Research Topics
| P J HotezSummaryAffiliation: The George Washington University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malariaPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, District of Columbia, USA
PLoS Med 3:e102. 2006- The co-distribution of Plasmodium falciparum and hookworm among African schoolchildrenSimon Brooker
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
Malar J 5:99. 2006..This is despite the potential public health importance of co-infection and synergistic opportunities for control... - X-ray structures of Na-GST-1 and Na-GST-2 two glutathione S-transferase from the human hookworm Necator americanusOluwatoyin A Asojo
Department of Pathology and Microbiology, College of Medicine Nebraska Medical Center, Omaha, NE 68198 6495, USA
BMC Struct Biol 7:42. 2007..Parasite GSTs also play significant roles in multi-drug resistance and the modulation of host-immune defense mechanisms... 
Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine InitiativePeter J Hotez
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC, USA
Int J Parasitol 33:1245-58. 2003..Another challenge will be to produce anti-hookworm vaccine antigens at high yield low cost suitable for immunising large impoverished populations living in the developing nations of the tropics...- Effect of vaccination with a recombinant fusion protein encoding an astacinlike metalloprotease (MTP-1) secreted by host-stimulated Ancylostoma caninum third-stage infective larvaePeter J Hotez
Department of Microbiology and Tropical Medicine and Sabin Vaccine Institute, The George Washington University Medical Center, 2300 Eye Street NW, Washington, DC 20037, USA
J Parasitol 89:853-5. 2003..89; P = 0.04), suggesting that this molecule offers promise as a recombinant vaccine... - Control of neglected tropical diseasesPeter J Hotez
Sabin Vaccine Institute, and the Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
N Engl J Med 357:1018-27. 2007 - New technologies for the control of human hookworm infectionPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, 2300 I Street, NW Washington, DC 20037, USA
Trends Parasitol 22:327-31. 2006..g. tribendimidine) and a recombinant hookworm vaccine. It is hoped that, ultimately, anthelmintic vaccination will be linked to deworming as part of an expanded control package... - Should we establish a North American school of global health sciences?Peter J Hotez
Department of Microbiology and Tropical Medicine, Global Health, Epidemiology and Biostatistics, The George Washington University, Washington, DC 20037, USA
Am J Med Sci 328:71-7. 2004..The North American school, possibly in association with one of the existing schools of medicine or public health, would provide interdisciplinary training to produce a new generation of global health scientists... - Hookworm infectionPeter J Hotez
Department of Microbiology and Tropical Medicine, George Washington University, Washington, DC 20037, USA
N Engl J Med 351:799-807. 2004 - The National Institutes of Health roadmap and the developing worldPeter J Hotez
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
J Investig Med 52:246-7. 2004 - Control of onchocerciasis--the next generationPeter J Hotez
Sabin Vaccine Institute and Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
Lancet 369:1979-80. 2007 - Hookworm: "the great infection of mankind"Peter J Hotez
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC, USA
PLoS Med 2:e67. 2005 
Multivalent anthelminthic vaccine to prevent hookworm and schistosomiasisPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, DC, USA
Expert Rev Vaccines 7:745-52. 2008..A multivalent anthelminthic vaccine for hookworm infection and schistosomiasis would represent an important new tool for combating disease and poverty...
