Research Topics
| Karen E HoffmanSummaryAffiliation: The University of Texas Country: USA Publications
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Detail Information
Publications
Management of older men with clinically localized prostate cancer: the significance of advanced age and comorbidityKaren E Hoffman
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Semin Radiat Oncol 22:284-94. 2012..Prostate cancer management decisions for older patients should be tailored based on an individual patient's health status, coexisting medical conditions, life expectancy, and tumor characteristics...- Optimising radiation treatment decisions for patients who receive neoadjuvant chemotherapy and mastectomyKaren E Hoffman
Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Lancet Oncol 13:e270-6. 2012..Randomised clinical trial data are needed to assess whether postmastectomy radiation therapy can be safely omitted in selected women with good response to neoadjuvant chemotherapy... - Recommendations for post-prostatectomy radiation therapy in the United States before and after the presentation of randomized trialsKaren E Hoffman
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
J Urol 185:116-20. 2011.... - Prostate cancer screening in men 75 years old or older: an assessment of self-reported health status and life expectancyKaren E Hoffman
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Urol 183:1798-802. 2010..In this study we evaluated the influence of health status and life expectancy on prostate specific antigen screening in older men in the United States before the 2008 United States Preventive Services Task Force guidelines... 
Adjuvant therapy for elderly patients with resected gastric adenocarcinoma: population-based practices and treatment effectivenessKaren E Hoffman
Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA
Cancer 118:248-57. 2012..A study was undertaken to determine the survival benefit of postoperative chemoradiation therapy for elderly patients with resected gastric adenocarcinoma...- Reduced penile size and treatment regret in men with recurrent prostate cancer after surgery, radiotherapy plus androgen deprivation, or radiotherapy aloneArti Parekh
Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Urology 81:130-4. 2013..To report the relative incidence of the perceived reduction in penile size across prostate cancer treatment modalities and to describe its effect on quality of life and treatment regret... - Impact of evidence-based clinical guidelines on the adoption of postmastectomy radiation in older womenShervin M Shirvani
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
Cancer 117:4595-605. 2011..Accordingly, the authors used the Surveillance, Epidemiology, and End Results (SEER)-Medicare cohort to determine whether the use of PMRT has increased in response to evidence-based guidelines... - Prostate cancer-specific mortality after definitive radiation therapy: who dies of disease?Michelle M Kim
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard Unit 97, Houston, TX 77030 4009, USA
Eur J Cancer 48:1664-71. 2012.... - Is androgen deprivation therapy necessary in all intermediate-risk prostate cancer patients treated in the dose escalation era?Katherine O Castle
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Int J Radiat Oncol Biol Phys 85:693-9. 2013.... - Influence of androgen deprivation therapy on all-cause mortality in men with high-risk prostate cancer and a history of congestive heart failure or myocardial infarctionPaul L Nguyen
Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Int J Radiat Oncol Biol Phys 82:1411-6. 2012.... - PSA response to neoadjuvant androgen deprivation therapy is a strong independent predictor of survival in high-risk prostate cancer in the dose-escalated radiation therapy eraSean E McGuire
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
Int J Radiat Oncol Biol Phys 85:e39-46. 2013.... - Cardiovascular comorbidity and treatment regret in men with recurrent prostate cancerPaul L Nguyen
Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
BJU Int 110:201-5. 2012.... - Comorbidity, body mass index, and age and the risk of nonprostate-cancer-specific mortality after a postradiation prostate-specific antigen recurrencePaul L Nguyen
Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Cancer 116:610-5. 2010..Therefore, our ability to determine who would benefit from salvage hormonotherapy (HT) would be enhanced if an individual's risk of nonprostate-cancer-specific mortality were known... - Predicting the risk of pelvic node involvement among men with prostate cancer in the contemporary eraPaul L Nguyen
Harvard Radiation Oncology Program, Boston, MA, USA
Int J Radiat Oncol Biol Phys 74:104-9. 2009..We examined the accuracy of this formula in contemporary patients... - Risk of all-cause and prostate cancer-specific mortality after brachytherapy in men with small prostate sizePaul L Nguyen
Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, MA 02115, USA
Int J Radiat Oncol Biol Phys 79:1318-22. 2011..Brachytherapy for prostate cancer can be technically challenging in men with small prostates (≤20 cc), but it is unknown whether their outcomes are different than those of men with larger prostates... - Is primary prostate cancer treatment influenced by likelihood of extraprostatic disease? A surveillance, epidemiology and end results patterns of care studyJordan A Holmes
Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Int J Radiat Oncol Biol Phys 84:88-94. 2012..To examine the patterns of primary treatment in a recent population-based cohort of prostate cancer patients, stratified by the likelihood of extraprostatic cancer as predicted by disease characteristics available at diagnosis... - Barriers to the implementation of surveillance for stage I testicular seminomaNils D Arvold
Harvard Radiation Oncology Program, Harvard Medical School, Boston, Massachusetts, USA
Int J Radiat Oncol Biol Phys 84:383-9. 2012..Because studies suggest that radiation oncologists in the United States continue to recommend RT for these patients, we sought to identify factors associated with management recommendations... - Improvement in prostate cancer survival over time: a 20-year analysisMichelle M Kim
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009 USA
Cancer J 18:1-8. 2012..This study aimed to evaluate the changes in outcome for men with localized prostate cancer treated with definitive external beam radiation therapy during a 20-year period at a comprehensive cancer center... - Adoption of preoperative radiation therapy for rectal cancer from 2000 to 2006: a Surveillance, Epidemiology, and End Results Patterns-of-Care StudyRaymond H Mak
Harvard Radiation Oncology Program, Boston, MA, USA
