MARY HATTEN

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc Development and cancer of the cerebellum
    Mary E Hatten
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065, USA
    Trends Neurosci 34:134-42. 2011
  2. pmc Gene expression profiling of preplate neurons destined for the subplate: genes involved in transcription, axon extension, neurotransmitter regulation, steroid hormone signaling, and neuronal survival
    Hilleary Osheroff
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065, USA
    Cereb Cortex 19:i126-34. 2009
  3. pmc WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation
    Sandrine L Anne
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 8:e81769. 2013
  4. pmc Multitasking on the run
    Mary E Hatten
    is at the Laboratory of Developmental Neurobiology, The Rockefeller University, New York, United States
    elife 2:e00641. 2013
  5. ncbi request reprint New directions in neuronal migration
    Mary E Hatten
    Laboratory of Developmental Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Science 297:1660-3. 2002
  6. ncbi request reprint Large-scale genomic approaches to brain development and circuitry
    Mary E Hatten
    Laboratory of Developmental Neurobiology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Annu Rev Neurosci 28:89-108. 2005
  7. pmc LIS-less neurons don't even make it to the starting gate
    Mary E Hatten
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10021, USA
    J Cell Biol 170:867-71. 2005
  8. ncbi request reprint A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
    Shiaoching Gong
    GENSAT Project, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 260, New York 10021, USA
    Nature 425:917-25. 2003
  9. pmc Astn2, a novel member of the astrotactin gene family, regulates the trafficking of ASTN1 during glial-guided neuronal migration
    Perrin M Wilson
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10065, USA
    J Neurosci 30:8529-40. 2010
  10. ncbi request reprint Molecular markers of neuronal progenitors in the embryonic cerebellar anlage
    Daniver Morales
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021 6399, USA
    J Neurosci 26:12226-36. 2006

Research Grants

  1. GENETICS OF CEREBELLAR AXON FORMATION
    MARY HATTEN; Fiscal Year: 2000
  2. MOLECULAR MECHANISMS OF GRANULE CELL MIGRATION
    MARY HATTEN; Fiscal Year: 2000
  3. Embryonic Development of the Cerebellum
    MARY HATTEN; Fiscal Year: 2007
  4. GENETICS OF CEREBELLAR AXON FORMATION
    MARY HATTEN; Fiscal Year: 2001
  5. Role of mPAR6 Polarity CNS Neuronal Migration
    MARY HATTEN; Fiscal Year: 2009
  6. Embryonic Development of the Cerebellum
    MARY HATTEN; Fiscal Year: 2006
  7. MOLECULAR MECHANISMS OF GRANULE CELL MIGRATION
    MARY HATTEN; Fiscal Year: 2006
  8. MOLECULAR MECHANISMS OF GRANULE CELL MIGRATION
    MARY HATTEN; Fiscal Year: 2005
  9. Role of mPAR6 Polarity CNS Neuronal Migration
    MARY HATTEN; Fiscal Year: 2006
  10. MOLECULAR MECHANISMS OF GRANULE CELL MIGRATION
    MARY HATTEN; Fiscal Year: 2007

Collaborators

  • N Heintz
  • David J Solecki
  • Charles R Gerfen
  • Tarun Kapoor
  • Shiaoching Gong
  • Sandrine L Anne
  • Toshifumi Tomoda
  • Perrin M Wilson
  • Hilleary Osheroff
  • Jee Hae Kim
  • Enrique Salero
  • Daniver Morales
  • Niels C Adams
  • David A Murphy
  • Linda Van Aelst
  • Eve Ellen Govek
  • Olivier Ayrault
  • Martine F Roussel
  • Xiaodong Zhu
  • Robert H Fryer
  • Yin Fang
  • Alexander Cummins
  • Martin Doughty
  • Carroll R Harbaugh
  • Caixin Zhan
  • Norma J Nowak
  • Kasia Losos
  • Gabrielle Leblanc
  • Nicholas Didkovsky
  • Chen Zheng
  • Martin L Doughty
  • Uta B Schambra
  • Alexandra Joyner
  • Margaret Cooper
  • Gunnar Dietz

