V W Hu

Summary

Affiliation: The George Washington University
Country: USA

Publications

  1. ncbi Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines
    Tewarit Sarachana
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, 2300 Eye St NW, Washington, DC 20037, USA
    Genome Med 2:23. 2010
  2. ncbi Radiolabeling revisited: metabolic labeling with (35)S-methionine inhibits cell cycle progression, proliferation, and survival
    V W Hu
    Department of Biochemistry, The George Washington University, School of Medicine and Health Sciences, Washington, D C 20037, USA
    FASEB J 14:448-54. 2000
  3. ncbi Gene expression profiling of lymphoblasts from autistic and nonaffected sib pairs: altered pathways in neuronal development and steroid biosynthesis
    Valerie W Hu
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, DC, USA
    PLoS ONE 4:e5775. 2009
  4. ncbi Novel clustering of items from the Autism Diagnostic Interview-Revised to define phenotypes within autism spectrum disorders
    Valerie W Hu
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, 2300 Eye St, N W, Washington, DC 20037, USA
    Autism Res 2:67-77. 2009
  5. ncbi Gene expression profiling differentiates autism case-controls and phenotypic variants of autism spectrum disorders: evidence for circadian rhythm dysfunction in severe autism
    Valerie W Hu
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, 2300 Eye St, N W, Washington, DC 20037, USA
    Autism Res 2:78-97. 2009
  6. ncbi Gene expression profiling of lymphoblastoid cell lines from monozygotic twins discordant in severity of autism reveals differential regulation of neurologically relevant genes
    Valerie W Hu
    The George Washington University Medical Center, Dept of Biochemistry and Molecular Biology, 2300 Eye St, N W Washington, DC 20037, USA
    BMC Genomics 7:118. 2006
  7. ncbi 3H-thymidine is a defective tool with which to measure rates of DNA synthesis
    Valerie W Hu
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    FASEB J 16:1456-7. 2002
  8. ncbi Metabolic radiolabeling: experimental tool or Trojan horse? (35)S-Methionine induces DNA fragmentation and p53-dependent ROS production
    V W Hu
    Department of Biochemistry and Molecular Biology, The George Washington University, School of Medicine and Health Sciences, Washington, DC 20037, USA
    FASEB J 15:1562-8. 2001
  9. ncbi Novel autism subtype-dependent genetic variants are revealed by quantitative trait and subphenotype association analyses of published GWAS data
    Valerie W Hu
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, DC, United States of America
    PLoS ONE 6:e19067. 2011
  10. ncbi Does metabolic radiolabeling stimulate the stress response? Gene expression profiling reveals differential cellular responses to internal beta vs. external gamma radiation
    Nicholas F Marko
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, 2300 Eye St, N W, Washington, DC 20037, USA
    FASEB J 17:1470-86. 2003

Research Grants

  1. Genomic analyses of autism spectrum disorders
    VALERIE HU; Fiscal Year: 2007

Collaborators

Detail Information

Publications11

  1. ncbi Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines
    Tewarit Sarachana
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, 2300 Eye St NW, Washington, DC 20037, USA
    Genome Med 2:23. 2010
    ..CONCLUSIONS : Findings from this study strongly suggest that dysregulation of miRNA expression contributes to the observed alterations in gene expression and, in turn, may lead to the pathophysiological conditions underlying autism...
  2. ncbi Radiolabeling revisited: metabolic labeling with (35)S-methionine inhibits cell cycle progression, proliferation, and survival
    V W Hu
    Department of Biochemistry, The George Washington University, School of Medicine and Health Sciences, Washington, D C 20037, USA
    FASEB J 14:448-54. 2000
    ....
  3. ncbi Gene expression profiling of lymphoblasts from autistic and nonaffected sib pairs: altered pathways in neuronal development and steroid biosynthesis
    Valerie W Hu
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, DC, USA
    PLoS ONE 4:e5775. 2009
    ..Global gene expression profiling of cultured cells from ASD probands thus serves as a window to underlying metabolic and signaling deficits that may be relevant to the pathobiology of autism...
  4. ncbi Novel clustering of items from the Autism Diagnostic Interview-Revised to define phenotypes within autism spectrum disorders
    Valerie W Hu
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, 2300 Eye St, N W, Washington, DC 20037, USA
    Autism Res 2:67-77. 2009
    ....
  5. ncbi Gene expression profiling differentiates autism case-controls and phenotypic variants of autism spectrum disorders: evidence for circadian rhythm dysfunction in severe autism
    Valerie W Hu
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, 2300 Eye St, N W, Washington, DC 20037, USA
    Autism Res 2:78-97. 2009
    ..Among the genes common to all three subgroups of ASD are 20 novel genes mostly in putative noncoding regions, which appear to associate with androgen sensitivity and which may underlie the strong 4:1 bias toward affected males...
  6. ncbi Gene expression profiling of lymphoblastoid cell lines from monozygotic twins discordant in severity of autism reveals differential regulation of neurologically relevant genes
    Valerie W Hu
    The George Washington University Medical Center, Dept of Biochemistry and Molecular Biology, 2300 Eye St, N W Washington, DC 20037, USA
    BMC Genomics 7:118. 2006
    ....
  7. ncbi 3H-thymidine is a defective tool with which to measure rates of DNA synthesis
    Valerie W Hu
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    FASEB J 16:1456-7. 2002
    ..Because 3H-thymidine perturbs the very process it was employed to study, experiments using 3H-thymidine to monitor DNA synthesis and cell proliferation should be interpreted with caution...
  8. ncbi Metabolic radiolabeling: experimental tool or Trojan horse? (35)S-Methionine induces DNA fragmentation and p53-dependent ROS production
    V W Hu
    Department of Biochemistry and Molecular Biology, The George Washington University, School of Medicine and Health Sciences, Washington, DC 20037, USA
    FASEB J 15:1562-8. 2001
    ....
  9. ncbi Novel autism subtype-dependent genetic variants are revealed by quantitative trait and subphenotype association analyses of published GWAS data
    Valerie W Hu
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, DC, United States of America
    PLoS ONE 6:e19067. 2011
    ..This study underscores the advantage of incorporating both quantitative traits as well as subphenotypes into large-scale genome-wide analyses of complex disorders...
  10. ncbi Does metabolic radiolabeling stimulate the stress response? Gene expression profiling reveals differential cellular responses to internal beta vs. external gamma radiation
    Nicholas F Marko
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, 2300 Eye St, N W, Washington, DC 20037, USA
    FASEB J 17:1470-86. 2003
    ....
  11. ncbi Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain
    Anhthu Nguyen
    Correspondence Department of Biochemistry and Molecular Biology, George Washington University Medical Center, 2300 Eye St, N W, Washington, DC 20037, USA
    FASEB J 24:3036-51. 2010
    ..Our data thus confirm the role of epigenetic regulation of gene expression via differential DNA methylation in idiopathic autism, and furthermore link molecular changes in a peripheral cell model with brain pathobiology in autism...

Research Grants2

  1. Genomic analyses of autism spectrum disorders
    VALERIE HU; Fiscal Year: 2007
    ..Reliable biomarkers would greatly facilitate the early and definitive detection of these disorders, thereby permitting early intervention and therapy. ..