Jenny S Henkel

Summary

Affiliation: The Methodist Hospital
Country: USA

Publications

  1. pmc Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival
    Jenny S Henkel
    Department of Neurology, The Methodist Hospital Research Institute, Houston, TX, USA
    EMBO Mol Med 5:64-79. 2013
  2. doi request reprint Microglia in ALS: the good, the bad, and the resting
    Jenny S Henkel
    Department of Neurology, Methodist Neurological Institute, The Methodist Hospital Research Institute, The Methodist Hospital, 6560 Fannin Street, Houston, TX 77030, USA
    J Neuroimmune Pharmacol 4:389-98. 2009
  3. ncbi request reprint Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia
    Qin Xiao
    Department of Neurology, Methodist Neurological Institute, Houston, Texas 77030, USA
    J Neurochem 102:2008-19. 2007
  4. pmc Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis
    David R Beers
    Department of Neurology, Methodist Neurological Institute, Suite ST 802, 6560 Fannin Street, Houston, TX 77030, USA
    Brain 134:1293-314. 2011
  5. pmc Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice
    David R Beers
    Department of Neurology, Methodist Neurological Institute, The Methodist Hospital Research Institute, The Methodist Hospital, Houston, TX 77030, USA
    Brain Behav Immun 25:1025-35. 2011
  6. pmc Extracellular mutant SOD1 induces microglial-mediated motoneuron injury
    Weihua Zhao
    Department of Neurology, Methodist Neurological Institute, The Methodist Research Institute, The Methodist Hospital, Houston, Texas, USA
    Glia 58:231-43. 2010
  7. pmc CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS
    David R Beers
    Department of Neurology, Methodist Neurological Institute, Houston, TX, USA
    Proc Natl Acad Sci U S A 105:15558-63. 2008
  8. pmc Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
    David R Beers
    Department of Neurology, Methodist Neurological Institute, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:16021-6. 2006
  9. pmc Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms
    Weihua Zhao
    Department of Neurology, Methodist Neurological Institute, The Methodist Hospital, Houston, TX 77030, USA
    Neurobiol Dis 48:418-28. 2012
  10. ncbi request reprint Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue
    Jenny S Henkel
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Ann Neurol 55:221-35. 2004

Collaborators

Detail Information

Publications16

  1. pmc Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival
    Jenny S Henkel
    Department of Neurology, The Methodist Hospital Research Institute, Houston, TX, USA
    EMBO Mol Med 5:64-79. 2013
    ..Collectively, these data suggest that Tregs and Th2 lymphocytes influence disease progression rates. Importantly, early reduced FoxP3 levels could be used to identify rapidly progressing patients...
  2. doi request reprint Microglia in ALS: the good, the bad, and the resting
    Jenny S Henkel
    Department of Neurology, Methodist Neurological Institute, The Methodist Hospital Research Institute, The Methodist Hospital, 6560 Fannin Street, Houston, TX 77030, USA
    J Neuroimmune Pharmacol 4:389-98. 2009
    ..Thus, the cumulative evidence suggests that inflammation plays a central role in ALS and manipulating these microglial effector functions may potentially modify the outcome of this devastating disease...
  3. ncbi request reprint Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia
    Qin Xiao
    Department of Neurology, Methodist Neurological Institute, Houston, Texas 77030, USA
    J Neurochem 102:2008-19. 2007
    ..Thus, relative to wild-type microglia, mSOD1(G93A) microglia were more neurotoxic and induced more motoneuron injury than similarly treated wild-type microglia...
  4. pmc Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis
    David R Beers
    Department of Neurology, Methodist Neurological Institute, Suite ST 802, 6560 Fannin Street, Houston, TX 77030, USA
    Brain 134:1293-314. 2011
    ....
  5. pmc Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice
    David R Beers
    Department of Neurology, Methodist Neurological Institute, The Methodist Hospital Research Institute, The Methodist Hospital, Houston, TX 77030, USA
    Brain Behav Immun 25:1025-35. 2011
    ....
  6. pmc Extracellular mutant SOD1 induces microglial-mediated motoneuron injury
    Weihua Zhao
    Department of Neurology, Methodist Neurological Institute, The Methodist Research Institute, The Methodist Hospital, Houston, Texas, USA
    Glia 58:231-43. 2010
    ..This link between mSOD1 and innate immunity may offer novel therapeutic targets in ALS...
  7. pmc CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS
    David R Beers
    Department of Neurology, Methodist Neurological Institute, Houston, TX, USA
    Proc Natl Acad Sci U S A 105:15558-63. 2008
    ..These glial/T-cell interactions establish a novel target for therapeutic intervention in ALS and possibly other neurodegenerative diseases...
  8. pmc Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
    David R Beers
    Department of Neurology, Methodist Neurological Institute, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:16021-6. 2006
    ..This study confirms the importance of microglia as a double-edged sword, and focuses on the importance of targeting microglia to minimize cytotoxicity and maximize neuroprotection in neurodegenerative diseases...
  9. pmc Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms
    Weihua Zhao
    Department of Neurology, Methodist Neurological Institute, The Methodist Hospital, Houston, TX 77030, USA
    Neurobiol Dis 48:418-28. 2012
    ..These data suggest that mSOD1 Tregs contribute to the slowly progressing phase in ALS mice and may offer a novel therapeutic option for ALS patients...
  10. ncbi request reprint Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue
    Jenny S Henkel
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Ann Neurol 55:221-35. 2004
    ..These results support the involvement of immune/inflammatory responses in amplifying motor neuron degeneration in ALS...
  11. ncbi request reprint Novel therapeutic targets in neurodegenerative diseases: lessons from amyotrophic lateral sclerosis
    Stanley H Appel
    Department of Neurology, Methodist Neurological Institute, 6560 Fannin, Suite 802, Houston, TX 77030, USA
    Curr Neurol Neurosci Rep 8:353-5. 2008
  12. ncbi request reprint Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism
    Weihua Zhao
    Department of Neurology, Baylor College of Medicine, One Baylor Plaza, NB 302, Houston, TX, 77030, USA
    J Neuropathol Exp Neurol 63:964-77. 2004
    ..These data suggest that free radicals released from activated microglia may initiate MN injury by increasing the susceptibility of the MN AMPA/kainate receptor to the toxic effects of glutamate...
  13. ncbi request reprint The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS
    Jenny S Henkel
    Department of Neurology, Methodist Research Institute, 6560 Fannin St, Suite 902, Houston, TX 77030, USA
    Mol Cell Neurosci 31:427-37. 2006
    ..CD68+ cells were present at 39 days of age. Although it is not clear if these responses are protective or injurious, the early increased MCP-1 expression and CD68+ cell presence indicate early preexisting injury...
  14. ncbi request reprint PARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients
    Seung H Kim
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neuropathol Exp Neurol 62:88-103. 2003
    ....
  15. doi request reprint T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?
    Stanley H Appel
    Department of Neurology, Methodist Neurological Institute, The Methodist Hospital Research Institute, The Methodist Hospital, Houston, TX, USA
    Trends Immunol 31:7-17. 2010
    ..A greater understanding of the T cell population that mediates these effects, as well as the molecular signals involved should provide targets for neuroprotective immunomodulation to treat these devastating neurodegenerative diseases...
  16. doi request reprint Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS
    Bing Liao
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China
    Exp Neurol 237:147-52. 2012
    ..Thus, harnessing the neuroprotective potential of microglia may provide novel avenues for ALS therapies...