Matthew N Hill

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc Endogenous cannabinoid signaling is required for voluntary exercise-induced enhancement of progenitor cell proliferation in the hippocampus
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, B C, Canada
    Hippocampus 20:513-23. 2010
  2. pmc Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Neuropsychopharmacology 34:2733-45. 2009
  3. ncbi request reprint Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect
    Ryan J McLaughlin
    Department of Psychology, University of British Columbia, Vancouver, Canada
    Behav Pharmacol 18:431-8. 2007
  4. pmc Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurochem 106:2322-36. 2008
  5. ncbi request reprint Involvement of the endocannabinoid system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of the hypothalamic-pituitary-adrenal axis
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Neuropsychopharmacology 31:2591-9. 2006
  6. doi request reprint Protracted cannabinoid administration elicits antidepressant behavioral responses in rats: role of gender and noradrenergic transmission
    Anna C Morrish
    Department of Psychology, University of British Columbia, Vancouver, B C, Canada
    Physiol Behav 98:118-24. 2009
  7. pmc Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway
    Ryan J McLaughlin
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Eur Neuropsychopharmacol 22:664-71. 2012
  8. pmc Endogenous cannabinoid signaling is essential for stress adaptation
    Matthew N Hill
    Departments of Psychology and Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada V6T1Z3
    Proc Natl Acad Sci U S A 107:9406-11. 2010
  9. ncbi request reprint Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    Hippocampus 18:221-6. 2008
  10. ncbi request reprint Electroconvulsive shock treatment differentially modulates cortical and subcortical endocannabinoid activity
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurochem 103:47-56. 2007

Detail Information

Publications44

  1. pmc Endogenous cannabinoid signaling is required for voluntary exercise-induced enhancement of progenitor cell proliferation in the hippocampus
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, B C, Canada
    Hippocampus 20:513-23. 2010
    ..These data demonstrate that the endocannabinoid system in the hippocampus is sensitive to environmental change and suggest that it is a mediator of experience-induced plasticity...
  2. pmc Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Neuropsychopharmacology 34:2733-45. 2009
    ..Taken together, these findings suggest that the degree to which stressful stimuli reduce amygdalar AEA/CB(1) receptor signaling contributes to the magnitude of the HPA response...
  3. ncbi request reprint Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect
    Ryan J McLaughlin
    Department of Psychology, University of British Columbia, Vancouver, Canada
    Behav Pharmacol 18:431-8. 2007
    ..Collectively, these data highlight the potential importance of changes in the hippocampal endocannabinoid system following stress or antidepressant treatment with respect to the manifestation and/or treatment of depression...
  4. pmc Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurochem 106:2322-36. 2008
    ....
  5. ncbi request reprint Involvement of the endocannabinoid system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of the hypothalamic-pituitary-adrenal axis
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Neuropsychopharmacology 31:2591-9. 2006
    ....
  6. doi request reprint Protracted cannabinoid administration elicits antidepressant behavioral responses in rats: role of gender and noradrenergic transmission
    Anna C Morrish
    Department of Psychology, University of British Columbia, Vancouver, B C, Canada
    Physiol Behav 98:118-24. 2009
    ..These results show that protracted administration of a CB(1) receptor agonist produces an antidepressant-like response in the FST in both sexes, which appears to involve the noradrenergic system...
  7. pmc Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway
    Ryan J McLaughlin
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Eur Neuropsychopharmacol 22:664-71. 2012
    ....
  8. pmc Endogenous cannabinoid signaling is essential for stress adaptation
    Matthew N Hill
    Departments of Psychology and Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada V6T1Z3
    Proc Natl Acad Sci U S A 107:9406-11. 2010
    ....
  9. ncbi request reprint Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    Hippocampus 18:221-6. 2008
    ....
  10. ncbi request reprint Electroconvulsive shock treatment differentially modulates cortical and subcortical endocannabinoid activity
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurochem 103:47-56. 2007
    ....
  11. ncbi request reprint Endocannabinoids modulate stress-induced suppression of hippocampal cell proliferation and activation of defensive behaviours
    Matthew N Hill
    Department of Psychology and the Brain Research Centre, University of British Columbia, Vancouver, BC, Canada V6T1Z4
    Eur J Neurosci 24:1845-9. 2006
    ..They also suggest that endocannabinoids may play a complex role in the regulation of neurogenesis via cell proliferation in the hippocampus...
  12. ncbi request reprint Endocannabinoid modulation of male rat sexual behavior
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada, V6T1Z4
    Psychopharmacology (Berl) 198:479-86. 2008
    ..The aim of this experiment was to determine the effect of pharmacological facilitation or antagonism of endocannabinoid signaling on male rat sexual behavior...
