Research Topics
Species | Matthew N HillSummaryAffiliation: The Rockefeller University Country: USA Publications
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Publications
Endogenous cannabinoid signaling is required for voluntary exercise-induced enhancement of progenitor cell proliferation in the hippocampusMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, B C, Canada
Hippocampus 20:513-23. 2010..These data demonstrate that the endocannabinoid system in the hippocampus is sensitive to environmental change and suggest that it is a mediator of experience-induced plasticity...- Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axisMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Neuropsychopharmacology 34:2733-45. 2009..Taken together, these findings suggest that the degree to which stressful stimuli reduce amygdalar AEA/CB(1) receptor signaling contributes to the magnitude of the HPA response... - Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatmentMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
J Neurochem 106:2322-36. 2008.... 
Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effectRyan J McLaughlin
Department of Psychology, University of British Columbia, Vancouver, Canada
Behav Pharmacol 18:431-8. 2007..Collectively, these data highlight the potential importance of changes in the hippocampal endocannabinoid system following stress or antidepressant treatment with respect to the manifestation and/or treatment of depression...- Involvement of the endocannabinoid system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of the hypothalamic-pituitary-adrenal axisMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Neuropsychopharmacology 31:2591-9. 2006.... - Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampusMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Hippocampus 18:221-6. 2008.... - Endogenous cannabinoid signaling is essential for stress adaptationMatthew N Hill
Departments of Psychology and Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada V6T1Z3
Proc Natl Acad Sci U S A 107:9406-11. 2010.... 
Protracted cannabinoid administration elicits antidepressant behavioral responses in rats: role of gender and noradrenergic transmissionAnna C Morrish
Department of Psychology, University of British Columbia, Vancouver, B C, Canada
Physiol Behav 98:118-24. 2009..These results show that protracted administration of a CB(1) receptor agonist produces an antidepressant-like response in the FST in both sexes, which appears to involve the noradrenergic system...- Electroconvulsive shock treatment differentially modulates cortical and subcortical endocannabinoid activityMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
J Neurochem 103:47-56. 2007.... - Endocannabinoids modulate stress-induced suppression of hippocampal cell proliferation and activation of defensive behavioursMatthew N Hill
Department of Psychology and the Brain Research Centre, University of British Columbia, Vancouver, BC, Canada V6T1Z4
Eur J Neurosci 24:1845-9. 2006..They also suggest that endocannabinoids may play a complex role in the regulation of neurogenesis via cell proliferation in the hippocampus... - Endocannabinoid modulation of male rat sexual behaviorBoris B Gorzalka
Department of Psychology, University of British Columbia, Vancouver, BC, Canada, V6T1Z4
Psychopharmacology (Berl) 198:479-86. 2008..The aim of this experiment was to determine the effect of pharmacological facilitation or antagonism of endocannabinoid signaling on male rat sexual behavior... - Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stressMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, B C, Canada
Psychoneuroendocrinology 34:1257-62. 2009..The magnitude of these responses did not differ between depressed and control subjects. These are the first data to demonstrate that the peripheral endocannabinoid/NAE system is responsive to exposure to stress... - Estrogen recruits the endocannabinoid system to modulate emotionalityMatthew N Hill
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T1Z4
Psychoneuroendocrinology 32:350-7. 2007..Collectively, these data demonstrate that estrogen may elicit changes in emotional behavior through an endocannabinoid mechanism, and suggest that inhibition of FAAH represents a therapeutic target for anxiety and depression in women... - Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contentsMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada
J Neural Transm 115:1673-9. 2008..These data suggest that monoaminergic neurotransmission can regulate the endocannabinoid system and further indicates a role of the endocannabinoid system in affective illness and its treatment... - Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonistsMatthew N Hill
Department of Psychology and the Brain Research Centre, University of British Columbia, Vancouver, V6T1Z4, BC, Canada
Psychopharmacology (Berl) 187:245-59. 2006.... - Estrogenic regulation of limbic cannabinoid receptor bindingCaitlin J N Riebe
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Psychoneuroendocrinology 35:1265-9. 2010..These data provide a putative biochemical mechanism mediating the observed behavioral and physiological sex differences in the effects of cannabinoids, particularly with respect to stress and emotional behavior... - Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stressMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
Neuropsychopharmacology 30:508-15. 2005.... - Monoaminergic neurotransmission contributes to cannabinoid-induced activation of the hypothalamic-pituitary-adrenal axisRyan J McLaughlin
Department of Psychology, University of British Columbia, Vancouver, B C V6T1Z4, Canada
Eur J Pharmacol 624:71-6. 2009..These data suggest that acute administration of exogenous cannabinoid ligands activates the HPA axis indirectly through an increase in serotonergic and noradrenergic neurotransmission... - Increased sensitivity to restraint stress and novelty-induced emotionality following long-term, high dose cannabinoid exposureMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
Psychoneuroendocrinology 31:526-36. 2006..This interaction was not seen in the basolateral amygdala. Together, these findings suggest that chronic high dose, but not low dose, cannabinoid administration may result in increased emotionality and sensitization of the stress axis... - Long-term kindling of the basolateral amygdala impairs copulatory behavior in male ratsOrsolya Magyar
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
Neurosci Lett 390:162-5. 2005..These results suggest that kindled rats may exhibit elevated levels of endogenous serotonin during exposure to a female rat, which would attenuate copulatory behavior, while concurrently increasing WDS expression... - Chronic corticosterone treatment increases the endocannabinoid 2-arachidonylglycerol in the rat amygdalaMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, B.C. Canada V6T1Z4
