Dan Ning Hu

Summary

Affiliation: The New York Eye and Ear Infirmary
Country: USA

Publications

  1. ncbi request reprint Effect of prostaglandins A(2), E(1), F(2 alpha)and latanoprost on cultured human iridal melanocytes
    D N Hu
    Tissue Culture Center, Departments of Pathology and Laboratory Medicine and Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, NY 10003, USA
    Exp Eye Res 70:113-20. 2000
  2. ncbi request reprint Isolation and characterization of two novel colon cancer cell lines from Chinese patients
    Dan Ning Hu
    Cell Culture Laboratory of Department of Medical Research, Show Chuan Memorial Hospital, Changhua, Taiwan
    In Vitro Cell Dev Biol Anim 43:105-8. 2007
  3. ncbi request reprint Methodology for evaluation of melanin content and production of pigment cells in vitro
    Dan Ning Hu
    Tissue Culture Center, Department of Pathology, The New York Eye and Ear Infirmary and New York Medical College, New York, NY, USA
    Photochem Photobiol 84:645-9. 2008
  4. ncbi request reprint Isolation, purification and cultivation of conjunctival melanocytes
    Dan Ning Hu
    Tissue Culture Center, The New York Eye and Ear Infirmary, 310 E 14th Street, New York, NY 10003, USA
    Exp Eye Res 84:655-62. 2007
  5. doi request reprint Population-based incidence of conjunctival melanoma in various races and ethnic groups and comparison with other melanomas
    Dan Ning Hu
    Department of Pathology, New York Eye and Ear Infirmary, New York, New York 10003, USA
    Am J Ophthalmol 145:418-423. 2008
  6. ncbi request reprint Photobiology of ocular melanocytes and melanoma
    Dan Ning Hu
    The New York Eye and Ear Infirmary, New York Medical College, New York, NY 10003, USA
    Photochem Photobiol 81:506-9. 2005
  7. ncbi request reprint [Cell culture in ophthalmology: culture of specific cell types]
    Dan Ning Hu
    Zhonghua Yan Ke Za Zhi 39:312-6. 2003
  8. ncbi request reprint [Basic techniques and environment of cell culture in ophthalmology]
    Dan Ning Hu
    Tissue Culture Center, New York Eye and Ear Infirmary, New York Medical College, New York 10003, USA
    Zhonghua Yan Ke Za Zhi 39:246-50. 2003
  9. ncbi request reprint Uveal melanocytes, ocular pigment epithelium, and Müller cells in culture: in vitro toxicology
    Dan Ning Hu
    Tissue Culture Center, The New York Eye and Ear Infirmary, New York, New York 10003, USA
    Int J Toxicol 21:465-72. 2002
  10. ncbi request reprint Hepatocyte growth factor is increased in the aqueous humor of glaucomatous eyes
    D N Hu
    Tissue Culture Center, Department of Pathology and Laboratory Medicine, The New York Eye and Ear Infirmary, New York 10003, USA
    J Glaucoma 10:152-7. 2001

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Effect of prostaglandins A(2), E(1), F(2 alpha)and latanoprost on cultured human iridal melanocytes
    D N Hu
    Tissue Culture Center, Departments of Pathology and Laboratory Medicine and Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, NY 10003, USA
    Exp Eye Res 70:113-20. 2000
    ....
  2. ncbi request reprint Isolation and characterization of two novel colon cancer cell lines from Chinese patients
    Dan Ning Hu
    Cell Culture Laboratory of Department of Medical Research, Show Chuan Memorial Hospital, Changhua, Taiwan
    In Vitro Cell Dev Biol Anim 43:105-8. 2007
    ..In another cell line (SHH-1), CGH analysis revealed that -1p13 was the only cytogenetic anomaly...
  3. ncbi request reprint Methodology for evaluation of melanin content and production of pigment cells in vitro
    Dan Ning Hu
    Tissue Culture Center, Department of Pathology, The New York Eye and Ear Infirmary and New York Medical College, New York, NY, USA
    Photochem Photobiol 84:645-9. 2008
    ....