  13. ncbi request reprint Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, 2136 West Mall, Canada V6T 1Z4
    Eur Neuropsychopharmacol 15:593-9. 2005
    ..These data suggest that enhancement of CB1 receptor signaling results in antidepressant effects in the forced swim test similar to that seen following conventional antidepressant administration...
  14. pmc Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, B C, Canada
    Psychoneuroendocrinology 34:1257-62. 2009
    ..The magnitude of these responses did not differ between depressed and control subjects. These are the first data to demonstrate that the peripheral endocannabinoid/NAE system is responsive to exposure to stress...
  15. pmc Estrogenic regulation of limbic cannabinoid receptor binding
    Caitlin J N Riebe
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Psychoneuroendocrinology 35:1265-9. 2010
    ..These data provide a putative biochemical mechanism mediating the observed behavioral and physiological sex differences in the effects of cannabinoids, particularly with respect to stress and emotional behavior...
  16. ncbi request reprint Estrogen recruits the endocannabinoid system to modulate emotionality
    Matthew N Hill
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T1Z4
    Psychoneuroendocrinology 32:350-7. 2007
    ..Collectively, these data demonstrate that estrogen may elicit changes in emotional behavior through an endocannabinoid mechanism, and suggest that inhibition of FAAH represents a therapeutic target for anxiety and depression in women...
  17. ncbi request reprint Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonists
    Matthew N Hill
    Department of Psychology and the Brain Research Centre, University of British Columbia, Vancouver, V6T1Z4, BC, Canada
    Psychopharmacology (Berl) 187:245-59. 2006
    ..Cannabinoid CB1 receptors are expressed in the prefrontal cortex, but their role in mediating executive functions such as behavioral flexibility is unclear...
  18. pmc Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada
    J Neural Transm 115:1673-9. 2008
    ..These data suggest that monoaminergic neurotransmission can regulate the endocannabinoid system and further indicates a role of the endocannabinoid system in affective illness and its treatment...
  19. ncbi request reprint Long-term kindling of the basolateral amygdala impairs copulatory behavior in male rats
    Orsolya Magyar
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
    Neurosci Lett 390:162-5. 2005
    ..These results suggest that kindled rats may exhibit elevated levels of endogenous serotonin during exposure to a female rat, which would attenuate copulatory behavior, while concurrently increasing WDS expression...
  20. ncbi request reprint Chronic corticosterone treatment increases the endocannabinoid 2-arachidonylglycerol in the rat amygdala
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, B C Canada V6T1Z4
    Eur J Pharmacol 528:99-102. 2005
    ..Given the role of amygdalar endocannabinoids in the regulation of emotionality, this suggests that the ability of glucocorticoids to influence affective behavior may involve interactions with regulation of endocannabinoid content...
  21. pmc Temporal changes in N-acylethanolamine content and metabolism throughout the peri-adolescent period
    Tiffany T Y Lee
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    Synapse 67:4-10. 2013
    ....
  22. doi request reprint Monoaminergic neurotransmission contributes to cannabinoid-induced activation of the hypothalamic-pituitary-adrenal axis
    Ryan J McLaughlin
    Department of Psychology, University of British Columbia, Vancouver, B C V6T1Z4, Canada
    Eur J Pharmacol 624:71-6. 2009
    ..These data suggest that acute administration of exogenous cannabinoid ligands activates the HPA axis indirectly through an increase in serotonergic and noradrenergic neurotransmission...
  23. ncbi request reprint Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Neuropsychopharmacology 30:508-15. 2005
    ....
  24. ncbi request reprint Increased sensitivity to restraint stress and novelty-induced emotionality following long-term, high dose cannabinoid exposure
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Psychoneuroendocrinology 31:526-36. 2006
    ..This interaction was not seen in the basolateral amygdala. Together, these findings suggest that chronic high dose, but not low dose, cannabinoid administration may result in increased emotionality and sensitization of the stress axis...
  25. ncbi request reprint Prolonged cannabinoid treatment results in spatial working memory deficits and impaired long-term potentiation in the CA1 region of the hippocampus in vivo
    Matthew N Hill
    Department of Psychology and the Brain Research Centre, 2136 West Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Eur J Neurosci 20:859-63. 2004
    ..These results indicate that long-term cannabinoid exposure can produce marked deficits in reference and working memory performance, and also impair hippocampal synaptic plasticity in vivo...
  26. doi request reprint Precipitated withdrawal counters the adverse effects of subchronic cannabinoid administration on male rat sexual behavior
    Caitlin J Riebe
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, British Columbia, Canada V6T1Z4
    Neurosci Lett 472:171-4. 2010
    ....
  27. ncbi request reprint Functional role of the endocannabinoid system and AMPA/kainate receptors in 5-HT2A receptor-mediated wet dog shakes
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, B C, Canada V6T 1Z4
    Eur J Pharmacol 516:28-33. 2005
    ....
  28. ncbi request reprint Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 35:1575-85. 2011
    ..Ultimately, these data present a compelling picture of the putative role of the endocannabinoid system in the processes subserving both the development and treatment of depression...