Eur J Pharmacol 528:99-102. 2005..Given the role of amygdalar endocannabinoids in the regulation of emotionality, this suggests that the ability of glucocorticoids to influence affective behavior may involve interactions with regulation of endocannabinoid content... - Precipitated withdrawal counters the adverse effects of subchronic cannabinoid administration on male rat sexual behaviorCaitlin J Riebe
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, British Columbia, Canada V6T1Z4
Neurosci Lett 472:171-4. 2010.... - Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim testMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, 2136 West Mall, Canada V6T 1Z4
Eur Neuropsychopharmacol 15:593-9. 2005..These data suggest that enhancement of CB1 receptor signaling results in antidepressant effects in the forced swim test similar to that seen following conventional antidepressant administration... - Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressantsBoris B Gorzalka
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Prog Neuropsychopharmacol Biol Psychiatry 35:1575-85. 2011..Ultimately, these data present a compelling picture of the putative role of the endocannabinoid system in the processes subserving both the development and treatment of depression... - Altered responsiveness of serotonin receptor subtypes following long-term cannabinoid treatmentMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Int J Neuropsychopharmacol 9:277-86. 2006..This may partially explain the association between excessive cannabis consumption and the induction of affective disease... - 5-HT(2A) receptor mediated neuronal activation within the paraventricular nucleus of the hypothalamus is desensitized following prolonged glucocorticoid treatmentTiffany T Y Lee
Department of Psychology, University of British Columbia, Vancouver, BC Canada V6T1Z4
Eur J Pharmacol 602:54-7. 2009.... - Circulating endocannabinoid concentrations and sexual arousal in womenCarolin Klein
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
J Sex Med 9:1588-601. 2012..e., arachidonoylethanolamide [AEA] and 2-arachidonoylglycerol [2-AG]) and sexual functioning have been conducted in any species... - Enhancement of anxiety-like responsiveness to the cannabinoid CB(1) receptor agonist HU-210 following chronic stressMatthew N Hill
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
Eur J Pharmacol 499:291-5. 2004..These findings suggest that chronic stress enhances either cannabinoid receptor responsivity or one of the interacting systems implicated in emotional states... - Functional role of the endocannabinoid system and AMPA/kainate receptors in 5-HT2A receptor-mediated wet dog shakesBoris B Gorzalka
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, B C, Canada V6T 1Z4
Eur J Pharmacol 516:28-33. 2005.... - Regulation of endocannabinoid signaling by stress: implications for stress-related affective disordersBoris B Gorzalka
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T1Z4
Neurosci Biobehav Rev 32:1152-60. 2008.... - Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral outputMatthew N Hill
Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
J Neurosci 30:14980-6. 2010..Collectively, these data demonstrate the importance of endocannabinoid signaling at multiple levels as both a regulator and an effector of the stress response... - Chronic stress differentially regulates cannabinoid CB1 receptor binding in distinct hippocampal subfieldsMatthew N Hill
Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
Eur J Pharmacol 614:66-9. 2009.... - Rapid elevations in limbic endocannabinoid content by glucocorticoid hormones in vivoMatthew N Hill
Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
Psychoneuroendocrinology 35:1333-8. 2010..These data provide in vivo support for non-genomic steroid effects in mammals and suggest that AEA is a mediator of these effects... - Involvement of the endocannabinoid system in the neurobehavioural effects of stress and glucocorticoidsMatthew N Hill
Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10065, USA
Prog Neuropsychopharmacol Biol Psychiatry 34:791-7. 2010..Collectively, these studies reveal a complex interplay between endocannabinoids and the HPA axis, and further identify endocannabinoid signaling as a critical regulator of the stress response... - Temporal changes in N-acylethanolamine content and metabolism throughout the peri-adolescent periodTiffany T Y Lee
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
Synapse 67:4-10. 2013.... - Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathwayRyan J McLaughlin
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Eur Neuropsychopharmacol 22:664-71. 2012.... - Serum contents of endocannabinoids are correlated with blood pressure in depressed womenW S Vanessa Ho
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Lipids Health Dis 11:32. 2012.... - Male-female differences in the effects of cannabinoids on sexual behavior and gonadal hormone functionBoris B Gorzalka
Department of Psychology, University of British Columbia, Vancouver, Canada, BC V6T 1Z4
Horm Behav 58:91-9. 2010..Historical milestones and promising future directions in the area of cannabinoid and sexuality research are also outlined in this review... - Integration of endocannabinoid signaling into the neural network regulating stress-induced activation of the hypothalamic-pituitary-adrenal axisBoris B Gorzalka
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Curr Top Behav Neurosci 1:289-306. 2009..The relevance of this relationship has not been fully explored with respect to both normal homeostasis and pathological states characterized by alterations in HPA axis function, but will be a focus of future research... - Prolonged cannabinoid treatment results in spatial working memory deficits and impaired long-term potentiation in the CA1 region of the hippocampus in vivoMatthew N Hill
Department of Psychology and the Brain Research Centre, 2136 West Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
Eur J Neurosci 20:859-63. 2004..These results indicate that long-term cannabinoid exposure can produce marked deficits in reference and working memory performance, and also impair hippocampal synaptic plasticity in vivo... - Corticosterone attenuates the antidepressant-like effects elicited by melatonin in the forced swim test in both male and female ratsMatthew N Hill
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, B.C, Canada V6T 1Z4
Prog Neuropsychopharmacol Biol Psychiatry 27:905-11. 2003..01), as well as attenuate the anti-immobility effects of melatonin (P=.03). These findings suggest that while melatonin may possess antidepressant-like qualities, high levels of corticosterone seem capable of attenuating these effects... - Augmentation of the development of behavioral tolerance to cannabinoid administration through pavlovian conditioningMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, B.C, Canada
Neuropsychobiology 49:94-100. 2004....