  4. ncbi request reprint Isolation, purification and cultivation of conjunctival melanocytes
    Dan Ning Hu
    Tissue Culture Center, The New York Eye and Ear Infirmary, 310 E 14th Street, New York, NY 10003, USA
    Exp Eye Res 84:655-62. 2007
    ....
  5. doi request reprint Population-based incidence of conjunctival melanoma in various races and ethnic groups and comparison with other melanomas
    Dan Ning Hu
    Department of Pathology, New York Eye and Ear Infirmary, New York, New York 10003, USA
    Am J Ophthalmol 145:418-423. 2008
    ..To investigate racial and ethnic differences in the incidence of conjunctival melanoma in a large population-based study...
  6. ncbi request reprint Photobiology of ocular melanocytes and melanoma
    Dan Ning Hu
    The New York Eye and Ear Infirmary, New York Medical College, New York, NY 10003, USA
    Photochem Photobiol 81:506-9. 2005
    ..Recently, in vitro studies indicate that this phenomenon is determined both by cellular factors and environmental factors...
  7. ncbi request reprint [Cell culture in ophthalmology: culture of specific cell types]
    Dan Ning Hu
    Zhonghua Yan Ke Za Zhi 39:312-6. 2003
  8. ncbi request reprint [Basic techniques and environment of cell culture in ophthalmology]
    Dan Ning Hu
    Tissue Culture Center, New York Eye and Ear Infirmary, New York Medical College, New York 10003, USA
    Zhonghua Yan Ke Za Zhi 39:246-50. 2003
  9. ncbi request reprint Uveal melanocytes, ocular pigment epithelium, and Müller cells in culture: in vitro toxicology
    Dan Ning Hu
    Tissue Culture Center, The New York Eye and Ear Infirmary, New York, New York 10003, USA
    Int J Toxicol 21:465-72. 2002
    ..Cultured uveal melanocytes, pigment epithelial cells, and Müller cells can be used to study the toxicology of these cells in vitro...
  10. ncbi request reprint Hepatocyte growth factor is increased in the aqueous humor of glaucomatous eyes
    D N Hu
    Tissue Culture Center, Department of Pathology and Laboratory Medicine, The New York Eye and Ear Infirmary, New York 10003, USA
    J Glaucoma 10:152-7. 2001
    ..To assess the concentrations of hepatocyte growth factor (HGF) in the aqueous humor of eyes with glaucoma compared with control eyes with cataract only...
  11. ncbi request reprint Regulation of growth and melanogenesis of uveal melanocytes
    D N Hu
    Tissue Culture Center, Department of Pathology and Laboratory Medicine, The New York Eye and Ear Infirmary, New York 10003, USA
    Pigment Cell Res 13:81-6. 2000
    ..The differences of the in vivo behavior between uveal and epidermal melanocytes may be determined by both cellular factors and environmental factors...
  12. ncbi request reprint Isolation and cultivation of human articular chondrocytes
    Dan Ning Hu
    Cell Culture Laboratory, New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY 10003, USA
    Kaohsiung J Med Sci 18:113-20. 2002
    ..Cultured chondrocytes provide an in vitro model system for studying the physiology and pathology of human articular chondrocytes and may be used for autologous transplantation of chondrocytes to treat articular cartilage defects...
  13. ncbi request reprint A functional study on prostanoid receptors involved in cultured human iridal melanocyte stimulation
    D N Hu
    Tissue Culture Center, Department of Pathology and Laboratory Medicine, The New York Eye and Ear Infirmary, 310 E 14th Street, New York, NY 10003, U S A
    Exp Eye Res 73:93-100. 2001
    ....
