M W Hetzer

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. ncbi request reprint Pushing the envelope: structure, function, and dynamics of the nuclear periphery
    Martin W Hetzer
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Annu Rev Cell Dev Biol 21:347-80. 2005
  2. ncbi request reprint The role of the nuclear envelope in cellular organization
    M A D'Angelo
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Mol Life Sci 63:316-32. 2006
  3. pmc The nuclear envelope
    Martin W Hetzer
    Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, La Jolla, California 92037, USA
    Cold Spring Harb Perspect Biol 2:a000539. 2010
  4. pmc Border control at the nucleus: biogenesis and organization of the nuclear membrane and pore complexes
    Martin W Hetzer
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Dev Cell 17:606-16. 2009
  5. doi request reprint Shaping the endoplasmic reticulum into the nuclear envelope
    Daniel J Anderson
    Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Cell Sci 121:137-42. 2008
  6. pmc Structure, dynamics and function of nuclear pore complexes
    Maximiliano A D'Angelo
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Trends Cell Biol 18:456-66. 2008
  7. doi request reprint Nuclear pore biogenesis into an intact nuclear envelope
    Christine M Doucet
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Chromosoma 119:469-77. 2010
  8. pmc Nuclear pore complexes: guardians of the nuclear genome
    M Capelson
    Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, La Jolla, California 92037, USA
    Cold Spring Harb Symp Quant Biol 75:585-97. 2010
  9. ncbi request reprint Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulum
    Daniel J Anderson
    Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Cell Biol 9:1160-6. 2007
  10. ncbi request reprint Nuclear pores form de novo from both sides of the nuclear envelope
    Maximiliano A D'Angelo
    Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 312:440-3. 2006

Research Grants

  1. Nuclear Membrane Fusion in Xenopus Egg Extracts
    Martin W Hetzer; Fiscal Year: 2010

Collaborators

  • Tobias C Walther
  • I W Mattaj
  • Daniel J Anderson
  • Maximiliano A D'Angelo
  • Christine M Doucet
  • Maya Capelson
  • M Capelson
  • M A D'Angelo
  • Roberta Schulte
  • Yun Liang
  • C Doucet
  • Ulrich Wagner
  • Jessica A Talamas
  • William Mair
  • Siler H Panowski
  • Joshua P Hsiao
  • Marcela Raices
  • Jesse D Vargas
  • Erin Richard

Detail Information

Publications17

  1. ncbi request reprint Pushing the envelope: structure, function, and dynamics of the nuclear periphery
    Martin W Hetzer
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Annu Rev Cell Dev Biol 21:347-80. 2005
    ..Despite the importance of the NE for eukaryotic cell life, relatively little is known about its biogenesis or many of its functions. We thus are far from understanding the molecular etiology of a diverse group of NE-associated diseases...
  2. ncbi request reprint The role of the nuclear envelope in cellular organization
    M A D'Angelo
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Mol Life Sci 63:316-32. 2006
    ..It is our goal to provide a comprehensive view of the NE and to discuss possible implications of NE-associated changes for gene expression, chromatin organization and signal transduction...
  3. pmc The nuclear envelope
    Martin W Hetzer
    Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, La Jolla, California 92037, USA
    Cold Spring Harb Perspect Biol 2:a000539. 2010
    ..Here, I summarize our current understanding of the dynamic remodeling of the NE during the cell cycle...
  4. pmc Border control at the nucleus: biogenesis and organization of the nuclear membrane and pore complexes
    Martin W Hetzer
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Dev Cell 17:606-16. 2009
    ..These nuclear pore complexes are essential for the control of nucleocytoplasmic exchange. Many of the NE and nuclear pore proteins are thought to play crucial roles in gene regulation and thus are increasingly linked to human diseases...
  5. doi request reprint Shaping the endoplasmic reticulum into the nuclear envelope
    Daniel J Anderson
    Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Cell Sci 121:137-42. 2008
    ..In contrast to previous models, which proposed vesicle fusion to be the principal mechanism of NE formation, these new studies suggest that the nuclear membrane forms by the chromatin-mediated reshaping of the ER...
  6. pmc Structure, dynamics and function of nuclear pore complexes
    Maximiliano A D'Angelo
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Trends Cell Biol 18:456-66. 2008
    ..In this review, we discuss the most recent developments in the nuclear-pore-complex field, focusing on the assembly, disassembly, maintenance and function of this macromolecular structure...
  7. doi request reprint Nuclear pore biogenesis into an intact nuclear envelope
    Christine M Doucet
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Chromosoma 119:469-77. 2010
    ..We will then discuss conserved and diverging mechanisms between post-mitotic and interphase assembly of the proteinaceous structure in light of recently published data...
  8. pmc Nuclear pore complexes: guardians of the nuclear genome
    M Capelson
    Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, La Jolla, California 92037, USA
    Cold Spring Harb Symp Quant Biol 75:585-97. 2010
    ..In addition, we summarize new data suggesting that NPCs represent dynamic hubs for the integration of gene regulation and nuclear transport processes...
  9. ncbi request reprint Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulum
    Daniel J Anderson
    Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Cell Biol 9:1160-6. 2007
    ..Thus, chromatin plays an active role in reshaping of the ER during NE formation...
  10. ncbi request reprint Nuclear pores form de novo from both sides of the nuclear envelope
    Maximiliano A D'Angelo
    Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 312:440-3. 2006
    ..Newly formed nuclear pore complexes did not contain structural components of preexisting pores, suggesting that they can form de novo...
  11. pmc Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells
    Maximiliano A D'Angelo
    Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 136:284-95. 2009
    ....
  12. pmc Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation
    Daniel J Anderson
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    J Cell Biol 182:911-24. 2008
    ..Our results provide evidence that ER-shaping proteins are directly involved in the reconstruction of the nuclear compartment and that morphological restructuring of the ER is the principal mechanism of NE formation in vivo...
  13. pmc The role of nuclear pores in gene regulation, development and disease
    Maya Capelson
    Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, La Jolla, California 92037, USA
    EMBO Rep 10:697-705. 2009
    ..Here, we review the transport-dependent and transport-independent roles of NPCs in the regulation of nuclear function and gene expression...
  14. pmc Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo
    Daniel J Anderson
    Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, La Jolla, CA 92037, USA
    J Cell Biol 186:183-91. 2009
    ..These data suggest that functionally distinct classes of chromatin-interacting membrane proteins, which are present at nonsaturating levels, collaborate to rapidly reestablish the nuclear compartment at the end of mitosis...
  15. pmc The life cycle of the metazoan nuclear envelope
    Daniel J Anderson
    Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 20:386-92. 2008
    ..We will review recent insights into nuclear membrane dynamics during the cell cycle...
  16. pmc Cell cycle-dependent differences in nuclear pore complex assembly in metazoa
    Christine M Doucet
    Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, 92037 CA, USA
    Cell 141:1030-41. 2010
    ..Our results suggest that in organisms with open mitosis, NPCs assemble via two distinct mechanisms to accommodate cell cycle-dependent differences in NE topology...
  17. pmc Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes
    Maya Capelson
    Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 140:372-83. 2010
    ....

Research Grants5

  1. Nuclear Membrane Fusion in Xenopus Egg Extracts
    Martin W Hetzer; Fiscal Year: 2010
    ..g. Rab GTPases) are involved in NE formation. As an alternative approach we will use photo-affinity methods, overlay assays and proteomic approaches to identify the second GTPase. ..