Int J Radiat Oncol Biol Phys 80:978-84. 2011..We evaluated the use of preoperative RT after the presentation of the landmark German rectal study results and examined the impact of tumor and sociodemographic factors on receiving preoperative RT... - Topical hyaluronic acid vs. standard of care for the prevention of radiation dermatitis after adjuvant radiotherapy for breast cancer: single-blind randomized phase III clinical trialCHELSEA PINNIX
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Int J Radiat Oncol Biol Phys 83:1089-94. 2012..To determine the efficacy of an emulsion containing hyaluronic acid to reduce the development of ≥ Grade 2 radiation dermatitis after adjuvant breast radiation compared with best supportive care... - Cost implications of the rapid adoption of newer technologies for treating prostate cancerPaul L Nguyen
Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
J Clin Oncol 29:1517-24. 2011..We assessed temporal trends in their utilization and their impact on national health care spending... - Association of androgen deprivation therapy with cardiovascular death in patients with prostate cancer: a meta-analysis of randomized trialsPaul L Nguyen
Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
JAMA 306:2359-66. 2011.... - Which patients with undetectable PSA levels 5 years after radical prostatectomy are still at risk of recurrence?--implications for a risk-adapted follow-up strategyDeborah A Ahove
Smith College, Northhampton, Massachusetts, USA
Urology 76:1201-5. 2010..To determine the predictors of late prostate-specific antigen (PSA) failure among men with an undetectable PSA level 5 years after radical prostatectomy (RP)... - Evaluation of the MD Anderson Prognostic Index for local-regional recurrence after breast conserving therapy in patients receiving neoadjuvant chemotherapyCatherine L Akay
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Ann Surg Oncol 19:901-7. 2012..The current study was undertaken to evaluate this prognostic index in an independent cohort... - Influence of year of diagnosis, patient age, and sociodemographic status on recommending adjuvant radiation treatment for stage I testicular seminomaKaren E Hoffman
Department of Radiation Oncology, Brigham and Women s Hospital, 375 Longwood Ave, Boston, MA 02115, USA
J Clin Oncol 26:3937-42. 2008..This study evaluated ART trends in the United States and the impact of clinical and sociodemographic factors on ART recommendations... - Cardiac motion during deep-inspiration breath-hold: implications for breast cancer radiotherapyXiaochun Wang
Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 82:708-14. 2012..We measured the displacement of the left anterior descending artery (LAD) and heart owing to cardiac motion during DIBH, relative to the standard tangential fields for left breast cancer radiotherapy... - Prostate cancer-specific mortality and the extent of therapy in healthy elderly men with high-risk prostate cancerKaren E Hoffman
Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA
Cancer 116:2590-5. 2010..The authors of this report compared the use of brachytherapy alone with combined brachytherapy, external-beam radiation to the prostate and seminal vesicles, and androgen-suppression therapy (CMT) in this population... - External-beam accelerated partial breast irradiation using multiple proton beam configurationsXiaochun Wang
Department of Radiation Physics, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 80:1464-72. 2011.... - Rectal dose-volume histogram parameters are associated with long-term patient-reported gastrointestinal quality of life after conventional and high-dose radiation for prostate cancer: a subgroup analysis of a randomized trialPaul L Nguyen
Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Int J Radiat Oncol Biol Phys 78:1081-5. 2010..2 GyE) or high-dose (79.2 GyE) radiation for prostate cancer... - Nomogram to predict the benefit of radiation for older patients with breast cancer treated with conservative surgeryJeffrey M Albert
The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
J Clin Oncol 30:2837-43. 2012..However, it is not known whether this recommendation should extend to other older women. Accordingly, we developed a nomogram to predict the likelihood of long-term breast preservation with and without RT... - Prospective randomized trial of 5-fluorouracil, doxorubicin, and cyclophosphamide (FAC) versus paclitaxel and FAC (TFAC) in patients with operable breast cancer: impact of taxane chemotherapy on locoregional controlJeffrey M Albert
Department of Radiation Oncology, Unit 97, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Breast Cancer Res Treat 128:421-7. 2011..Historically inferior LRC with AC chemotherapy alone versus AC + T may have been due to an inadequate duration of systemic therapy and not due to the absence of paclitaxel... - Psychological distress in long-term survivors of adult-onset cancer: results from a national surveyKaren E Hoffman
Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Arch Intern Med 169:1274-81. 2009..As advances in cancer screening and treatment increase the number of long-term cancer survivors, it is important to understand the long-term psychological sequelae of the cancer experience... 
External beam radiation treatment for rectal cancer is associated with a decrease in subsequent prostate cancer diagnosisKaren E Hoffman
Harvard Radiation Oncology Program, Harvard Medical School, Boston, Massachusetts, USA
Cancer 112:943-9. 2008..The effect of this incidental exposure on subsequent prostate cancer diagnosis was investigated using the Surveillance, Epidemiology, and End Results (SEER) cancer registry...- Radiation therapy modalities in prostate cancerThomas J Pugh
From the Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
J Natl Compr Canc Netw 11:414-21. 2013..This article reviews technologic advances that have enhanced radiation delivery and describes contemporary radiation treatment techniques for prostate cancer... - Emergence of integrated urology-radiation oncology practices in the State of TexasPavan M Jhaveri
Section of Radiation Oncology, Department of Radiology, Baylor College of Medicine, Houston, Texas, USA
Int J Radiat Oncol Biol Phys 84:15-9. 2012..We sought to characterize the emergence of such practices in Texas, their extent of physical integration, and their potential effect on patient travel times for radiation therapy... - Radiation therapy for pediatric central nervous system tumorsKaren E Hoffman
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
J Child Neurol 24:1387-96. 2009..The long-term clinical benefits of proton radiation in the pediatric population are just beginning to be reported in the literature...