  14. ncbi request reprint Efficacy and safety of voriconazole as an additive in Optisol GS: a preservation medium for corneal donor tissue
    David C Ritterband
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, NY 10003, USA
    Cornea 26:343-7. 2007
    ..To assess the endothelial toxicity and the microbiological efficacy of voriconazole (100 microg/mL) as an antimicrobial additive to Optisol GS...
  15. ncbi request reprint Population-based incidence of uveal melanoma in various races and ethnic groups
    Dan Ning Hu
    Department of Pathology, New York Eye and Ear Infirmary, New York, New York 10003, USA
    Am J Ophthalmol 140:612-7. 2005
    ..To investigate racial/ethnic differences in the development of uveal malignant melanoma in a large population-based study...
  16. doi request reprint Ultraviolet-A irradiation upregulated urokinase-type plasminogen activator in pterygium fibroblasts through ERK and JNK pathways
    Shih Chun Chao
    Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan
    Invest Ophthalmol Vis Sci 54:999-1007. 2013
    ..The purpose of our study was to investigate the effects of UVA on the expression of uPA in cultured pterygium fibroblasts...
  17. pmc Effects of melatonin and its receptor antagonist on retinal pigment epithelial cells against hydrogen peroxide damage
    Richard B Rosen
    Department of Ophthalmology, New York Eye and Ear Infirmary, New York Medical College, New York, NY, USA
    Mol Vis 18:1640-8. 2012
    ....
  18. doi request reprint Comparison of eumelanin and pheomelanin content between cultured uveal melanoma cells and normal uveal melanocytes
    Dan Ning Hu
    Tissue Culture Center, Department of Pathology, New York Eye and Ear Infirmary, New York Medical College, New York, USA
    Melanoma Res 19:75-9. 2009
    ..Low melanin and EM content may make melanoma cells more susceptible to mutagenic effects of ultraviolet radiation and oxidative stress, which may enhance the proliferation of melanoma cells and accelerate progression of melanoma...
  19. ncbi request reprint Latitude and incidence of ocular melanoma
    Guo Pei Yu
    Biostatistics and Epidemiology Service, The New York Eye and Ear Infirmary, USA
    Photochem Photobiol 82:1621-6. 2006
    ....
  20. ncbi request reprint Tissue plasminogen activator is released into cultured medium by cultured human uveal melanocytes
    Yafei Wang
    Vision Immunology Center, Department of Pathology, University of Connecticut Health Center, Farmington, CT, USA
    Pigment Cell Res 15:373-8. 2002
    ..Therefore, this function of uveal melanocytes may play a role in intraocular matrix remodeling, fibrinolysis and aqueous humor outflow...
  21. ncbi request reprint Vascular endothelial growth factor is increased in aqueous humor of glaucomatous eyes
    Dan Ning Hu
    Tissue Culture Center, Department of Pathology and Laboratory Medicine, The New York Eye and Ear Infirmary, New York, New York 10003, USA
    J Glaucoma 11:406-10. 2002
    ..To assess the concentrations of vascular endothelial growth factor (VEGF) in aqueous humor in eyes with and without glaucoma...
  22. doi request reprint Interleukin-1beta increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via the p38 MAPK/NF-kappaB pathway
    Dan Ning Hu
    Tissue Culture Center, Department of Pathology, New York Eye and Ear Infirmary, New York Medical College, New York, New York 10003, USA
    Invest Ophthalmol Vis Sci 52:3767-74. 2011
    ..Interleukin (IL)-6 is a proinflammatory cytokine. The authors studied the expression of IL-6 in cultured human uveal melanocytes (UMs) and their modulation by IL-1β and explored the relevant signal pathways...
  23. doi request reprint Cytotoxic effect and induction of apoptosis in human cervical cancer cells by Antrodia camphorata
    Pei Yu Yang
    Department of Medical Research, Show Chwan Memorial Hospital, Changhua, Taiwan, ROC
    Am J Chin Med 41:1169-80. 2013
    ..camphorata is cytotoxic to cervical cancer cells through both extrinsic and intrinsic apoptotic mechanisms. It could be used as a novel phytotherapeutic agent or auxiliary therapy in the treatment of cervical cancer...
