Research Topics
| MARY HATTENSummaryAffiliation: The Rockefeller University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Development and cancer of the cerebellumMary E Hatten
Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065, USA
Trends Neurosci 34:134-42. 2011..A better understanding of the developmental origins of these tumors will have significant implications for enhancing the treatment of this important childhood cancer...- Multitasking on the runMary E Hatten
is at the Laboratory of Developmental Neurobiology, The Rockefeller University, New York, United States
elife 2:e00641. 2013..Researchers combine genetics and imaging to reveal that individual granule cells in the cerebellum integrate sensory and motor information... 
New directions in neuronal migrationMary E Hatten
Laboratory of Developmental Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
Science 297:1660-3. 2002..This review discusses the choreography of these different migratory mechanisms within the context of genetic approaches that have defined their molecular mechanisms...- Large-scale genomic approaches to brain development and circuitryMary E Hatten
Laboratory of Developmental Neurobiology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
Annu Rev Neurosci 28:89-108. 2005..In this review, we summarize current phenotype- and genotype-driven approaches to discover novel CNS-expressed genes, as well as current approaches to carry out large-scale, gene-expression screens in the CNS... - LIS-less neurons don't even make it to the starting gateMary E Hatten
Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10021, USA
J Cell Biol 170:867-71. 2005..Thus, the primary action of the mutation is to disrupt the production of neurons in the developing brain as well as their migration... - A gene expression atlas of the central nervous system based on bacterial artificial chromosomesShiaoching Gong
GENSAT Project, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 260, New York 10021, USA
Nature 425:917-25. 2003..The atlas, library of BAC vectors and BAC transgenic mice generated in this screen provide a rich resource that allows a broad array of investigations not previously available to the neuroscience community... - Astn2, a novel member of the astrotactin gene family, regulates the trafficking of ASTN1 during glial-guided neuronal migrationPerrin M Wilson
Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10065, USA
J Neurosci 30:8529-40. 2010..Together, these findings suggest that ASTN2 regulates the levels of ASTN1 in the plasma membrane and that the release of neuronal adhesions to the glial fiber during neuronal locomotion involves the intracellular trafficking of ASTN1... - Molecular markers of neuronal progenitors in the embryonic cerebellar anlageDaniver Morales
Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021 6399, USA
J Neurosci 26:12226-36. 2006..These results identify molecular pathways that offer new insights on the development of the nuclear and cortical structures of the cerebellum, as well as components of the cerebellar circuitry... - Mice that lack astrotactin have slowed neuronal migrationNiels C Adams
Laboratory of Developmental Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
Development 129:965-72. 2002..Consequences of this are poorer balance and coordination. Thus, astrotactin functions in migration along glial processes in vivo, a process required for generating laminar structures and for the development of synaptic partner systems... - Role of Unc51.1 and its binding partners in CNS axon outgrowthToshifumi Tomoda
Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021 6399, USA
Genes Dev 18:541-58. 2004..Thus, our results demonstrate that the Unc51.1-containing protein complex governs axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons... - Neuronal polarity in CNS developmentDavid J Solecki
Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021, USA
Genes Dev 20:2639-47. 2006.... - Gene expression profiling of preplate neurons destined for the subplate: genes involved in transcription, axon extension, neurotransmitter regulation, steroid hormone signaling, and neuronal survivalHilleary Osheroff
Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065, USA
Cereb Cortex 19:i126-34. 2009..These experiments therefore reveal genetic markers, which identify subplate neurons from the earliest stages of their development, and genes with enriched expression in subplate neurons during early stages of corticogenesis... - Par6alpha signaling controls glial-guided neuronal migrationDavid J Solecki
Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021, USA
Nat Neurosci 7:1195-203. 2004..Thus, we propose that during neuronal migration the centrosome acts to coordinate cytoskeletal dynamics in response to mPar6alpha-mediated signaling... - Differentiation of ES cells into cerebellar neuronsEnrique Salero
Laboratory of Developmental Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
Proc Natl Acad Sci U S A 104:2997-3002. 2007..These results underscore the utility of treating ES cells with local, inductive signals that regulate CNS neuronal development in vivo as a strategy for cell replacement therapy of defined neuronal populations... - Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructsShiaoching Gong
Gene Expression Nervous System Atlas Project, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
J Neurosci 27:9817-23. 2007 - mPar6 alpha controls neuronal migrationDavid J Solecki
Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021, USA
J Neurosci 26:10624-5. 2006..Subsequently, mPar6alpha signaling controls the migration of immature granule neurons down the Bergmann glial fibers into the internal granule cell layer in which they establish synaptic connections...
Research Grants
- GENETICS OF CEREBELLAR AXON FORMATIONMARY HATTEN; Fiscal Year: 2004..In the BAC transgenic animals we can examine the effect of kinase-deficient neurons on the development of the other cerebellar neurons and glia. ..
- Embryonic Development of the CerebellumMARY HATTEN; Fiscal Year: 2006..abstract_text> ..
- Embryonic Development of the CerebellumMARY HATTEN; Fiscal Year: 2007..abstract_text> ..
- MOLECULAR MECHANISMS OF GRANULE CELL MIGRATIONMARY HATTEN; Fiscal Year: 2007..This information should broaden our view of the mechanisms that control CNS migrations and of the downstream events important to neuronal differentiation within the neural layers. ..
- Role of mPar6 Polarity in CNS Neuronal MigrationMARY HATTEN; Fiscal Year: 2007..Together, these experiments will provide novel information on the regulation of neuronal migration in cortical regions of developing brain. ..
- Embryonic Development of the CerebellumMARY HATTEN; Fiscal Year: 2003..abstract_text> ..
- MOLECULAR MECHANISMS OF GRANULE CELL MIGRATIONMARY HATTEN; Fiscal Year: 1993....
- MOLECULAR MECHANISMS OF GRANULE CELL MIGRATIONMARY HATTEN; Fiscal Year: 2002..Finally, being able to view the movements of granule cells in real time in situ will inform about the relationship between axon (parallel fiber) extension and the locomotion of the granule neuron down the Bergmann glial fiber. ..
- Role of mPAR6 Polarity CNS Neuronal MigrationMARY ELIZABETH HATTEN; Fiscal Year: 2010..Together, these experiments will provide novel information on the regulation of neuronal migration in cortical regions of developing brain. ..