Genomes and Genes


Michelle A T Hildebrandt


Affiliation: The University of Texas
Country: USA


  1. Kelemen L, Earp M, Fridley B, Chenevix Trench G, Fasching P, Beckmann M, et al. rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology. Int J Mol Sci. 2018;19: pubmed publisher
    ..51, p = 1.7 × 10-28), and nonsignificantly in five MOC tumors. The association results, along with inconclusive tumor eQTL findings, suggest that a true effect of rs495139 might be small. ..
  2. Hildebrandt M, Tan W, Tamboli P, Huang M, Ye Y, Lin J, et al. Kinome expression profiling identifies IKBKE as a predictor of overall survival in clear cell renal cell carcinoma patients. Carcinogenesis. 2012;33:799-803 pubmed publisher
    ..Overall, these results support a novel role for IKBKE expression in modulating overall survival in ccRCC patients. ..
  3. Reyes M, Ma J, Grove M, Ater J, Morrison A, Hildebrandt M. RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin. Toxicol Appl Pharmacol. 2018;356:44-53 pubmed publisher
    ..Pathway analysis identified the top canonical pathways involved in response, implicating DNA damage repair response and the cell cycle as having roles in the development of doxorubicin-induced cardiotoxicity in the human cardiomyocyte. ..
  4. Hildebrandt M, Reyes M, Lin M, He Y, Nguyen S, Hawk E, et al. Germline Genetic Variants in the Wnt/β-Catenin Pathway as Predictors of Colorectal Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2016;25:540-6 pubmed publisher
    ..These variants may be informative in colorectal cancer risk assessment to identify individuals at increased risk who would be candidates for screening. ..
  5. Reyes M, Ye Y, Zhou Y, Liang A, Kopetz S, Rodriquez M, et al. Predictors of health-related quality of life and association with survival may identify colorectal cancer patients at high risk of poor prognosis. Qual Life Res. 2017;26:319-330 pubmed publisher
    ..Our findings identify potential mediators for HR-QoL and suggest that baseline HR-QoL assessment may be prognostic for CRC. ..
  6. Hildebrandt M, Reyes M, Wu X, Pu X, Thompson K, Ma J, et al. Hypertension Susceptibility Loci are Associated with Anthracycline-related Cardiotoxicity in Long-term Childhood Cancer Survivors. Sci Rep. 2017;7:9698 pubmed publisher