M S Horwitz

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Requirements for viral-mediated autoimmune diabetes: beta-cell damage and immune infiltration
    M S Horwitz
    Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Autoimmun 16:211-7. 2001
  2. ncbi request reprint Primary demyelination in transgenic mice expressing interferon-gamma
    M S Horwitz
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Med 3:1037-41. 1997
  3. ncbi request reprint Detailed in vivo analysis of interferon-gamma induced major histocompatibility complex expression in the the central nervous system: astrocytes fail to express major histocompatibility complex class I and II molecules
    M S Horwitz
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    Lab Invest 79:235-42. 1999
  4. pmc Protection from lethal coxsackievirus-induced pancreatitis by expression of gamma interferon
    M S Horwitz
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 73:1756-66. 1999
  5. ncbi request reprint A critical role for inducible nitric oxide synthase in host survival following coxsackievirus B4 infection
    M Flodstrom
    Department of Immunology, The Scripps Research Institute, 10 550 North Torrey Pines Road, La Jolla, California 92037, USA
    Virology 281:205-15. 2001
  6. pmc T-cell receptors from virus-specific cytotoxic T lymphocytes recognizing a single immunodominant nine-amino-acid viral epitope show marked diversity
    M S Horwitz
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037
    J Virol 68:352-7. 1994
  7. pmc Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains
    Y Li
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 18:1601-10. 1998
  8. pmc The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses
    J M Bergelson
    Division of Infectious Diseases, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Virol 72:415-9. 1998
  9. ncbi request reprint The effect of CD28/B7 blockade on alloreactive T and B cells after liver cell transplantation
    B Reddy
    Department of Medicine, Marion Bessin Research Liver Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Transplantation 71:801-11. 2001
  10. pmc Adenovirus E3 14.7-kilodalton protein, an antagonist of tumor necrosis factor cytolysis, increases the virulence of vaccinia virus in severe combined immunodeficient mice
    J M Tufariello
    Department of Microbiology, Albert Einstein College of Medicine, Bronx, NY 10461
    Proc Natl Acad Sci U S A 91:10987-91. 1994

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Requirements for viral-mediated autoimmune diabetes: beta-cell damage and immune infiltration
    M S Horwitz
    Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Autoimmun 16:211-7. 2001
    ..Therefore, the primary role of CB4 in the development of IDDM is to infect tissue, resulting in the presentation of sequestered islet antigen, the stimulation of preexisting autoreactive T cells, and the initiation of disease...
  2. ncbi request reprint Primary demyelination in transgenic mice expressing interferon-gamma
    M S Horwitz
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Med 3:1037-41. 1997
    ..These results demonstrate a direct role for IFN-gamma as an inducer of CNS demyelination leading to disease and provide new opportunities for dissecting the mechanism of demyelination...
  3. ncbi request reprint Detailed in vivo analysis of interferon-gamma induced major histocompatibility complex expression in the the central nervous system: astrocytes fail to express major histocompatibility complex class I and II molecules
    M S Horwitz
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    Lab Invest 79:235-42. 1999
    ..This finding suggests that, although microglia and oligodendrocytes may participate in the antigen presentation process in the organism, we found no in vivo evidence to support the concept that astrocytes act as antigen-presenting cells...
  4. pmc Protection from lethal coxsackievirus-induced pancreatitis by expression of gamma interferon
    M S Horwitz
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 73:1756-66. 1999
    ..In conclusion, IFN-gamma protects from lethal coxsackievirus infection by activating macrophages in an iNOS-independent manner...
  5. ncbi request reprint A critical role for inducible nitric oxide synthase in host survival following coxsackievirus B4 infection
    M Flodstrom
    Department of Immunology, The Scripps Research Institute, 10 550 North Torrey Pines Road, La Jolla, California 92037, USA
    Virology 281:205-15. 2001
    ..Moreover, the data support the existence of an organ-specific dependency on NO for a rapid clearance of CB4...
  6. pmc T-cell receptors from virus-specific cytotoxic T lymphocytes recognizing a single immunodominant nine-amino-acid viral epitope show marked diversity
    M S Horwitz
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037
    J Virol 68:352-7. 1994
    ....
  7. pmc Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains
    Y Li
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 18:1601-10. 1998
    ..These data suggest that FIP-2 is one of the cellular targets for Ad E3-14.7K and that its mechanism of affecting cell death involves the TNF receptor, RIP, or a downstream molecule affected by either of these two molecules...
  8. pmc The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses
    J M Bergelson
    Division of Infectious Diseases, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Virol 72:415-9. 1998
    ..Analysis of receptor expression in human and murine tissues should be useful in defining factors governing virus tropism in vivo...
  9. ncbi request reprint The effect of CD28/B7 blockade on alloreactive T and B cells after liver cell transplantation
    B Reddy
    Department of Medicine, Marion Bessin Research Liver Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Transplantation 71:801-11. 2001
    ..Strategies to specifically antagonize CD8+ T cells or to modulate MHC class I expression in association with costimulatory blockade by CTLA4Ig may enhance the clinical feasibility of transplanting allogeneic hepatocytes...
  10. pmc Adenovirus E3 14.7-kilodalton protein, an antagonist of tumor necrosis factor cytolysis, increases the virulence of vaccinia virus in severe combined immunodeficient mice
    J M Tufariello
    Department of Microbiology, Albert Einstein College of Medicine, Bronx, NY 10461
    Proc Natl Acad Sci U S A 91:10987-91. 1994
    ..7(-)/TNF. SCID mice infected intranasally with VV without TNF showed a dramatic increase in acute disease and succumbed within the first 1-2 weeks after infection, independent of Ad 14.7K expression...
  11. ncbi request reprint A non-immunogenic adenoviral vector, coexpressing CTLA4Ig and bilirubin-uridine-diphosphoglucuronateglucuronosyltransferase permits long-term, repeatable transgene expression in the Gunn rat model of Crigler-Najjar syndrome
    N R Thummala
    Department of Medicine, Albert Einstein College of Medicine, New York, NY 10461, USA
    Gene Ther 9:981-90. 2002
    ..High levels of adenovirus-specific antibodies and CTL, and hepatic inflammation were found. This is the first demonstration that coexpression of CTLA4Ig permits prolonged expression and repeatable gene transfer by an adenoviral vector...