Research Topics | M W HetzerSummaryAffiliation: The Salk Institute Country: USA Publications
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Publications
Pushing the envelope: structure, function, and dynamics of the nuclear peripheryMartin W Hetzer
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
Annu Rev Cell Dev Biol 21:347-80. 2005..Despite the importance of the NE for eukaryotic cell life, relatively little is known about its biogenesis or many of its functions. We thus are far from understanding the molecular etiology of a diverse group of NE-associated diseases...- The role of the nuclear envelope in cellular organizationM A D'Angelo
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
Cell Mol Life Sci 63:316-32. 2006..It is our goal to provide a comprehensive view of the NE and to discuss possible implications of NE-associated changes for gene expression, chromatin organization and signal transduction... 
The nuclear envelopeMartin W Hetzer
Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, La Jolla, California 92037, USA
Cold Spring Harb Perspect Biol 2:a000539. 2010..Here, I summarize our current understanding of the dynamic remodeling of the NE during the cell cycle...
Border control at the nucleus: biogenesis and organization of the nuclear membrane and pore complexesMartin W Hetzer
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Dev Cell 17:606-16. 2009..These nuclear pore complexes are essential for the control of nucleocytoplasmic exchange. Many of the NE and nuclear pore proteins are thought to play crucial roles in gene regulation and thus are increasingly linked to human diseases...- Shaping the endoplasmic reticulum into the nuclear envelopeDaniel J Anderson
Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
J Cell Sci 121:137-42. 2008..In contrast to previous models, which proposed vesicle fusion to be the principal mechanism of NE formation, these new studies suggest that the nuclear membrane forms by the chromatin-mediated reshaping of the ER... - Structure, dynamics and function of nuclear pore complexesMaximiliano A D'Angelo
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Trends Cell Biol 18:456-66. 2008..In this review, we discuss the most recent developments in the nuclear-pore-complex field, focusing on the assembly, disassembly, maintenance and function of this macromolecular structure... - Nuclear pore biogenesis into an intact nuclear envelopeChristine M Doucet
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
Chromosoma 119:469-77. 2010..We will then discuss conserved and diverging mechanisms between post-mitotic and interphase assembly of the proteinaceous structure in light of recently published data... - Nuclear pore complexes: guardians of the nuclear genomeM Capelson
Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, La Jolla, California 92037, USA
Cold Spring Harb Symp Quant Biol 75:585-97. 2010..In addition, we summarize new data suggesting that NPCs represent dynamic hubs for the integration of gene regulation and nuclear transport processes... - Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulumDaniel J Anderson
Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
Nat Cell Biol 9:1160-6. 2007..Thus, chromatin plays an active role in reshaping of the ER during NE formation... - Nuclear pores form de novo from both sides of the nuclear envelopeDaniel J Anderson
Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 312:440-3. 2006..Newly formed nuclear pore complexes did not contain structural components of preexisting pores, suggesting that they can form de novo... - Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cellsMaximiliano A D'Angelo
Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell 136:284-95. 2009.... - Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formationDaniel J Anderson
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
J Cell Biol 182:911-24. 2008..Our results provide evidence that ER-shaping proteins are directly involved in the reconstruction of the nuclear compartment and that morphological restructuring of the ER is the principal mechanism of NE formation in vivo... - The role of nuclear pores in gene regulation, development and diseaseMaya Capelson
Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, La Jolla, California 92037, USA
EMBO Rep 10:697-705. 2009..Here, we review the transport-dependent and transport-independent roles of NPCs in the regulation of nuclear function and gene expression... - Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivoDaniel J Anderson
Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, La Jolla, CA 92037, USA
J Cell Biol 186:183-91. 2009..These data suggest that functionally distinct classes of chromatin-interacting membrane proteins, which are present at nonsaturating levels, collaborate to rapidly reestablish the nuclear compartment at the end of mitosis... - The life cycle of the metazoan nuclear envelopeDaniel J Anderson
Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
Curr Opin Cell Biol 20:386-92. 2008..We will review recent insights into nuclear membrane dynamics during the cell cycle... - Cell cycle-dependent differences in nuclear pore complex assembly in metazoaChristine M Doucet
Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, 92037 CA, USA
Cell 141:1030-41. 2010..Our results suggest that in organisms with open mitosis, NPCs assemble via two distinct mechanisms to accommodate cell cycle-dependent differences in NE topology... - Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotesMaya Capelson
Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell 140:372-83. 2010....
Research Grants
- Nuclear Membrane Fusion in Xenopus Egg ExtractsMartin W Hetzer; Fiscal Year: 2010..g. Rab GTPases) are involved in NE formation. As an alternative approach we will use photo-affinity methods, overlay assays and proteomic approaches to identify the second GTPase. ..