  24. ncbi request reprint The role of A2E in prevention or enhancement of light damage in human retinal pigment epithelial cells
    Joan E Roberts
    Department of Natural Sciences, Fordham University, New York, NY 10023, USA
    Photochem Photobiol 75:184-90. 2002
    ..These results imply that the role of A2E is not simple and may change over the course of a lifetime. A2E itself may play a protective role in the young eye but a toxic role in older eyes...
  25. doi request reprint Population-based incidence of vulvar and vaginal melanoma in various races and ethnic groups with comparisons to other site-specific melanomas
    Dan Ning Hu
    Department of Pathology, New York Eye and Ear Infirmary, New York Medical College, Valhalla, New York, USA
    Melanoma Res 20:153-8. 2010
    ..The slight decrease of incidence of vulvar melanoma in dark pigmented individuals may be related to the biochemical protective effects of melanin (as an antioxidant) rather than their photo-screen effects...
  26. ncbi request reprint Role of ocular melanin in ophthalmic physiology and pathology
    Dan Ning Hu
    Tissue Culture Center, Department of Pathology, The New York Eye and Ear Infirmary and New York Medical College, New York, NY, USA
    Photochem Photobiol 84:639-44. 2008
    ....
  27. doi request reprint Expression of neurotrophin receptors by retinoinvasive uveal melanoma
    Tatyana Milman
    The New York Eye and Ear Infirmary, New York City, New York 10003, USA
    Melanoma Res 22:164-8. 2012
    ..This study failed to demonstrate a direct causation between the expression of neurotrophin receptors and a retinoinvasive uveal melanoma growth pattern...
  28. ncbi request reprint Simulated microgravity induced damage in human retinal pigment epithelial cells
    Joan E Roberts
    Department of Natural Sciences, Fordham University, New York, NY 10023, USA
    Mol Vis 12:633-8. 2006
    ..The goal of this study was to determine the potential damage to the human retina that may occur from weightlessness during space flight using simulated microgravity...
  29. doi request reprint Antrodia camphorata induces apoptosis and enhances the cytotoxic effect of paclitaxel in human ovarian cancer cells
    Fu Shing Liu
    Cancer Center, Show Chwan Memorial Hospital, Changhua, Taiwan, Republic of China
    Int J Gynecol Cancer 21:1172-9. 2011
    ..camphorata could inhibit the growth of ovarian cancer cells and examined the possible mechanisms involved. We also examined whether the cytotoxic effect of paclitaxel on ovarian cancer cells would be affected by A. camphorata...
  30. pmc Overexpression of urokinase-type plasminogen activator in pterygia and pterygium fibroblasts
    Shih Chun Chao
    Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan
    Mol Vis 17:23-31. 2011
    ....
  31. ncbi request reprint Efficacy and safety of moxifloxacin as an additive in Optisol-GS a preservation medium for corneal donor tissue
    David C Ritterband
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, NY 10003, USA
    Cornea 25:1084-9. 2006
    ..To assess the endothelial toxicity and the microbiological efficacy of moxifloxacin (250 microg/mL) as an additive to Optisol-GS...
  32. doi request reprint Curcumin protects against hyperosmoticity-induced IL-1beta elevation in human corneal epithelial cell via MAPK pathways
    Min Chen
    Tissue Culture Center, Department of Pathology, New York Eye and Ear Infirmary, 310 E 14th Street, New York, NY 10003, USA
    Exp Eye Res 90:437-43. 2010
    ..The present study suggests that curcumin might have therapeutic potential for treating dry eye disease...
  33. ncbi request reprint Arsenic trioxide induces apoptosis in uveal melanoma cells through the mitochondrial pathway
    Miao Ju Chen
    Department of Medical Research, Show Chwan Memorial Hospital, Changhua, Taiwan
    Am J Chin Med 38:1131-42. 2010
    ..This report is the first to evaluate the complete mitochondria-dependent apoptotic pathway of ATO in uveal melanoma cells. These results can be used to improve the clinical effectiveness of ATO treatment for uveal melanoma...
