J Travis Hinson
Affiliation: The Jackson Laboratory
Cohn R, Thakar K, Lowe A, Ladha F, Pettinato A, Romano R, et al
. A Contraction Stress Model of Hypertrophic Cardiomyopathy due to Sarcomere Mutations. Stem Cell Reports. 2018;: pubmed publisher
Chopra A, Kutys M, Zhang K, Polacheck W, Sheng C, Luu R, et al
. Force Generation via ?-Cardiac Myosin, Titin, and ?-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Dev Cell. 2018;44:87-96.e5 pubmed publisher
..Ablating protocostameres or decoupling titin from protocostameres abolishes sarcomere assembly. Together these results identify the mechanical and molecular components critical for human cardiac sarcomerogenesis. ..
Hinson J, Chopra A, Lowe A, Sheng C, Gupta R, Kuppusamy R, et al
. Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis. Cell Rep. 2016;17:3292-3304 pubmed publisher
..Our results establish critical connections among metabolic sensing, myocyte survival, and TGF? signaling. ..