A Holz

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi Myelin-associated oligodendrocytic basic protein: identification of an encephalitogenic epitope and association with multiple sclerosis
    A Holz
    Viral Immunobiology Laboratory, Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 164:1103-9. 2000
  2. ncbi Neither B lymphocytes nor antibodies directed against self antigens of the islets of Langerhans are required for development of virus-induced autoimmune diabetes
    A Holz
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 165:5945-53. 2000
  3. ncbi Pathological changes in the islet milieu precede infiltration of islets and destruction of beta-cells by autoreactive lymphocytes in a transgenic model of virus-induced IDDM
    M Von Herrath
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Autoimmun 10:231-8. 1997
  4. ncbi Measles virus infection in a transgenic model: virus-induced immunosuppression and central nervous system disease
    M B Oldstone
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell 98:629-40. 1999
  5. ncbi Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence
    A Holz
    Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 163:5374-82. 1999
  6. ncbi Local IL-4 expression in the lung reduces pulmonary influenza-virus-specific secondary cytotoxic T cell responses
    A Bot
    Department of Neuropharmacology, Division of Virology, IMM6, The Scripps Research Institute, La Jolla, CA 92037, USA
    Virology 269:66-77. 2000
  7. pmc Constitutive beta cell expression of IL-12 does not perturb self-tolerance but intensifies established autoimmune diabetes
    A Holz
    Viral Immunobiology Laboratory, Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 108:1749-58. 2001
  8. ncbi Evidence that the hypermutated M protein of a subacute sclerosing panencephalitis measles virus actively contributes to the chronic progressive CNS disease
    J B Patterson
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 291:215-25. 2001

Collaborators

Detail Information

Publications8

  1. ncbi Myelin-associated oligodendrocytic basic protein: identification of an encephalitogenic epitope and association with multiple sclerosis
    A Holz
    Viral Immunobiology Laboratory, Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 164:1103-9. 2000
    ..Thus, a novel myelin Ag, MOBP aa 37-60, plays a role in rodent autoimmune CNS disease, and its human MOBP counterpart is associated with the human demyelinating disease multiple sclerosis...
  2. ncbi Neither B lymphocytes nor antibodies directed against self antigens of the islets of Langerhans are required for development of virus-induced autoimmune diabetes
    A Holz
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 165:5945-53. 2000
    ..Hence, the RIP-LCMV model is not only useful for understanding the pathogenetic mechanisms of how islets are destroyed and spared but also for evaluating therapeutic strategies before onset of clinical diabetes...
  3. ncbi Pathological changes in the islet milieu precede infiltration of islets and destruction of beta-cells by autoreactive lymphocytes in a transgenic model of virus-induced IDDM
    M Von Herrath
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Autoimmun 10:231-8. 1997
    ..Thus, beta-cell destruction by activated autoreactive lymphocytes is a multifactorial process that is likely to require changes within the islet milieu or dysfunction of islets...
  4. ncbi Measles virus infection in a transgenic model: virus-induced immunosuppression and central nervous system disease
    M B Oldstone
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell 98:629-40. 1999
    ..Infectious virus was recovered from the CNS, replicated primarily in neurons, and spread to distal sites presumably by fast axonal transport. Thus, a small animal model is available for analysis of MV pathogenesis...
  5. ncbi Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence
    A Holz
    Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 163:5374-82. 1999
    ..Selective inhibition of the STAT4 signal transduction pathway might constitute a novel and attractive approach to prevent clinical insulin-dependent diabetes mellitus in prediabetic individuals at risk...
  6. ncbi Local IL-4 expression in the lung reduces pulmonary influenza-virus-specific secondary cytotoxic T cell responses
    A Bot
    Department of Neuropharmacology, Division of Virology, IMM6, The Scripps Research Institute, La Jolla, CA 92037, USA
    Virology 269:66-77. 2000
    ..The reduction of memory CTL in the presence of IL-4 might have consequences for understanding the course of influenza infection in situations where T(H)2 immunity is increased...
  7. pmc Constitutive beta cell expression of IL-12 does not perturb self-tolerance but intensifies established autoimmune diabetes
    A Holz
    Viral Immunobiology Laboratory, Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 108:1749-58. 2001
    ..Thus, the ectopic expression of IL-12 does not spontaneously break tolerance and activate antigen-specific T cells in the periphery, but it does worsen ongoing autoimmune disease...
  8. ncbi Evidence that the hypermutated M protein of a subacute sclerosing panencephalitis measles virus actively contributes to the chronic progressive CNS disease
    J B Patterson
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 291:215-25. 2001
    ....