The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and eliminationPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, DC, USA
PLoS Negl Trop Dis 2:e300. 2008..Ultimately, the roadmap for the control and elimination of the more widespread NTDs will require an inter-sectoral approach that bridges public health, social services, and environmental interventions...- Loss of laboratory instruction in American medical schools: erosion of Flexner's view of "scientific medical education."Peter J Hotez
Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington DC 20037, USA
Am J Med Sci 325:10-4. 2003..Because it is unlikely that many American medical schools have either the will or means to make substantive changes in their laboratory-based curricula, novel solutions to restoring laboratory-based medical education may be required... - Recent progress in integrated neglected tropical disease controlPeter Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, 2300 I Street NW, Washington, DC 20037, USA
Trends Parasitol 23:511-4. 2007..who.int/dg/speeches/2007). Outlined here is a summary of the recent progress in global efforts to integrate NTD control, with an emphasis on the challenges that lie ahead... - Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of wormsAlex Loukas
Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, DC, USA
J Infect Dis 189:1952-61. 2004..These results indicate that cysteine proteases involved in parasite nutrition are promising candidates as vaccines against hookworm disease... - The impact of concurrent and treated Ancylostoma ceylanicum hookworm infections on the immunogenicity of a recombinant hookworm vaccine in hamstersKashinath Ghosh
Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
J Infect Dis 193:155-62. 2006..The hookworm-associated immunodepression may have important implications for design of clinical trials of human vaccines and vaccination strategies... - Effect of combining the larval antigens Ancylostoma secreted protein 2 (ASP-2) and metalloprotease 1 (MTP-1) in protecting hamsters against hookworm infection and disease caused by Ancylostoma ceylanicumSusana Mendez
Department of Microbiology and Tropical Medicine and Sabin Vaccine Institute, The George Washington University Medical Center, Rose Hall 736, 2300 Eye Street, NW, Washington, DC 20037, USA
Vaccine 23:3123-30. 2005..Taken together, these data suggest that combination of two or more antigens may present an effective vaccine development strategy to improve protection and/or disease symptoms in affected individuals... - Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animalsJeffrey Bethony
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
FASEB J 19:1743-5. 2005..These findings provide strong support for the development of an effective recombinant vaccine against hookworm infection in humans... - Effect of vaccinations with recombinant fusion proteins on Ancylostoma caninum habitat selection in the canine intestinePeter J Hotez
Department of Microbiology and Tropical Medicine, Sabin Vaccine Institute, George Washington University Medical Center, 2300 Eye Street NW, Washington, D.C. 20037, USA
J Parasitol 88:684-90. 2002..Female adult hookworms were more likely to migrate into the colon than were males. Anti-enzyme and anti-enzyme inhibitor antibodies correlated with an alteration in adult hookworm habitat selection in the canine gastroinntestinal tract... - Hookworm vaccinesDavid J Diemert
Sabin Vaccine Institute, George Washington University, Washington, DC 20037, USA
Clin Infect Dis 46:282-8. 2008..Plans call for eventual development of a vaccine that will combine at least 2 hookworm antigens--one targeting the larval stage of the life cycle and another targeting the adult worm living in the gastrointestinal tract... - Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migrationAngela L Williamson
Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, DC, USA
Infect Immun 74:961-7. 2006..The data strongly suggest that Ac-MTP-1 is critical for the invasion process of hookworm larvae, and moreover, that antibodies against the enzyme can neutralize its function and inhibit migration... - Vaccines against blood-feeding nematodes of humans and livestockJ M Bethony
Centro de Pesquisas René Rachou CPqRR, A FIOCRUZ em Minas Gerais Rene Rachou Research Center CPqRR, The Oswaldo Cruz Foundation, Minas Gerais, Brazil
Parasitology 133:S63-79. 2006.... - Host cytokine production, lymphoproliferation, and antibody responses during the course of Ancylostoma ceylanicum infection in the Golden Syrian hamsterSusana Mendez
Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Ross Hall, Rm 726, 2300 Eye St NW, Washington, DC 20037, USA
Infect Immun 73:3402-7. 2005..The findings demonstrate a similarity in immune responses between hamsters and humans infected with hookworms, suggesting that hamsters will be a useful animal model species for examining host immunity to human hookworm infections... - Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookwormJeffrey Bethony
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC, 20037, USA
Lancet 367:1521-32. 2006..Concerns about the sustainability of periodic deworming with benzimidazole anthelmintics and the emergence of resistance have prompted efforts to develop and test new control tools... - Biochemical characterization and vaccine potential of a heme-binding glutathione transferase from the adult hookworm Ancylostoma caninumBin Zhan
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