  34. ncbi request reprint Microbiological spectrum and antibiotic sensitivity in endophthalmitis: a 25-year review
    Ronald C Gentile
    Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York Department of Ophthalmology, Winthrop University Hospital, Mineola, New York Electronic address
    Ophthalmology 121:1634-42. 2014
    ....
  35. pmc Urinary 6-sulfatoxymelatonin level in age-related macular degeneration patients
    Richard Rosen
    Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY 10003, USA
    Mol Vis 15:1673-9. 2009
    ....
  36. doi request reprint Progress in the studies of etiology, epidemiology and pathogenesis of ocular melanomas
    Danning Hu
    Department of Pathology and Ophthalmology, New York Medical College, New York, NY, USA
    Eye Sci 26:18-22. 2011
    ..Therefore, independent studies are required for each type of melanoma to discover their own etiology and pathogenesis, and to develop relevant novel prevention and treatment procedures...
  37. ncbi request reprint Uveal melanocytes produce matrix metalloproteinases-2 and -9 in vitro
    Shu Chen Chu
    Department of Food Science, Chungtai Institute of Health Sciences and Technology, Taichung, Taiwan
    Pigment Cell Res 17:636-42. 2004
    ....
  38. ncbi request reprint Uveal melanocytes do not respond to or express receptors for alpha-melanocyte-stimulating hormone
    Li Li
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0592, USA
    Invest Ophthalmol Vis Sci 47:4507-12. 2006
    ..This study was designed to examine the evidence that alpha-melanocyte-stimulating hormone (alpha-MSH), which is thought to be the mediator of UV response in the skin, has any role to play in uveal melanocytes...
  39. ncbi request reprint Blue light irradiation inhibits the production of HGF by human retinal pigment epithelium cells in vitro
    Rengyuan Chu
    Department of Ophthalmology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China
    Photochem Photobiol 82:1247-50. 2006
    ..As HGF promotes survival of RPE cells and retinal neurons, the inhibition of production of HGF by visible light, especially by blue light, may enhance the phototoxic effects of visible light on the RPE and retinal neurons...
  40. ncbi request reprint Expression of melanin-related genes in cultured adult human retinal pigment epithelium and uveal melanoma cells
    Fan Lu
    Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical College and Key Laboratory of Vision Science, Ministry of Health PR China, Wenzhou China
    Mol Vis 13:2066-72. 2007
    ..This study investigated melanin content and production and expression of tyrosinase (TYR), tyrosinase-related-protein-1 (TRP1), tyrosinase-related-protein-2 (TRP2), and P gene in cultured human RPE cells and uveal melanoma cells...
  41. ncbi request reprint [Culture and study on melanogenesis of mongolian uveal melanocytes in vitro]
    Xiang Tian Zhou
    School of Optometry and Ophthalmology, Wenzhou Medical College, Wenzhou 325000, China
    Zhonghua Yan Ke Za Zhi 40:104-7. 2004
    ..To establish cell lines of Mongolian uveal melanocytes from adult donor eyes, and to study melanogenesis of these cells in vitro...
  42. doi request reprint Latitude and uveal melanoma
    Dan Ning Hu
    Ophthalmology 115:757; author reply 757-9. 2008
  43. doi request reprint Cyclin-dependent kinase inhibitor roscovitine induces cell cycle arrest and apoptosis in rabbit retinal pigment epithelial cells
    Pei Chang Wu
    Department of Ophthalmology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Kaohsiung Hsien, Taiwan
    J Ocul Pharmacol Ther 24:25-33. 2008
    ..This in vitro study investigated the antiproliferative and apoptotic effects of roscovitine in cultured rabbit retinal pigment epithelial (RPE) cells...
