive and Molecular Endocrinology, Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210 1093, USA
    Anticancer Res 30:1937-46. 2010
    ..To understand the tumor suppression characteristics of PTPRG, we studied its tumor suppressive function in an athymic mouse model and evaluated factors that can potentially regulate its expression in breast cancer cells...
  14. pmc Epigenetic silencing mediated through activated PI3K/AKT signaling in breast cancer
    Tao Zuo
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Cancer Res 71:1752-62. 2011
    ..These combined treatments synergistically relieve gene silencing and suppress cancer cell growth in vitro and in xenografts. The new finding has important implications for improving targeted cancer therapies in the future...
  15. ncbi request reprint Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells
    Yi Wen Huang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine and The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:1925-33. 2006
    ..The (-)-gossypol enantiomer is a more potent inhibitor of cancer cell growth. Here, the molecular mechanisms of apoptosis induced by (-)-gossypol were studied in human prostate cancer cells...
  16. pmc Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells
    Yu I Weng
    Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
    Toxicol Appl Pharmacol 248:111-21. 2010
    ..Combination of our exposure model with epigenetic analysis and other biochemical assays can give insight into the heritable effect of low-dose BPA in human cells...
  17. ncbi request reprint Effect of keratinocyte growth factor on cell viability in primary cultured human prostate cancer stromal cells
    Yi Wen Huang
    Laboratory of Reproductive and Molecular Endocrinology, Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1900 Coffey Road, Columbus, OH 43210, USA
    J Steroid Biochem Mol Biol 100:24-33. 2006
    ..In summary, KGF has an autocrine effect and serves as a survival factor in primary cultured human prostate cancer stromal cells...
  18. pmc Promoter hypermethylation of CIDEA, HAAO and RXFP3 associated with microsatellite instability in endometrial carcinomas
    Yi Wen Huang
    Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Gynecol Oncol 117:239-47. 2010
    ..The purpose of this study is to identify novel hypermethylated loci associated with clinicopathologic variables in endometrioid endometrial carcinomas...
  19. ncbi request reprint Conjugated linoleic acid (CLA) modulates prostaglandin E2 (PGE2) signaling in canine mammary cells
    Li Shu Wang
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:889-98. 2006
    ..Moreover, a PGE2 receptor subtype, EP2, is highly expressed in mammary tumors. Thus, various studies have implicated the important role of PGE2 and EP2 in COX-2-regulated tumor development...
  20. ncbi request reprint Primary cultured human breast epithelial cells up-regulate protein disulfide isomerase in response to zeranol
    Michael Scott Updike
    Department of Animal Sciences, College of Food, Agricultural and Environmental Sciences, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 27:407-10. 2007
    ..Research targets on gene-nutrient interactions may give useful information for the development of a novel diet-based intervention for the at-risk population...
  21. ncbi request reprint Decreased MCF-7 breast cancer cell proliferation by serum from a selected line of beef cattle
    Michael S Updike
    Department of Animal Sciences, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 25:871-4. 2005
    ..In conclusion, model systems employing agricultural animals may provide novel insight into mechanisms of cell proliferation...
  22. pmc Conjugated linoleic acid induces apoptosis through estrogen receptor alpha in human breast tissue
    Li Shu Wang
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    BMC Cancer 8:208. 2008
    ..Our research interest is to examine the effects of CLA on the induction of apoptosis in human breast tissues...
  23. pmc Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer
    Yi Wen Huang
    Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 69:9038-46. 2009
    ..Unlike the notion that promoter hypomethylation may upregulate an oncogene, we present a new paradigm in which hypermethylation-mediated silencing of a microRNA derepresses its oncogenic target in cancer cells...
  24. pmc Aberrant transforming growth factor beta1 signaling and SMAD4 nuclear translocation confer epigenetic repression of ADAM19 in ovarian cancer
    Michael Wy Chan
    Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210 1234, USA
    Neoplasia 10:908-19. 2008
    ..Given the emerging role of ADAMs family proteins in growth factor regulation in normal cells, we suggest that epigenetic dysregulation of ADAM19 may contribute to the neoplastic process in ovarian cancer...
  25. pmc Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study
    Li Shu Wang
    Department of Internal Medicine, Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, Ohio 43240, USA
    Clin Cancer Res 17:598-610. 2011
    ....
  26. ncbi request reprint (-)-Gossypol reduces invasiveness in metastatic prostate cancer cells
    Yi Wen Huang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH, U S A
    Anticancer Res 29:2179-88. 2009
    ..Gossypol, a polyphenolic compound present in cottonseeds, possesses anti-proliferative and proapoptotic effects in various cancer cells...
  27. pmc Identification of candidate epigenetic biomarkers for ovarian cancer detection
    Yi Wen Huang
    Molecular Biology and Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Oncol Rep 22:853-61. 2009
    ..Molecular therapies, by reversing the aberrant epigenomes using inhibitory agents or by abrogating the upstream signaling pathways that convey the epigenomic perturbations, may be developed into promising treatment regimens...
  28. pmc Differential contributory roles of nucleotide excision and homologous recombination repair for enhancing cisplatin sensitivity in human ovarian cancer cells
    Qi En Wang
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    Mol Cancer 10:24. 2011
    ....
  29. ncbi request reprint Keratinocyte growth factor (KGF) regulates estrogen receptor-alpha (ER-alpha) expression and cell apoptosis via phosphatidylinositol 3-kinase (PI3K)/Akt pathway in human breast cancer cells
    Hsiang Lin Chang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 29:3195-205. 2009
    ..Therefore, we hypothesized that a possible mechanism for developing Tam resistance could be the regulation of ER-alpha and Bcl-2 family proteins through modulation of Akt activity...
  30. pmc Canonical and atypical E2Fs regulate the mammalian endocycle
    Hui Zi Chen
    Solid Tumor Biology Program, Department of Molecular Virology, Immunology and Medical Genetics, Department of Molecular Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Nat Cell Biol 14:1192-202. 2012
    ..These results provide in vivo evidence for a direct role of E2F family members in regulating non-traditional cell cycles in mammals...
  31. ncbi request reprint Comparing multiple ChIP-sequencing experiments
    Hatice Gulcin Ozer
    Department of Biomedical Informatics, The Ohio State University, Columbus, OH, 43210, USA
    J Bioinform Comput Biol 9:269-82. 2011
    ..In this study, we present a method that can effectively select differential regions of the genome based on protein-binding profiles over multiple experiments using real data points without any normalization among the samples...