P J Hotez

Summary

Affiliation: The George Washington University
Country: USA

Publications

  1. pmc Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, District of Columbia, USA
    PLoS Med 3:e102. 2006
  2. pmc Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, United States of America
    PLoS Negl Trop Dis 3:e412. 2009
  3. pmc The co-distribution of Plasmodium falciparum and hookworm among African schoolchildren
    Simon Brooker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    Malar J 5:99. 2006
  4. pmc X-ray structures of Na-GST-1 and Na-GST-2 two glutathione S-transferase from the human hookworm Necator americanus
    Oluwatoyin A Asojo
    Department of Pathology and Microbiology, College of Medicine Nebraska Medical Center, Omaha, NE 68198 6495, USA
    BMC Struct Biol 7:42. 2007
  5. ncbi request reprint Recent progress in integrated neglected tropical disease control
    Peter Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, 2300 I Street NW, Washington, DC 20037, USA
    Trends Parasitol 23:511-4. 2007
  6. ncbi request reprint Control of onchocerciasis--the next generation
    Peter J Hotez
    Sabin Vaccine Institute and Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    Lancet 369:1979-80. 2007
  7. ncbi request reprint New technologies for the control of human hookworm infection
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, 2300 I Street, NW Washington, DC 20037, USA
    Trends Parasitol 22:327-31. 2006
  8. ncbi request reprint Control of neglected tropical diseases
    Peter J Hotez
    Sabin Vaccine Institute, and the Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    N Engl J Med 357:1018-27. 2007
  9. pmc Hookworm: "the great infection of mankind"
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC, USA
    PLoS Med 2:e67. 2005
  10. ncbi request reprint Should we establish a North American school of global health sciences?
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, Global Health, Epidemiology and Biostatistics, The George Washington University, Washington, DC 20037, USA
    Am J Med Sci 328:71-7. 2004

Research Grants

  1. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2002
  2. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2001
  3. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2000
  4. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2002