Infect Immun 73:6903-11. 2005..7%) following challenge with heterologous Necator americanus larvae. These studies suggest that Ac-GST-1 is a possible drug and vaccine target for hookworm infection... - Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trialsGaddam Narsa Goud
Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Ross Hall 736, 2300 Eye Street NW, Washington, DC 20037, USA
Vaccine 23:4754-64. 2005..The processes developed and tested for the high yield production of recombinant Na-ASP-2 provide a foundation for clinical vaccine development... - Vaccines to combat the neglected tropical diseasesJeffrey M Bethony
Microbiology, Immunology, and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
Immunol Rev 239:237-70. 2011..Also highlighted are the contributions being made by non-profit product development partnerships that are working to overcome some of the economic challenges in vaccine manufacture, clinical testing, and global access... - An ounce of prevention on a budget: a nonprofit approach to developing vaccines against neglected diseasesMaria Elena Bottazzi
The George Washington University, The Human Hookworm Vaccine Initiative, Department of Microbiology, Immunology and Tropical Medicine, 2300 Eye Street NW, Ross Hall Room 733, Washington, DC 20037, USA
Expert Rev Vaccines 5:189-98. 2006..Throughout this perspective, special emphasis is placed on the growing promise that product development public-private partnerships hold for developing vaccines for the world's poorest people... - Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogsRicardo T Fujiwara
Department of Microbiology and Tropical Medicine, The George Washington University, 2300 Eye Street, Ross Hall Room 727, Medical Center, Washington, DC 20037, USA
Vaccine 24:501-9. 2006.... - Developing vaccines to combat hookworm infection and intestinal schistosomiasisPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
Nat Rev Microbiol 8:814-26. 2010..New genomic, proteomic, immunological and X-ray crystallographic data have led to the discovery of several promising candidate vaccine antigens. Here, we describe recent progress in this field and the rationale for vaccine development... - Ac-FAR-1, a 20 kDa fatty acid- and retinol-binding protein secreted by adult Ancylostoma caninum hookworms: gene transcription pattern, ligand binding properties and structural characterisationSridhar Basavaraju
Department of Microbiology and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, DC 20037, USA
Mol Biochem Parasitol 126:63-71. 2003..This is the first demonstration of a functional FAR secreted by adult hookworms and provides further evidence that FAR proteins secreted by parasitic nematodes are crucial to parasitism... - Randomized, placebo-controlled, double-blind trial of the Na-ASP-2 hookworm vaccine in unexposed adultsJeffrey M Bethony
Department of Microbiology, Immunology and Tropical Medicine, George Washington University Health Center, Washington, DC 20037, United States
Vaccine 26:2408-17. 2008.... - A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookwormsAngela L Williamson
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
J Biol Chem 279:35950-7. 2004.... - Erosion of William Henry Welch's concept of the hygienic laboratory in our nation's schools of public health and medicinePeter J Hotez
Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington DC 20037, USA
Public Health Rep 118:184-6. 2003 - Ac-SAA-1, an immunodominant 16 kDa surface-associated antigen of infective larvae and adults of Ancylostoma caninumBin Zhan
Department of Microbiology and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, 2300 Eye Street NW, Washington, DC 20037, USA
Int J Parasitol 34:1037-45. 2004..7%) invasion of hookworm L(3) into dog skin in vitro. Together these results suggest that Ancylostoma caninum surface-associated antigen-1 offers promise as a protective vaccine antigen... - Combating tropical infectious diseases: report of the Disease Control Priorities in Developing Countries ProjectPeter J Hotez
George Washington University, Washington, DC, USA
Clin Infect Dis 38:871-8. 2004..Application of technologies must be cost-effective and intensified research is essential if these and other scourges are to be controlled or eliminated in the 21st century... - A developmentally regulated metalloprotease secreted by host-stimulated Ancylostoma caninum third-stage infective larvae is a member of the astacin family of proteasesBin Zhan
Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, 725 Ross Hall, 2300 Eye Street NW, Washington, DC 20037, USA
Mol Biochem Parasitol 120:291-6. 2002 - Escalating the global fight against neglected tropical diseases through interventions in the Asia Pacific regionPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, District of Columbia, USA
Adv Parasitol 72:31-53. 2010..Through a global network for NTDs, an innovative finance mechanism Is being created to control the most common neglected diseases across Asia... - Emerging patterns of hookworm infection: influence of aging on the intensity of Necator infection in Hainan Province, People's Republic of ChinaJeffrey Bethony
George Washington University, Washington, DC, USA
Clin Infect Dis 35:1336-44. 2002..None of the other 26 personal or 32 household risk factors were found to be significant. The importance of aging in Necator infection reveals an emerging public health problem among the elderly population of developing countries... - Cloning, yeast expression, isolation, and vaccine testing of recombinant Ancylostoma-secreted protein (ASP)-1 and ASP-2 from Ancylostoma ceylanicumGaddam Narsa Goud