  44. doi request reprint Characterization of melanin in human iridal and choroidal melanocytes from eyes with various colored irides
    Kazumasa Wakamatsu
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Melanoma Res 21:97-105. 2008
    ....
  45. ncbi request reprint Mechanism and clinical significance of prostaglandin-induced iris pigmentation
    Johan W Stjernschantz
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Box 572 BMC, S 751 82 Uppsala, Sweden
    Surv Ophthalmol 47:S162-75. 2002
    ....
  46. ncbi request reprint Treatment of vitiligo by transplantation of cultured pure melanocyte suspension: analysis of 120 cases
    Yu Fu Chen
    Department of Dermatology, Show Chwan Memorial Hospital, Changhua City, Taiwan
    J Am Acad Dermatol 51:68-74. 2004
    ..Surgical techniques offer a potential solution for patients with vitiligo who fail to respond to medical treatments...
  47. ncbi request reprint Professor Chenghu Zhou (1896 - 1978)
    Dan Ning Hu
    Yan Ke Xue Bao 18:129-30. 2002
  48. ncbi request reprint Bilateral asymmetry in Chinese families with cleft lip with or without cleft palate
    Katherine Neiswanger
    Department of Oral and Maxillofacial Surgery and Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Cleft Palate Craniofac J 42:192-6. 2005
    ..To determine if Chinese individuals with nonsyndromic cleft lip with or without cleft palate (CL/P) display more bilateral asymmetry than do their unaffected relatives...
  49. ncbi request reprint Time-resolved microspectrofluorimetry and fluorescence lifetime imaging of hypericin in human retinal pigment epithelial cells
    Paola Taroni
    INFM Department of Physics and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
    Photochem Photobiol 81:524-8. 2005
    ..The latter change is observed also when high concentrations are reached locally, due to more efficient localization within the cell...
  50. ncbi request reprint The influence of hypotonicity on large-conductance calcium-activated potassium channels in human retinal pigment epithelial cells
    Shwu Jiuan Sheu
    Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    J Ocul Pharmacol Ther 20:563-75. 2004
    ..These findings support the evidence for the coupling of volume swelling to the functional activity of BK(Ca) channels...
  51. ncbi request reprint Effects of retinoic acid on retinal pigment epithelium from excised membranes from proliferative vitreoretinopathy
    Wen Chuan Wu
    Department of Ophthalmology, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Ocul Pharmacol Ther 21:44-54. 2005
    ..e., until the breakdown of the blood-retinal barrier has been repaired, is essential for the success of drug treatment of PVR...
  52. ncbi request reprint Stretch-stimulated activity of large conductance calcium-activated potassium channels in human retinal pigment epithelial cells
    Shwu Jiuan Sheu
    Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, Republic of China
    J Ocul Pharmacol Ther 21:429-35. 2005
    ..The aim of this study was to investigate the effect of membrane stretch on the activity of BK(Ca) channels and determine whether change in BK(Ca)-channel activity induced by membrane stretch can be altered in the presence of riluzole...
  53. ncbi request reprint Effects of topoisomerase II inhibitors on retinal pigment epithelium and experimental proliferative vitreoretinopathy
    Hsi Kung Kuo
    Department of Ophthalmology, Chang Gung Memorial Hospital Kaohsiung Medical Center, and Chang Gung University, College of Medicine, Kaohsiung, Taiwan
    J Ocul Pharmacol Ther 23:14-20. 2007
    ....
  54. pmc Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wort
    Albert R Wielgus
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Photochem Photobiol 83:706-13. 2007
    ..Thus, ingested SJW is potentially phototoxic to the retina and could contribute to retinal or early macular degeneration...
  55. ncbi request reprint A comparative study of effects of antiproliferative drugs on human retinal pigment epithelial cells in vitro
    Wen Chuan Wu
    Department of Ophthalmology, College of Medicine, Kaohsiung Medical University, Taiwan
    J Ocul Pharmacol Ther 18:251-64. 2002
    ....