Detail Information

Publications92

  1. pmc Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, District of Columbia, USA
    PLoS Med 3:e102. 2006
  2. pmc Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, United States of America
    PLoS Negl Trop Dis 3:e412. 2009
    ..A full assessment is an important step for disease control priorities, particularly in Nigeria and the Democratic Republic of Congo, where the greatest number of NTDs may occur...
  3. pmc The co-distribution of Plasmodium falciparum and hookworm among African schoolchildren
    Simon Brooker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    Malar J 5:99. 2006
    ..This is despite the potential public health importance of co-infection and synergistic opportunities for control...
  4. pmc X-ray structures of Na-GST-1 and Na-GST-2 two glutathione S-transferase from the human hookworm Necator americanus
    Oluwatoyin A Asojo
    Department of Pathology and Microbiology, College of Medicine Nebraska Medical Center, Omaha, NE 68198 6495, USA
    BMC Struct Biol 7:42. 2007
    ..Parasite GSTs also play significant roles in multi-drug resistance and the modulation of host-immune defense mechanisms...
  5. ncbi request reprint Recent progress in integrated neglected tropical disease control
    Peter Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, 2300 I Street NW, Washington, DC 20037, USA
    Trends Parasitol 23:511-4. 2007
    ..who.int/dg/speeches/2007). Outlined here is a summary of the recent progress in global efforts to integrate NTD control, with an emphasis on the challenges that lie ahead...
  6. ncbi request reprint Control of onchocerciasis--the next generation
    Peter J Hotez
    Sabin Vaccine Institute and Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    Lancet 369:1979-80. 2007
  7. ncbi request reprint New technologies for the control of human hookworm infection
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, 2300 I Street, NW Washington, DC 20037, USA
    Trends Parasitol 22:327-31. 2006
    ..g. tribendimidine) and a recombinant hookworm vaccine. It is hoped that, ultimately, anthelmintic vaccination will be linked to deworming as part of an expanded control package...
  8. ncbi request reprint Control of neglected tropical diseases
    Peter J Hotez
    Sabin Vaccine Institute, and the Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    N Engl J Med 357:1018-27. 2007
  9. pmc Hookworm: "the great infection of mankind"
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC, USA
    PLoS Med 2:e67. 2005
  10. ncbi request reprint Should we establish a North American school of global health sciences?
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, Global Health, Epidemiology and Biostatistics, The George Washington University, Washington, DC 20037, USA
    Am J Med Sci 328:71-7. 2004
    ..The North American school, possibly in association with one of the existing schools of medicine or public health, would provide interdisciplinary training to produce a new generation of global health scientists...
  11. pmc The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, DC, USA
    PLoS Negl Trop Dis 2:e300. 2008
    ..Ultimately, the roadmap for the control and elimination of the more widespread NTDs will require an inter-sectoral approach that bridges public health, social services, and environmental interventions...
  12. doi request reprint Multivalent anthelminthic vaccine to prevent hookworm and schistosomiasis
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, DC, USA
    Expert Rev Vaccines 7:745-52. 2008
    ..A multivalent anthelminthic vaccine for hookworm infection and schistosomiasis would represent an important new tool for combating disease and poverty...
  13. ncbi request reprint Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC, USA
    Int J Parasitol 33:1245-58. 2003
    ..Another challenge will be to produce anti-hookworm vaccine antigens at high yield low cost suitable for immunising large impoverished populations living in the developing nations of the tropics...
  14. ncbi request reprint Effect of vaccination with a recombinant fusion protein encoding an astacinlike metalloprotease (MTP-1) secreted by host-stimulated Ancylostoma caninum third-stage infective larvae
    Peter J Hotez
    Department of Microbiology and Tropical Medicine and Sabin Vaccine Institute, The George Washington University Medical Center, 2300 Eye Street NW, Washington, DC 20037, USA
    J Parasitol 89:853-5. 2003
    ..89; P = 0.04), suggesting that this molecule offers promise as a recombinant vaccine...
  15. ncbi request reprint Loss of laboratory instruction in American medical schools: erosion of Flexner's view of "scientific medical education."
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington DC 20037, USA
    Am J Med Sci 325:10-4. 2003
    ..Because it is unlikely that many American medical schools have either the will or means to make substantive changes in their laboratory-based curricula, novel solutions to restoring laboratory-based medical education may be required...
  16. ncbi request reprint Hookworm infection
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    N Engl J Med 351:799-807. 2004
  17. ncbi request reprint The National Institutes of Health roadmap and the developing world
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
    J Investig Med 52:246-7. 2004
  18. ncbi request reprint Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of worms
    Alex Loukas
    Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, DC, USA
    J Infect Dis 189:1952-61. 2004