Department of Microbiology and Tropical Medicine and Pathology, George Washington University, and The Sabin Vaccine Institute, Washington, DC
J Infect Dis 189:919-29. 2004..These results indicate that ASP-2 is a promising molecule for the development of a hookworm vaccine... - The antipoverty vaccinesPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and the Sabin Vaccine Institute, Washington, DC 20037, USA
Vaccine 24:5787-99. 2006..Early development of such antipoverty vaccines will require the establishment of product development public-private partnerships and partnerships with innovative developing countries where these diseases are endemic... - Neglected tropical disease vaccinesPeter J Hotez
Sabin Vaccine Institute, DC 20006, USA
Biologicals 37:160-4. 2009..This would be an important step towards achieving the Millennium Development Goals for sustainable poverty reduction by 2015... - Neglected infections of poverty in the United States of AmericaPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, D C, USA
PLoS Negl Trop Dis 2:e256. 2008.... - Helminth infections: the great neglected tropical diseasesPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
J Clin Invest 118:1311-21. 2008..Ultimately, these advances in molecular and medical helminth biology should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans... - A secreted protein from the human hookworm necator americanus binds selectively to NK cells and induces IFN-gamma productionGeorge C-F Hsieh
Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
J Immunol 173:2699-704. 2004..Such an interaction could provide a means of cross-regulating deleterious Th2 immune responses in the host, thereby contributing to the long-term survival of N. americanus... - Molecular characterisation of the Ancylostoma-secreted protein family from the adult stage of Ancylostoma caninumBin Zhan
Department of Microbiology and Tropical Medicine, Ross Hall, Room 736, 2300 Eye Street NW, The George Washington University, Washington, DC 20037, USA
Int J Parasitol 33:897-907. 2003..The functions of the adult Ancylostoma-secreted proteins are unknown, although the secretion of multiple family members by the adult suggests an important role in the establishment or maintenance of the parasitic relationship... - Helminth infections of children: prospects for controlPeter J Hotez
Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
Adv Exp Med Biol 568:135-44. 2005 - Molecular cloning and purification of Ac-TMP, a developmentally regulated putative tissue inhibitor of metalloprotease released in relative abundance by adult Ancylostoma hookwormsBin Zhan
Department of Microbiology and Tropical Medicine, George Washington University Medical Center and Albert B Sabin Vaccine Institute, Washington, District of Columbia 20037, USA
Am J Trop Med Hyg 66:238-44. 2002..To our knowledge, this is the first description of a TIMP from a parasitic invertebrate... - Digestive proteases of blood-feeding nematodesAngela L Williamson
Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington DC 20037, USA
Trends Parasitol 19:417-23. 2003..Numerous laboratories are actively investigating these molecules as antiparasite vaccine targets... - Human hookworm infection in the 21st centurySimon Brooker
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Adv Parasitol 58:197-288. 2004..There are also on-going efforts to develop novel anthelmintic drugs and anti-hookworm vaccines... - Necator americanus: maintenance through one hundred generations in golden hamsters (Mesocricetus auratus). I. Host sex-associated differences in hookworm burden and fecundityXue Jian
Institute of Parasitic Diseases, Chinese Centers for Disease Control and Prevention, 207 Rui Jin Er Lu, Shanghai 200025, PR China
Exp Parasitol 104:62-6. 2003..This unique adaptation of N. americanus to hamsters permits its use for purposes of anthelminthic drug and vaccine development... - Fighting tropical diseasesJeffrey D Sachs
Science 311:1521. 2006 - A family of cathepsin B cysteine proteases expressed in the gut of the human hookworm, Necator americanusNajju Ranjit
School of Life Sciences, Queensland University of Technology, Brisbane, QLD, Australia
Mol Biochem Parasitol 160:90-9. 2008..These data show that N. americanus expresses a family of intestinal CatBs, many of which are likely to be involved in nutrient acquisition and therefore are potential targets for chemotherapies and vaccines... - Helminth vaccines: from mining genomic information for vaccine targets to systems used for protein expressionJohn P Dalton
School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
Int J Parasitol 33:621-40. 2003.... - Hookworm aspartic protease, Na-APR-2, cleaves human hemoglobin and serum proteins in a host-specific fashionAngela L Williamson
Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Queensland, Australia
J Infect Dis 187:484-94. 2003..americanus cathepsin D, Na-APR-1. Antiserum against Na-APR-2 inhibited migration of 50% of third-stage N. americanus larvae through skin, which suggests that aspartic proteases might be effective vaccines against human hookworm disease... - Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificityAngela L Williamson
Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, QLD, Australia
