PETER HEDLUND

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor
    Peter B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neurosci Lett 481:12-6. 2010
  2. pmc The 5-HT7 receptor and disorders of the nervous system: an overview
    Peter B Hedlund
    Department of Molecular Biology, MB10, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 206:345-54. 2009
  3. pmc The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder
    Peter B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neurosci Lett 414:247-51. 2007
  4. ncbi request reprint 5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern
    Peter B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 58:831-7. 2005
  5. ncbi request reprint 8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents
    Peter B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Pharmacol 487:125-32. 2004
  6. pmc The 5-HT7 receptor is involved in allocentric spatial memory information processing
    Gor Sarkisyan
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Behav Brain Res 202:26-31. 2009
  7. ncbi request reprint Mice lacking 5-HT receptors show specific impairments in contextual learning
    Amanda J Roberts
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Neurosci 19:1913-22. 2004
  8. ncbi request reprint Functional, molecular and pharmacological advances in 5-HT7 receptor research
    Peter B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Pharmacol Sci 25:481-6. 2004
  9. pmc The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior
    Gor Sarkisyan
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Behav Brain Res 209:99-108. 2010
  10. ncbi request reprint A novel mRNA expressed along brain ventricles
    Patria E Danielson
    The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Brain Res Gene Expr Patterns 1:83-8. 2002

Research Grants

Collaborators

Detail Information

Publications13

  1. pmc LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor
    Peter B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neurosci Lett 481:12-6. 2010
    ..In vivo it was demonstrated that LP-211, and to a lesser degree RA-7, induced hypothermia in 5-HT(7)(+/+) but not in 5-HT(7)(-/-) mice. Our results suggest that LP-211 can be used as a 5-HT(7) receptor agonist in vivo...
  2. pmc The 5-HT7 receptor and disorders of the nervous system: an overview
    Peter B Hedlund
    Department of Molecular Biology, MB10, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 206:345-54. 2009
    ..The 5-HT(7) receptor is a more recently discovered G-protein-coupled receptor for serotonin. The functions and possible clinical relevance of this receptor are not yet fully understood...
  3. pmc The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder
    Peter B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neurosci Lett 414:247-51. 2007
    ....
  4. ncbi request reprint 5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern
    Peter B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 58:831-7. 2005
    ....
  5. ncbi request reprint 8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents
    Peter B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Pharmacol 487:125-32. 2004
    ..3 mg/kg 8-OH-DPAT. Thus, both 5-HT(7) and 5-HT(1A) receptors are involved in a complex manner in thermoregulation, with the 5-HT(7) receptor being more important at lower, possibly more physiological, concentrations...
  6. pmc The 5-HT7 receptor is involved in allocentric spatial memory information processing
    Gor Sarkisyan
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Behav Brain Res 202:26-31. 2009
    ..From the current data we conclude that the 5-HT(7)(-/-) mice performed by remembering a simple sequence of actions that resulted in successfully locating a hidden target in a static environment...
  7. ncbi request reprint Mice lacking 5-HT receptors show specific impairments in contextual learning
    Amanda J Roberts
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Neurosci 19:1913-22. 2004
    ..The results indicate an important role for the 5-HT(7) receptor in contextual hippocampal-dependent learning and suggest a possible neuronal correlate for such a role is present within the CA1 region of the hippocampus...
  8. ncbi request reprint Functional, molecular and pharmacological advances in 5-HT7 receptor research
    Peter B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Pharmacol Sci 25:481-6. 2004
    ..Hypotheses driving current research indicate that this receptor might be involved in mood regulation, suggesting that the 5-HT7 receptor is a putative target in the treatment of depression...
  9. pmc The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior
    Gor Sarkisyan
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Behav Brain Res 209:99-108. 2010
    ..The data furthermore support the hypothesis that the 5-HT(7) receptor might be a suitable target for treating depression...
  10. ncbi request reprint A novel mRNA expressed along brain ventricles
    Patria E Danielson
    The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Brain Res Gene Expr Patterns 1:83-8. 2002
    ..In the periphery, ovary had an expression level similar to the brain, whereas testes had a much higher level of expression...
  11. pmc Inactivation of the 5-HT(7) receptor partially blocks phencyclidine-induced disruption of prepulse inhibition
    Svetlana Semenova
    Department of Psychiatry, University of California, San Diego, USA
    Biol Psychiatry 63:98-105. 2008
    ..Further, several antidepressant and antipsychotic drugs have high affinity for the 5-HT(7) receptor...
  12. ncbi request reprint Contribution of spinal 5-HT1A and 5-HT7 receptors to locomotor-like movement induced by 8-OH-DPAT in spinal cord-transected mice
    Eric S Landry
    Laval University Medical Center, Quebec, Canada
    Eur J Neurosci 24:535-46. 2006
    ..The results, with selective antagonists and knockout animals, provide compelling evidence of a specific contribution of both receptor subtypes to spinal locomotor rhythmogenesis in vivo...
  13. ncbi request reprint Descending command systems for the initiation of locomotion in mammals
    Larry M Jordan
    Department of Physiology, Spinal Cord Research Centre, The University of Manitoba, 730 William Avenue, BMSB 425, Winnipeg, Manitoba, Canada R3E 3J7
    Brain Res Rev 57:183-91. 2008
    ..We conclude that the PPR is the source of a descending 5-HT command pathway that activates the CPG via 5-HT(7) and 5-HT(2A) receptors. Further experiments are necessary to define the putative glutamatergic, DA, and NA command pathways...

Research Grants4

  1. The 5-HT7 receptor in models of psychiatric disorders
    PETER HEDLUND; Fiscal Year: 2007
    ..These studies will provide valuable data for possible improvements of the therapy for disorders that afflicts large groups of the population. ..
  2. The 5-HT7 receptor in models of psychiatric disorders
    PETER HEDLUND; Fiscal Year: 2009
    ..These studies will provide valuable data for possible improvements of the therapy for disorders that afflicts large groups of the population. ..