    ..These results indicate that cysteine proteases involved in parasite nutrition are promising candidates as vaccines against hookworm disease...
  19. ncbi request reprint Effect of combining the larval antigens Ancylostoma secreted protein 2 (ASP-2) and metalloprotease 1 (MTP-1) in protecting hamsters against hookworm infection and disease caused by Ancylostoma ceylanicum
    Susana Mendez
    Department of Microbiology and Tropical Medicine and Sabin Vaccine Institute, The George Washington University Medical Center, Rose Hall 736, 2300 Eye Street, NW, Washington, DC 20037, USA
    Vaccine 23:3123-30. 2005
    ..Taken together, these data suggest that combination of two or more antigens may present an effective vaccine development strategy to improve protection and/or disease symptoms in affected individuals...
  20. ncbi request reprint The impact of concurrent and treated Ancylostoma ceylanicum hookworm infections on the immunogenicity of a recombinant hookworm vaccine in hamsters
    Kashinath Ghosh
    Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
    J Infect Dis 193:155-62. 2006
    ..The effect of concurrent (active) and treated hookworm infections on the immunogenicity of vaccination with the recombinant fusion protein Ay-Ancylostoma-secreted protein 2 was analyzed in the Golden Syrian hamster...
  21. ncbi request reprint Effect of vaccinations with recombinant fusion proteins on Ancylostoma caninum habitat selection in the canine intestine
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, Sabin Vaccine Institute, George Washington University Medical Center, 2300 Eye Street NW, Washington, D C 20037, USA
    J Parasitol 88:684-90. 2002
    ..Female adult hookworms were more likely to migrate into the colon than were males. Anti-enzyme and anti-enzyme inhibitor antibodies correlated with an alteration in adult hookworm habitat selection in the canine gastroinntestinal tract...
  22. ncbi request reprint Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals
    Jeffrey Bethony
    Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
    FASEB J 19:1743-5. 2005
    ..These findings provide strong support for the development of an effective recombinant vaccine against hookworm infection in humans...
  23. doi request reprint Hookworm vaccines
    David J Diemert
    Sabin Vaccine Institute, George Washington University, Washington, DC 20037, USA
    Clin Infect Dis 46:282-8. 2008
    ..Plans call for eventual development of a vaccine that will combine at least 2 hookworm antigens--one targeting the larval stage of the life cycle and another targeting the adult worm living in the gastrointestinal tract...
  24. pmc Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migration
    Angela L Williamson
    Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, DC, USA
    Infect Immun 74:961-7. 2006
    ..The data strongly suggest that Ac-MTP-1 is critical for the invasion process of hookworm larvae, and moreover, that antibodies against the enzyme can neutralize its function and inhibit migration...
  25. ncbi request reprint Vaccines against blood-feeding nematodes of humans and livestock
    J M Bethony
    Centro de Pesquisas René Rachou CPqRR, A FIOCRUZ em Minas Gerais Rene Rachou Research Center CPqRR, The Oswaldo Cruz Foundation, Minas Gerais, Brazil
    Parasitology 133:S63-79. 2006
    ....
  26. pmc Vaccines to combat the neglected tropical diseases
    Jeffrey M Bethony
    Microbiology, Immunology, and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
    Immunol Rev 239:237-70. 2011
    ..Also highlighted are the contributions being made by non-profit product development partnerships that are working to overcome some of the economic challenges in vaccine manufacture, clinical testing, and global access...
  27. doi request reprint Developing vaccines to combat hookworm infection and intestinal schistosomiasis
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    Nat Rev Microbiol 8:814-26. 2010
    ..New genomic, proteomic, immunological and X-ray crystallographic data have led to the discovery of several promising candidate vaccine antigens. Here, we describe recent progress in this field and the rationale for vaccine development...
  28. doi request reprint Randomized, placebo-controlled, double-blind trial of the Na-ASP-2 hookworm vaccine in unexposed adults
    Jeffrey M Bethony
    Department of Microbiology, Immunology and Tropical Medicine, George Washington University Health Center, Washington, DC 20037, United States
    Vaccine 26:2408-17. 2008
    ....
  29. ncbi request reprint Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm
    Jeffrey Bethony
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC, 20037, USA
    Lancet 367:1521-32. 2006
    ..Concerns about the sustainability of periodic deworming with benzimidazole anthelmintics and the emergence of resistance have prompted efforts to develop and test new control tools...
  30. ncbi request reprint An ounce of prevention on a budget: a nonprofit approach to developing vaccines against neglected diseases
    Maria Elena Bottazzi
    The George Washington University, The Human Hookworm Vaccine Initiative, Department of Microbiology, Immunology and Tropical Medicine, 2300 Eye Street NW, Ross Hall Room 733, Washington, DC 20037, USA
    Expert Rev Vaccines 5:189-98. 2006
    ..Throughout this perspective, special emphasis is placed on the growing promise that product development public-private partnerships hold for developing vaccines for the world's poorest people...
  31. ncbi request reprint Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials
    Gaddam Narsa Goud
    Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Ross Hall 736, 2300 Eye Street NW, Washington, DC 20037, USA