FASEB J 16:1458-60. 2002.... - Saturation of the secretory pathway by overexpression of a hookworm (Necator americanus) Protein (Na-ASP1)Mehmet Inan
Department of Chemical Engineering, University of Nebraska, Lincoln, NE USA
Methods Mol Biol 389:65-76. 2007..However, increasing gene copy number of Na-ASP1 protein in P. pastoris saturated secretory capacity and therefore, decreased the amount of secreted protein in clones harboring multiple copies of Na-ASP1 gene... - Soil-transmitted helminth infections: updating the global pictureNilanthi R de Silva
Department of Parasitology, Faculty of Medicine, University of Kelaniya, PO Box 6, Ragama, Sri Lanka
Trends Parasitol 19:547-51. 2003 - Crystallization and preliminary X-ray analysis of Na-ASP-1, a multi-domain pathogenesis-related-1 protein from the human hookworm parasite Necator americanusOluwatoyin A Asojo
Eppley Institute for Research in Cancer and Allied Diseases, 987696 Nebraska Medical Center, Omaha, NE 68198 7696, USA
Acta Crystallogr Sect F Struct Biol Cryst Commun 61:391-4. 2005..7, b = 74.27, c = 84.60 A, beta = 112.12 degrees. An initial molecular-replacement solution has been obtained with one monomer in the asymmetric unit... - Synergistic associations between hookworm and other helminth species in a rural community in BrazilFiona M Fleming
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
Trop Med Int Health 11:56-64. 2006..More research is needed to examine the rates of re-infection and immune responses after chemotherapy, and to what extent the effects of polyparasitism are altered by chemotherapy... - Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogsAlex Loukas
Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
PLoS Med 2:e295. 2005..The parasites subsequently digest hemoglobin in their intestines using a cascade of proteolysis that begins with the Ancylostoma caninum aspartic protease 1, APR-1... - "Rapid-impact interventions": how a policy of integrated control for Africa's neglected tropical diseases could benefit the poorDavid H Molyneux
Lymphatic Filariasis Support Centre at the Liverpool School of Tropical Medicine, Liverpool, United Kingdom
PLoS Med 2:e336. 2005 - Contrasting patterns in the small-scale heterogeneity of human helminth infections in urban and rural environments in BrazilSimon Brooker
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, WCIE 7HT, UK
Int J Parasitol 36:1143-51. 2006..We suggest that such species-specific differences in patterns of infection by environment are primarily due to variation in exposure and parasite life cycle, although host genetic factors cannot be ruled out... - Age-related changes in hookworm infection, anaemia and iron deficiency in an area of high Necator americanus hookworm transmission in south-eastern BrazilSimon Brooker
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Trans R Soc Trop Med Hyg 101:146-54. 2007..Our results indicate that, even in areas where there is a low overall prevalence of anaemia, hookworm can still have an important impact on host iron status, especially in school-aged children and the elderly... - Health innovation networks to help developing countries address neglected diseasesCarlos M Morel
Center for Technological Development in Health, Oswaldo Cruz Foundation FIOCRUZ, Avenida Brasil 4365, Rio de Janeiro, RJ 21040 900, Brazil
Science 309:401-4. 2005..Here we highlight a complementary and increasingly important means to improve health equity: the growing ability of some developing countries to undertake health innovation... - X-ray structure of Na-ASP-2, a pathogenesis-related-1 protein from the nematode parasite, Necator americanus, and a vaccine antigen for human hookworm infectionOluwatoyin A Asojo
Eppley Institute for Research in Cancer and Allied Diseases, 987696 Nebraska Medical Center, Omaha, NE 68198 7696, USA
J Mol Biol 346:801-14. 2005..From these modeling studies, possible binding modes were predicted. In addition, this first structure of a PR-1 protein from parasitic helminths may shed light on the molecular basis of host-parasite interactions... - Molecular cloning and characterization of Ac-mep-1, a developmentally regulated gut luminal metalloendopeptidase from adult Ancylostoma caninum hookwormsBrian F Jones
Medical Helminthology Laboratory, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA
Mol Biochem Parasitol 119:107-16. 2002..Adult worm sections probed with these antisera localized Ac-mep-1 to the microvilli of the worm gastrointestinal tract suggesting a possible role for this enzyme in digestion of the parasite blood meal... - Neglected tropical diseases and HIV/AIDSPeter J Hotez
Lancet 368:1865-6. 2006 - Cures for the Third World's problems: the application of genomics to the diseases plaguing the developing world may have huge medical and economic benefits for those countries and might even prevent armed conflictSamuel Broder
Clera Genomics, Rockville, MD, USA
EMBO Rep 3:806-12. 2002 - Epidemiology of plasmodium-helminth co-infection in Africa: populations at risk, potential impact on anemia, and prospects for combining controlSimon Brooker
London School of Hygiene and Tropical Medicine, Kepel Street, London, United Kingdom
Am J Trop Med Hyg 77:88-98. 2007..We suggest that both school-age children and pregnant women--groups which have the highest risk of anemia--would benefit from an integrated approach to malaria and helminth control...
Research Grants
- HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENTPeter Hotez; Fiscal Year: 2002..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..