M P Holsapple

Summary

Affiliation: The Dow Chemical Company
Country: USA

Publications

  1. ncbi request reprint Autoimmunity by pesticides: a critical review of the state of the science
    Michael P Holsapple
    Toxicology and Environmental Research and Consulting, 1803 Building, Midland, MI 48674, USA
    Toxicol Lett 127:101-9. 2002
  2. pmc Immunotoxicogenomics: the potential of genomics technology in the immunotoxicity risk assessment process
    Robert W Luebke
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 94:22-7. 2006
  3. ncbi request reprint Developmental immunotoxicity testing: a review
    Michael P Holsapple
    Toxicology and Environmental Research and Consulting, Dow Chemical Company, 1803 Building, Midland, MI 48674, USA
    Toxicology 185:193-203. 2003
  4. doi request reprint Dose response considerations in risk assessment--an overview of recent ILSI activities
    Michael P Holsapple
    International Life Sciences Institute, Health and Environmental Sciences Institute, One Thomas Circle, NW, Ninth Floor, Washington, DC 20005 5802, USA
    Toxicol Lett 180:85-92. 2008
  5. ncbi request reprint Developmental immunotoxicology and risk assessment: a workshop summary
    M P Holsapple
    Hum Exp Toxicol 21:473-8. 2002
  6. ncbi request reprint Influence of p53 zygosity on select sperm parameters of the mouse
    M S Marty
    Health and Environmental Research Laboratories, The Dow Chemical Company, 1803 Building, Midland, MI 48674, USA
    Mutat Res 427:39-45. 1999
  7. ncbi request reprint Research strategies for safety evaluation of nanomaterials, part II: toxicological and safety evaluation of nanomaterials, current challenges and data needs
    Michael P Holsapple
    ILSI Health and Environmental Sciences Institute, One Thomas Circle, NW, 9th Floor, Washington, District of Columbia 20005, USA
    Toxicol Sci 88:12-7. 2005
  8. ncbi request reprint A proposed testing framework for developmental immunotoxicology (DIT)
    Michael P Holsapple
    ILSI Health Science and Environmental Sciences Institute, Washington, DC 20005, USA
    Toxicol Sci 83:18-24. 2005
  9. doi request reprint What's so special about the developing immune system?
    Leigh Ann Burns-Naas
    Drug Safety Research and Development, Pfizer Global Research and Development, California, USA
    Int J Toxicol 27:223-54. 2008
  10. ncbi request reprint Relevance and follow-up of positive results in in vitro genetic toxicity assays: an ILSI-HESI initiative
    Veronique Thybaud
    Drug Safety Evaluation, Sanofi Aventis, 94400 Vitry sur Seine, France
    Mutat Res 633:67-79. 2007