    Vaccine 23:4754-64. 2005
    ..The processes developed and tested for the high yield production of recombinant Na-ASP-2 provide a foundation for clinical vaccine development...
  32. ncbi request reprint Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs
    Ricardo T Fujiwara
    Department of Microbiology and Tropical Medicine, The George Washington University, 2300 Eye Street, Ross Hall Room 727, Medical Center, Washington, DC 20037, USA
    Vaccine 24:501-9. 2006
    ....
  33. ncbi request reprint Ac-SAA-1, an immunodominant 16 kDa surface-associated antigen of infective larvae and adults of Ancylostoma caninum
    Bin Zhan
    Department of Microbiology and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, 2300 Eye Street NW, Washington, DC 20037, USA
    Int J Parasitol 34:1037-45. 2004
    ..7%) invasion of hookworm L(3) into dog skin in vitro. Together these results suggest that Ancylostoma caninum surface-associated antigen-1 offers promise as a protective vaccine antigen...
  34. pmc Biochemical characterization and vaccine potential of a heme-binding glutathione transferase from the adult hookworm Ancylostoma caninum
    Bin Zhan
    Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
    Infect Immun 73:6903-11. 2005
    ..7%) following challenge with heterologous Necator americanus larvae. These studies suggest that Ac-GST-1 is a possible drug and vaccine target for hookworm infection...
  35. ncbi request reprint A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms
    Angela L Williamson
    Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
    J Biol Chem 279:35950-7. 2004
    ....
  36. pmc Host cytokine production, lymphoproliferation, and antibody responses during the course of Ancylostoma ceylanicum infection in the Golden Syrian hamster
    Susana Mendez
    Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Ross Hall, Rm 726, 2300 Eye St NW, Washington, DC 20037, USA
    Infect Immun 73:3402-7. 2005
    ..The findings demonstrate a similarity in immune responses between hamsters and humans infected with hookworms, suggesting that hamsters will be a useful animal model species for examining host immunity to human hookworm infections...
  37. pmc Erosion of William Henry Welch's concept of the hygienic laboratory in our nation's schools of public health and medicine
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington DC 20037, USA
    Public Health Rep 118:184-6. 2003
  38. ncbi request reprint Ac-FAR-1, a 20 kDa fatty acid- and retinol-binding protein secreted by adult Ancylostoma caninum hookworms: gene transcription pattern, ligand binding properties and structural characterisation
    Sridhar V Basavaraju
    Department of Microbiology and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, DC 20037, USA
    Mol Biochem Parasitol 126:63-71. 2003
    ..This is the first demonstration of a functional FAR secreted by adult hookworms and provides further evidence that FAR proteins secreted by parasitic nematodes are crucial to parasitism...
  39. ncbi request reprint Combating tropical infectious diseases: report of the Disease Control Priorities in Developing Countries Project
    Peter J Hotez
    George Washington University, Washington, DC, USA
    Clin Infect Dis 38:871-8. 2004
    ..Application of technologies must be cost-effective and intensified research is essential if these and other scourges are to be controlled or eliminated in the 21st century...
  40. doi request reprint Escalating the global fight against neglected tropical diseases through interventions in the Asia Pacific region
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, District of Columbia, USA
    Adv Parasitol 72:31-53. 2010
    ..Through a global network for NTDs, an innovative finance mechanism Is being created to control the most common neglected diseases across Asia...
  41. doi request reprint Neglected tropical disease vaccines
    Peter J Hotez
    Sabin Vaccine Institute, DC 20006, USA
    Biologicals 37:160-4. 2009
    ..This would be an important step towards achieving the Millennium Development Goals for sustainable poverty reduction by 2015...
  42. ncbi request reprint Emerging patterns of hookworm infection: influence of aging on the intensity of Necator infection in Hainan Province, People's Republic of China
    Jeffrey Bethony
    George Washington University, Washington, DC, USA
    Clin Infect Dis 35:1336-44. 2002
    ..None of the other 26 personal or 32 household risk factors were found to be significant. The importance of aging in Necator infection reveals an emerging public health problem among the elderly population of developing countries...
  43. ncbi request reprint Cloning, yeast expression, isolation, and vaccine testing of recombinant Ancylostoma-secreted protein (ASP)-1 and ASP-2 from Ancylostoma ceylanicum
    Gaddam Narsa Goud
    Department of Microbiology and Tropical Medicine and Pathology, George Washington University, and The Sabin Vaccine Institute, Washington, DC
    J Infect Dis 189:919-29. 2004
    ..These results indicate that ASP-2 is a promising molecule for the development of a hookworm vaccine...
  44. ncbi request reprint A developmentally regulated metalloprotease secreted by host-stimulated Ancylostoma caninum third-stage infective larvae is a member of the astacin family of proteases
    Bin Zhan
    Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, 725 Ross Hall, 2300 Eye Street NW, Washington, DC 20037, USA
    Mol Biochem Parasitol 120:291-6. 2002
  45. ncbi request reprint The antipoverty vaccines
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and the Sabin Vaccine Institute, Washington, DC 20037, USA