  29. doi request reprint 5-HT(2A) receptor mediated neuronal activation within the paraventricular nucleus of the hypothalamus is desensitized following prolonged glucocorticoid treatment
    Tiffany T Y Lee
    Department of Psychology, University of British Columbia, Vancouver, BC Canada V6T1Z4
    Eur J Pharmacol 602:54-7. 2009
    ....
  30. ncbi request reprint Altered responsiveness of serotonin receptor subtypes following long-term cannabinoid treatment
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Int J Neuropsychopharmacol 9:277-86. 2006
    ..This may partially explain the association between excessive cannabis consumption and the induction of affective disease...
  31. pmc Circulating endocannabinoid concentrations and sexual arousal in women
    Carolin Klein
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    J Sex Med 9:1588-601. 2012
    ..e., arachidonoylethanolamide [AEA] and 2-arachidonoylglycerol [2-AG]) and sexual functioning have been conducted in any species...
  32. doi request reprint Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T1Z4
    Neurosci Biobehav Rev 32:1152-60. 2008
    ....
  33. ncbi request reprint Enhancement of anxiety-like responsiveness to the cannabinoid CB(1) receptor agonist HU-210 following chronic stress
    Matthew N Hill
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
    Eur J Pharmacol 499:291-5. 2004
    ..These findings suggest that chronic stress enhances either cannabinoid receptor responsivity or one of the interacting systems implicated in emotional states...
  34. pmc Chronic stress differentially regulates cannabinoid CB1 receptor binding in distinct hippocampal subfields
    Matthew N Hill
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Eur J Pharmacol 614:66-9. 2009
    ....
  35. pmc Rapid elevations in limbic endocannabinoid content by glucocorticoid hormones in vivo
    Matthew N Hill
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Psychoneuroendocrinology 35:1333-8. 2010
    ..These data provide in vivo support for non-genomic steroid effects in mammals and suggest that AEA is a mediator of these effects...
  36. pmc Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output
    Matthew N Hill
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
    J Neurosci 30:14980-6. 2010
    ..Collectively, these data demonstrate the importance of endocannabinoid signaling at multiple levels as both a regulator and an effector of the stress response...
  37. pmc Involvement of the endocannabinoid system in the neurobehavioural effects of stress and glucocorticoids
    Matthew N Hill
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10065, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:791-7. 2010
    ..Collectively, these studies reveal a complex interplay between endocannabinoids and the HPA axis, and further identify endocannabinoid signaling as a critical regulator of the stress response...
  38. ncbi request reprint Sex, drugs, and adult neurogenesis: Sex-dependent effects of escalating adolescent cannabinoid exposure on adult hippocampal neurogenesis, stress reactivity, and amphetamine sensitization
    Tiffany T Y Lee
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Hippocampus 24:280-92. 2014
    ..2013 Wiley Periodicals, Inc. ..
  39. pmc Serum contents of endocannabinoids are correlated with blood pressure in depressed women
    W S Vanessa Ho
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Lipids Health Dis 11:32. 2012
    ....
  40. doi request reprint Integration of endocannabinoid signaling into the neural network regulating stress-induced activation of the hypothalamic-pituitary-adrenal axis
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Curr Top Behav Neurosci 1:289-306. 2009
    ..The relevance of this relationship has not been fully explored with respect to both normal homeostasis and pathological states characterized by alterations in HPA axis function, but will be a focus of future research...
  41. ncbi request reprint Male-female differences in the effects of cannabinoids on sexual behavior and gonadal hormone function
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, Vancouver, Canada, BC V6T 1Z4
    Horm Behav 58:91-9. 2010
    ..Historical milestones and promising future directions in the area of cannabinoid and sexuality research are also outlined in this review...
  42. ncbi request reprint Augmentation of the development of behavioral tolerance to cannabinoid administration through pavlovian conditioning
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, B C, Canada
    Neuropsychobiology 49:94-100. 2004
    ....
  43. ncbi request reprint Morphological and behavioral evidence for impaired prefrontal cortical function in female CB1 receptor deficient mice
    Tiffany T Y Lee
    University of British Columbia, Department of Psychology, 2136 West Mall, Vancouver, Canada V6T 1Z4 Electronic address
    Behav Brain Res 271:106-10. 2014
    ....
  44. ncbi request reprint Corticosterone attenuates the antidepressant-like effects elicited by melatonin in the forced swim test in both male and female rats
    Matthew N Hill
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, B C, Canada V6T 1Z4
    Prog Neuropsychopharmacol Biol Psychiatry 27:905-11. 2003
    ..01), as well as attenuate the anti-immobility effects of melatonin (P=.03). These findings suggest that while melatonin may possess antidepressant-like qualities, high levels of corticosterone seem capable of attenuating these effects...