Detail Information

Publications16

  1. ncbi request reprint Autoimmunity by pesticides: a critical review of the state of the science
    Michael P Holsapple
    Toxicology and Environmental Research and Consulting, 1803 Building, Midland, MI 48674, USA
    Toxicol Lett 127:101-9. 2002
    ....
  2. pmc Immunotoxicogenomics: the potential of genomics technology in the immunotoxicity risk assessment process
    Robert W Luebke
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 94:22-7. 2006
    ..To help move the science of immunotoxicogenomics forward, a partnership of industry, academia, and government was suggested to address data gaps, validation, quality assurance, and protocol development...
  3. ncbi request reprint Developmental immunotoxicity testing: a review
    Michael P Holsapple
    Toxicology and Environmental Research and Consulting, Dow Chemical Company, 1803 Building, Midland, MI 48674, USA
    Toxicology 185:193-203. 2003
    ..Ultimately, the primary conclusion from this workshop was that developmental immunotoxicology, as a science, is still in its infancy and is not ready to be applied in a risk assessment strategy...
  4. doi request reprint Dose response considerations in risk assessment--an overview of recent ILSI activities
    Michael P Holsapple
    International Life Sciences Institute, Health and Environmental Sciences Institute, One Thomas Circle, NW, Ninth Floor, Washington, DC 20005 5802, USA
    Toxicol Lett 180:85-92. 2008
    ..How these new insights into the dose-response will affect our definition of threshold, and our understanding of the distinction between adverse and adaptive effects remain to be determined...
  5. ncbi request reprint Developmental immunotoxicology and risk assessment: a workshop summary
    M P Holsapple
    Hum Exp Toxicol 21:473-8. 2002
    ..Overall, the panel deemed the area of developmental immunotoxicity to be still in its infancy and outlined strategies that could lead to the development of standard practices...
  6. ncbi request reprint Influence of p53 zygosity on select sperm parameters of the mouse
    M S Marty
    Health and Environmental Research Laboratories, The Dow Chemical Company, 1803 Building, Midland, MI 48674, USA
    Mutat Res 427:39-45. 1999
    ....
  7. ncbi request reprint Research strategies for safety evaluation of nanomaterials, part II: toxicological and safety evaluation of nanomaterials, current challenges and data needs
    Michael P Holsapple
    ILSI Health and Environmental Sciences Institute, One Thomas Circle, NW, 9th Floor, Washington, District of Columbia 20005, USA
    Toxicol Sci 88:12-7. 2005
    ....
  8. ncbi request reprint A proposed testing framework for developmental immunotoxicology (DIT)
    Michael P Holsapple
    ILSI Health Science and Environmental Sciences Institute, Washington, DC 20005, USA
    Toxicol Sci 83:18-24. 2005
    ....
  9. doi request reprint What's so special about the developing immune system?
    Leigh Ann Burns-Naas
    Drug Safety Research and Development, Pfizer Global Research and Development, California, USA
    Int J Toxicol 27:223-54. 2008
    ..The overall objective of this review is to provide a 'snapshot' of the current state-of-the-science of DIT. Despite significant progress, DIT is still evolving and it is our hope that this review will advance the science...
  10. ncbi request reprint Relevance and follow-up of positive results in in vitro genetic toxicity assays: an ILSI-HESI initiative
    Veronique Thybaud
    Drug Safety Evaluation, Sanofi Aventis, 94400 Vitry sur Seine, France
    Mutat Res 633:67-79. 2007
    ....
  11. ncbi request reprint Evaluating emerging issues in epidemiology
    James J Collins
    The Dow Chemical Co, Midland, MI 48674, USA
    Regul Toxicol Pharmacol 48:296-307. 2007
    ..We further recommend frequent and timely communication with all stakeholders, and the development of research approaches to fill gaps when the scientific data on an issue are limited...
  12. ncbi request reprint Methodologies for developmental immunotoxicity (DIT) testing
    Rodney R Dietert
    Department of Microbiology and Immunology, College of Veterinary Medicine, C 5 135 VMC, N Tower Rd, Cornell University, Ithaca, NY 14853, USA
    Methods 41:123-31. 2007
    ..However, multi-cytokine analysis needs to be standardized in terms of optimum source for analysis and protocol...
  13. ncbi request reprint Species comparison of anatomical and functional immune system development
    Michael P Holsapple
    ILSI Health and Environmental Sciences Institute, Washington, DC 20005 5802, USA
    Birth Defects Res B Dev Reprod Toxicol 68:321-34. 2003
    ..The development of the immune system in humans will be compared to what is known in mice, rats, dogs and nonhuman primates...
  14. ncbi request reprint Mode of action in relevance of rodent liver tumors to human cancer risk
    Michael P Holsapple
    ILSI Health and Environmental Sciences Institute, Washington, DC 20005, USA
    Toxicol Sci 89:51-6. 2006
    ....
  15. ncbi request reprint Symposium summary: children's health risk--what's so special about the developing immune system?
    Michael P Holsapple
    ILSI Health and Environmental Sciences Institute, Washington, DC 20005 5802, USA
    Toxicol Appl Pharmacol 199:61-70. 2004
    ....
  16. ncbi request reprint Developmental toxicology evaluations--issues with including neurotoxicology and immunotoxicology assessments in reproductive toxicology studies
    Gregory S Ladics
    The DuPont Company, Haskell Laboratory, Newark, Delaware 19714, USA
    Toxicol Sci 88:24-9. 2005
    ..The group agreed to consider the HESI ACSA Life Stages Task Force recommendations as a next step to address some of the issues and challenges raised during this session...