    Vaccine 24:5787-99. 2006
    ..Early development of such antipoverty vaccines will require the establishment of product development public-private partnerships and partnerships with innovative developing countries where these diseases are endemic...
  46. pmc Neglected infections of poverty in the United States of America
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, D C, USA
    PLoS Negl Trop Dis 2:e256. 2008
    ....
  47. ncbi request reprint Molecular characterisation of the Ancylostoma-secreted protein family from the adult stage of Ancylostoma caninum
    Bin Zhan
    Department of Microbiology and Tropical Medicine, Ross Hall, Room 736, 2300 Eye Street NW, The George Washington University, Washington, DC 20037, USA
    Int J Parasitol 33:897-907. 2003
    ..The functions of the adult Ancylostoma-secreted proteins are unknown, although the secretion of multiple family members by the adult suggests an important role in the establishment or maintenance of the parasitic relationship...
  48. pmc Helminth infections: the great neglected tropical diseases
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
    J Clin Invest 118:1311-21. 2008
    ..Ultimately, these advances in molecular and medical helminth biology should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans...
  49. ncbi request reprint A secreted protein from the human hookworm necator americanus binds selectively to NK cells and induces IFN-gamma production
    George C F Hsieh
    Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
    J Immunol 173:2699-704. 2004
    ..Such an interaction could provide a means of cross-regulating deleterious Th2 immune responses in the host, thereby contributing to the long-term survival of N. americanus...
  50. ncbi request reprint Helminth infections of children: prospects for control
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
    Adv Exp Med Biol 568:135-44. 2005
  51. ncbi request reprint Digestive proteases of blood-feeding nematodes
    Angela L Williamson
    Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington DC 20037, USA
    Trends Parasitol 19:417-23. 2003
    ..Numerous laboratories are actively investigating these molecules as antiparasite vaccine targets...
  52. ncbi request reprint Molecular cloning and purification of Ac-TMP, a developmentally regulated putative tissue inhibitor of metalloprotease released in relative abundance by adult Ancylostoma hookworms
    Bin Zhan
    Department of Microbiology and Tropical Medicine, George Washington University Medical Center and Albert B Sabin Vaccine Institute, Washington, District of Columbia 20037, USA
    Am J Trop Med Hyg 66:238-44. 2002
    ..To our knowledge, this is the first description of a TIMP from a parasitic invertebrate...
  53. ncbi request reprint X-ray structure of Na-ASP-2, a pathogenesis-related-1 protein from the nematode parasite, Necator americanus, and a vaccine antigen for human hookworm infection
    Oluwatoyin A Asojo
    Eppley Institute for Research in Cancer and Allied Diseases, 987696 Nebraska Medical Center, Omaha, NE 68198 7696, USA
    J Mol Biol 346:801-14. 2005
    ..From these modeling studies, possible binding modes were predicted. In addition, this first structure of a PR-1 protein from parasitic helminths may shed light on the molecular basis of host-parasite interactions...
  54. pmc Crystallization and preliminary X-ray analysis of Na-ASP-1, a multi-domain pathogenesis-related-1 protein from the human hookworm parasite Necator americanus
    Oluwatoyin A Asojo
    Eppley Institute for Research in Cancer and Allied Diseases, 987696 Nebraska Medical Center, Omaha, NE 68198 7696, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:391-4. 2005
    ..7, b = 74.27, c = 84.60 A, beta = 112.12 degrees. An initial molecular-replacement solution has been obtained with one monomer in the asymmetric unit...
  55. ncbi request reprint Hookworm aspartic protease, Na-APR-2, cleaves human hemoglobin and serum proteins in a host-specific fashion
    Angela L Williamson
    Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Queensland, Australia
    J Infect Dis 187:484-94. 2003
    ..americanus cathepsin D, Na-APR-1. Antiserum against Na-APR-2 inhibited migration of 50% of third-stage N. americanus larvae through skin, which suggests that aspartic proteases might be effective vaccines against human hookworm disease...
  56. ncbi request reprint Fighting tropical diseases
    Jeffrey D Sachs
    Science 311:1521. 2006
  57. ncbi request reprint Neglected tropical diseases and HIV/AIDS
    Peter J Hotez
    Lancet 368:1865-6. 2006
  58. ncbi request reprint Age-related changes in hookworm infection, anaemia and iron deficiency in an area of high Necator americanus hookworm transmission in south-eastern Brazil
    Simon Brooker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Trans R Soc Trop Med Hyg 101:146-54. 2007
    ..Our results indicate that, even in areas where there is a low overall prevalence of anaemia, hookworm can still have an important impact on host iron status, especially in school-aged children and the elderly...
  59. ncbi request reprint Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificity
    Angela L Williamson
    Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, QLD, Australia
    FASEB J 16:1458-60. 2002
    ....
  60. pmc Contrasting patterns in the small-scale heterogeneity of human helminth infections in urban and rural environments in Brazil
    Simon Brooker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, WCIE 7HT, UK
    Int J Parasitol 36:1143-51. 2006
