M P HolsappleSummaryAffiliation: The Dow Chemical Company Country: USA Publications
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Detail Information
Publications
Autoimmunity by pesticides: a critical review of the state of the scienceMichael P Holsapple
Toxicology and Environmental Research and Consulting, 1803 Building, Midland, MI 48674, USA
Toxicol Lett 127:101-9. 2002....
Immunotoxicogenomics: the potential of genomics technology in the immunotoxicity risk assessment processRobert W Luebke
Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 94:22-7. 2006..To help move the science of immunotoxicogenomics forward, a partnership of industry, academia, and government was suggested to address data gaps, validation, quality assurance, and protocol development...- Developmental immunotoxicity testing: a reviewMichael P Holsapple
Toxicology and Environmental Research and Consulting, Dow Chemical Company, 1803 Building, Midland, MI 48674, USA
Toxicology 185:193-203. 2003..Ultimately, the primary conclusion from this workshop was that developmental immunotoxicology, as a science, is still in its infancy and is not ready to be applied in a risk assessment strategy... 
Dose response considerations in risk assessment--an overview of recent ILSI activitiesMichael P Holsapple
International Life Sciences Institute, Health and Environmental Sciences Institute, One Thomas Circle, NW, Ninth Floor, Washington, DC 20005 5802, USA
Toxicol Lett 180:85-92. 2008..How these new insights into the dose-response will affect our definition of threshold, and our understanding of the distinction between adverse and adaptive effects remain to be determined...- Developmental immunotoxicology and risk assessment: a workshop summaryM P Holsapple
Hum Exp Toxicol 21:473-8. 2002..Overall, the panel deemed the area of developmental immunotoxicity to be still in its infancy and outlined strategies that could lead to the development of standard practices... - Influence of p53 zygosity on select sperm parameters of the mouseM S Marty
Health and Environmental Research Laboratories, The Dow Chemical Company, 1803 Building, Midland, MI 48674, USA
Mutat Res 427:39-45. 1999.... - Research strategies for safety evaluation of nanomaterials, part II: toxicological and safety evaluation of nanomaterials, current challenges and data needsMichael P Holsapple
ILSI Health and Environmental Sciences Institute, One Thomas Circle, NW, 9th Floor, Washington, District of Columbia 20005, USA
Toxicol Sci 88:12-7. 2005.... - A proposed testing framework for developmental immunotoxicology (DIT)Michael P Holsapple
ILSI Health Science and Environmental Sciences Institute, Washington, DC 20005, USA
Toxicol Sci 83:18-24. 2005.... - What's so special about the developing immune system?Leigh Ann Burns-Naas
Drug Safety Research and Development, Pfizer Global Research and Development, California, USA
Int J Toxicol 27:223-54. 2008..The overall objective of this review is to provide a 'snapshot' of the current state-of-the-science of DIT. Despite significant progress, DIT is still evolving and it is our hope that this review will advance the science... - Relevance and follow-up of positive results in in vitro genetic toxicity assays: an ILSI-HESI initiativeVeronique Thybaud
Drug Safety Evaluation, Sanofi Aventis, 94400 Vitry sur Seine, France
Mutat Res 633:67-79. 2007.... - Evaluating emerging issues in epidemiologyJames J Collins
The Dow Chemical Co, Midland, MI 48674, USA
Regul Toxicol Pharmacol 48:296-307. 2007..We further recommend frequent and timely communication with all stakeholders, and the development of research approaches to fill gaps when the scientific data on an issue are limited... - Methodologies for developmental immunotoxicity (DIT) testingRodney R Dietert
Department of Microbiology and Immunology, College of Veterinary Medicine, C 5 135 VMC, N Tower Rd, Cornell University, Ithaca, NY 14853, USA
Methods 41:123-31. 2007..However, multi-cytokine analysis needs to be standardized in terms of optimum source for analysis and protocol... - Species comparison of anatomical and functional immune system developmentMichael P Holsapple
ILSI Health and Environmental Sciences Institute, Washington, DC 20005 5802, USA
Birth Defects Res B Dev Reprod Toxicol 68:321-34. 2003..The development of the immune system in humans will be compared to what is known in mice, rats, dogs and nonhuman primates... - Mode of action in relevance of rodent liver tumors to human cancer riskMichael P Holsapple
ILSI Health and Environmental Sciences Institute, Washington, DC 20005, USA
Toxicol Sci 89:51-6. 2006.... - Symposium summary: children's health risk--what's so special about the developing immune system?Michael P Holsapple
ILSI Health and Environmental Sciences Institute, Washington, DC 20005 5802, USA
Toxicol Appl Pharmacol 199:61-70. 2004.... - Developmental toxicology evaluations--issues with including neurotoxicology and immunotoxicology assessments in reproductive toxicology studiesGregory S Ladics
The DuPont Company, Haskell Laboratory, Newark, Delaware 19714, USA
Toxicol Sci 88:24-9. 2005..The group agreed to consider the HESI ACSA Life Stages Task Force recommendations as a next step to address some of the issues and challenges raised during this session...