Detail Information

Publications17

  1. pmc Development and cancer of the cerebellum
    Mary E Hatten
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065, USA
    Trends Neurosci 34:134-42. 2011
    ..A better understanding of the developmental origins of these tumors will have significant implications for enhancing the treatment of this important childhood cancer...
  2. pmc Gene expression profiling of preplate neurons destined for the subplate: genes involved in transcription, axon extension, neurotransmitter regulation, steroid hormone signaling, and neuronal survival
    Hilleary Osheroff
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065, USA
    Cereb Cortex 19:i126-34. 2009
    ..These experiments therefore reveal genetic markers, which identify subplate neurons from the earliest stages of their development, and genes with enriched expression in subplate neurons during early stages of corticogenesis...
  3. pmc WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation
    Sandrine L Anne
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 8:e81769. 2013
    ..Importantly, WNT3 inhibits proliferation of medulloblastoma tumor growth in mouse models by a similar mechanism. Thus, the present study suggests a novel role for WNT3 as a regulator of neurogenesis and repressor of neural tumors. ..
  4. pmc Multitasking on the run
    Mary E Hatten
    is at the Laboratory of Developmental Neurobiology, The Rockefeller University, New York, United States
    elife 2:e00641. 2013
    ..Researchers combine genetics and imaging to reveal that individual granule cells in the cerebellum integrate sensory and motor information...
  5. ncbi request reprint New directions in neuronal migration
    Mary E Hatten
    Laboratory of Developmental Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Science 297:1660-3. 2002
    ..This review discusses the choreography of these different migratory mechanisms within the context of genetic approaches that have defined their molecular mechanisms...
  6. ncbi request reprint Large-scale genomic approaches to brain development and circuitry
    Mary E Hatten
    Laboratory of Developmental Neurobiology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Annu Rev Neurosci 28:89-108. 2005
    ..In this review, we summarize current phenotype- and genotype-driven approaches to discover novel CNS-expressed genes, as well as current approaches to carry out large-scale, gene-expression screens in the CNS...
  7. pmc LIS-less neurons don't even make it to the starting gate
    Mary E Hatten
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10021, USA
    J Cell Biol 170:867-71. 2005
    ..Thus, the primary action of the mutation is to disrupt the production of neurons in the developing brain as well as their migration...
  8. ncbi request reprint A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
    Shiaoching Gong
    GENSAT Project, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 260, New York 10021, USA
    Nature 425:917-25. 2003
    ..The atlas, library of BAC vectors and BAC transgenic mice generated in this screen provide a rich resource that allows a broad array of investigations not previously available to the neuroscience community...
  9. pmc Astn2, a novel member of the astrotactin gene family, regulates the trafficking of ASTN1 during glial-guided neuronal migration
    Perrin M Wilson
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10065, USA
    J Neurosci 30:8529-40. 2010
    ..Together, these findings suggest that ASTN2 regulates the levels of ASTN1 in the plasma membrane and that the release of neuronal adhesions to the glial fiber during neuronal locomotion involves the intracellular trafficking of ASTN1...
  10. ncbi request reprint Molecular markers of neuronal progenitors in the embryonic cerebellar anlage
    Daniver Morales
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021 6399, USA
    J Neurosci 26:12226-36. 2006
    ..These results identify molecular pathways that offer new insights on the development of the nuclear and cortical structures of the cerebellum, as well as components of the cerebellar circuitry...
  11. ncbi request reprint Mice that lack astrotactin have slowed neuronal migration
    Niels C Adams
    Laboratory of Developmental Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Development 129:965-72. 2002
    ..Consequences of this are poorer balance and coordination. Thus, astrotactin functions in migration along glial processes in vivo, a process required for generating laminar structures and for the development of synaptic partner systems...
  12. pmc Role of Unc51.1 and its binding partners in CNS axon outgrowth
    Toshifumi Tomoda
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021 6399, USA
    Genes Dev 18:541-58. 2004
    ..Thus, our results demonstrate that the Unc51.1-containing protein complex governs axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons...
  13. ncbi request reprint Neuronal polarity in CNS development
    David J Solecki
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 20:2639-47. 2006
    ....
  14. ncbi request reprint Par6alpha signaling controls glial-guided neuronal migration
    David J Solecki
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021, USA
    Nat Neurosci 7:1195-203. 2004
    ..Thus, we propose that during neuronal migration the centrosome acts to coordinate cytoskeletal dynamics in response to mPar6alpha-mediated signaling...
  15. pmc Differentiation of ES cells into cerebellar neurons
    Enrique Salero
    Laboratory of Developmental Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 104:2997-3002. 2007
    ..These results underscore the utility of treating ES cells with local, inductive signals that regulate CNS neuronal development in vivo as a strategy for cell replacement therapy of defined neuronal populations...
  16. ncbi request reprint Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs
    Shiaoching Gong
    Gene Expression Nervous System Atlas Project, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 27:9817-23. 2007
  17. ncbi request reprint mPar6 alpha controls neuronal migration
    David J Solecki
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 26:10624-5. 2006
    ..Subsequently, mPar6alpha signaling controls the migration of immature granule neurons down the Bergmann glial fibers into the internal granule cell layer in which they establish synaptic connections...