    ..We suggest that such species-specific differences in patterns of infection by environment are primarily due to variation in exposure and parasite life cycle, although host genetic factors cannot be ruled out...
  61. ncbi request reprint Synergistic associations between hookworm and other helminth species in a rural community in Brazil
    Fiona M Fleming
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    Trop Med Int Health 11:56-64. 2006
    ..To identify possible synergistic associations of hookworm and other helminths...
  62. ncbi request reprint Helminth vaccines: from mining genomic information for vaccine targets to systems used for protein expression
    John P Dalton
    School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Int J Parasitol 33:621-40. 2003
    ....
  63. ncbi request reprint Necator americanus: maintenance through one hundred generations in golden hamsters (Mesocricetus auratus). I. Host sex-associated differences in hookworm burden and fecundity
    Xue Jian
    Institute of Parasitic Diseases, Chinese Centers for Disease Control and Prevention, 207 Rui Jin Er Lu, Shanghai 200025, PR China
    Exp Parasitol 104:62-6. 2003
    ..This unique adaptation of N. americanus to hamsters permits its use for purposes of anthelminthic drug and vaccine development...
  64. ncbi request reprint A family of cathepsin B cysteine proteases expressed in the gut of the human hookworm, Necator americanus
    Najju Ranjit
    School of Life Sciences, Queensland University of Technology, Brisbane, QLD, Australia
    Mol Biochem Parasitol 160:90-9. 2008
    ..These data show that N. americanus expresses a family of intestinal CatBs, many of which are likely to be involved in nutrient acquisition and therefore are potential targets for chemotherapies and vaccines...
  65. pmc Human hookworm infection in the 21st century
    Simon Brooker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Adv Parasitol 58:197-288. 2004
    ..There are also on-going efforts to develop novel anthelmintic drugs and anti-hookworm vaccines...
  66. ncbi request reprint Health innovation networks to help developing countries address neglected diseases
    Carlos M Morel
    Center for Technological Development in Health, Oswaldo Cruz Foundation FIOCRUZ, Avenida Brasil 4365, Rio de Janeiro, RJ 21040 900, Brazil
    Science 309:401-4. 2005
    ..Here we highlight a complementary and increasingly important means to improve health equity: the growing ability of some developing countries to undertake health innovation...
  67. ncbi request reprint Molecular cloning and characterization of Ac-mep-1, a developmentally regulated gut luminal metalloendopeptidase from adult Ancylostoma caninum hookworms
    Brian F Jones
    Medical Helminthology Laboratory, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA
    Mol Biochem Parasitol 119:107-16. 2002
    ..Adult worm sections probed with these antisera localized Ac-mep-1 to the microvilli of the worm gastrointestinal tract suggesting a possible role for this enzyme in digestion of the parasite blood meal...
  68. ncbi request reprint Saturation of the secretory pathway by overexpression of a hookworm (Necator americanus) Protein (Na-ASP1)
    Mehmet Inan
    Department of Chemical Engineering, University of Nebraska, Lincoln, NE USA
    Methods Mol Biol 389:65-76. 2007
    ..However, increasing gene copy number of Na-ASP1 protein in P. pastoris saturated secretory capacity and therefore, decreased the amount of secreted protein in clones harboring multiple copies of Na-ASP1 gene...
  69. pmc "Rapid-impact interventions": how a policy of integrated control for Africa's neglected tropical diseases could benefit the poor
    David H Molyneux
    Lymphatic Filariasis Support Centre at the Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS Med 2:e336. 2005
  70. pmc Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogs
    Alex Loukas
    Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS Med 2:e295. 2005
    ..The parasites subsequently digest hemoglobin in their intestines using a cascade of proteolysis that begins with the Ancylostoma caninum aspartic protease 1, APR-1...
  71. ncbi request reprint Soil-transmitted helminth infections: updating the global picture
    Nilanthi R de Silva
    Department of Parasitology, Faculty of Medicine, University of Kelaniya, PO Box 6, Ragama, Sri Lanka
    Trends Parasitol 19:547-51. 2003
  72. pmc Epidemiology of plasmodium-helminth co-infection in Africa: populations at risk, potential impact on anemia, and prospects for combining control
    Simon Brooker
    London School of Hygiene and Tropical Medicine, Kepel Street, London, United Kingdom
    Am J Trop Med Hyg 77:88-98. 2007
    ..We suggest that both school-age children and pregnant women--groups which have the highest risk of anemia--would benefit from an integrated approach to malaria and helminth control...
  73. pmc Cures for the Third World's problems: the application of genomics to the diseases plaguing the developing world may have huge medical and economic benefits for those countries and might even prevent armed conflict
    Samuel Broder
    Clera Genomics, Rockville, MD, USA
    EMBO Rep 3:806-12. 2002

Research Grants4

  1. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2002
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
  2. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2001
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
  3. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2000
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
  4. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2002
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..