Research Grants29

  1. GENETICS OF CEREBELLAR AXON FORMATION
    MARY HATTEN; Fiscal Year: 2000
    ..In the BAC transgenic animals we can examine the effect of kinase-deficient neurons on the development of the other cerebellar neurons and glia. ..
  2. MOLECULAR MECHANISMS OF GRANULE CELL MIGRATION
    MARY HATTEN; Fiscal Year: 2000
    ..Finally, being able to view the movements of granule cells in real time in situ will inform about the relationship between axon (parallel fiber) extension and the locomotion of the granule neuron down the Bergmann glial fiber. ..
  3. Embryonic Development of the Cerebellum
    MARY HATTEN; Fiscal Year: 2007
    ..abstract_text> ..
  4. GENETICS OF CEREBELLAR AXON FORMATION
    MARY HATTEN; Fiscal Year: 2001
    ..In the BAC transgenic animals we can examine the effect of kinase-deficient neurons on the development of the other cerebellar neurons and glia. ..
  5. Role of mPAR6 Polarity CNS Neuronal Migration
    MARY HATTEN; Fiscal Year: 2009
    ..Together, these experiments will provide novel information on the regulation of neuronal migration in cortical regions of developing brain. ..
  6. Embryonic Development of the Cerebellum
    MARY HATTEN; Fiscal Year: 2006
    ..abstract_text> ..
  7. MOLECULAR MECHANISMS OF GRANULE CELL MIGRATION
    MARY HATTEN; Fiscal Year: 2006
    ..This information should broaden our view of the mechanisms that control CNS migrations and of the downstream events important to neuronal differentiation within the neural layers. ..
  8. MOLECULAR MECHANISMS OF GRANULE CELL MIGRATION
    MARY HATTEN; Fiscal Year: 2005
    ..This information should broaden our view of the mechanisms that control CNS migrations and of the downstream events important to neuronal differentiation within the neural layers. ..
  9. Role of mPAR6 Polarity CNS Neuronal Migration
    MARY HATTEN; Fiscal Year: 2006
    ..Together, these experiments will provide novel information on the regulation of neuronal migration in cortical regions of developing brain. ..
  10. MOLECULAR MECHANISMS OF GRANULE CELL MIGRATION
    MARY HATTEN; Fiscal Year: 2007
    ..This information should broaden our view of the mechanisms that control CNS migrations and of the downstream events important to neuronal differentiation within the neural layers. ..
  11. Role of mPar6 Polarity in CNS Neuronal Migration
    MARY HATTEN; Fiscal Year: 2007
    ..Together, these experiments will provide novel information on the regulation of neuronal migration in cortical regions of developing brain. ..
  12. MOLECULAR MECHANISMS OF GRANULE CELL MIGRATION
    MARY HATTEN; Fiscal Year: 2004
    ..This information should broaden our view of the mechanisms that control CNS migrations and of the downstream events important to neuronal differentiation within the neural layers. ..
  13. GENETICS OF CEREBELLAR AXON FORMATION
    MARY HATTEN; Fiscal Year: 2004
    ..In the BAC transgenic animals we can examine the effect of kinase-deficient neurons on the development of the other cerebellar neurons and glia. ..
  14. MOLECULAR MECHANISMS OF GRANULE CELL MIGRATION
    MARY HATTEN; Fiscal Year: 1999
    ..Finally, being able to view the movements of granule cells in real time in situ will inform about the relationship between axon (parallel fiber) extension and the locomotion of the granule neuron down the Bergmann glial fiber. ..
  15. MOLECULAR MECHANISMS OF GRANULE CELL MIGRATION
    MARY HATTEN; Fiscal Year: 1993
    ....
  16. GENETICS OF CEREBELLAR AXON FORMATION
    MARY HATTEN; Fiscal Year: 2000
    ..In the BAC transgenic animals we can examine the effect of kinase-deficient neurons on the development of the other cerebellar neurons and glia. ..
  17. MOLECULAR MECHANISMS OF GRANULE CELL MIGRATION
    MARY HATTEN; Fiscal Year: 2001
    ..Finally, being able to view the movements of granule cells in real time in situ will inform about the relationship between axon (parallel fiber) extension and the locomotion of the granule neuron down the Bergmann glial fiber. ..
  18. MOLECULAR MECHANISMS OF GRANULE CELL MIGRATION
    MARY HATTEN; Fiscal Year: 2002
    ..Finally, being able to view the movements of granule cells in real time in situ will inform about the relationship between axon (parallel fiber) extension and the locomotion of the granule neuron down the Bergmann glial fiber. ..
  19. GENETICS OF CEREBELLAR AXON FORMATION
    MARY HATTEN; Fiscal Year: 2002
    ..In the BAC transgenic animals we can examine the effect of kinase-deficient neurons on the development of the other cerebellar neurons and glia. ..
  20. Embryonic Development of the Cerebellum
    MARY HATTEN; Fiscal Year: 2003
    ..abstract_text> ..
  21. GENETICS OF CEREBELLAR AXON FORMATION
    MARY HATTEN; Fiscal Year: 2003
    ..In the BAC transgenic animals we can examine the effect of kinase-deficient neurons on the development of the other cerebellar neurons and glia. ..
  22. Role of mPAR6 Polarity CNS Neuronal Migration
    MARY ELIZABETH HATTEN; Fiscal Year: 2010
    ..Together, these experiments will provide novel information on the regulation of neuronal migration in cortical regions of developing brain. ..